Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5398-5404

  Cheng, Xian Chao ^a   Wang, Qiang ^a   Fang, Hao ^a   Tang, Wei ^b   Xu, Wen Fang ^a  

^a SHANDONG UNIVERSITY   (China)

^b University of Tokyo   (Japan)

Author keywords

IC50; MMP 2 inhibitors; Sulfonyl pyrrolidine derivatives; Synthesis

Indexed keywords

2 (TOLUENE 4 SULFONYL) 6,10 DIOXA 2 AZASPIRO[4.5]DECANE 3 CARBOXYLIC ACID HYDROXYAMIDE; 2 (TOLUENE 4 SULFONYL) 6,11 DIOXA 2 AZASPIRO[4.6]UNDECANE 3 CARBOXYLIC ACID HYDROXYAMIDE; 7 (TOLUENE 4 SULFONYL) 1,4 DIOXA 7 AZASPIRO[4.4]NONANE 8 CARBOXYLIC ACID HYDROXYAMIDE; 7 BENZENESULFONYL 1,4 DIOXA 7 AZASPIRO[4.4]NONANE 8 CARBOXYLIC ACID HYDROXYAMIDE; CGS 27023A; GELATINASE A; GELATINASE INHIBITOR; LY 52; MATRIX METALLOPROTEINASE INHIBITOR; MICROSOMAL AMINOPEPTIDASE; PRINOMASTAT; PYRROLIDINE DERIVATIVE; SULFONYLPYRROLIDINE DERIVATIVE;

ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTIGENS, CD13; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; MATRIX METALLOPROTEINASE 2; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEASE INHIBITORS; PYRROLIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 43749091066     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.027     Document Type: Article

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