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Volumn 24, Issue 10, 2009, Pages 1323-1341

Angiogenesis and liver fibrogenesis

Author keywords

Hepatic myofibroblasts; Hepatic stellate cells; Liver angiogenesis; Pro angiogenic cytokines; VEGF

Indexed keywords

ANIMAL; ANOXIA; BLOOD VESSEL; EXPERIMENTAL LIVER CIRRHOSIS; HUMAN; LIVER CIRRHOSIS; LIVER DISEASE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PATHOPHYSIOLOGY; REVIEW;

EID: 75349088284     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (66)

References (106)
  • 1
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and paltelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams T.J., Lee L.B., Murray L.J., Pryer N.K. and Cherrington J.M. (2003). SU11248 inhibits KIT and paltelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol. Cancer. Ther. 2, 471-478.
    • (2003) Mol. Cancer. Ther , vol.2 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3    Pryer, N.K.4    Cherrington, J.M.5
  • 4
    • 0037129380 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease
    • Angulo P. (2002). Non-alcoholic fatty liver disease. N. Engl. J. Med. 346, 1221-1231.
    • (2002) N. Engl. J. Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 6
    • 0033980284 scopus 로고    scopus 로고
    • Hypoxic stimulation of vascular endothelial growthfactor expression in activated rat hepatic stellate cells
    • Ankoma-Sey V., Wang Y. and Dai Z. (2000). Hypoxic stimulation of vascular endothelial growthfactor expression in activated rat hepatic stellate cells. Hepatology 31, 141-148.
    • (2000) Hepatology , vol.31 , pp. 141-148
    • Ankoma-Sey, V.1    Wang, Y.2    Dai, Z.3
  • 7
    • 25444463573 scopus 로고    scopus 로고
    • Endothelial/pericyte interactions
    • Armulik A., Abramsson A. and Betsholtz C. (2005). Endothelial/pericyte interactions. Circ. Res. 97, 512-523.
    • (2005) Circ. Res , vol.97 , pp. 512-523
    • Armulik, A.1    Abramsson, A.2    Betsholtz, C.3
  • 8
    • 0028785458 scopus 로고
    • Evidence that hypoxiamarkers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver
    • Arteel G.E., Thurman R.G., Yates J.M. and Raleigh J.A. (1995). Evidence that hypoxiamarkers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver. Br. J. Cancer 72, 889-895.
    • (1995) Br. J. Cancer , vol.72 , pp. 889-895
    • Arteel, G.E.1    Thurman, R.G.2    Yates, J.M.3    Raleigh, J.A.4
  • 9
    • 0030990409 scopus 로고    scopus 로고
    • Chronic enteralethanol treatment causes hypoxia in rat liver tissue in vivo
    • Arteel G.E., Imuro Y., Yin M., Raleigh J.A. and Thurman R.G. (1997). Chronic enteralethanol treatment causes hypoxia in rat liver tissue in vivo. Hepatology 25, 920-926.
    • (1997) Hepatology , vol.25 , pp. 920-926
    • Arteel, G.E.1    Imuro, Y.2    Yin, M.3    Raleigh, J.A.4    Thurman, R.G.5
  • 11
    • 0025734994 scopus 로고
    • Perisinusoidal stellate cells of the liver: Important roles in retinol metabolism and fibrosis
    • Blomhoff R. and Wake K. (1991). Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J. 5, 271-277.
    • (1991) FASEB J , vol.5 , pp. 271-277
    • Blomhoff, R.1    Wake, K.2
  • 12
    • 34447106967 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha expression in experimental cirrhosis: Correlation with vascular endothelial growth factor expression and angiogenesis
    • Bozova S. and Elpek G.O. (2007). Hypoxia-inducible factor-1alpha expression in experimental cirrhosis: correlation with vascular endothelial growth factor expression and angiogenesis. APMIS 115, 795-801.
    • (2007) APMIS , vol.115 , pp. 795-801
    • Bozova, S.1    Elpek, G.O.2
  • 16
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. (2003). Angiogenesis in health and disease. Nat. Med. 9, 653-660.
