메뉴 건너뛰기




Volumn 16, Issue 8, 2003, Pages 994-1003

Dimethylarsine and trimethylarsine are potent genotoxins in vitro

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC; DIMETHYLARSINE; DIMETHYLARSINOUS ACID; DITHIOERYTHRITOL; DITHIOL DERIVATIVE; DNA; METHANEARSONIC ACID; METHYLARSINE; METHYLARSONOUS ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SODIUM BOROHYDRIDE; TOXIN; TRIMETHYLARSINE; TRIMETHYLARSINE OXIDE; UNCLASSIFIED DRUG;

EID: 0042863393     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx034063h     Document Type: Article
Times cited : (68)

References (57)
  • 1
    • 0003771986 scopus 로고    scopus 로고
    • National Academy Press, Washington, DC
    • NAS (1999) Arsenic in Drinking Water, National Academy Press, Washington, DC.
    • (1999) Arsenic in Drinking Water
  • 2
    • 0042984068 scopus 로고
    • Arsenic
    • An updating of IARC monographs 1-42, International Agency for Research on Cancer, Lyon, France
    • IARC (1987) Arsenic. Overall Evaluations of Carcinogenicity. An updating of IARC monographs 1-42, Suppl. 7, pp 100-106, International Agency for Research on Cancer, Lyon, France.
    • (1987) Overall Evaluations of Carcinogenicity , Issue.SUPPL. 7 , pp. 100-106
  • 4
    • 0037119139 scopus 로고    scopus 로고
    • Arsenic round the world: A review
    • Mandal, B. K., and Suzuki, K. T. (2002) Arsenic round the world: a review. Talanta 58, 201-235.
    • (2002) Talanta , vol.58 , pp. 201-235
    • Mandal, B.K.1    Suzuki, K.T.2
  • 5
    • 0035015116 scopus 로고    scopus 로고
    • Genetic toxicology of a paradoxical human carcinogen, arsenic: A review
    • Basu, A., Mahata, J., Gupta, S., and Giri, A. K. (2001) Genetic toxicology of a paradoxical human carcinogen, arsenic: a review. Mutat. Res. 488, 171-194.
    • (2001) Mutat. Res. , vol.488 , pp. 171-194
    • Basu, A.1    Mahata, J.2    Gupta, S.3    Giri, A.K.4
  • 6
    • 0008517022 scopus 로고    scopus 로고
    • Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity
    • Aposhian, H. V. (1997) Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. Annu. Rev. Pharmacol. Toxicol. 37, 397-419.
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 397-419
    • Aposhian, H.V.1
  • 7
    • 0037184792 scopus 로고    scopus 로고
    • Mechanisms of arsenic biotransformation
    • Vahter, M. (2002) Mechanisms of arsenic biotransformation. Toxicology 181, 211-217.
    • (2002) Toxicology , vol.181 , pp. 211-217
    • Vahter, M.1
  • 10
    • 0033675692 scopus 로고    scopus 로고
    • Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine
    • Le, X. C., Ma, M., Cullen, W. R., Aposhian, H. V., Lu, X., and Zheng, B. (2000) Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine. Environ. Health Perspect. 108, 1015-1018.
    • (2000) Environ. Health Perspect. , vol.108 , pp. 1015-1018
    • Le, X.C.1    Ma, M.2    Cullen, W.R.3    Aposhian, H.V.4    Lu, X.5    Zheng, B.6
  • 11
    • 0034329575 scopus 로고    scopus 로고
    • Speciation of key arsenic metabolic intermediates in human urine
    • Le, X. C., Lu, X., Ma, M., Cullen, W. R., Aposhian, H. V., and Zheng, B. (2000) Speciation of key arsenic metabolic intermediates in human urine. Anal. Chem. 72, 5172-5177.
