Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin

Cancer Research

Volumn 57, Issue 13, 1997, Pages 2630-2637

  O'Brien, Thomas G ^a   Megosh, Louis C ^a   Gilliard, Gwendolyn ^a   Peralta Soler, Alejandro ^a  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ORNITHINE DECARBOXYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; EPIDERMIS; HAIR FOLLICLE; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN CARCINOGENESIS; SKIN CARCINOMA; TRANSGENIC MOUSE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BENZO(A)PYRENE; HAIR FOLLICLE; IMMUNOHISTOCHEMISTRY; METHYLNITRONITROSOGUANIDINE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; ORNITHINE DECARBOXYLASE; PUTRESCINE; SKIN; SKIN NEOPLASMS; SPERMIDINE; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS;

EID: 0030741841     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Balmain, A., Ramsden, M., Bowden, G, T., and Smith, J. Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature (Lond.), 307: 658-660, 1984.
2. Conti, C. J., Aidaz, C. M., O'Connell, J., Klein-Szanto, A. J. P., and Slaga, T. J. Aneuploidy, an early event in mouse skin tumor development. Carcinogenesis (Lond.), 7: 1845-1848, 1986.
3. Scribner, J. D., Süss, R. Tumor initiation and promotion In: G. W. Richter and M. A. Epstein (eds.), International Review of Experimental Pathology, Vol. 18, pp. 137-198. New York: Academic Press, Inc., 1978.
4. Diamond, L., O'Brien, T. G., and Baird, W. M. Tumor promoters and the mechanisms of tumor promotion. Adv. Cancer Res., 32: 1-74, 1980.
5. O'Brien, T. G., Koza, R. A., and Gilmour, S. K. Alterations in polyamine metabolism in epithelial tumors of the skin. In: T. P. Pretlow and T. A. Pretlow (eds.), Biochemical and Molecular Aspects of Selected Cancers, pp. 291-309. New York: Academic Press, Inc., 1994.
6. Verma, A. K., Erickson, D., and Dolnick, B. J. Increased mouse epidermal ornithine decarboxylase activity by the tumour promoter 12-0-tetradecanoylphorbol 13-acetate involves increased amounts of both enzyme protein and messenger RNA. Biochem, J., 237: 297-300, 1986.
7. Gilmour, S. K., Verma, A. K., Madara, T., and O'Brien, T. G. Regulation of ornithine decarboxylase gene expression in mouse epidermis and epidermal tumors during two-stage tumorigenesis. Cancer Res., 47: 1221-1225, 1987.
8. O'Brien, T. G., Simsiman, R. C., and Boutwell, R. K. Induction of the polyamine biosynthetic enzymes in mouse epidermis by tumor-promoting agents. Cancer Res., 35: 1662-1670, 1975.
9. Koza, R. A., Megosh, L. C., Palmieri, M., and O'Brien, T. G. Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas. Carcinogenesis (Lond.), 12: 1619-1625, 1991.
10. Verma, A. K., Shapas, B. G., Rice, H. M., and Boutwell, R. K. Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and skin tumor promotion. Cancer Res., 39: 419-425, 1979.
11. Takigawa, M., Verma, A. K., Simsiman, R. C., and Boutwell, R. K. Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase. α-difluoromethylornithine. Biochem. Biophys. Res. Commun., 105: 969-976, 1982.
12. Weeks, C. F., Hermann, A. L., Nelson, F. R., and Slaga, T. S. α-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits promoter-induced polyamine accumulation and Carcinogenesis in mouse skin. Proc. Natl. Acad. Sci. USA, 79: 6028-6032, 1982.
13. Vassar, R., and Fuchs, E. Transgenic mice provide new insights into the role of TGF-α during epidermal development and differentiation. Genes Dev., 5: 714-727, 1991.