    • (2003) Nat. Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 17
    • 2042535361 scopus 로고    scopus 로고
    • Manipulating angiogenesis in medicine
    • Carmeliet P. (2004). Manipulating angiogenesis in medicine. J Intern. Med. 255, 538-561.
    • (2004) J Intern. Med , vol.255 , pp. 538-561
    • Carmeliet, P.1
  • 18
    • 0036234428 scopus 로고    scopus 로고
    • Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis
    • Corpechot C., Barbu V., Wendum D., Kinnman N., Rey C., Poupon R., Housset C. and Rosmorduc O. (2002a). Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology 35, 1010-1021.
    • (2002) Hepatology , vol.35 , pp. 1010-1021
    • Corpechot, C.1    Barbu, V.2    Wendum, D.3    Kinnman, N.4    Rey, C.5    Poupon, R.6    Housset, C.7    Rosmorduc, O.8
  • 19
    • 0036168357 scopus 로고    scopus 로고
    • Hepatocyte growth factor and c-Met inhibition by hepatic cell hypoxia: A potential mechanism for liver regeneration failure in experimental cirrhosis
    • Corpechot C., Barbu V., Wendum D., Chignard N., Housset C., PouponR. and Rosmorduc O. (2002b). Hepatocyte growth factor and c-Met inhibition by hepatic cell hypoxia: a potential mechanism for liver regeneration failure in experimental cirrhosis. Am. J. Pathol. 160, 613-620.
    • Am. J. Pathol , vol.160 , pp. 613-620
    • Corpechot, C.1    Barbu, V.2    Wendum, D.3    Chignard, N.4    Housset, C.5    Poupon, R.6    Rosmorduc, O.7
  • 20
    • 33845323729 scopus 로고    scopus 로고
    • Sunitinib
    • Deeks E.D. and Keating G.M. (2006). Sunitinib. Drugs 66, 2255-2266.
    • (2006) Drugs , vol.66 , pp. 2255-2266
    • Deeks, E.D.1    Keating, G.M.2
  • 22
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • Dewhirst M.W., Cao Y. and Moeller B. (2008). Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nature Rev. Cancer 8, 424-438.
    • (2008) Nature. Rev. Cancer , vol.8 , pp. 424-438
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 24
    • 0035195887 scopus 로고    scopus 로고
    • Leptin regulation of the immune response and the immunodeficiency of malnutrition
    • Faggioni R., Feingold K.R. and Grunfeld C. (2001). Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J. 15, 2565-2571.
    • (2001) FASEB J , vol.15 , pp. 2565-2571
    • Faggioni, R.1    Feingold, K.R.2    Grunfeld, C.3
  • 25
    • 1542347683 scopus 로고    scopus 로고
    • Anti-VEGF receptor-2 monoclonal antibody prevents portalsystemic collateral vessel formation in portal hypertensive mice
    • Fernandez M., Vizzutti F., Garcia-Pagan J.C., Rodes J. and Bosch J. (2004). Anti-VEGF receptor-2 monoclonal antibody prevents portalsystemic collateral vessel formation in portal hypertensive mice. Gastroenterology 126, 886-894
    • (2004) Gastroenterology , vol.126 , pp. 886-894
    • Fernandez, M.1    Vizzutti, F.2    Garcia-Pagan, J.C.3    Rodes, J.4    Bosch, J.5
  • 26
    • 20444367984 scopus 로고    scopus 로고
    • Inhibition of VEGF receptor-2 decreases the development hyperdynamic splanchnic circulation and portalsystemic collateral vessels in portal hypertensive rats
    • Fernandez M., Mejias M., Angermayr B., Garcia-Pagan J.C., Rodes J. and Bosch J. (2005). Inhibition of VEGF receptor-2 decreases the development hyperdynamic splanchnic circulation and portalsystemic collateral vessels in portal hypertensive rats. J. Hepatol. 43, 98-103.
    • (2005) J. Hepatol , vol.43 , pp. 98-103
    • Fernandez, M.1    Mejias, M.2    Angermayr, B.3    Garcia-Pagan, J.C.4    Rodes, J.5    Bosch, J.6
  • 27
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., Gerber H. and LeCouter J. (2003). The biology of VEGF and its receptors. Nat. Med. 9, 669-676.
