Nuclear functions of the HMG proteins

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1799, Issue 1-2, 2010, Pages 3-14

  Reeves, Raymond ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HIGH MOBILITY GROUP A PROTEIN; HIGH MOBILITY GROUP B PROTEIN; HIGH MOBILITY GROUP N PROTEIN; HIGH MOBILITY GROUP PROTEIN;

APOPTOSIS; CELL STRUCTURE; CHROMATIN STRUCTURE; DNA REPAIR; EMBRYO DEVELOPMENT; GENE FUNCTION; HUMAN; NUCLEOSOME; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; CELL NUCLEUS; HIGH MOBILITY GROUP PROTEINS; HMGA PROTEINS; HMGB PROTEINS; HMGN PROTEINS; HUMANS; NUCLEOSOMES;

MAMMALIA;

EID: 74549187994     PISSN: 18749399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2009.09.001     Document Type: Review

References (180)

1. The HMG Chromosomal Proteins, Academic Press, London, 1982.
2. Adair J.E., Kwon Y., Dement G.A., Smerdon M.J., and Reeves R. Inhibition of nucleotide excision repair by high mobility group protein HMGA1. J. Biol. Chem. 280 (2005) 32184
3. Adair J.E., Maloney S.C., Dement G.A., Wertzler K.J., Smerdon M.J., and Reeves R. High-mobility group A1 proteins inhibit expression of nucleotide excision repair factor xeroderma pigmentosum group A. Cancer Res. 67 (2007) 6044
4. Adams P.D. Remodeling chromatin for senescence. Aging Cell 6 (2007) 425
5. Agalioti T., Lomvardas S., Parekh B., Yie J., Maniatis T., and Thanos D. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell 103 (2000) 667
6. Agresti A., and Bianchi M.E. HMGB proteins and gene expression. Curr. Opin. Genet. Dev. 13 (2003) 170
7. Agresti A., Scaffidi P., Riva A., Caiolfa V.R., and Bianchi M.E. GR and HMGB1 interact only within chromatin and influence each other's residence time. Mol. Cell 18 (2005) 109
8. Aravind L., and Landsman D. AT-hook motifs identified in a wide variety of DNA-binding proteins. Nucleic Acids Res. 26 (1998) 4413
9. Attema J.L., Reeves R., Murray V., Levichkin I., Temple M.D., Tremethick D.J., and Shannon M.F. The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation. J. Immunol. 169 (2002) 2466
10. Bandyopadhyay D., Curry J.L., Lin Q., Richards H.W., Chen D., Hornsby P.J., Timchenko N.A., and Medrano E.E. Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Aging Cell 6 (2007) 577
11. Bandyopadhyay D., and Medrano E.E. The emerging role of epigenetics in cellular and organismal aging. Exp. Gerontol. 38 (2003) 1299
12. Banks G.C., Mohr B., and Reeves R. The HMG-I(Y) A.T-hook peptide motif confers DNA-binding specificity to a structured chimeric protein. J. Biol. Chem. 274 (1999) 16536
13. Belova G.I., Postnikov Y.V., Furusawa T., Birger Y., and Bustin M. Chromosomal protein HMGN1 enhances the heat shock-induced remodeling of Hsp70 chromatin. J. Biol. Chem. 283 (2008) 8080
14. Bianchi M.E. DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 81 (2007) 1
15. Bianchi M.E., and Agresti A. HMG proteins: dynamic players in gene regulation and differentiation. Curr. Opin. Genet. Dev. 15 (2005) 496
16. Bianchi M.E., and Manfredi A. Chromatin and cell death. Biochim. Biophys. Acta 1677 (2004) 181
17. Bianchi M.E., and Manfredi A.A. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol. Rev. 220 (2007) 35
18. Birger Y., Catez F., Furusawa T., Lim J.H., Prymakowska-Bosak M., West K.L., Postnikov Y.V., Haines D.C., and Bustin M. Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1. Cancer Res. 65 (2005) 6711
19. Birger Y., West K.L., Postnikov Y.V., Lim J.H., Furusawa T., Wagner J.P., Laufer C.S., Kraemer K.H., and Bustin M. Chromosomal protein HMGN1 enhances the rate of DNA repair in chromatin. EMBO J. 22 (2003) 1665
20. Bonaldi T., Langst G., Strohner R., Becker P.B., and Bianchi M.E. The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding. EMBO J. 21 (2002) 6865