    • (2000) Anal. Chem. , vol.72 , pp. 5172-5177
    • Le, X.C.1    Lu, X.2    Ma, M.3    Cullen, W.R.4    Aposhian, H.V.5    Zheng, B.6
  • 12
    • 0035419866 scopus 로고    scopus 로고
    • Determination of trivalent methylated arsenicals in biological matrixes
    • Del Razo, L. M., Styblo, M., Cullen, W. R., and Thomas, D. J. (2001) Determination of trivalent methylated arsenicals in biological matrixes. Toxicol. Appl. Pharmacol. 174, 282-293.
    • (2001) Toxicol. Appl. Pharmacol. , vol.174 , pp. 282-293
    • Del Razo, L.M.1    Styblo, M.2    Cullen, W.R.3    Thomas, D.J.4
  • 13
    • 0033712061 scopus 로고    scopus 로고
    • Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue
    • Sampayo-Reyes, A., Zakharyan, R. A., Healy, S. M., and Aposhian, H. V. (2000) Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue. Chem. Res. Toxicol. 13, 1181-1186.
    • (2000) Chem. Res. Toxicol. , vol.13 , pp. 1181-1186
    • Sampayo-Reyes, A.1    Zakharyan, R.A.2    Healy, S.M.3    Aposhian, H.V.4
  • 14
    • 0035819871 scopus 로고    scopus 로고
    • A concise review of the toxicity and carcinogenicity of dimethylarsinic acid
    • Kenyon, E. M., and Hughes, M. F. (2001) A concise review of the toxicity and carcinogenicity of dimethylarsinic acid. Toxicology 160, 227-236.
    • (2001) Toxicology , vol.160 , pp. 227-236
    • Kenyon, E.M.1    Hughes, M.F.2
  • 15
    • 0024347404 scopus 로고
    • Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice
    • Yamanaka, K., Hasegawa, A., Sawamura, R., and Okada, S. (1989) Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice. Biochem. Biophys. Res. Commun. 165, 43-50.
    • (1989) Biochem. Biophys. Res. Commun. , vol.165 , pp. 43-50
    • Yamanaka, K.1    Hasegawa, A.2    Sawamura, R.3    Okada, S.4
  • 17
    • 0025989134 scopus 로고
    • Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice
    • Yamanaka, K., Hasegawa, A., Sawamura, R., and Okada, S. (1991) Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice. Toxicol. Appl. Pharmacol. 108, 205-213.
    • (1991) Toxicol. Appl. Pharmacol. , vol.108 , pp. 205-213
    • Yamanaka, K.1    Hasegawa, A.2    Sawamura, R.3    Okada, S.4
  • 18
    • 0027219597 scopus 로고
    • Cross-link formation between DNA and nuclear proteins by in vivo and in vitro exposure of cells to dimethylarsinic acid
    • Yamanaka, K., Tezuka, M., Kato, K., Hasegawa, A., and Okada, S. (1993) Cross-link formation between DNA and nuclear proteins by in vivo and in vitro exposure of cells to dimethylarsinic acid. Biochem. Biophys. Res. Commun. 191, 1184-1191.
    • (1993) Biochem. Biophys. Res. Commun. , vol.191 , pp. 1184-1191
    • Yamanaka, K.1    Tezuka, M.2    Kato, K.3    Hasegawa, A.4    Okada, S.5
  • 19
    • 0029877529 scopus 로고    scopus 로고
    • Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice
    • Yamanaka, K., Ohtsubo, K., Hasegawa, A., Hayashi, H., Ohji, H., Kanisawa, M., and Okada, S. (1996) Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice. Carcinogenesis 17, 767-770.
    • (1996) Carcinogenesis , vol.17 , pp. 767-770
    • Yamanaka, K.1    Ohtsubo, K.2    Hasegawa, A.3    Hayashi, H.4    Ohji, H.5    Kanisawa, M.6    Okada, S.7
  • 20
    • 0031461075 scopus 로고    scopus 로고
    • Metabolic methylation is a possible genotoxicity-enhancing process of inorganic arsenics
    • Yamanaka, K., Hayashi, H., Tachikawa, M., Kato, K., Hasegawa, A., Oku, N., and Okada, S. (1997) Metabolic methylation is a possible genotoxicity-enhancing process of inorganic arsenics. Mutat. Res. 394, 95-101.