    • (2003) Nat. Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.2    Lecouter, J.3
  • 28
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis: From bench to bedside
    • Friedman S.L. (2003). Liver fibrosis: from bench to bedside. J. Hepatol. 38 (Suppl. 1), S38-S53.
    • (2003) J. Hepatol , vol.38 , Issue.SUPPL. 1
    • Friedman, S.L.1
  • 29
    • 15244356690 scopus 로고    scopus 로고
    • Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications
    • Friedman S.L. (2004). Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications. Nat. Clin. Pract. Gastroenterol. Hepatol. 1, 98-105.
    • (2004) Nat. Clin. Pract. Gastroenterol. Hepatol , vol.1 , pp. 98-105
    • Friedman, S.L.1
  • 30
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • Friedman S.L. (2008a). Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol. Rev. 88, 125-172.
    • (2008) Physiol. Rev , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 31
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman S.L. (2008b). Mechanisms of hepatic fibrogenesis. Gastroenterology 134, 1655-1669.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 34
    • 0034808310 scopus 로고    scopus 로고
    • History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells
    • Geerts A. (2001). History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Sem. Liver Dis. 21, 311-335.
    • (2001) Sem. Liver Dis , vol.21 , pp. 311-335
    • Geerts, A.1
  • 38
    • 0036288668 scopus 로고    scopus 로고
    • Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver
    • Honda H., Ikejima K., Hirose M., Yoshikawa M., Lang T., Enomoto N. and Sato N. (2002). Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver. Hepatology 36, 12-21.
    • (2002) Hepatology , vol.36 , pp. 12-21
    • Honda, H.1    Ikejima, K.2    Hirose, M.3    Yoshikawa, M.4    Lang, T.5    Enomoto, N.6    Sato, N.7
  • 39
    • 0034198919 scopus 로고    scopus 로고
    • Leptin: A multifunctional hormone
    • Huang L. and Li C. (2000). Leptin: a multifunctional hormone. Cell. Res. 10, 81-92.
    • (2000) Cell. Res , vol.10 , pp. 81-92
    • Huang, L.1    Li, C.2
  • 40
    • 0031891667 scopus 로고    scopus 로고
    • Suppressive effect of the angiogenesis inhibitor TNP-470 on the development of carcinogen-induced hepatic nodules in rats
    • Ikebe T., Yamamoto T., Kubo S., Hirohashi K., Kinoshita H., Kaneda K. and Sakurai M. (1998). Suppressive effect of the angiogenesis inhibitor TNP-470 on the development of carcinogen-induced hepatic nodules in rats. Jpn. J. Cancer Res. 89, 143-149.
    • (1998) Jpn. J. Cancer Res , vol.89 , pp. 143-149
    • Ikebe, T.1    Yamamoto, T.2    Kubo, S.3    Hirohashi, K.4    Kinoshita, H.5    Kaneda, K.6    Sakurai, M.7
  • 41
    • 0030863065 scopus 로고    scopus 로고
    • Expression of platelet-derived growth factor and its receptor in livers of patients with chronic liver disease
    • Ikura Y., Morimoto H., Ogami M., Jomura H., Ikeoka N. and Sakurai M. (1997). Expression of platelet-derived growth factor and its receptor in livers of patients with chronic liver disease. J. Gastroenterol. 32, 496-501.
    • (1997) J. Gastroenterol , vol.32 , pp. 496-501
    • Ikura, Y.1    Morimoto, H.2    Ogami, M.3    Jomura, H.4    Ikeoka, N.5    Sakurai, M.6
  • 42
  • 44
    • 0036252855 scopus 로고    scopus 로고
    • Matrix metalloproteinases and angiogenesis
    • Jackson C. (2002). Matrix metalloproteinases and angiogenesis. Curr. Opin. Nephrol. Hypertens. 11, 295-299.
    • (2002) Curr. Opin. Nephrol. Hypertens , vol.11 , pp. 295-299
    • Jackson, C.1
  • 46
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain R.K. (2003). Molecular regulation of vessel maturation. Nat. Med. 9, 685-693.
    • (2003) Nat. Med , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 47
    • 43249095919 scopus 로고    scopus 로고
    • Tumour angiogenesis
    • Kerbel R.S. (2008). Tumour angiogenesis. New Engl. J. Med. 358, 2039-2050.
