Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 24, 2006, Pages 8286-8294

  Zhang, Li ^a,b   Zhang, Jie ^a   Fang, Hao ^a   Wang, Qiang ^a   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

^b QINGDAO UNIVERSITY   (China)

Author keywords

Cinnamoyl pyrrolidine derivatives; IC50; MMPs inhibitors

Indexed keywords

CINNAMOYL PYRROLIDINE DERIVATIVE; GELATINASE A; GELATINASE B; GELATINASE INHIBITOR; HYDROXYPROLINE; METHYL 1 (CINNAMOYL 4 CINNAMOYLOXY)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 [3 (3,4 DIMETHOXYPHENYL)ACRYLOYL] 4 PROPIONYLOXYPYRROLIDINE 2 CARBOXYLATE; METHYL 1 [3 (4 METHOXYPHENYL)ACRYLOYL] 4 (3 PHENYLPROPANOYLOXY)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 [3 (4 METHOXYPHENYL)ACRYLOYL] 4 (3,4,5 TRIMETHOXYBENZOYLOXY) PYRROLIDINE 2 CARBOXYLATE; METHYL 1 [3 (4 METHOXYPHENYL)ACRYLOYL] 4 (PROPIONYLOXY)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 [3 (4 METHOXYPHENYL)ACRYLOYL] 4 [3 (4 METHOXYPHENYL)ACRYLOYLOXY] PYRROLIDINE 2 CARBOXYLATE; METHYL 1 CINNAMOYL 4 (3 PHENYLPROPANOYLOXY)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 CINNAMOYL 4 (3,4,5 TRIMETHOXYBENZOYLOXY)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 CINNAMOYL 4 (PROPIONYLOXY)PYRROLIDINE 2 CARBOXYLATE; METHYL 1 CINNAMOYL 4 [3 (3,4 DIMETHOXYPHENYL)ACRYLOYLOXY]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 CINNAMOYL 4 [3 (4 METHOXYPHENYL)ACRYLOYLOXY]PYRROLIDINE 2 CARBOXYLATE; METHYL 1 CINNAMOYL 4 HYDROXYPYRROLIDINE 2 CARBOXYLATE; METHYL 4 (4 CHLOROBENZOYLOXY) 1 [3 (4 METHOXYPHENYL)ACRYLOYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 4 (4 CHLOROBENZOYLOXY) 1 CINNAMOYLPYRROLIDINE 2 CARBOXYLATE; METHYL 4 (BUTYLOXY) 1 CINNAMOYLPYRROLIDINE 2 CARBOXYLATE; METHYL 4 (BUTYRYLOXY) 1 [3 (4 METHOXYPHENYL)ACRYLOYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 4 (CINNAMOYLOXY) 1 [3 (4 METHOXYPHENYL)ACRYLOYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 4 [3 (3,4 DIMETHOXYPHENYL)ACRYLOYLOXY] 1 [3 (4 METHOXYPHENYL) ACRYLOYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 4 ACETOXY 1 [3 (3,4 DIMETHOXYPHENYL)ACRYLOYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 4 ACETOXY 1 [3 (4 METHOXYPHENYL)ACRYLOYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 4 ACETOXY 1 CINNAMOYLPYRROLIDINE 2 CARBOXYLATE; METHYL 4 BUTYRYLOXY 1 [3 (3,4 DIMETHOXYPHENYL)ACRYLOYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 4 HYDROXY 1 [3 (4 METHOXYPHENYL)ACRYLOYL]PYRROLIDINE 2 CARBOXYLATE; METHYL 4 HYDROXYL 1 [3 (3,4 DIMETHOXYPHENYL)ACRYLOYL]PYRROLIDINE 2 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

CAFFEIC ACIDS; CINNAMATES; DRUG DESIGN; ENZYME INHIBITORS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MOLECULAR STRUCTURE; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRINITROBENZENESULFONIC ACID;

EID: 33750506919     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.09.015     Document Type: Article

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