The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis

Science Signaling

Volumn 2, Issue 95, 2009, Pages

  Ashique, Amir M ^a   Choe, Youngshik ^b   Karlen, Mattias ^c   May, Scott R ^d   Phamluong, Khanhky ^a   Solloway, Mark J ^a   Ericson, Johan ^c   Peterson, Andrew S ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; IFT172 PROTEIN; INTRAFLAGELLAR TRANSPORT PROTEIN; PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI3; TRANSCRIPTION FACTOR RFX4; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; RFX4 PROTEIN, MOUSE; SHH PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CENTRAL NERVOUS SYSTEM; CILIOGENESIS; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EUKARYOTIC FLAGELLUM; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; MOUSE MUTANT; NERVE FIBER; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPINAL CORD; TELENCEPHALON; TRANSCRIPTION REGULATION; ANIMAL; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MUTATION; PHYSIOLOGY;

ERINACEIDAE; INVERTEBRATA; VERTEBRATA;

ANIMALS; CENTRAL NERVOUS SYSTEM; CILIA; DNA-BINDING PROTEINS; HEDGEHOG PROTEINS; MICE; MUTATION; SIGNAL TRANSDUCTION; SPINAL CORD; TELENCEPHALON; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 73949128987     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000602     Document Type: Article

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46. Acknowledgments: We thank S. Scales for the Gli3 antibody; J. L. Rubenstein for DNA constructs; L. Komuves for microscopy assistance; S. Endoh-Yamagami, D. Wilson, and K. Zarbalis for technical advice and insightful discussions; G. Pan and R. Ybarra for maintaining the mouse colony; and Genentech Department of Assay and Automation Technology, Center for Advanced Light Microscopy, Laboratory of Animal Research, Oligo Facility, and Sequencing Facility for support services. This study was supported by Genentech. The Genentech employed authors may or may not benefit financially from the publication of this paper. Support to J. Ericson provided by The Swedish Foundation for Strategic Research and The Swedish Natural Research Council. Author contributions: This study was primarily driven by A.M.A. A.M.A, Y.C., M.K., S.R.M., and P.K. participated in the design, execution and interpretation of experiments. A.M.A. wrote the manuscript in collaboration with M.J.S. and A.S.P. A.S.P, M.J.S., and J.E. supervised the design and interpretation of the studies.