    • (2008) New Engl. J. Med , vol.358 , pp. 2039-2050
    • Kerbel, R.S.1
  • 49
    • 0029793998 scopus 로고    scopus 로고
    • The fumagillin analogue TNP-470 inhibits DNA synthesis of vascular smooth muscle cells stimulated by plateletderived growth factor and insulin-like growth factor-I. Possible involvment of cyclin-dependent kinase 2
    • Koyama H., Nishizawa Y., Hosoi M., Fukumoto S., Kogawa K., Shioi A. and Morii H. (1996). The fumagillin analogue TNP-470 inhibits DNA synthesis of vascular smooth muscle cells stimulated by plateletderived growth factor and insulin-like growth factor-I. Possible involvment of cyclin-dependent kinase 2. Circ. Res. 79, 757-764.
    • (1996) Circ. Res , vol.79 , pp. 757-764
    • Koyama, H.1    Nishizawa, Y.2    Hosoi, M.3    Fukumoto, S.4    Kogawa, K.5    Shioi, A.6    Morii, H.7
  • 51
    • 0035821645 scopus 로고    scopus 로고
    • The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner
    • Lara-Pezzi E., Roche S., Andrisani O.M., Sánchez-Madrid F. and López-Cabrera M. (2001). The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner. Oncogene 20, 3323-3331.
    • (2001) Oncogene , vol.20 , pp. 3323-3331
    • Lara-Pezzi, E.1    Roche, S.2    Andrisani, O.M.3    Sánchez-Madrid, F.4    López-Cabrera, M.5
  • 53
    • 0036022846 scopus 로고    scopus 로고
    • Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    • Leclercq I.A., Farrel G.C., Schriemer R. and Robertson G.R. (2002). Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J. Hepatol. 37, 206-213.
    • (2002) J. Hepatol , vol.37 , pp. 206-213
    • Leclercq, I.A.1    Farrel, G.C.2    Schriemer, R.3    Robertson, G.R.4
  • 54
    • 33947414087 scopus 로고    scopus 로고
    • Sinusoidal remodeling and angiogenesis: A new function for the liver specific pericyte?
    • Lee S.J., Semela D., Iredale J. and Shah V.H. (2007). Sinusoidal remodeling and angiogenesis: a new function for the liver specific pericyte? Hepatology 45, 817-825.
    • (2007) Hepatology , vol.45 , pp. 817-825
    • Lee, S.J.1    Semela, D.2    Iredale, J.3    Shah, V.H.4
  • 55
    • 0034277167 scopus 로고    scopus 로고
    • The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia and stroke: Insights from genetic studies
    • Luttun A., Dewerchin M., Collen D. and Carmeliet P. (2000). The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia and stroke: insights from genetic studies, Curr. Atheroscler. Rep. 2, 407-416.
    • (2000) Curr. Atheroscler. Rep , vol.2 , pp. 407-416
    • Luttun, A.1    Dewerchin, M.2    Collen, D.3    Carmeliet, P.4
  • 56
    • 0035184889 scopus 로고    scopus 로고
    • Hepatitis B virus X protein transactivates inducible nitric oxide synthase gene promoter through the proximal nuclear factor kappaB-binding site: Evidence that cytoplasmic location of X protein is essential for gene transactivation
    • Majano P., Lara-Pezzi E., López-Cabrera M., Apolinario A., Moreno-Otero R. and García-Monzón C. (2001). Hepatitis B virus X protein transactivates inducible nitric oxide synthase gene promoter through the proximal nuclear factor kappaB-binding site: evidence that cytoplasmic location of X protein is essential for gene transactivation. Hepatology 34, 1218-1224.
    • (2001) Hepatology , vol.34 , pp. 1218-1224
    • Majano, P.1    Lara-Pezzi, E.2    López-Cabrera, M.3    Apolinario, A.4    Moreno-Otero, R.5    García-Monzón, C.6
  • 57
    • 0036240891 scopus 로고    scopus 로고
    • Leptin and liver fibrosis: A matter of fat
    • Marra F. (2002). Leptin and liver fibrosis: a matter of fat. Gastroenterology 122, 1529-1532.
