Augmented adriamycin sensitivity in cells transduced with an antisense tumor necrosis factor gene is mediated by caspase-3 downstream from reactive oxygen species

Japanese Journal of Cancer Research

Volumn 92, Issue 9, 2001, Pages 983-988

  Sasaki, Masahiro ^a   Kobayashi, Daisuke ^a   Watanabe, Naoki ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antisense; Caspase 3; Reactive oxygen species; Tumor necrosis factor

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CASPASE 3; CASPASE INHIBITOR; DOXORUBICIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR;

ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE SEQUENCE; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PANCREAS CARCINOMA; PRIORITY JOURNAL;

ACETYLCYSTEINE; ADENOCARCINOMA; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; GENES, P53; HUMANS; NEOPLASM PROTEINS; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OLIGOPEPTIDES; OXIDATIVE STRESS; PANCREATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034786169     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb01189.x     Document Type: Article

References (21)

1. Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide
2. Inhibition of P-glycoprotein and recovery of drug sensitivity of human acute leukemic blast cells by multidrug resistance gene (mdr1) antisense oligonucleotides
3. Endogenous tumor necrosis factor inhibits the cytotoxicity of exogenous tumor necrosis factor and adriamycin in pancreatic carcinoma cells
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5. Endogenous tumor necrosis factor functions as a resistant factor against adriamycin
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13. Activation of the CD95 (APO-1/Fas) pathway in drug- and gamma-irradiation-induced apoptosis of brain tumor cells
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15. A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy
16. Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines
17. Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently from activation of caspases in Fas signaling
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20. Endogenous tumor necrosis factor functions as a resistant factor against hyperthermic cytotoxicity in pancreatic carcinoma cells via enhancement of the heat shock element-binding activity of heat shock factor 1
21. Hsp 70 exerts its anti-apoptotic function downstream of caspase-3 like proteases