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0032458247
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Structure and function of the interferon-β enhanceosome
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Comprehensive review of the earlier work on the interferon-β enhanceosome.
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Maniatis T., Falvo J.V., Kim T.H., Kim T.K., Lin C.H., Parekh B.S., and Wathelet M.G. Structure and function of the interferon-β enhanceosome. Cold Spring Harb Symp Quant Biol 63 (1998) 609-620. Comprehensive review of the earlier work on the interferon-β enhanceosome.
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Maniatis, T.1
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0033681250
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Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter
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In this work, the authors show that the INF-β enhancer is nucleosome-free and that activation after virus infection leads to recruitment of GCN5, CBP/p300 and PolII, SWI/SNF and TFIID to the promoter.
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Agalioti T., Lomvardas S., Parekh B., Yie J., Maniatis T., and Thanos D. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell 103 (2000) 667-678. In this work, the authors show that the INF-β enhancer is nucleosome-free and that activation after virus infection leads to recruitment of GCN5, CBP/p300 and PolII, SWI/SNF and TFIID to the promoter.
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0034122095
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Assembly of a functional beta interferon enhanceosome is dependent on ATF-2/c-Jun heterodimer orientation
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Falvo J.V., Parekh B.S., Lin C.H., Fraenkel E., and Maniatis T. Assembly of a functional beta interferon enhanceosome is dependent on ATF-2/c-Jun heterodimer orientation. Mol Cell Biol 20 (2000) 4814-4825
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Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer
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Crystallographic, biochemical, and mutational analyses are combined to analyze the ATF-2/c-Jun and IRF-3 binding and complex formation on the INF-β enhancer. Cooperative binding occurs because the DNA-binding sites overlap and the DNA conformations are complementary.
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Panne D., Maniatis T., and Harrison S.C. Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. EMBO J 23 (2004) 4384-4393. Crystallographic, biochemical, and mutational analyses are combined to analyze the ATF-2/c-Jun and IRF-3 binding and complex formation on the INF-β enhancer. Cooperative binding occurs because the DNA-binding sites overlap and the DNA conformations are complementary.
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Panne, D.1
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Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer
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Crystallographic analysis of IRF-3 DNA-binding domains in complex with the PRDIII-I region of the human IFN-β enhancer. In vivo analysis shows that mutations in any IRF-binding site abolish transcription of the enhancer.
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Escalante C.R., Nistal-Villan E., Shen L., Garcia-Sastre A., and Aggarwal A.K. Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. Mol Cell 26 (2007) 703-716. Crystallographic analysis of IRF-3 DNA-binding domains in complex with the PRDIII-I region of the human IFN-β enhancer. In vivo analysis shows that mutations in any IRF-binding site abolish transcription of the enhancer.
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34250017968
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An atomic model of the interferon-beta enhanceosome
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Determination of the crystal structure of NFκB, IRF-7, and IRF-3 bound to the enhancer sequence and of four IRF-3 DNA-binding domains bound to the enhancer. Together with a previously determined structure this work leads to a complete atomic model of the fully assembled enhanceosome. The role of the essential enhanceosome components IRF-3 and IRF-7 is addressed.
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Panne D., Maniatis T., and Harrison S.C. An atomic model of the interferon-beta enhanceosome. Cell 129 (2007) 1111-1123. Determination of the crystal structure of NFκB, IRF-7, and IRF-3 bound to the enhancer sequence and of four IRF-3 DNA-binding domains bound to the enhancer. Together with a previously determined structure this work leads to a complete atomic model of the fully assembled enhanceosome. The role of the essential enhanceosome components IRF-3 and IRF-7 is addressed.
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An ATF/CREB binding site is required for virus induction of the human interferon-β gene
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The authors show using knock-out mice that IRF-7 is essential for type I interferon production. Absence of IRF-7 alone or combined absence of IRF-3 and IRF-7 prevents induction of INF-β or INF-α.
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Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7
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Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription
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Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
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Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation
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Structure of NFκB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter
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Structure of NFκB p50 homodimer bound to a kappa B site
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Coordination of a transcriptional switch by HMGI(Y) acetylation
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Comprehensive study of the timing of transcription factor association with the estrogen receptor-inducible pS2 promoter. The Authors show, using sequential ChIP that estrogen-induced transcription is a cyclical process and transcription factors are recruited in defined phases.
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