14. Bailleul, B., Surani, M. A., White, S., Barton, S. C., Brown, K. Blessing, M., Jorcano, J., and Balmain, A. Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter. Cell, 62: 696-708, 1990.
15. Werner, S., Weinberg, W., Liao, X., Peters, K. G., Blessing, M., Yuspa, S. H., Weiner, R. L., and Williams, L. T. Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. EMBO J., 12: 2635-2643, 1993.
16. Blessing, M., Nanney, L. B., King, L. E., Jones, C. M., and Hogan, G. L. M. Transgenic mice as a model to study the role of TGF-β related molecules in hair follicles. Genes Dev., 7: 204-215, 1993.
17. Ramirez, A., Vidal, M., Bravo, A., Larcher, F., and Jorcano, J. L. A 5′-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice. Proc. Natl. Acad. Sci. USA, 92: 4783-4787, 1995.
18. Megosh, L., Gilmour, S. K., Rosson, D., Peralta Soler, A., Blessing, M., Sawicki, J. A., and O'Brien, T. G. Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase. Cancer Res., 55: 4205-4209, 1995.
19. Peralta Soler, A., Gilliard, G., Megosh, L. C., and O'Brien, T. G. Modulation of murine hair follicle function by alterations in ornithine decarboxylase activity. J. Invest. Dermatol., 106: 1108-1113, 1996.
20. O'Brien, T. G., and Diamond, L. Ornithine decarboxylase induction and DNA synthesis in hamster embryo cell cultures treated with tumor-promoting phorbol diesters. Cancer Res., 37: 3895-3900, 1977.
21. DiGiovanni, J. Genetics of susceptibility to mouse skin tumor promotion. In: A. E. Sirica (ed.), The Pathology of Neoplasia, pp. 247-273. New York: Plenum Publishing Corp., 1989.
22. Molloy, C. J., and Laskin, J. D. Keratin polypeptide expression in mouse epidermis and cultured epidermal cells. Differentiation, 37: 86-97, 1989.
23. Stenback, F., Pete, R., and Shubik, P. Initiation and promotion at different ages and doses in 2200 mice: methods and the apparent persistence of initiated cells. Br. J. Cancer, 44: 1-14, 1981.
24. Hennings, H. Devor, D., Wenk, M. L., Slaga, T. J., Former, B., Colburn, N. H., Bowden, G. T., Elgjo, K., and Yuspa, S. H. Comparison of two-stage epidermal carcinogenesis initiated by 7,12-dimehylbenz(a)anthracene or N-methyl-N′-nitro-N-nitrosoguanidine in newborn and adult SENCAR and BALB/c mice. Cancer Res., 41: 773-779, 1981.
25. Ghadially, F. N. The role of the hair follicle in the origin and evolution of some cutaneous neoplasms of man and experimental animals. Cancer (Phila.), 14: 801-816, 1961.
26. Bhisey, R. A., Iyengar, B., and Sirsat, S. M. Effects of the active tumor promoter, TPA, on hair follicle growth and development of hair on large tumors in the mouse skin: a comparison with human adnexal lesions. J. Cancer Res. Clin. Oncol., 102: 245-252, 1982.
27. Cotsarellis, G., Sun, T-T., and Lavker, R. M. Label-retaining cells reside in the bulge area of pilosebasceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell, 61: 1329-1335, 1990.
28. Halmekytö, M., Syrjänen, Jänne, J., and Alhonen, L. Enhanced papilloma formation in response to skin tumor promotion in transgenic mice overexpressing the human ornithine decarboxylase gene. Biochem. Biophys. Res. Commun., 187: 493-497, 1992.
29. O'Brien, T. G., Simsiman, R. C., and Boutwell, R. K. Induction of the polyamine biosynthetic enzymes in mouse epidermis and their specificity tor tumor promotion. Cancer Res., 35: 2426-2433, 1975.
30. Auvinen, M., Paasinen, A., Anderson, L. C., and Holtta, E. Ornilhine decarboxylase activity is critical for cell transformation. Nature (Lond.), 360: 355-358, 1992.