    • (1997) Mutat. Res. , vol.394 , pp. 95-101
    • Yamanaka, K.1    Hayashi, H.2    Tachikawa, M.3    Kato, K.4    Hasegawa, A.5    Oku, N.6    Okada, S.7
  • 21
    • 0030904996 scopus 로고    scopus 로고
    • DNA single-strand breaks in L-132 cells resulting from inhibition of repair polymerization shortly after exposure to dimethylarsinic acid
    • Yamanaka, K., Hayashi, H., Kato, K., Hasegawa, A., Oku, N., and Okada, S. (1997) DNA single-strand breaks in L-132 cells resulting from inhibition of repair polymerization shortly after exposure to dimethylarsinic acid. Biol. Pharm. Bull. 20, 163-167.
    • (1997) Biol. Pharm. Bull. , vol.20 , pp. 163-167
    • Yamanaka, K.1    Hayashi, H.2    Kato, K.3    Hasegawa, A.4    Oku, N.5    Okada, S.6
  • 22
    • 0034724957 scopus 로고    scopus 로고
    • The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice
    • Yamanaka, K., Katsumata, K., Ikuma, K., Hasegawa, A., Nakano, M., and Okada, S. (2000) The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice. Cancer Lett. 152, 79-85.
    • (2000) Cancer Lett. , vol.152 , pp. 79-85
    • Yamanaka, K.1    Katsumata, K.2    Ikuma, K.3    Hasegawa, A.4    Nakano, M.5    Okada, S.6
  • 23
    • 0035860357 scopus 로고    scopus 로고
    • Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-oxo-2′-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis
    • Yamanaka, K., Takabayashi, F., Mizoi, M., An, Y., Hasegawa, A., and Okada, S. (2001) Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-oxo-2′ -deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis. Biochem. Biophys. Res. Commun. 287, 66-70.
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 66-70
    • Yamanaka, K.1    Takabayashi, F.2    Mizoi, M.3    An, Y.4    Hasegawa, A.5    Okada, S.6
  • 24
    • 0034986099 scopus 로고    scopus 로고
    • Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenic, in mice promotes skin tumorigenesis initiated by dimethylbenz[a]anthracene with or without ultraviolet B as a promoter
    • Yamanaka, K., Mizol, M., Kato, K., Hasegawa, A., Nakano, M., and Okada, S. (2001) Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenic, in mice promotes skin tumorigenesis initiated by dimethylbenz[a]anthracene with or without ultraviolet B as a promoter. Biol. Pharm. Bull. 24, 510-514.
    • (2001) Biol. Pharm. Bull. , vol.24 , pp. 510-514
    • Yamanaka, K.1    Mizol, M.2    Kato, K.3    Hasegawa, A.4    Nakano, M.5    Okada, S.6
  • 25
    • 0028032352 scopus 로고
    • Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals
    • Yamanaka, K., and Okada, S. (1994) Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals. Environ. Health Perspect. 102(Suppl. 3), 37-40.
    • (1994) Environ. Health Perspect. , vol.102 , Issue.SUPPL. 3 , pp. 37-40
    • Yamanaka, K.1    Okada, S.2
  • 26
    • 0024427816 scopus 로고
    • DNA strand breaks in mammalian tissues induced by methylarsenics
    • Yamanaka, K., Hasegawa, A., Sawamura, R., and Okada, S. (1989) DNA strand breaks in mammalian tissues induced by methylarsenics. Biol. Trace Elem. Res. 21, 413-417.
