Design, synthesis, and activity of caffeoyl pyrrolidine derivatives as potential gelatinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 19, 2004, Pages 5171-5180

  Li, Ya Lin ^a   Xu, Wen Fang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Caffonyl pyrrolidine derivatives; IC 50; MMPs inhibitors

Indexed keywords

1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 2 CARBOMETHOXY 4 AZIDOPYRROLIDINE; 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 2 N HYDROXYAMIDE 4 (2 PHENYLETHANOYL)AMIDEPYRROLIDINE; 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 2 N HYDROXYAMIDE 4 (3 PHENYLPROPANOYL)AMIDEPYRROLIDINE; 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 2 N HYDROXYAMIDE 4 (3 PYRIDINYLCARBONYL)AMIDEPYRROLIDINE; 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 2 N HYDROXYAMIDE 4 [(4 METHYLPHENYL)SULFONYL]AMIDEPYRROLIDINE; 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 2 N HYDROXYAMIDE 4 [3 (4 METHOXY) 2 PROPENOYL]AMIDEPYRROLIDINE; 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 2 N HYDROXYAMIDE 4 PROPANOYLAMIDEPYRROLIDINE; 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 [(2 PHENYLETHANOYL)AMIDE] 2 PYRROLIDINECARBOXYLATE; 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 HEXANOYLAMIDE 2 N HYDROXYAMIDEPYRROLIDINE; 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 HYDROXY 2 N HYDROXYAMIDOPYRROLIDINE; 4 [1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 5 (CARBOMETHOXY)TETRAHYDRO 1H 3 PYRROLIDINE]AMIDE 4 OXOBUTANOIC ACID; 4 AMINE 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 2 PYRROLIDINECARBOXYLATE; GELATINASE INHIBITOR; METHYL 1 [3 (3 DIMETHOXYPHENYL) 2 PROPENOYL] 4 HYDROXY 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIACETYLOXYPHENYL) 2 PROPENOYL] 4 [(4 METHYLPHENYL) SULFONYL]OXY 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIACETYLOXYPHENYL) 2 PROPENOYL] 4 [(METHYLSULFONYL)OXY] 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIACETYLOXYPHENYL) 2 PROPENOYL] 4 HYDROXY 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIHYDROXYPHENYL) 2 PROPENOYL] 4 [(4 METHYLPHENYL)SULFONYL] OXY 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIHYDROXYPHENYL) 2 PROPENOYL] 4 [(METHYLSULFONYL)OXY] 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 (3,4,5 TRIACETYLOXYBENZOYL)OXY 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 [(2 PHENYLPROPANOYL)AMIDE] 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 [(3 PYRIDINYLCARBONYL) AMIDE] 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 [(4 METHYLPHENYL)SULFONYL] AMIDE 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 [(4 METHYLPHENYL)SULFONYL] OXY 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 [(METHYLSULFONYL)AMIDE] 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 [(METHYLSULFONYL)OXY] 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 [3 (4 METHOXY) 2 PROPENOYL]AMIDE 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 HEXANOYLAMIDE 2 PYRROLIDINECARBOXYLATE; METHYL 1 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 4 PROPANOYLAMIDE 2 PYRROLIDINECARBOXYLATE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; LUNG METASTASIS; MALE; METHYLATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; CAFFEIC ACIDS; CARCINOMA, EHRLICH TUMOR; DRUG DESIGN; GELATINASES; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED STRAINS; NEOPLASM METASTASIS; PROTEIN BINDING; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4444250592     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.07.025     Document Type: Article

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