21. Bourachot B., Yaniv M., and Muchardt C. The activity of mammalian brm/SNF2alpha is dependent on a high-mobility-group protein I/Y-like DNA binding domain. Mol. Cell Biol. 19 (1999) 3931
22. Bustin M. Revised nomenclature for high mobility group (HMG) chromosomal proteins. Trends Biochem. Sci. 26 (2001) 152
23. Bustin M. At the crossroads of necrosis and apoptosis: signaling to multiple cellular targets by HMGB1. Sci. STKE 2002 (2002) E39
24. Bustin M. Chromatin unfolding and activation by HMGN(*) chromosomal proteins. Trends Biochem. Sci. 26 (2001) 431
25. Bustin M. Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins. Mol. Cell. Biol. 19 (1999) 5237
26. Bustin M., Catez F., and Lim J.H. The dynamics of histone H1 function in chromatin. Mol. Cell 17 (2005) 617
27. Bustin M., and Reeves R. HMG chromosomal proteins: architectural components that facilitate chromatin function. Prog. Nucleic Acids Res. Mol. Biol. 54 (1996) 35-100
28. Cairns B.R., Schlichter A., Erdjument-Bromage H., Tempst P., Kornberg R.D., and Winston F. Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol. Cell 4 (1999) 715
29. Catez F., Brown D.T., Misteli T., and Bustin M. Competition between histone H1 and HMGN proteins for chromatin binding sites. EMBO Rep. 3 (2002) 760
30. Catez F., Lim J.H., Hock R., Postnikov Y.V., and Bustin M. HMGN dynamics and chromatin function. Biochem. Cell. Biol. 81 (2003) 113
31. Catez F., Yang H., Tracey K.J., Reeves R., Misteli T., and Bustin M. Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin. Mol. Cell. Biol. 24 (2004) 4321
32. Cherukuri S., Hock R., Ueda T., Catez F., Rochman M., and Bustin M. Cell cycle-dependent binding of HMGN proteins to chromatin. Mol. Biol. Cell 19 (2008) 1816
33. Cleynen I., and Van de Ven W.J. The HMGA proteins: a myriad of functions (Review). Int. J. Oncol. 32 (2008) 289
34. Cmarik J.L., Li Y., Ogram S.A., Min H., Reeves R., and Colburn N.H. Tumor promoter induces high mobility group HMG-Y protein expression in transformation-sensitive but not -resistant cells. Oncogene 16 (1998) 3387
35. Collado M., Blasco M.A., and Serrano M. Cellular senescence in cancer and aging. Cell 130 (2007) 223
36. Collins C.J., and Sedivy J.M. Involvement of the INK4a/Arf gene locus in senescence. Aging Cell 2 (2003) 145
37. Das D., and Scovell W.M. The binding interaction of HMG-1 with the TATA-binding protein/TATA complex. J. Biol. Chem. 276 (2001) 32597
38. Dasgupta A., and Scovell W.M. TFIIA abrogates the effects of inhibition by HMGB1 but not E1A during the early stages of assembly of the transcriptional preinitiation complex. Biochim. Biophys. Acta 1627 (2003) 101
39. De M., Visone I.R., Fedele M., Petrocca F., Palmieri D., Martinez H.J., Forzati F., Croce C.M., and Fusco A. Regulation of microRNA expression by HMGA1 proteins. Oncogene 28 (2009) 1432
40. Dement G.A., Treff N.R., Magnuson N.S., Franceschi V., and Reeves R. Dynamic mitochondrial localization of nuclear transcription factor HMGA1. Exp. Cell Res. 307 (2005) 388
41. Diana F., Sgarra R., Manfioletti G., Rustighi A., Poletto D., Sciortino M.T., Mastino A., and Giancotti V. A link between apoptosis and degree of phosphorylation of high mobility group A1a protein in leukemic cells. J. Biol. Chem. 276 (2001) 11354
42. Ding H.F., Rimsky S., Batson S.C., Bustin M., and Hansen U. Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14. Science 265 (1994) 796
43. Disney J.E., Johnson K.R., Magnuson N.S., Sylvester S.R., and Reeves R. High-mobility group protein HMG-I localizes to G/Q- and C-bands of human and mouse chromosomes. J. Cell Biol. 109 (1989) 1975
44. Duncan B., and Zhao K. HMGA1 mediates the activation of the CRYAB promoter by BRG1. DNA Cell Biol. 26 (2007) 745