    • (1989) Biol. Trace Elem. Res. , vol.21 , pp. 413-417
    • Yamanaka, K.1    Hasegawa, A.2    Sawamura, R.3    Okada, S.4
  • 27
    • 0025274032 scopus 로고
    • Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical
    • Yamanaka, K., Hoshino, M., Okamoto M., Sawamura, R., Hasegawa, A., and Okada, S. (1990) Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical. Biochem. Biophys. Res. Commun. 168, 58-64.
    • (1990) Biochem. Biophys. Res. Commun. , vol.168 , pp. 58-64
    • Yamanaka, K.1    Hoshino, M.2    Okamoto, M.3    Sawamura, R.4    Hasegawa, A.5    Okada, S.6
  • 30
    • 0037036581 scopus 로고    scopus 로고
    • Plasmid DNA damage caused by methylated arsenicals, ascorbic acid and human liver ferritin
    • Ahmad, S., Kitchin, K. T., and Cullen, W. R. (2002) Plasmid DNA damage caused by methylated arsenicals, ascorbic acid and human liver ferritin. Toxicol. Lett. 133, 47-57.
    • (2002) Toxicol. Lett. , vol.133 , pp. 47-57
    • Ahmad, S.1    Kitchin, K.T.2    Cullen, W.R.3
  • 31
    • 0034667885 scopus 로고    scopus 로고
    • Arsenic species that cause release of iron from ferritin and generation of activated oxygen
    • Ahmad, S., Kitchin, K. T., and Cullen, W. R. (2002) Arsenic species that cause release of iron from ferritin and generation of activated oxygen. Arch. Biochem. Biophys. 382, 195-202.
    • (2002) Arch. Biochem. Biophys. , vol.382 , pp. 195-202
    • Ahmad, S.1    Kitchin, K.T.2    Cullen, W.R.3
  • 33
    • 0037972159 scopus 로고    scopus 로고
    • Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA
    • Schwerdtle, T., Walter, I., Mackiw, I., and Hartwig, A. (2003) Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA. Carcinogenesis 24, 967-974.
    • (2003) Carcinogenesis , vol.24 , pp. 967-974
    • Schwerdtle, T.1    Walter, I.2    Mackiw, I.3    Hartwig, A.4
  • 35
    • 0040211486 scopus 로고
    • A new type of compound containing arsenic
    • Burrows, G. J., and Turner, E. E. (1920) A new type of compound containing arsenic. J. Chem. Soc. Trans. 1373-1380.
    • (1920) J. Chem. Soc. Trans. , pp. 1373-1380
    • Burrows, G.J.1    Turner, E.E.2
  • 36
    • 0041982528 scopus 로고
    • Ph.D. Thesis, University of British Columbia
    • Nelson, J. C. (1993) Ph.D. Thesis, University of British Columbia.
    • (1993)
    • Nelson, J.C.1
  • 37
    • 33845184777 scopus 로고
    • Arsenic speciation in the environment
    • Cullen W. R., and Reimer, K. J. (1989) Arsenic speciation in the environment. Chem. Rev. 89, 713-764.
    • (1989) Chem. Rev. , vol.89 , pp. 713-764
    • Cullen, W.R.1    Reimer, K.J.2
  • 38
    • 0021263213 scopus 로고
    • The reduction of trimethylarsine oxide to trimethylarsine by thiols: A mechanistic model for the biological reduction of arsenicals
    • Cullen, W. R., McBride, B. C., and Reglinski, J. (1984) The reduction of trimethylarsine oxide to trimethylarsine by thiols: a mechanistic model for the biological reduction of arsenicals. J. Inorg. Biochem. 21, 45-60.
    • (1984) J. Inorg. Biochem. , vol.21 , pp. 45-60
    • Cullen, W.R.1    McBride, B.C.2    Reglinski, J.3
  • 39
    • 0034917334 scopus 로고    scopus 로고
    • Role of metabolism in arsenic toxicity
    • Vahter, M., and Concha, G. (2001) Role of metabolism in arsenic toxicity. Pharmacol. Toxicol. 89, 1-5.
