Oncogene expression profiles in K6/ODC mouse skin and papillomas following a chronic exposure to monomethylarsonous acid

Journal of Biochemical and Molecular Toxicology

Volumn 23, Issue 6, 2009, Pages 406-418

  Delker, Don A ^a   Geter, David R ^a   Roop, Barbara C ^a   Ward, William O ^a   Ahlborn, Gene J ^a   Allen, James W ^a   Nelson, Gail M ^a   Ouyang, Ming ^b   Welsh, William ^b   Chen, Yan ^c   O'Brien, Thomas ^c   Kitchin, Kirk T ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c ODC Mouse Group Inc   (United States)

Author keywords

Arsenic; Gene expression; K6 ODC mouse; Monomethylarsonous acid; Skin; Squamous papillomas

Indexed keywords

ARSENIC DERIVATIVE; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; COMPLEMENTARY RNA; DRINKING WATER; MITOGEN ACTIVATED PROTEIN KINASE; MONOMETHYLARSONOUS ACID; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL CYCLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENOMICS; LINEAR REGRESSION ANALYSIS; LIPID METABOLISM; LONG TERM EXPOSURE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; ONCOGENE FOSL1; ONCOGENE MYC; ONCOGENE RAC1; PAPILLOMA; PRINCIPAL COMPONENT ANALYSIS; RNA HYBRIDIZATION; RNA ISOLATION; RNA PROCESSING; SIGNAL TRANSDUCTION; SKIN; SKIN TUMOR; STUDENT T TEST; UNINDEXED SEQUENCE;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BAYES THEOREM; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION PROFILING; HSP90 HEAT-SHOCK PROTEINS; KERATIN-6; LINEAR MODELS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; ONCOGENES; ORGANOMETALLIC COMPOUNDS; ORNITHINE DECARBOXYLASE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAPILLOMA; PRINCIPAL COMPONENT ANALYSIS; SKIN; SKIN NEOPLASMS;

MUS; MUS MUSCULUS;

EID: 74749098396     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.20304     Document Type: Article

References (63)