    • (2002) Gastroenterology , vol.122 , pp. 1529-1532
    • Marra, F.1
  • 58
    • 0033583773 scopus 로고    scopus 로고
    • Inhibition of hepatic stellate cell contraction during activation in vitro by vascular endothelial growth factor in association with upregulation of FLT tyrosine kinase receptor family, FLT-1
    • Mashiba S., Mochida S., Ishikawa K., Inao M., Matsui A., Ohno A., Ikeda H., Nagoshi S., Shibuya M. and Fujiwara K. (1999). Inhibition of hepatic stellate cell contraction during activation in vitro by vascular endothelial growth factor in association with upregulation of FLT tyrosine kinase receptor family, FLT-1. Biochem. Biophys. Res. Commun. 258, 674-678.
    • (1999) Biochem. Biophys. Res. Commun , vol.258 , pp. 674-678
    • Mashiba, S.1    Mochida, S.2    Ishikawa, K.3    Inao, M.4    Matsui, A.5    Ohno, A.6    Ikeda, H.7    Nagoshi, S.8    Shibuya, M.9    Fujiwara, K.10
  • 59
    • 0032755278 scopus 로고    scopus 로고
    • Peribiliary capillary plexus around interlobular bile ducts in various chronic liver diseases: An immunohistochemical and morphometric study
    • Matsunaga Y, Terada T. (1999). Peribiliary capillary plexus around interlobular bile ducts in various chronic liver diseases: an immunohistochemical and morphometric study. Pathol. Int. 49, 869-873.
    • (1999) Pathol. Int , vol.49 , pp. 869-873
    • Matsunaga, Y.1    Terada, T.2
  • 62
    • 0346555901 scopus 로고    scopus 로고
    • Review article: Immunopathogenetic and therapeutic aspects of autoimmune hepatitis
    • Medina J., García-Buey L. and Moreno-Otero R. (2003b). Review article: immunopathogenetic and therapeutic aspects of autoimmune hepatitis. Aliment. Pharmacol. Ther. 17, 1-16.
    • (2003) Aliment. Pharmacol. Ther , vol.17 , pp. 1-16
    • Medina, J.1    García-Buey, L.2    Moreno-Otero, R.3
  • 66
    • 28844464923 scopus 로고    scopus 로고
    • Neovascularization, angiogenesis, and vascular remodeling in portal hypertension
    • Sanyal A.J. and Shah V.H. (eds). Humana Press. Totowa (NJ)
    • Morales-Ruiz M. and Jimenez W. (2005). Neovascularization, angiogenesis, and vascular remodeling in portal hypertension. In: Portal hypertension: pathobiology, evaluation and treatment. Sanyal A.J. and Shah V.H. (eds). Humana Press. Totowa (NJ). pp 99-112.
    • (2005) Portal Hypertension: Pathobiology, Evaluation and Treatment , pp. 99-112
    • Morales-Ruiz, M.1    Jimenez, W.2
  • 68
    • 69949160564 scopus 로고    scopus 로고
    • Redox mechanisms in hepatic chronic wound healing and liver fibrogenesis
    • Novo E. and Parola M. (2008). Redox mechanisms in hepatic chronic wound healing and liver fibrogenesis. Fibrogenesis Tissue Repair 1, 5.
    • (2008) Fibrogenesis Tissue Repair , vol.1 , pp. 5
    • Novo, E.1    Parola, M.2
  • 70
    • 84862065631 scopus 로고    scopus 로고
    • Intracellular redox changes and C-jun N-terminal kinase activation as crucial events in cytokineinduced chemotaxis of human activated hepatic stellate cells
    • S184 abstract 484
    • Novo E., Valfrè di Bonzo L.V., Bertolani C., Povero D., Busletta C., Cannito S., Zamara E., Compagnone A., Colombatto S., Marra F., Pinzani M. and Parola M. (2008b). Intracellular redox changes and C-jun N-terminal kinase activation as crucial events in cytokineinduced chemotaxis of human activated hepatic stellate cells. J. Hepatol. 48 (Suppl.2), S184 abstract 484.
