Global gene expression associated with hepatocarcinogenesis in adult male mice induced by in utero arsenic exposure

Environmental Health Perspectives

Volumn 114, Issue 3, 2006, Pages 404-411

  Liu, Jie ^a   Xie, Yaxiong ^a   Ducharme, Danica M K ^b   Shen, Jun ^a   Diwan, Bhalchandra A ^c   Merrick, B Alex ^b   Grissom, Sherry F ^b   Tucker, Charles J ^b   Paules, Richard S ^b   Tennant, Raymond ^b   Waalkes, Michael P ^a  

^a National Cancer Institute   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Agilent mouse oligo 22K microarray; Arsenic; Hepatocellular carcinoma; Real time RT PCR; Transplacental exposure; Western blotting

Indexed keywords

ALPHA FETOPROTEIN; ARSENIC; ARSENITE SODIUM; BRCA1 PROTEIN; BRCA2 PROTEIN; CELL CYCLE PROTEIN; CERULOPLASMIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN E; CYTOCHROME P450 2B9; CYTOKERATIN 18; CYTOKERATIN 19; CYTOKERATIN 8; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; HEAT SHOCK PROTEIN; HEME OXYGENASE 1; K RAS PROTEIN; LIPOCORTIN 2; LIPOPROTEIN LIPASE; MYC PROTEIN; ONCOPROTEIN; PROLACTIN RECEPTOR; PROTEIN P16; SCATTER FACTOR RECEPTOR; SOMATOMEDIN; TUMOR MARKER; UNINDEXED DRUG; UVOMORULIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENETIC CODE; GENOME ANALYSIS; HISTOPATHOLOGY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MICROARRAY ANALYSIS; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TOXICOGENETICS; TRANSPLACENTAL CARCINOGENESIS; UNINDEXED SEQUENCE; WESTERN BLOTTING;

ANIMALS; ARSENIC; CARCINOMA, HEPATOCELLULAR; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; LIVER; LIVER NEOPLASMS; MALE; MATERNAL-FETAL EXCHANGE; MICE; MICE, INBRED C3H; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; TOXICOGENETICS;

ANIMALIA;

EID: 33644749318     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1097/01.sla.0000201544.36473.a2     Document Type: Article

References (52)

