Targeted disruption of NF-κB1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: A critical role of p50 in chromatin remodeling

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 298, Issue 2, 2010, Pages

  Rajendrasozhan, Saravanan ^a   Chung, Sangwoon ^a   Sundar, Isaac K ^a   Yao, Hongwei ^a   Rahman, Irfan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Chronic obstructive pulmonary disease; Histone modification; I B kinase 2; Nuclear factor B; Oxidants

Indexed keywords

CIGARETTE SMOKE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HISTONE H3; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P50; TRANSCRIPTION FACTOR RELA;

ACETYLATION; ANIMAL EXPERIMENT; ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DNA BINDING; EMPHYSEMA; EXPOSURE; GENE DISRUPTION; INFLAMMATION; INFLAMMATORY CELL; MOUSE; NONHUMAN; PATHOGENESIS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

ANIMALS; CHROMATIN ASSEMBLY AND DISASSEMBLY; GENE TARGETING; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; NF-KAPPA B P50 SUBUNIT; PNEUMONIA; PULMONARY EMPHYSEMA; SMOKE; SMOKING; TRANSCRIPTION FACTOR RELA;

EID: 74949088495     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00265.2009     Document Type: Article

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