31. Shantz, L. M., and Pegg, A. E. Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation. Cancer Res., 54: 2313-2316, 1994.
32. Moshier, J., Dosescu, J., Skunca, M., and Luk, G. Transformation of NIH 3T3 cells by ornithine decarboxylase overexpression. Cancer Res., 53: 2618-2622, 1993.
33. Clifford, A., Morgan, D., Yuspa, S. H., Peralta Soler, A., and Gilmour, S. Role of ornithine decarboxylase in epidermal carcinogenesis. Cancer Res., 55: 1680-1686, 1995.
34. Hibshoosh, H., Johnson, M., and Weinstein, I. B. Effects of overexpression of ornithine decarboxylase (ODC) on growth control and oncogene-induced cell transformation. Oncogene, 6. 739-743, 1991.
35. Miller, S. J., Sun, T-T., and Lavker, R. M. Hair follicles, stem cells, and skin cancer. J. Invest. Dermatol., 100: 288S-294S, 1993.
36. Morris, R. J., Fischer, S. M., and Slaga, T. J. Evidence that a slowly cycling population of adult murine epidermal cells retain carcinogen. Cancer Res., 46: 3061-3066, 1986.
37. Gilmour, S., Aglow, E., and O'Brien, T. G. Heterogeneity of ornithine decarboxylase expression in 12-0-tetradecanoylphorbol-13-acetute-treuted mouse skin and in epidermal tumors. Carcinogenesis (Lond.), 7: 943-947, 1986.
38. Hennings, H., Shores, R., Mitcholl, P., Spangler, E. F., and Yuspa, S. H. Induction of papillomas with a high probability of conversion to malignancy. Carcinogenesis (Lond.), 6: 1607-1610, 1985.
39. Wang, X-J., Greenhalgh, D. A., Eckhardt, J. N., Rothnagel, J. A., and Roop, D. R. Hpidermal expression of transforming growth factor-α in transgenic mice: induction of spontaneous and l2-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression. Mol. Carcinog., 10: 15-22, 1994.
40. Glick, A. B., Kulkarni, A. B., Tennenbaum, T., Hennings, H., Flanders, K. C., O'Reilly, M., Sporn, M. B., Karhon, S., and Yuspa, S. H. Loss of expression of TGF-β in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc. Natl. Acad. Sci. USA, 90: 6076-6080, 1993.
41. Furstenberger, G., Rogers, M., Schnapke, R., Bauer, G., Holler, P., and Marks, F. Stimulatory role of transforming growth factors in multistage skin Carcinogenesis: possible explanation for the tumor-inducing effect of wounding in initialed NMRI mouse skin. Int. J. Cancer, 43: 915-921, 1989.
42. Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., and Akhurst, R. J. TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell, 86: 531-542, 1996.
43. Oberyszyn, T. M., Sabourin, C. L. K., Bijar, G. N., Boros, L. G., and Robertson, F. M. Interleukin-1α: gene expression and localization of Inlerleukin-1α protein during tumor promotion. Mol. Carcinog., 7: 238-240, 1993.
44. Loeb, L. A. Mutator phenotype may be required for multistage Carcinogenesis. Cancer Res., 51: 3075-3079, 1991.
45. Kingsnorth, A. N., King, W. W. K., Diekema, K. A., McCann, P. P., Ross, J. S., and Malt, R. A. Inhibition of ornithine decarboxylase with 2-difluoromethylornithine: reduced incidence of dimethylhydrazine-induced colon tumors in mice. Cancer Res., 43: 2545-2549, 1983.
46. Abeloff, M. D., Rosen, S. T., Luk, G. D., Baylin, S. B., Zeltzman, M., and Sjoerdsma, A. Phase II trials of α-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer. Cancer Treat. Rep., 70: 843-845, 1986.