1. IARC Monograph. Some drinking-water disinfectants and contaminants, including arsenic. IARC Monogr Eval Carcinog Risks Hum 2004;84:1-477.
2. Yoshida T, YamauchiH, Fan SunG. Chronic health effects in people exposed to arsenic via the drinkingwater:Doseresponse relationships in review. ToxicolAppl Pharmacol 2004;198(3):243-252.
3. Mizoi M, Takabayashi F, Nakano M, An Y, Sagesaka Y, Kato K, Okada S, Yamanaka K. The role of trivalent dimethylated arsenic in dimethylarsinic acid-promoted skin and lung tumorigenesis in mice: Tumor-promoting action through the induction of oxidative stress. Toxicol Lett 2005;158(2):87-94.
4. Morikawa T, Wanibuchi H, Morimura K, Ogawa M, Fukushima S. Promotion of skin carcinogenesis by dimethylarsinic acid in keratin (K6)/ODC transgenic mice. Jpn J Cancer Res 2000;91(6):579-581.
5. Motiwale L, Ingle AD, Rao KV. Mouse skin tumor promotion by sodium arsenate is associated with enhanced PCNA expression. Cancer Lett 2005;223(1):27-35.
6. Uddin AN, Burns FJ, Rossman TG. Vitamin E and organoselenium prevent the cocarcinogenic activity of arsenite with solar UVR in mouse skin. Carcinogenesis 2005;26(12):2179-2186.
7. Chen Y, Megosh LC, Gilmour SK, Sawicki JA, O'Brien TG. K6/ODC transgenic mice as a sensitive model for carcinogen identification. Toxicol Lett 2000;116(1-2):27-35.
8. Chen Y, O'Brien TG, Del Razo LM, Thomas DJ, Kitchin KT. Tissue levels of arsenicals and skin tumor response following administration of monomethylarsonous acid and arsenite to K6/ODC mice. J Environ Pathol Toxicol Oncol 2008;27(1):43-52.
9. Humble MC, Trempus CS, Spalding JW, Cannon RE, Tennant RW. Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: A review. Oncogene 2005;24(56):8217-8228.
10. Delker DA, Yano BL, Gollapudi BB. V-Ha-ras gene expression in liver and kidney of transgenic Tg.AC mice following chemically induced tissue injury. Toxicol Sci 1999;50(1):90-97.
11. Megosh L, Gilmour SK, Rosson D, Soler AP, Blessing M, Sawicki JA, O'Brien TG. Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase. Cancer Res 1995;55(19):4205-4209.
12. O'Brien TG, Megosh LC, Gilliard G, Soler AP. Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin. Cancer Res 1997;57(13):2630-2637.
13. Basu A, Mahata J, Gupta S, Giri AK. Genetic toxicology of a paradoxical human carcinogen, arsenic: A review. Mutat Res 2001;488(2):171-194.
14. Mass MJ, Tennant A, Roop BC, Cullen WR, Styblo M, Thomas DJ, Kligerman AD. Methylated trivalent arsenic species are genotoxic. Chem Res Toxicol 2001;14(4):355-361.
15. Nesnow S, Roop BC, Lambert G, Kadiiska M, Mason RP, Cullen WR, Mass MJ. DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species. Chem Res Toxicol 2002;15(12):1627-1634.
16. Kligerman AD, Doerr CL, Tennant AH, Harrington-Brock K, Allen JW, Winkfield E, Poorman-Allen P, Kundu B, Funasaka K, Roop BC, Mass MJ, DeMarini DM. Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: Induction of chromosomal mutations but not gene mutations. Environ Mol Mutagen 2003;42(3):192-205.
17. Andrewes P, Kitchin KT, Wallace K. Dimethylarsine and trimethylarsine are potent genotoxins in vitro. Chem Res Toxicol 2003;16(8):994-1003.
18. Waalkes MP, Liu J, Ward JM, Diwan BA. Animal models for arsenic carcinogenesis: Inorganic arsenic is a transplacental carcinogen in mice. Toxicol Appl Pharmacol 2004;198(3):377-384.
19. Wei M, Wanibuchi H, Morimura K, Iwai S, Yoshida K, Endo G, Nakae D, Fukushima S. Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis 2002;23(8):1387-1397.
20. Arnold LL, Eldan M, van Gemert M, Capen CC, Cohen SM. Chronic studies evaluating the carcinogenicity of monomethylarsonic acid in rats and mice. Toxicology 2003;190(3):197-219.
21. Rea MA, Gregg JP, Qin Q, Phillips MA, Rice RH. Global alteration of gene expression in human keratinocytes by inorganic arsenic. Carcinogenesis 2005;24(4):747-756.
22. Bae DS, Hanneman WH, Yang RS, Campain JA. Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: Application of cDNA microarray technology. Environ Health Perspect 2002;110(Suppl 6):931-941.
23. Hamadeh HK, Trouba KJ, Amin RP, Afshari CA, Germolec D. Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes. Toxicol Sci 2002;69(2):306-316.
24. Baldi P, Long AD. A Bayesian framework for the analysis of microarray expression data: Regularized t-test and statistical inferences of gene changes. Bioinformatics 2001;17(6):509-519.
25. Raychaudhuri S, Stuart JM, Altman RB. Principal components analysis to summarize microarray experiments: Application to sporulation time series. Pac Symp Biocomput 2000;455-466.
26. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003;4(5):P3.
27. Kitchin KT. Recent advances in arsenic carcinogenesis: Modes of action, animal model systems, and methylated arsenic metabolites. Toxicol Appl Pharmacol 2001;172(3):249-261.
28. Cohen SM, Arnold LL, Uzvolgyi E, Cano M, St John M, Yamamoto S, Lu X, Le XC. Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat. Chem Res Toxicol 2002;15(9):1150-1157.
29. Styblo M, Drobna Z, Jaspers I, Lin S, Thomas DJ. The role of biomethylation in toxicity and carcinogenicity of arsenic: A research update. Environ Health Perspect 2002;110(Suppl 5):767-771.
30. Teng SC, Chen YY, Su YN, Chou PC, Chiang YC, Tseng SF, Wu KJ. Direct activation of HSP90A transcription by c-Myc contributes to c-Myc-induced transformation. J Biol Chem 2004;279(15):14649-14655.
31. Nakamura S, Tatuno I, NoguchiY,KitagawaM,Kohn LD, Saito Y, Hirai A. 73-kDa Heat shock cognate protein interacts directly with p27Kip1, a cyclin-dependent kinas inhibitor during G1/S transition. Biochem Biophys Res Commun 1999;257:340-343.