1. Anderson LM, Diwan BA, Fear NT, Roman E. 2000. Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models. Environ Health Perspect 108(suppl 3):573-594.
2. Benbrahim-Tallaa L, Waterland RA, Styblo M, Achanzar WE, Webber MM, Waalkes MP. 2005. Molecular events associated with arsenic-induced malignant transformation of human prostate epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol Appl Pharmacol 206:288-298.
3. Bencko V, Wagner V, Wagnerova M, Batora J. 1988. Immunological profiles in workers of a power plant burning coal rich in arsenic content. J Hyg Epidemiol Microbiol Immunol. 32:137-146.
4. Calvisi DF, Ladu S, Conner EA, Factor VM, Thorgeirsson SS. 2004. Disregulation of E-cadherin in transgenic mouse models of liver cancer. Lab Invest 84:1137-1147.
5. Centeno JA, Mullick FG, Martinez L, Page NP, Gibb H, Longfellow D, et al. 2002. Pathology related to chronic arsenic exposure. Environ Health Perspect 110(suppl 5):883-886.
6. Chattopadhyay S, Bhaumik S, Nag Chaudhury A, Das Gupta S, 2002. Arsenic-induced changes in growth development and apoptosis in neonatal and adult brain cells in vivoand in tissue culture. Toxicol Lett 128:73-84.
7. Chen CJ, Yu MW, Liaw, YF. 1997. Epidemiological characteristics and risk factors of hepatocellular carcinoma. J Gastroenterol Hepatol 12:S294-308.
8. Chen H, Li S, Liu J, Diwan BA, Barrett JC, Waalkes MP. 2004. Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis. Carcinogenesis 25:1779-1786.
9. Chen H, Liu J, Merrick BA, Waalkes MP. 2001a. Genetic events associated with arsenic-induced malignant transformation: applications of cDNA microarray technology. Mol Carcinog 30:79-87.
10. Chen H, Liu J, Zhao CQ, Diwan BA, Merrick BA, Waalkes MP. 2001b. Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation. Toxicol Appl Pharmacol 175:260-268.
11. Chen Y, Ahsan H. 2004. Cancer burden from arsenic in drinking water in Bangladesh. Am J Public Health 94:741-744.
12. Chiu HF, Ho SC, Wang LY, Wu TN, Yang CY. 2004. Does arsenic exposure increase the risk for liver cancer? J Toxicol Environ Health A 67:1491-1500.
13. Concha G, Vogler G, Lezcano D, Nermell B, Vahter M. 1998. Exposure to inorganic arsenic metabolites during early human development. Toxicol Sci 44:185-190.
14. Cook JD, Davis BJ, Cai SL, Barrett JC, Conti CJ, Walker CL. 2005. Interaction between genetic susceptibility and early life environmental exposure determines tumor suppressor gene penetrance. Proc Natl Acad Sci USA 102:8644-8649.
15. Cui X, Li S, Shraim A, Kobayashi Y, Hayakawa T, Kanno S, et al. 2004. Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver. Toxicol Pathol 32:64-72.
16. Deane NG, Parker MA, Aramandla R, Diehl L, Lee WJ, Washington MK, et al. 2001. Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice. Cancer Res 61:5389-5395.
17. Emoto K, Sawada H, Yamada Y, Fujimoto H, Takahama Y, Ueno M, et al. 2001. Annexin II overexpression is correlated with poor prognosis in human gastric carcinoma. Anticancer Res 21:1339-1345.
18. Germolec DR, Spalding J, Yu HS, Chen GS, Simeonova PP, Humble MC, et al. 1998. Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors. Am J Pathol 153:1775-1785.
19. IARC (International Agency for Research on Cancer). 1987. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42. IARC Monogr Eval Carcinog Risks Hum (suppl 7).
20. Iida M, Anna CH, Hartis J, Bruno M, Wetmore B, Dubin JR, et al. 2003. Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643. Carcinogenesis 24:757-770.
21. Institute of Laboratory Animal Resources. 1996. Guide for the Care and Use of Laboratory Animals. 7th ed. Washington, DC:The National Academies Press.
22. Kitchin KT. 2001. Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol Appl Pharmacol 172:249-261.
23. Leslie EM, Haimeur A, Waalkes MP. 2004. Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required. J Biol Chem 279:32700-32708.
24. Liu J, Chen H, Miller DS, Saavedra JE, Keefer LK, Johnson DR, et al. 2001a. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Mol Pharmacol 60:302-309.
25. Liu J, Kadiiska MB, Liu Y, Lu T, Qu W, Waalkes MP 2001b. Stressrelated gene expression in mice treated with inorganic arsenicals. Toxicol Sci 61:314-320.
26. Liu J, Liu Y, Goyer RA, Achanzar W, Waalkes MP. 2000. Metallothionein-I/II null mice are more sensitive than wildtype mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals. Toxicol Sci 55:460-467.
