Synthesis of new sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 17, 2008, Pages 7932-7938

  Cheng, Xian Chao ^a   Wang, Qiang ^a   Fang, Hao ^a   Tang, Wei ^b   Xu, Wen Fang ^a  

^a SHANDONG UNIVERSITY   (China)

^b University of Tokyo   (Japan)

Author keywords

IC50; MMP 2 inhibitors; Pyrrolidine derivatives; Synthesis

Indexed keywords

1 (TOLUENE 4 SULFONYL) 4 (TOLUENE 4 SULFONYLOXY)PYRROLIDINE 2 CARBOXYLIC ACID METHYL ESTER; 1 BENZENESULFONYL 4 BENZENESULFONYLOXYPYRROLIDINE 2 CARBOXYLIC ACID METHYL ESTER; 1 BENZENESULFONYL 4 HYDROXYPYRROLIDINE 2 CARBOXYLIC ACID HYDROXYAMIDE; 4 HYDROXY 1 (TOLUENE 4 SULFONYL)PYRROLIDINE 2 CARBOXYLIC ACID HYDROXYAMIDE; CGS 27023A; DOCKING PROTEIN; GELATINASE A; LY 52; MATRIX METALLOPROTEINASE INHIBITOR; MICROSOMAL AMINOPEPTIDASE; PRINOMASTAT; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG DETERMINATION; DRUG POTENCY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANTIGENS, CD13; BINDING SITES; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MATRIX METALLOPROTEINASE 2; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROTEASE INHIBITORS; PYRROLIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 50349090567     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.073     Document Type: Article

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