45. Dunker A.K., Lawson J.D., Brown C.J., Williams R.M., Romero P., Oh J.S., Oldfield C.J., Campen A.M., Ratliff C.M., Hipps K.W., Ausio J., Nissen M.S., Reeves R., Kang C., Kissinger C.R., Bailey R.W., Griswold M.D., Chiu W., Garner E.C., and Obradovic Z. Intrinsically disordered protein. J. Mol. Graph. Model. 19 (2001) 26
46. Ellwood K.B., Yen Y.M., Johnson R.C., and Carey M. Mechanism for specificity by HMG-1 in enhanceosome assembly. Mol. Cell. Biol. 20 (2000) 4359
47. Falvo J.V., Thanos D., and Maniatis T. Reversal of intrinsic DNA bends in the IFN beta gene enhancer by transcription factors and the architectural protein HMG I(Y). Cell 83 (1995) 1101
48. Fashena S.J., Reeves R., and Ruddle N.H. A poly(dA-dT) upstream activating sequence binds high-mobility group I protein and contributes to lymphotoxin (tumor necrosis factor-beta) gene regulation. Mol. Cell. Biol. 12 (1992) 894
49. Fedele M., Pentimalli F., Baldassarre G., Battista S., Klein-Szanto A.J., Kenyon L., Visone R., De M., Ciarmiello I.A., Arra C., Viglietto G., Croce C.M., and Fusco A. Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene 24 (2005) 3427
50. Fedele M., Pierantoni G.M., Berlingieri M.T., Battista S., Baldassarre G., Munshi N., Dentice M., Thanos D., Santoro M., Viglietto G., and Fusco A. Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells. Cancer Res. 61 (2001) 4583
51. Fedele M., Pierantoni G.M., Visone R., and Fusco A. Critical role of the HMGA2 gene in pituitary adenomas. Cell Cycle 5 (2006) 2045
52. Fedele M., Visone R., De M., Troncone I.G., Palmieri D., Battista S., Ciarmiello A., Pallante P., Arra C., Melillo R.M., Helin K., Croce C.M., and Fusco A. HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell 9 (2006) 459
53. Fousteri M., Vermeulen W., van Zeeland A.A., and Mullenders L.H. Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo. Mol. Cell 23 (2006) 471
54. Frasca F., Rustighi A., Malaguarnera R., Altamura S., Vigneri P., Del S.G., Giancotti V., Pezzino V., Vigneri R., and Manfioletti G. HMGA1 inhibits the function of p53 family members in thyroid cancer cells. Cancer Res. 66 (2006) 2980
55. Friedmann M., Holth L.T., Zoghbi H.Y., and Reeves R. Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. Nucleic Acids Res. 21 (1993) 4259
56. Funayama R., Saito M., Tanobe H., and Ishikawa F. Loss of linker histone H1 in cellular senescence. J. Cell Biol. 175 (2006) 869
57. Furusawa T., Lim J.H., Catez F., Birger Y., Mackem S., and Bustin M. Down-regulation of nucleosomal binding protein HMGN1 expression during embryogenesis modulates Sox9 expression in chondrocytes. Mol. Cell. Biol. 26 (2006) 592
58. Fusco A., and Fedele M. Roles of HMGA proteins in cancer. Nat. Rev. Cancer 7 (2007) 899
59. Gabellini D., Green M.R., and Tupler R. Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle. Cell 110 (2002) 339
60. Gaffen S.L. Signaling domains of the interleukin 2 receptor. Cytokine 14 (2001) 63
61. Gerlitz G., Hock R., Ueda T., and Bustin M. The dynamics of HMG protein-chromatin interactions in living cells. Biochem. Cell Biol. 87 (2009) 127
62. Harrer M., Luhrs H., Bustin M., Scheer U., and Hock R. Dynamic interaction of HMGA1a proteins with chromatin. J. Cell. Sci. 117 (2004) 3459
63. He Q., Liang C.H., and Lippard S.J. Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 5768
64. Henderson A., Bunce M., Siddon N., Reeves R., and Tremethick D.J. High-mobility-group protein I can modulate binding of transcription factors to the U5 region of the human immunodeficiency virus type 1 proviral promoter. J. Virol. 74 (2000) 10523
65. Henderson A., Holloway A., Reeves R., and Tremethick D.J. Recruitment of SWI/SNF to the human immunodeficiency virus type 1 promoter. Mol. Cell. Biol. 24 (2004) 389
