Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes

Carcinogenesis

Volumn 22, Issue 12, 2001, Pages 1987-1992

  Ye, Lingxiang ^a   Zhang, Yuesheng ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL ISOTHIOCYANATE; BENZYL ISOTHIOCYANATE; GENE PRODUCT; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEIN; ISOTHIOCYANIC ACID; PHENETHYL ISOTHIOCYANATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFORAPHANE;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; CANCER PREVENTION; CELL LEVEL; CELL STRAIN HEPG2; CELLULAR IMMUNITY; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DETOXIFICATION; DIET; ENZYME ACTIVITY; ENZYME INDUCTION; GENE CONSTRUCT; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SKIN PAPILLOMA;

EID: 0035681887     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.12.1987     Document Type: Article

References (28)

1. The role of enzyme induction in protection against carcinogenesis
2. Chemoprevention by inducers of carcinogen detoxification enzymes
3. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
4. Anticarcinogenic activities of organic isothiocyanates: Chemistry and mechanisms
5. Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: Correlation between structure and potency as inducers of anticarcinogenic detoxification enzymes
6. Glucosinolates and their breakdown products in food and food plants
7. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
8. Chemoprevention by isothiocyanates
9. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
10. Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes
11. Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells
12. Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates
13. Antioxidant response element
14. Parallel induction of heme oxygenase-1 and chemoprotective Phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE)
15. Regulation of γ-glutamylcysteine synthetase subunit gene expression: Insights into transcriptional control of antioxidant defenses
16. Cellular response to cancer chemopreventive agents: Contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress
17. Development of a green fluorescent protein microplate assay for the screening of chemopreventive agents
18. Quantitative determination of isothiocyanates, dithiocyanates, carbon disulfide and related thiocarbonyl compounds by cyclocondensation with 1,2-benzenedithiol
19. Measurement of protein using bicinchoninic acid
20. An interactive computer program for determining areas bounded by drug concentration curves using lagrange interpolation
21. Blood glutathione concentrations in a large-scale human study
22. Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues
23. Glutathione S-transferases, the first enzymatic step in mercapturic acid formation
24. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis
25. The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations
26. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
27. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defense against oxidative stress
28. Disposition and pharmacokinetics of phenethyl isothiocyanate and 6-phenylhexyl isothiocyanate in F344 rats