Suppressive effect of the angiogenesis inhibitor TNP-470 on the development of carcinogen-induced hepatic nodules in rats

Japanese Journal of Cancer Research

Volumn 89, Issue 2, 1998, Pages 143-149

  Ikebe, Takashi ^a   Yamamoto, Takatsugu ^a   Kubo, Shoji ^a   Hirohashi, Kazuhiro ^a   Kinoshita, Hiroaki ^a   Kaneda, Kenji ^a   Sakurai, Masami ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiogenesis; Capillarization; Hepatocarcinogenesis; Liver; TNP 470

Indexed keywords

ANGIOGENESIS INHIBITOR; BLOOD CLOTTING FACTOR 8; CARCINOGEN; FUMAGILLOL CHLOROACETYLCARBAMATE; INK; N (2 FLUORENYL)ACETAMIDE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER NODULE; LIVER RESECTION; MALE; METASTASIS; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031891667     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1998.tb00542.x     Document Type: Article

References (33)

1. Arakawa, M., Kage, M., Sugihara, S., Nakashima, T., Suenaga, M. and Okuda, K. Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver. Gastroenterology, 91, 198-208 (1986).
2. Kenmochi, K., Sugihara, S. and Kojiro, M. Relationship of histologic grade of hepatocellular carcinoma (HCC) to tumor size, and demonstration of tumor cells of multiple different grades in single small HCC. Liver, 7, 18-26 (1987).
3. Sakurai, M., Wakasa, K., Monden, M., Yamada, T., Kuroda, C., Marukawa, T. and Okamura, J. Hepatocellular carcinoma in adenomatous hyperplasia of the liver. Cancer Chemother. Pharmacol., 23, 110-113 (1989).
4. Takayama, T., Makuuchi, M., Hirohasi, S., Sakamoto, M., Okazaki, N., Takayasu, K., Kosuge, T., Motoo, Y., Yamazaki, S. and Hasegawa, H. Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet, 336, 1150-1153 (1990).
5. Sakamoto, M., Hirohashi, S. and Shimosato, Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum. Pathol., 22, 172-178 (1991).
6. Okita, K., Yamashita, A. and Kurokawa, F. Multistep hepatocarcinogenesis in man. Gastroenterol. Surg., 16, 23-31 (1993).
7. Breedis, C. and Young, G. The blood supply of neoplasms in the liver. Am. J. Pathol., 30, 969-985 (1954).
8. Sonoda, T., Shirabe, K., Takenaka, K., Kanematsu, T., Yasumori, K. and Sugimachi, K. Angiographically undetected small hepatocellular carcinoma: clinicopathological characteristics, follow-up and treatment. Hepatology, 10, 1103-1107 (1989).
9. Yamamoto, T., Ikebe, T., Mikami, S., Shuto, T., Hirohashi, K., Kinoshita, H. and Sakurai, M. Immunohistochemistry and angiography in adenomatous hyperplasia and small hepatocellular carcinomas. Pathol. Int., 46, 364-371 (1996).
10. Yamamoto, T., Kaneda, K., Hirohashi, K., Kinoshita, H. and Sakurai, M. Sinusoidal capillarization and arterial blood supply continuously proceed with the advance of the stages of hepatocarcinogenesis in the rat. Jpn. J. Cancer Res., 87, 442-450 (1996).
11. Shoji, Y., Kaneda, K., Wake, K. and Mishima, Y. Light and electron microscopic analysis of liver sinusoids during hepatocarcinogenesis with 2-acetylaminofluorene in rats. Jpn. J. Cancer Res., 85, 491-498 (1994).
12. Folkman, J. and Shing, Y. Angiogenesis. J. Biol. Chem., 267, 10931-10934 (1992).
13. Ingber, D., Fujita, T., Kishimoto, S., Sudo, K., Kanamaru, T., Brem, H. and Folkman, J. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth. Nature, 348, 555-557 (1990).
14. Kusaka, M., Sudo, K., Fujita, T., Marui, S., Itoh, F., Ingber, D. and Folkman, J. Potent anti-angiogeneic action of AGM-1470: comparison to the fumagillin parent. Biochem. Biophys. Res. Commun., 174, 1070-1076 (1991).
15. Mori, S., Ueda, T., Kuratsu, S., Hosono, N., Izawa, K. and Uchida, A. Suppression of pulmonary metastasis by angiogenesis inhibitor TNP-470 in murine osteosarcoma. Int. J. Cancer, 61, 148-152 (1995).