66. Hill D.A., Pedulla M.L., and Reeves R. Directional binding of HMG-I(Y) on four-way junction DNA and the molecular basis for competitive binding with HMG-1 and histone H1. Nucleic Acids Res. 27 (1999) 2135
67. Hill D.A., Peterson C.L., and Imbalzano A.N. Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling. J. Biol. Chem. 280 (2005) 41777
68. Hill D.A., and Reeves R. Competition between HMG-I(Y), HMG-1 and histone H1 on four-way junction DNA. Nucleic Acids Res. 25 (1997) 3523
69. Himes S.R., Coles L.S., Reeves R., and Shannon M.F. High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters. Immunity 5 (1996) 479
70. Himes S.R., Reeves R., Attema J., Nissen M., Li Y., and Shannon M.F. The role of high-mobility group I(Y) proteins in expression of IL-2 and T cell proliferation. J. Immunol. 164 (2000) 3157
71. Hock R., Furusawa T., Ueda T., and Bustin M. HMG chromosomal proteins in development and disease. Trends Cell Biol. 17 (2007) 72
72. Hommura F., Katabami M., Leaner V.D., Donninger H., Sumter T.F., Resar L.M., and Birrer M.J. HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth in Rat1a cells. Mol. Cancer Res. 2 (2004) 305
73. Huth J.R., Bewley C.A., Nissen M.S., Evans J.N., Reeves R., Gronenborn A.M., and Clore G.M. The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif. Nat. Struct. Biol. 4 (1997) 657
74. Ito I., Fukazawa J., and Yoshida M. Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils. J. Biol. Chem. 282 (2007) 16336
75. Jeyapalan J.C., and Sedivy J.M. Cellular senescence and organismal aging. Mech. Ageing Dev. 129 (2008) 467
76. John S., Reeves R.B., Lin J.X., Child R., Leiden J.M., Thompson C.B., and Leonard W.J. Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins. Mol. Cell. Biol. 15 (1995) 1786
77. John S., Robbins C.M., and Leonard W.J. An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein. EMBO J. 15 (1996) 5627
78. Kas E., Poljak L., Adachi Y., and Laemmli U.K. A model for chromatin opening: stimulation of topoisomerase II and restriction enzyme cleavage of chromatin by distamycin. EMBO J. 12 (1993) 115
79. Knapp S., Muller S., Digilio G., Bonaldi T., Bianchi M.E., and Musco G. The long acidic tail of high mobility group box 1 (HMGB1) protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes. Biochemistry 43 (2004) 11992
80. Korner U., Bustin M., Scheer U., and Hock R. Developmental role of HMGN proteins in Xenopus laevis. Mech. Dev. 120 (2003) 1177
81. Krynetski E.Y., Krynetskaia N.F., Bianchi M.E., and Evans W.E. A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues. Cancer Res. 63 (2003) 100
82. Laemmli U.K., Kas E., Poljak L., and Adachi Y. Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains. Curr. Opin. Genet. Dev. 2 (1992) 275
83. Lafferty-Whyte K., Cairney C.J., Jamieson N.B., Oien K.A., and Keith W.N. Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms. Biochim. Biophys. Acta 1792 (2009) 341
84. Lehtonen S., and Lehtonen E. HMG-17 is an early marker of inductive interactions in the developing mouse kidney. Differentiation 67 (2001) 154
85. Liau S.S., Ashley S.W., and Whang E.E. Lentivirus-mediated RNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma. J. Gastrointest. Surg. 10 (2006) 1254
86. Liau S.S., Jazag A., Ito K., and Whang E.E. Overexpression of HMGA1 promotes anoikis resistance and constitutive Akt activation in pancreatic adenocarcinoma cells. Br. J. Cancer 96 (2007) 993
87. Liau S.S., and Whang E. HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma. Clin. Cancer Res. 14 (2008) 1470
88. Lim J.H., Catez F., Birger Y., West K.L., Prymakowska-Bosak M., Postnikov Y.V., and Bustin M. Chromosomal protein HMGN1 modulates histone H3 phosphorylation. Mol. Cell 15 (2004) 573
89. Lim J.H., West K.L., Rubinstein Y., Bergel M., Postnikov Y.V., and Bustin M. Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3. EMBO J. 24 (2005) 3038