    • (2008) J. Hepatol , vol.48 , Issue.SUPPL. 2
    • Novo, E.1    di Bonzo, V.L.V.2    Bertolani, C.3    Povero, D.4    Busletta, C.5    Cannito, S.6    Zamara, E.7    Compagnone, A.8    Colombatto, S.9    Marra, F.10    Pinzani, M.11    Parola, M.12
  • 71
    • 0031012852 scopus 로고    scopus 로고
    • Induction of hepatocyte growth factor activator messenger RNA in the liver following tissue injury and acute inflammation
    • Okajima A., Miyazawa K., Naitoh Y., Inoue K. and Kitamura N. (1997). Induction of hepatocyte growth factor activator messenger RNA in the liver following tissue injury and acute inflammation. Hepatology 25, 97-102.
    • (1997) Hepatology , vol.25 , pp. 97-102
    • Okajima, A.1    Miyazawa, K.2    Naitoh, Y.3    Inoue, K.4    Kitamura, N.5
  • 72
    • 0033065805 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: An immunohistochemical study
    • Okano J., Shiota G. and Kawasaki H. (1999). Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: an immunohistochemical study. Liver 19, 151-159.
    • (1999) Liver , vol.19 , pp. 151-159
    • Okano, J.1    Shiota, G.2    Kawasaki, H.3
  • 74
    • 34247863931 scopus 로고    scopus 로고
    • Abnormal lipid and glucose metabolism in obesity: Implications for non-alcoholic fatty liver disease
    • Parekh S. and Anania F.A. (2007) Abnormal lipid and glucose metabolism in obesity: implications for non-alcoholic fatty liver disease. Gastroenterology 132, 2191-207.
    • (2007) Gastroenterology , vol.132 , pp. 2191-2207
    • Parekh, S.1    Anania, F.A.2
  • 75
    • 0034869459 scopus 로고    scopus 로고
    • Oxidative stress-related molecules and liver fibrosis
    • Parola M. and Robino G. (2001). Oxidative stress-related molecules and liver fibrosis. J. Hepatol. 35, 297-306.
    • (2001) J. Hepatol , vol.35 , pp. 297-306
    • Parola, M.1    Robino, G.2
  • 76
    • 39749170639 scopus 로고    scopus 로고
    • Myofibroblast-like cells and liver fibrogenesis: Emerging concepts in a rapidly moving scenario
    • Parola M., Marra F. and Pinzani M. (2008). Myofibroblast-like cells and liver fibrogenesis: emerging concepts in a rapidly moving scenario. Mol. Asp. Med. 29, 58-66.
    • (2008) Mol. Asp. Med , vol.29 , pp. 58-66
    • Parola, M.1    Marra, F.2    Pinzani, M.3
  • 77
    • 0034810089 scopus 로고    scopus 로고
    • Cytokine receptor and signalling in hepatic stellate cells
    • Pinzani M. and Marra F. (2001). Cytokine receptor and signalling in hepatic stellate cells. Sem. Liv. Dis. 21, 397-417.
    • (2001) Sem. Liv. Dis , vol.21 , pp. 397-417
    • Pinzani, M.1    Marra, F.2
  • 78
    • 3543098600 scopus 로고    scopus 로고
    • Liver fibrosis-from the bench to clinical targets
    • Pinzani M. and Rombouts K. (2004). Liver fibrosis-from the bench to clinical targets. Dig. Liver Dis. 36, 231-242.
    • (2004) Dig. Liver Dis , vol.36 , pp. 231-242
    • Pinzani, M.1    Rombouts, K.2
  • 79
    • 0024840085 scopus 로고
    • Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells
    • Pinzani M., Gesualdo L., Sabbah G.M. and Abboud H.E. (1989). Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J. Clin. Invest. 84, 1786-1793.
    • (1989) J. Clin. Invest , vol.84 , pp. 1786-1793
    • Pinzani, M.1    Gesualdo, L.2    Sabbah, G.M.3    Abboud, H.E.4
  • 80
    • 0026775513 scopus 로고
    • Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients
    • Pinzani M., Failli P., Ruocco C., Casini A., Milani S., Baldi E., Giotti A. and Gentilini P. (1992). Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients. J. Clin. Invest. 90, 642-646.