16. Kamei, S., Okada, H., Inoue, Y., Yoshioka, T., Ogawa, Y. and Taguchi, H. Antitumor effects of angiogenesis inhibitor TNP-470 in rabbits bearing VX-2 carcinoma by arterial administration of microspheres and oil solution. J. Pharm. Exp. Ther., 264, 469-474 (1993).
17. Tanaka, H., Taniguchi, H., Mugitani, T., Koishi, Y., Masuyama, M., Higashida, T., Koyama, H., Suganuma, Y., Miyata, K., Takeuchi, K. and Takahasi, T. Intra-arterial administration of the angiogenesis inhibitor TNP-470 blocks liver metastasis in a rabbit model. Br. J. Cancer, 72, 650-653 (1995).
18. Konno, H., Tanaka, T., Matsuda, I., Kanai, T., Maruo, Y., Nishino, N., Nukamura, S. and Baba, S. Comparison of the inhibitory effect of the angiogenesis inhibitor, TNP-470, and mitomycin C on the growth and liver metastasis of human colon cancer. Int. J. Cancer, 61, 268-271 (1995).
19. Tanaka, H., Konno, H., Matsuda, I., Nakamura, S. and Baba, S. Prevention of hepatic metastasis of human colon cancer by angiogenesis inhibitor TNP-470. Cancer Res., 55, 836-839 (1995).
20. Yazaki, T., Takamiya, Y., Costello, P. C., Mineta, T., Menon, A. G., Rabkin, S. D. and Martuza, R. L. Inhibition of angiogenesis and growth of human non-malignant and malignant meningiomas by TNP-470. J. Neuro-Oncol., 23, 23-29 (1995).
21. Shiraishi, A., Ishiwata, T., Shoji, T. and Asano, G. Expression of PCNA, basic fibroblast growth factor, FGF-receptor and vascular endothelial growth factor in adenomas and carcinomas of human colon. Acta Histochem. Cytochem., 28, 21-29 (1995).
22. Mise, M., Arii, S., Higashituji, H., Furutani, M., Niwano, M., Harada, T., Ishigami, S., Toda, Y., Nakayama, H., Fukumoto, M., Fujita, J. and Imamura, M. Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor. Hepatology, 23, 455-463 (1996).
23. Solt, D. and Farber, E. New principle for the analysis of chemical carcinogenesis. Nature, 263, 701-703 (1976).
24. Otani, H. and Sasano, N. Characterization of microvasculature in the stroma of human colorectal carcinoma: an immunoelectron microscopic study of factor VIII/von Willebrand factor. J. Electron Microsc., 36, 204-212 (1987).
25. Antoine, N., Daukandt, M., Heinen, E., Simar, L. J. and Castronovo, V. In vitro and in vivo stimulation of the immune system by AGM-1470, a potent angiogenesis inhibitor. Am. J. Pathol., 148, 393-398 (1996).
26. Conway, J. G., Popp, J. A., Ji, S. and Thurman, R. G. Effect of size on portal circulation of hepatic nodules from carcinogen-treated rats. Cancer Res., 43, 3374-3379 (1983).
27. Conway, J. G., Popp, J. A. and Thurman, R. G. Microcirculation of hepatic nodules from diethylnitrosamine-treated rats. Cancer Res., 45, 3620-3625 (1985).
28. Farber, E. and Sarma, D. S. R. Hepatocarcinogenesis: a dynamic cellular perspective. Lab. Invest., 56, 4-22 (1987).
29. Satoh, K., Hatayama, I., Tateoka, N., Tamai, K., Shimizu, T., Tatematsu, M., Ito, N. and Sato, K. Transient induction of single GST-P positive hepatocytes by DEN. Carcinogenesis, 10, 2107-2111 (1989).
30. Tanaka, T., Mori, Y., Morishita, Y., Hara, A., Ohno, T., Kojima, T. and Mori, H. Inhibitory effect of singrin and indole-3-carbinol on diethylnitrosoamine-induced hepatocarcinogenesis in male ACI/N rats. Carcinogenesis, 11, 1403-1406 (1990).
31. Okamoto, K., Sugie, S., Ohnishi, M., Makita, H., Kawamori, T., Watanabe,T., Tanaka, T. and Mori, H. Chemopreventive effects of taurine on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. Jpn. J. Cancer Res., 87, 30-36 (1996).
32. Sell, S. Is there a liver stem cell ? Cancer Res., 50, 3811-3815 (1990).
33. Golding, M., Saraf, C. E., Lalani, E.-N., Anikumar, T. V., Edwards, R. J., Nagy, P., Thorgeirsson, S. S. and Alison, M. R. Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver. Hepatology, 22, 1243-1253 (1991).