90. Liu R., Liu H., Chen X., Kirby M., Brown P.O., and Zhao K. Regulation of CSF1 promoter by the SWI/SNF-like BAF complex. Cell 106 (2001) 309
91. Liu W.M., Guerra-Vladusic F.K., Kurakata S., Lupu R., and Kohwi-Shigematsu T. HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype. Cancer Res. 59 (1999) 5695
92. Lomvardas S., and Thanos D. Nucleosome sliding via TBP DNA binding in vivo. Cell 106 (2001) 685
93. Lomvardas S., and Thanos D. Modifying gene expression programs by altering core promoter chromatin architecture. Cell 110 (2002) 261
94. Lucas J., Bilzer A., Moll L., Zundorf I., Dingermann T., Eichinger L., Siol O., and Winckler T. The carboxy-terminal domain of Dictyostelium C-module-binding factor is an independent gene regulatory entity. PLoS One 4 (2009) e5012
95. Lund T., Holtlund J., Fredriksen M., and Laland S.G. On the presence of two new high mobility group-like proteins in HeLa S3 cells. FEBS Lett. 152 (1983) 163
96. Maffini M., Denes V., Sonnenschein C., Soto A., and Geck P. APRIN is a unique Pds5 paralog with features of a chromatin regulator in hormonal differentiation. J. Steroid Biochem. Mol. Biol. 108 (2008) 32
97. Maloney S.C., Adair J.E., Smerdon M.J., and Reeves R. Gene-specific nucleotide excision repair is impaired in human cells expressing elevated levels of high mobility group A1 nonhistone proteins. DNA Repair (Amst.) 6 (2007) 1371
98. Mao L., Wertzler K.J., Maloney S.C., Wang Z., Magnuson N.S., and Reeves R. HMGA1 levels influence mitochondrial function and mtDNA repair efficiency. Mol. Cell. Biol. ePubl. Aug. 17 (2009)
99. Merika M., and Thanos D. Enhanceosomes. Curr. Opin. Genet. Dev. 11 (2001) 205
100. Merika M., Williams A.J., Chen G., Collins T., and Thanos D. Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription. Mol. Cell 1 (1998) 277
101. Mott J.L., Kobayashi S., Bronk S.F., and Gores G.J. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 26 (2007) 6133
102. Munshi N., Agalioti T., Lomvardas S., Merika M., Chen G., and Thanos D. Coordination of a transcriptional switch by HMGI(Y) acetylation. Science 293 (2001) 1133
103. Munshi N., Merika M., Yie J., Senger K., Chen G., and Thanos D. Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome. Mol. Cell 2 (1998) 457
104. Munshi N., Yie Y., Merika M., Senger K., Lomvardas S., Agalioti T., and Thanos D. The IFN-beta enhancer: a paradigm for understanding activation and repression of inducible gene expression. Cold Spring Harb. Symp. Quant. Biol. 64 (1999) 149
105. Najimi M., Smets F., and Sokal E. Hepatocyte apoptosis. Methods Mol. Biol. 481 (2009) 59
106. Narita M. Cellular senescence and chromatin organisation. Br. J. Cancer 96 (2007) 686
107. Narita M., Narita M., Krizhanovsky V., Nunez S., Chicas A., Hearn S.A., Myers M.P., and Lowe S.W. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126 (2006) 503
108. Narita M., Nunez S., Heard E., Narita M., Lin A.W., Hearn S.A., Spector D.L., Hannon G.J., and Lowe S.W. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113 (2003) 703
109. Nissen M.S., Langan T.A., and Reeves R. Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein. J. Biol. Chem. 266 (1991) 19945
110. Nissen M.S., and Reeves R. Changes in superhelicity are introduced into closed circular DNA by binding of high mobility group protein I/Y. J. Biol. Chem. 270 (1995) 4355
111. Ogram S.A., and Reeves R. Differential regulation of a multipromoter gene. Selective 12-O-tetradecanoylphorbol-13-acetate induction of a single transcription start site in the HMG-I/Y gene. J. Biol. Chem. 270 (1995) 14235
112. Ohtani N., Mann D.J., and Hara E. Cellular senescence: its role in tumor suppression and aging. Cancer Sci. 100 (2009) 792
113. Ohtani N., Yamakoshi K., Takahashi A., and Hara E. The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J. Med. Invest. 51 (2004) 146