    • (2001) Pharmacol. Toxicol. , vol.89 , pp. 1-5
    • Vahter, M.1    Concha, G.2
  • 40
    • 33947435182 scopus 로고
    • Biological methylation
    • Challenger, F. (1945) Biological methylation. Chem. Rev. 36, 315-361.
    • (1945) Chem. Rev. , vol.36 , pp. 315-361
    • Challenger, F.1
  • 41
    • 84990543679 scopus 로고
    • A comparative study on acute toxicity of methylarsonic acid, dimethylarsinic acid and trimethylarsine oxide in mice
    • Kaise, T., Yamauchi, H., Horiguchi, Y., Tani, T., Watanabe, S., Hirayawa, T., and Fukui, S. (1989) A comparative study on acute toxicity of methylarsonic acid, dimethylarsinic acid and trimethylarsine oxide in mice. Appl. Organomet. Chem. 3, 273-277.
    • (1989) Appl. Organomet. Chem. , vol.3 , pp. 273-277
    • Kaise, T.1    Yamauchi, H.2    Horiguchi, Y.3    Tani, T.4    Watanabe, S.5    Hirayawa, T.6    Fukui, S.7
  • 42
    • 0030749513 scopus 로고    scopus 로고
    • Relative genotoxic potency of arsenic and its methylated metabolites
    • Moore, M. M., Harrington-Brock, K., and Doerr, C. L. (1997) Relative genotoxic potency of arsenic and its methylated metabolites. Mutat. Res. 386, 279-290.
    • (1997) Mutat. Res. , vol.386 , pp. 279-290
    • Moore, M.M.1    Harrington-Brock, K.2    Doerr, C.L.3
  • 43
    • 0034974261 scopus 로고    scopus 로고
    • Monomethylarsonous acid (MMA(III)) and arsenite: LD50 in hamsters and in vitro inhibition of pyruvate dehydrogenase
    • Petrick, J. S., Jagadish, B., Mash, E. A., and Aposhian, H. V. (2001) Monomethylarsonous acid (MMA(III)) and arsenite: LD50 in hamsters and in vitro inhibition of pyruvate dehydrogenase. Chem. Res. Toxicol. 14, 651-656.
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 651-656
    • Petrick, J.S.1    Jagadish, B.2    Mash, E.A.3    Aposhian, H.V.4
  • 46
    • 0033980631 scopus 로고    scopus 로고
    • Dose-dependent effects on tissue distribution and metabolism of dimethylarsinic acid in the mouse after intravenous administration
    • Hughes, M. F., Del Razo, L. M., and Kenyon, E. M. (2000) Dose-dependent effects on tissue distribution and metabolism of dimethylarsinic acid in the mouse after intravenous administration. Toxicology 143, 155-166.
    • (2000) Toxicology , vol.143 , pp. 155-166
    • Hughes, M.F.1    Del Razo, L.M.2    Kenyon, E.M.3
  • 47
    • 0035341195 scopus 로고    scopus 로고
    • Recent advances in arsenic carcinogenesis: Modes of action, animal model systems, and methylated arsenic metabolites
    • Kitchin, K. T. (2001) Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol. Appl. Pharmacol. 172, 249-261.
    • (2001) Toxicol. Appl. Pharmacol. , vol.172 , pp. 249-261
    • Kitchin, K.T.1
  • 48
    • 0034759637 scopus 로고    scopus 로고
    • The cellular metabolism and systemic toxicity of arsenic
    • Thomas, D. J., Styblo, M., and Lin, S. (2001) The cellular metabolism and systemic toxicity of arsenic. Toxicol. Appl. Pharmacol. 176, 127-144.