27. Liu J, Xie Y, Ward JM, Diwan BA, Waalkes MP. 2004. Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in uteroto inorganic arsenic. Toxicol Sci 77:249-257.
28. Liu J, Zheng B, Aposhian HV, Zhou Y, Chen ML, Zhang A, et al. 2002. Chronic arsenic poisoning from burning high-arseniccontaining coal in Guizhou, China. Environ Health Perspect 110:119-122.
29. Lu SC, Tsukamoto H, Mato JM. 2002. Role of abnormal methionine metabolism in alcoholic liver injury. Alcohol 27:155-162.
30. Lu T, Liu J, LeCluyse EL, Zhou YS, Cheng ML, Waalkes MP. 2001. Application of cDNA microarray to the study of arsenicinduced liver diseases in the population of Guizhou, China. Toxicol Sci 59:185-192.
31. Ma YX, Tomita Y, Fan S, Wu K, Tong Y, Zhao Z, et al. 2005. Structural determinants of the BRCA1 and estrogen receptor interaction. Oncogene 24:1831-1846.
32. Mickleburgh I, Burtle B, Hollas H, Campbell G, Chrzanowska-Lightowlers Z, Vedeler A, et al. 2005. Annexin A2 binds to the localization signal in the 3′ untranslated region of c-myc mRNA. FEBS J 272:413-21.
33. Morales KH, Ryan L, Kuo T-L, Wu M-M, Chen C-J. 2000. Risk of internal cancers from arsenic in the drinking water. Environ Health Perspect 108:655-661.
34. NRC (National Research Council). 1999. Arsenic in the Drinking Water. Washington, DC:National Academy Press.
35. Okada H, Kimura MT, Tan D, Fujiwara K, Igarashi J, Makuuchi M, et al. 2005. Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas. Int J Oncol 26:369-377.
36. Okoji RS, Yu RC, Maronpot RR, Froines JR. 2002. Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice. Carcinogenesis 23:777-785.
37. Pi J, Qu W, Reece JM, Kumagai Y, Waalkes MP. 2003. Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide. Exp Cell Res 290:234-245.
38. Prall OW, Rogan EM, Musgrove EA, Watts CK, Sutherland RL. 1998. c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry. Mol Cell Biol 18:4499-4508.
39. Rossman TG, Uddin AN, Burns FJ, Bosland MC. 2001. Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol Appl Pharmacol 176:64-71.
40. Santra A, Maiti A, Das S, Lahiri S, Charkaborty SK, Mazumder DN. 2000. Hepatic damage caused by chronic arsenic toxicity in experimental animals. J Toxicol Clin Toxicol 38:395-405.
41. Scharf JG, Braulke T. 2003. The role of the IGF axis in hepatocarcinogenesis. Horm Metab Res 35:685-693.
42. Simeonova PP, Wang S, Toriuma W, Kommineni V, Matheson J, Unimye N, et al. 2000. Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation. Cancer Res 60:3445-3453.
43. Takahashi M, Barrett JC, Tsutsui T. 2002. Transformation by inorganic arsenic compounds of normal Syrian hamster embryo cells into a neoplastic state in which they become anchorage-independent and cause tumors in newborn hamsters. Int J Cancer 99:629-634.
44. Trouba KJ, Wauson EM, Vorce RL. 2000. Sodium arseniteinduced dysregulation of proteins involved in proliferative signaling. Toxicol Appl Pharmacol 164:161-170.
45. Waalkes MP, Diwan BA, Rehm S, Ward JM, Moussa M, Cherian MG, et al. 1996. Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice. J Pharmacol Exp Ther 277:1026-1033.
46. Waalkes MP, Liu J, Chen H, Xie Y, Achanzar WE, Zhou YS, et al. 2004a. Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero. J Natl Cancer Inst 96:466-474.
47. Waalkes MP, Ward JM, Diwan BA. 2004b. Induction of tumors of the liver, lung, ovary, and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers. Carcinogenesis 25:133-141.
48. Waalkes MP, Ward JM, Liu J, Diwan BA. 2003. Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice. Toxicol Appl Pharmacol 186:7-17.
49. Wei M, Wanibuchi H, Morimura K, Iwai S, Yoshida K, Endo G, et al. 2002. Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis 23:1387-1397.
50. Xie Y, Trouba KJ, Liu J, Waalkes MP, Germolec DR. 2004. Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha- rastransgenic (Tg.AC) mice. Environ Health Perspect 112:1255-1263.
51. Zeng ZJ, Yang LY, Ding X, Wang W. 2004. Expressions of cysteine-rich61, connective tissue growth factor, and Nov genes in hepatocellular carcinoma and their clinical significance. World J Gastroenterol 10:3414-3418.
52. Zhou YS, Du H, Cheng M-L, Liu J, Zhang XJ, Xu L. 2002. The investigation of death from diseases caused by coal-burning type of arsenic poisoning. Chin J Endemiol 21:484-486.