114. Palvimo J., and Maenpaa P.H. Binding of high-mobility-group proteins HMG 14 and HMG 17 to DNA and histone H1 as influenced by phosphorylation. Biochim. Biophys. Acta 952 (1988) 172
115. Panne D. The enhanceosome. Curr. Opin. Struct. Biol. 18 (2008) 236
116. Paranjape S.M., Krumm A., and Kadonaga J.T. HMG17 is a chromatin-specific transcriptional coactivator that increases the efficiency of transcription initiation. Genes Dev. 9 (1995) 1978
117. Pash J.M., Alfonso P.J., and Bustin M. Aberrant expression of high mobility group chromosomal protein 14 affects cellular differentiation. J. Biol. Chem. 268 (1993) 13632
118. Passos J.F., Simillion C., Hallinan J., Wipat A., and von Z.T. Cellular senescence: unravelling complexity. Age (Dordr.) ePubl. July 18 (2009)
119. Phair R.D., Scaffidi P., Elbi C., Vecerova J., Dey A., Ozato K., Brown D.T., Hager G., Bustin M., and Misteli T. Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins. Mol. Cell. Biol. 24 (2004) 6393
120. Pierantoni G.M., Rinaldo C., Esposito F., Mottolese M., Soddu S., and Fusco A. High mobility group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity. Cell Death Differ. 13 (2006) 1554
121. Pierantoni G.M., Rinaldo C., Mottolese M., Di B.A., Esposito F., Soddu S., and Fusco A. High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2. J. Clin. Invest. 117 (2007) 693
122. Pil P.M., and Lippard S.J. Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin. Science 256 (1992) 234
123. Postnikov Y.V., Belova G.I., Lim J.H., and Bustin M. Chromosomal protein HMGN1 modulates the phosphorylation of serine 1 in histone H2A. Biochemistry 45 (2006) 15092
124. Postnikov Y.V., Herrera J.E., Hock R., Scheer U., and Bustin M. Clusters of nucleosomes containing chromosomal protein HMG-17 in chromatin. J. Mol. Biol. 274 (1997) 454
125. Postnikov Y.V., Trieschmann L., Rickers A., and Bustin M. Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores. J. Mol. Biol. 252 (1995) 423
126. Pruss D., Reeves R., Bushman F.D., and Wolffe A.P. The influence of DNA and nucleosome structure on integration events directed by HIV integrase. J. Biol. Chem. 269 (1994) 25031
127. Prymakowska-Bosak M., Hock R., Catez F., Lim J.H., Birger Y., Shirakawa H., Lee K., and Bustin M. Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins. Mol. Cell. Biol. 22 (2002) 6809
128. Prymakowska-Bosak M., Misteli T., Herrera J.E., Shirakawa H., Birger Y., Garfield S., and Bustin M. Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin. Mol. Cell. Biol. 21 (2001) 5169
129. Radic M.Z., Saghbini M., Elton T.S., Reeves R., and Hamkalo B.A. Hoechst 33258, distamycin A, and high mobility group protein I (HMG-I) compete for binding to mouse satellite DNA. Chromosoma 101 (1992) 602
130. Rattner B.P., Yusufzai T., and Kadonaga J.T. HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. Mol. Cell 34 (2009) 620
131. Reeves R. Structure and function of the HMGI(Y) family of architectural transcription factors. Environ. Health Perspect. 108 Suppl 5 (2000) 803
132. Reeves R. Molecular biology of HMGA proteins: hubs of nuclear function. Gene 277 (2001) 63
133. Reeves R. HMGA proteins: flexibility finds a nuclear niche?. Biochem. Cell. Biol. 81 (2003) 185
134. Reeves R., and Adair J.E. Role of high mobility group (HMG) chromatin proteins in DNA repair. DNA Repair (Amst.) 4 (2005) 926
135. Reeves R., and Beckerbauer L. HMGI/Y proteins: flexible regulators of transcription and chromatin structure. Biochim. Biophys. Acta 1519 (2001) 13
136. Reeves R., Langan T.A., and Nissen M.S. Phosphorylation of the DNA-binding domain of nonhistone high-mobility group I protein by cdc2 kinase: reduction of binding affinity. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 1671