32. Gertler FB, Niebuhr K, Reinhard M, Wehland J, Soriano P. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell 1996;87(2):227-239.
33. Westwick JK, Lambert QT, Clark GJ, Symons M, Van Aelst L, Pestell RG, Der CJ. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol Cell Biol 1997;17(3):1324-1335.
34. Ems-McClung SC, Zheng Y, Walczak CE. Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal. Mol Biol Cell 2004;15(1):46-57.
35. Jang SI, Kalinin A, Takahashi K, Marekov LN, Steinert PM. Characterization of human epiplakin: RNAimediated epiplakin depletion leads to the disruption of keratin and vimentin IF networks. J Cell Sci 2005;118(Pt 4):781-793.
36. Jaffe AB and Hall A. Rho GTPases in transformation and metastasis. Adv Cancer Res 2002;84:57-80.
37. Waalkes MP, Liu J, Germolec DR, Trempus CS, Cannon RE, Tokar EJ, Tennant RW, Ward JM, Diwan BA. Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics. Cancer Res 2008;68(20):8278-8285.
38. Verma A, Mohindru M, Deb DK, Sassano A, Kambhampati S, Ravandi F,Minucci S, Kalvakolanu DV, Platanias LC. Activation of Rac1 and the p38 mitogenactivated protein kinase pathway in response to arsenic trioxide. J Biol Chem 2002;277(47):44988-44995.
39. Bulavin DV, Fornace AJ Jr. p38 MAP kinase's emerging role as a tumor suppressor. Adv Cancer Res 2004;92:95-118.
40. Nelson GM, Ahlborn GJ, Delker DA, Kitchin KT, O'Brien TG,Chen Y,Kohan MJ, Roop BC,WardWO, Allen JW. Folate deficiency enhances arsenic effects on expression of genes involved in epidermal differentiation in transgenic K6/ODC mouse skin. Toxicology 2007;241(3):134-145.
41. Ahlborn GJ, Nelson GM, Ward WO, Knapp G, Allen JW, Ouyang M, Roop BC, Chen Y, O'Brien T, Kitchin KT, Delker DA. Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite. Toxiol Appl Pharmacol 2008;227(3):400-416.
42. Drobna Z, Jaspers I, Thomas DJ, Styblo M. Differential activation of AP-1 in human bladder epithelial cells by inorganic and methylated arsenicals. FASEB J 2003;17(1):67-69.
43. Hayes JD, McMahon M. Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett 2001;174(2):103-113.
44. Pi J, Qu W, Reece JM, Kumagai Y, Waalkes MP. Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: Involvement of hydrogen peroxide. Exp Cell Res 2003;290:234-245.
45. Oster SK, Ho CS, Soucie EL, Penn LZ. The myc oncogene: MarvelouslY Complex. Adv Cancer Res 2002;84:81-154.
46. Liu J, Xie Y, Ward JM, Diwan BA, Waalkes MP. Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic. Toxicol Sci 2004;77(2):249-207.
47. Liu J, Xie Y, Ducharme DM, Shen J, Diwan BA, Merrick BA,Grissom SF, Tucker CJ, PaulesRS, Tennant R,Waalkes MP. Global gene expression associated with hepatocarcinogenesis in adult male mice induced by in utero arsenic exposure. Environ Health Perspect 2006;114(3):404-411.
48. Chen H, Liu J, Zhao CQ, Diwan BA, Merrick BA, Waalkes MP. Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation. Toxicol Appl Pharmacol 2001;175:260-268.
49. Barrett JC, Lamb PW, Wang TC, Lee TC. Mechanisms of arsenic-induced cell transformation. Biol Trace Elem Res 1989;21:421-429.
50. Lee TC, Oshimura M, Barrett JC. Comparison of arsenicinduced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture. Carcinogenesis 1985;6(10):1421-1426.
51. Yih LH, Hsueh SW, Luu WS, Chiu TH, Lee TC. Arsenite induces prominent mitotic arrest via inhibition of G2 checkpoint activation in CGL-2 cells. Carcinogenesis 2005;26(1):53-63.
52. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998;278(10):5858-5868.
53. Zhang TC, SchmittMT, Mumford JL. Effects of arsenic on telomerase and telomeres in relation to cell proliferation and apoptosis in human keratinocytes and leukemia cells in vitro. Carcinogenesis 2003;24(11):1811-1817.
54. Liu SX, Athar M, Lippai I,Waldren C, Hei TK. Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity. Proc Natl Acad Sci USA 2001;98(4):1643-1648.
55. Kitchin KT, Ahmad S. Oxidative stress as a possible mode of action for arsenic carcinogenesis. Toxicol Lett 2003;137(1-2):3-13.
56. Gown AM, Jiang JJ, Matles H, Skelly M, Goodpaster T, Cass L, Reshatof M, Spaulding D, Coltrera MD. Validation of the S-phase specificity of histone (H3) in situ hybridization in normal and malignant cells. J Histochem Cytochem 1996;44:221-226.
57. Li J, Gorospe M, Barnes J, Liu Y. Tumor promoter arsenite stimulates histone H3 phosphoacetylation of protooncogenes c-fos and c-jun chromatin in human diploid fibroblasts. J Biol Chem 2003;278(15):13183-13191.
58. Arentson E, Faloon P, Seo J, Moon E, Studts JM, Fremont DH, Choi K. Oncogenic potential of the DNA replication licensing protein CDT1. Oncogene 2002;21(8):1150-1158.
59. Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li HC, Schütte M, Gordon R, Holstein GR, Martinelli G, Mehta P, Friedrich VL Jr, Robakis NK. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Mol Cell 1999;4:893-902.
60. Xia X, Qian S, Soriano S, Wu Y, Fletcher AM, Wang XJ, Koo EH,Wu X, ZhengH. Loss of presenilin 1 is associated with enhanced β-catenin signaling and skin tumorigenesis. Proc Natl Acad Sci USA 2001;98(19):10863- 10868.
61. Bug G, Gul H, Schwarz K, Pfeifer H, Kampfmann M, Zheng X, Beissert T, Boehrer S, Hoelzer D, Ottmann OG, Ruthardt M. Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Res 2005;65(7):2537-2541.
62. Hobbs CA, Paul BA, Gilmour SK. Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors. Cancer Res 2002;62:67-74.
63. Jakobsson A, Jorgensen JA, Jacobsson A. Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation. Am J Physiol Endocrinol Metab 2005;289(4):E517-526.