Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1598, Issue 1-2, 2002, Pages 10-23

  Feng, Yiqing ^a   Likos, John J ^a   Zhu, Leiming ^a   Woodward, Harold ^a   Munie, Grace ^a   McDonald, Joseph J ^a   Stevens, Anna M ^a   Howard, Carol P ^a   De Crescenzo, Gary A ^a   Welsch, Dean ^a   Shieh, Huey Sheng ^a   Stallings, William C ^a  

^a PFIZER INC   (United States)

Author keywords

3D heteronuclear NMR; Catalytic domain; Gelatinase; Inhibitor complex; Matrix metalloproteinase; Solution structure

Indexed keywords

BLOCKING AGENT; FIBRONECTIN; GELATINASE A; HYDROXAMIX ACID INHIBITOR; SC 74020; UNCLASSIFIED DRUG; HYDROXAMIC ACID; NEUTROPHIL COLLAGENASE;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPARATIVE STUDY; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; MATHEMATICAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN FOLDING; ENZYME ACTIVITY; GEOMETRY; HUMAN; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; HUMANS; HYDROXAMIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MATRIX METALLOPROTEINASE 2; MODELS, MOLECULAR; PROTEASE INHIBITORS; PROTEIN CONFORMATION; SULFONAMIDES;

INSERTION SEQUENCES;

EID: 0037194445     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0167-4838(02)00307-2     Document Type: Article

References (56)