137. Reeves R., Leonard W.J., and Nissen M.S. Binding of HMG-I(Y) imparts architectural specificity to a positioned nucleosome on the promoter of the human interleukin-2 receptor alpha gene. Mol. Cell. Biol. 20 (2000) 4666
138. Reeves R., and Nissen M.S. The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. J. Biol. Chem. 265 (1990) 8573
139. Reeves R., and Nissen M.S. Interaction of high mobility group-I (Y) nonhistone proteins with nucleosome core particles. J. Biol. Chem. 268 (1993) 21137
140. Reeves R., and Nissen M.S. Cell cycle regulation and functions of HMG-I(Y). Prog. Cell Cycle Res. 1 (1995) 339
141. Reeves R., and Wolffe A.P. Substrate structure influences binding of the non-histone protein HMG-I(Y) to free nucleosomal DNA. Biochemistry 35 (1996) 5063
142. Richards H.W., and Medrano E.E. Epigenetic marks in melanoma. Pigment Cell Melanoma Res. 22 (2009) 14
143. Saitoh Y., and Laemmli U.K. Metaphase chromosome structure: bands arise from a differential folding path of the highly AT-rich scaffold. Cell 76 (1994) 609
144. Scaffidi P., Misteli T., and Bianchi M.E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418 (2002) 191
145. Sedivy J.M., Banumathy G., and Adams P.D. Aging by epigenetics-a consequence of chromatin damage?. Exp. Cell Res. 314 (2008) 1909
146. Sgarra R., Diana F., Bellarosa C., Dekleva V., Rustighi A., Toller M., Manfioletti G., and Giancotti V. During apoptosis of tumor cells HMGA1a protein undergoes methylation: identification of the modification site by mass spectrometry. Biochemistry 42 (2003) 3575
147. Sgarra R., Diana F., Rustighi A., Manfioletti G., and Giancotti V. Increase of HMGA1a protein methylation is a distinctive characteristic of leukaemic cells induced to undergo apoptosis. Cell Death Differ. 10 (2003) 386
148. Sgarra R., Lee J., Tessari M.A., Altamura S., Spolaore B., Giancotti V., Bedford M.T., and Manfioletti G. The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. J. Biol. Chem. 281 (2006) 3764
149. Sgarra R., Rustighi A., Tessari M.A., Di Bernardo J., Altamura S., Fusco A., Manfioletti G., and Giancotti V. Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer. FEBS Lett. 574 (2004) 1
150. Singh M., D'Silva L., and Holak T.A. DNA-binding properties of the recombinant high-mobility-group-like AT-hook-containing region from human BRG1 protein. Biol. Chem. 387 (2006) 1469
151. Smith K.A. Interleukin-2. Curr. Opin. Immunol. 4 (1992) 271
152. Soloaga A., Thomson S., Wiggin G.R., Rampersaud N., Dyson M.H., Hazzalin C.A., Mahadevan L.C., and Arthur J.S. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J. 22 (2003) 2788
153. Solomon M.J., Strauss F., and Varshavsky A. A mammalian high mobility group protein recognizes any stretch of six A.T base pairs in duplex DNA. Proc. Natl. Acad. Sci. U. S. A. 83 (1986) 1276
154. Strick R., and Laemmli U.K. SARs are cis DNA elements of chromosome dynamics: synthesis of a SAR repressor protein. Cell 83 (1995) 1137
155. Su Y., Kwon C.S., Bezhani S., Huvermann B., Chen C., Peragine A., Kennedy J.F., and Wagner D. The N-terminal ATPase AT-hook-containing region of the Arabidopsis chromatin-remodeling protein SPLAYED is sufficient for biological activity. Plant J. 46 (2006) 685
156. Tessari M.A., Gostissa M., Altamura S., Sgarra R., Rustighi A., Salvagno C., Caretti G., Imbriano C., Mantovani R., Del S.G., Giancotti V., and Manfioletti G. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Mol. Cell. Biol. 23 (2003) 9104
157. Thanos D., and Maniatis T. Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell 83 (1995) 1091
158. Thomas J.O., and Travers A.A. HMG1 and 2, and related 'architectural' DNA-binding proteins. Trends Biochem. Sci. 26 (2001) 167