    • (2001) Toxicol. Appl. Pharmacol. , vol.176 , pp. 127-144
    • Thomas, D.J.1    Styblo, M.2    Lin, S.3
  • 49
    • 0037054933 scopus 로고    scopus 로고
    • Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: A possible reactive oxygen species mechanism
    • Nishikawa, T., Wanibuchi, H., Ogawa, M., Kinoshita, A., Morimura, K., Hiroi, T., Funae, Y., Kishida, H., Nakae, D., and Fukushima, S. (2000) Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: A possible reactive oxygen species mechanism. Int. J. Cancer 100, 136-139.
    • (2000) Int. J. Cancer , vol.100 , pp. 136-139
    • Nishikawa, T.1    Wanibuchi, H.2    Ogawa, M.3    Kinoshita, A.4    Morimura, K.5    Hiroi, T.6    Funae, Y.7    Kishida, H.8    Nakae, D.9    Fukushima, S.10
  • 50
    • 0041481353 scopus 로고    scopus 로고
    • Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats; Association with oxidative DNA damage and enhanced cell proliferation
    • Shen, J., Wanibuchi, H., Salim, E. I., Wei, M., Doi, K., and Fukushima, S. (2003) Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats; Association with oxidative DNA damage and enhanced cell proliferation. Proc. Am. Assoc. Cancer Res. 44, 98.
    • (2003) Proc. Am. Assoc. Cancer Res. , vol.44 , pp. 98
    • Shen, J.1    Wanibuchi, H.2    Salim, E.I.3    Wei, M.4    Doi, K.5    Fukushima, S.6
  • 51
    • 0034282707 scopus 로고    scopus 로고
    • Sampling of trace volatile metal(loid) compounds in ambient air using polymer bags: A convenient method
    • Haas, K., and Feldmann, J. (2000) Sampling of trace volatile metal(loid) compounds in ambient air using polymer bags: a convenient method. Anal. Chem. 72, 4205-4211.
    • (2000) Anal. Chem. , vol.72 , pp. 4205-4211
    • Haas, K.1    Feldmann, J.2
  • 52
    • 12244274337 scopus 로고    scopus 로고
    • Oxidative stress as a possible mode of action for arsenic
    • Kitchin, K. T., and Ahmad, S. (2003) Oxidative stress as a possible mode of action for arsenic. Toxicol. Lett. 137, 3-13.
    • (2003) Toxicol. Lett. , vol.137 , pp. 3-13
    • Kitchin, K.T.1    Ahmad, S.2
  • 53
    • 84972844141 scopus 로고
    • Metabolism and excretion of orally and intraperitoneally administered trimethylarsine oxide in the hamster
    • Yamauchi, H., Takahashi, K., and Yamamura, Y. (1988) Metabolism and excretion of orally and intraperitoneally administered trimethylarsine oxide in the hamster. Toxicol. Environ. Chem. 22, 69-76.
    • (1988) Toxicol. Environ. Chem. , vol.22 , pp. 69-76
    • Yamauchi, H.1    Takahashi, K.2    Yamamura, Y.3
  • 56
    • 0021924256 scopus 로고
    • Metabolism and excretion of orally administered arsenic trioxide in the hamster
    • Yamauchi, H., and Yamamura, Y. (1985) Metabolism and excretion of orally administered arsenic trioxide in the hamster. Toxicology 34, 113-121.
    • (1985) Toxicology , vol.34 , pp. 113-121
    • Yamauchi, H.1    Yamamura, Y.2
  • 57
    • 0041963073 scopus 로고    scopus 로고
    • Interaction of trivalent arsenicals with metallothionein
    • Jiang, G., Gong, Z., Li, X., Cullen, W. R., and Le, X. C. (2003) Interaction of trivalent arsenicals with metallothionein. Chem. Res. Toxicol. 16, 855-864.
    • (2003) Chem. Res. Toxicol. , vol.16 , pp. 855-864
    • Jiang, G.1    Gong, Z.2    Li, X.3    Cullen, W.R.4    Le, X.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.