    • (1992) J. Clin. Invest , vol.90 , pp. 642-646
    • Pinzani, M.1    Failli, P.2    Ruocco, C.3    Casini, A.4    Milani, S.5    Baldi, E.6    Giotti, A.7    Gentilini, P.8
  • 82
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh C.W. and Ratcliffe P. (2003). Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9, 677-684.
    • (2003) Nat. Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.2
  • 83
    • 40949142209 scopus 로고    scopus 로고
    • The role of hypoxia inducible factors in tumorigenesis
    • Rankin E.B. and Giaccia A.J. (2008). The role of hypoxia inducible factors in tumorigenesis. Cell Death Different. 15, 678-685.
    • (2008) Cell Death Different , vol.15 , pp. 678-685
    • Rankin, E.B.1    Giaccia, A.J.2
  • 84
    • 0034804406 scopus 로고    scopus 로고
    • Hepatic blood flow regulation by stellate cells in normal and injured liver
    • Rockey D.C. (2001). Hepatic blood flow regulation by stellate cells in normal and injured liver. Sem. Liver Dis. 21, 337-349.
    • (2001) Sem. Liver Dis , vol.21 , pp. 337-349
    • Rockey, D.C.1
  • 85
    • 0032857478 scopus 로고    scopus 로고
    • Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary fibrosis
    • Rosmorduc O., Wendum D., Corpechot C., Galy B., Sebbagh N., Raleigh J., Housset C. and Poupon R. (1999). Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary fibrosis. Am. J. Pathol. 155, 1065-1073.
    • (1999) Am. J. Pathol , vol.155 , pp. 1065-1073
    • Rosmorduc, O.1    Wendum, D.2    Corpechot, C.3    Galy, B.4    Sebbagh, N.5    Raleigh, J.6    Housset, C.7    Poupon, R.8
  • 87
    • 0036204924 scopus 로고    scopus 로고
    • Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice
    • Saxena N.K., Ikeda K., Rockey D.C., Friedman S.L. and Anania F.A. (2002). Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 35, 762-771.
    • (2002) Hepatology , vol.35 , pp. 762-771
    • Saxena, N.K.1    Ikeda, K.2    Rockey, D.C.3    Friedman, S.L.4    Anania, F.A.5
  • 88
    • 48549088729 scopus 로고    scopus 로고
    • Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function
    • Semela D., Das A., Langer D., Kang N., Leof E. and Shah V. (2008). Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function. Gastroenterology 135, 671-679.
    • (2008) Gastroenterology , vol.135 , pp. 671-679
    • Semela, D.1    Das, A.2    Langer, D.3    Kang, N.4    Leof, E.5    Shah, V.6
  • 89
    • 0034901463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
    • Semenza G.L. (2001). Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol. Med. 7, 345-350.
    • (2001) Trend. Mol. Med , vol.7 , pp. 345-350
    • Semenza, G.L.1
  • 90
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • Semenza G.L. (2004). Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology 19, 176-182.
    • (2004) Physiology , vol.19 , pp. 176-182
    • Semenza, G.L.1
  • 91
    • 0033071015 scopus 로고    scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor mRNA expression in patients with chronic hepatitis C and hepatocellular carcinoma
    • Shimoda K., Mori M., Shibuta K., Banner B.F. and Barnard GF. (1999). Vascular endothelial growth factor/vascular permeability factor mRNA expression in patients with chronic hepatitis C and hepatocellular carcinoma. Int. J. Oncol. 14, 353-359.
    • (1999) Int. J. Oncol , vol.14 , pp. 353-359
    • Shimoda, K.1    Mori, M.2    Shibuta, K.3    Banner, B.F.4    Barnard, G.F.5
  • 92
    • 0029820167 scopus 로고    scopus 로고
    • Inhibition of liver metastasis of human gastric carcinoma by angiogenesis inhibitor TNP-470
    • Shishido T., Yasoshima T., Denno R., Sato N. and Hirata K. (1996). Inhibition of liver metastasis of human gastric carcinoma by angiogenesis inhibitor TNP-470. Jpn. J. Cancer Res. 87, 958-962.