159. Travers A.A. Priming the nucleosome: a role for HMGB proteins?. EMBO Rep. 4 (2003) 131
160. Trieschmann L., Alfonso P.J., Crippa M.P., Wolffe A.P., and Bustin M. Incorporation of chromosomal proteins HMG-14/HMG-17 into nascent nucleosomes induces an extended chromatin conformation and enhances the utilization of active transcription complexes. EMBO J. 14 (1995) 1478
161. Ueda T., Postnikov Y.V., and Bustin M. Distinct domains in high mobility group N variants modulate specific chromatin modifications. J. Biol. Chem. 281 (2006) 10182
162. Vallone D., Battista S., Pierantoni G.M., Fedele M., Casalino L., Santoro M., Viglietto G., Fusco A., and Verde P. Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product. EMBO J. 16 (1997) 5310
163. Wang H., Bloom O., Zhang M., Vishnubhakat J.M., Ombrellino M., Che J., Frazier A., Yang H., Ivanova S., Borovikova L., Manogue K.R., Faist E., Abraham E., Andersson J., Andersson U., Molina P.E., Abumrad N.N., Sama A., and Tracey K.J. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285 (1999) 248
164. Wegner M., and Grummt F. Netropsin, distamycin and berenil interact differentially with a high-affinity binding site for the high mobility group protein HMG-I,. Biochem. Biophys. Res. Commun. 166 (1990) 1110
165. West K.L. HMGN proteins play roles in DNA repair and gene expression in mammalian cells. Biochem. Soc. Trans. 32 (2004) 918
166. West K.L., Castellini M.A., Duncan M.K., and Bustin M. Chromosomal proteins HMGN3a and HMGN3b regulate the expression of glycine transporter 1. Mol. Cell. Biol. 24 (2004) 3747
167. Williams R.S., Williams J.S., and Tainer J.A. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem. Cell. Biol. 85 (2007) 509
168. Wood L.J., Maher J.F., Bunton T.E., and Resar L.M. The oncogenic properties of the HMG-I gene family. Cancer Res. 60 (2000) 4256
169. Wood L.J., Mukherjee M., Dolde C.E., Xu Y., Maher J.F., Bunton T.E., Williams J.B., and Resar L.M. HMG-I/Y, a new c-Myc target gene and potential oncogene. Mol. Cell. Biol. 20 (2000) 5490
170. Xiao H., Sandaltzopoulos R., Wang H.M., Hamiche A., Ranallo R., Lee K.M., Fu D., and Wu C. Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions. Mol. Cell 8 (2001) 531
171. Xu Y., Sumter T.F., Bhattacharya R., Tesfaye A., Fuchs E.J., Wood L.J., Huso D.L., and Resar L.M. The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia. Cancer Res. 64 (2004) 3371
172. Yie J., Merika M., Munshi N., Chen G., and Thanos D. The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome. EMBO J. 18 (1999) 3074
173. Yie J., Senger K., and Thanos D. Mechanism by which the IFN-beta enhanceosome activates transcription. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 13108
174. Youn J.H., and Shin J.S. Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion. J. Immunol. 177 (2006) 7889
175. Zhang Q., and Wang Y. High mobility group proteins and their post-translational modifications. Biochim. Biophys. Acta 1784 (2008) 1159
176. Zhang R., Chen W., and Adams P.D. Molecular dissect ion of formation of senescence-associated heterochromatin foci. Mol. Cell. Biol. 27 (2007) 2343
177. Zhang R., Poustovoitov M.V., Ye X., Santos H.A., Chen W., Daganzo S.M., Erzberger J.P., Serebriiskii I.G., Canutescu A.A., Dunbrack R.L., Pehrson J.R., Berger J.M., Kaufman P.D., and Adams P.D. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev. Cell 8 (2005) 19
178. Zhao K., Kas E., Gonzalez E., and Laemmli U.K. SAR-dependent mobilization of histone H1 by HMG-I/Y in vitro: HMG-I/Y is enriched in H1-depleted chromatin. EMBO J. 12 (1993) 3237
179. Zhou X., Benson K.F., Ashar H.R., and Chada K. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 376 (1995) 771
180. Zlatanova J., and van H.K. Linker histones versus HMG1/2: a struggle for dominance?. BioEssays 20 (1998) 584