    • (1996) Jpn. J. Cancer Res , vol.87 , pp. 958-962
    • Shishido, T.1    Yasoshima, T.2    Denno, R.3    Sato, N.4    Hirata, K.5
  • 93
    • 1442305186 scopus 로고    scopus 로고
    • Emerging roles of targeted small molecule proteine-tyrosine kinase inhibitors in cancer therapy
    • Smith J.K., Mamoon M.N. and Duhe R.J. (2004). Emerging roles of targeted small molecule proteine-tyrosine kinase inhibitors in cancer therapy. Oncol. Res. 14, 175-225.
    • (2004) Oncol. Res , vol.14 , pp. 175-225
    • Smith, J.K.1    Mamoon, M.N.2    Duhe, R.J.3
  • 96
    • 33748111665 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance
    • Tilg H. and Hotamisligil G.S. (2006). Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 131, 934-945.
    • (2006) Gastroenterology , vol.131 , pp. 934-945
    • Tilg, H.1    Hotamisligil, G.S.2
  • 98
    • 0032477844 scopus 로고    scopus 로고
    • Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: The case for paracrine amplification of angiogenesis
    • Van Belle E., Witzenbichler B., Chen D., Silver M., Chang L., Schwall R. and Isner J.M. (1998). Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of angiogenesis. Circulation 97, 381-390.
    • (1998) Circulation , vol.97 , pp. 381-390
    • van Belle, E.1    Witzenbichler, B.2    Chen, D.3    Silver, M.4    Chang, L.5    Schwall, R.6    Isner, J.M.7
  • 99
    • 0035677961 scopus 로고    scopus 로고
    • Treatment resistance of solid tumours. Role of hypoxia and anemia
    • Vaupel P., Thews O. and Hoeckel M. (2001). Treatment resistance of solid tumours. Role of hypoxia and anemia. Med. Oncol. 18, 243-259.
    • (2001) Med. Oncol , vol.18 , pp. 243-259
    • Vaupel, P.1    Thews, O.2    Hoeckel, M.3
  • 100
    • 0033765497 scopus 로고    scopus 로고
    • Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in rats
    • Wang Y.Q., Ikeda K., Ikebe T., Hirakawa K., Sowa M., Nakatani K., Kawada N. and Kaneda K. (2000). Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in rats. Hepatology 32, 980-989.
    • (2000) Hepatology , vol.32 , pp. 980-989
    • Wang, Y.Q.1    Ikeda, K.2    Ikebe, T.3    Hirakawa, K.4    Sowa, M.5    Nakatani, K.6    Kawada, N.7    Kaneda, K.8
  • 101
  • 102
    • 0030752474 scopus 로고    scopus 로고
    • Peribiliary vascular plexus in primary sclerosing cholangitis and primary biliary cirrhosis
    • Washington K., Clavien P.A. and Killenberg P. (1997). Peribiliary vascular plexus in primary sclerosing cholangitis and primary biliary cirrhosis. Human Pathol. 28, 791-795.
    • (1997) Human Pathol , vol.28 , pp. 791-795
    • Washington, K.1    Clavien, P.A.2    Killenberg, P.3
  • 104
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity of endotoxin liver injury: Implication for the pathogenesis of steatohepatitis
    • Yang S.Q., Lin H.Z., Lane M.D., Clemens M. and Diehl A.M. (1997). Obesity increases sensitivity of endotoxin liver injury: implication for the pathogenesis of steatohepatitis. Procl. Natl. Acad. Sci. USA 94, 2557-2562.
    • (1997) Procl. Natl. Acad. Sci. USA , vol.94 , pp. 2557-2562
    • Yang, S.Q.1    Lin, H.Z.2    Lane, M.D.3    Clemens, M.4    Diehl, A.M.5
  • 105
    • 0033955026 scopus 로고    scopus 로고
    • Immunohistochemical analysis of cellmatrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis
    • Yasoshima M., Tsuneyama K., Harada K., Sasaki M., Gershwin M.E. and Nakanuma Y. (2000). Immunohistochemical analysis of cellmatrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis. J. Pathol. 190, 93-99.
    • (2000) J. Pathol , vol.190 , pp. 93-99
    • Yasoshima, M.1    Tsuneyama, K.2    Harada, K.3    Sasaki, M.4    Gershwin, M.E.5    Nakanuma, Y.6


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