메뉴 건너뛰기




Volumn 68, Issue 21, 2008, Pages 8723-8732

Tnk1/Kos1 knockout mice develop spontaneous tumors

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; GENE PRODUCT; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; GUANINE NUCLEOTIDE EXCHANGE FACTOR; KOS1 PROTEIN; PROTEIN TYROSINE KINASE; RAS PROTEIN; SOS PROTEIN; TNK1 PROTEIN; UNCLASSIFIED DRUG;

EID: 55349108502     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-1467     Document Type: Article
Times cited : (27)

References (40)
  • 1
    • 0030058725 scopus 로고    scopus 로고
    • Tnk1: A novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells
    • Hoehn GT, Stokland T, Amin S, et al. Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells. Oncogene 1996;12:903-13.
    • (1996) Oncogene , vol.12 , pp. 903-913
    • Hoehn, G.T.1    Stokland, T.2    Amin, S.3
  • 2
    • 34948864394 scopus 로고    scopus 로고
    • Thirty-eight-negative kinase1 (TNK1) facilitates TNFα-induced apoptosis by blocking NF-κB activation
    • Azoitei N, Brey A, Busch T, Fulda S, Adler G, Seufferlein T. Thirty-eight-negative kinase1 (TNK1) facilitates TNFα-induced apoptosis by blocking NF-κB activation. Oncogene 2007;26:6536-45.
    • (2007) Oncogene , vol.26 , pp. 6536-6545
    • Azoitei, N.1    Brey, A.2    Busch, T.3    Fulda, S.4    Adler, G.5    Seufferlein, T.6
  • 3
    • 0038121760 scopus 로고    scopus 로고
    • Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
    • Hoare K, Hoare S, Smith OM, Kalmaz G, Small D, May WS. Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling. Oncogene 2003;22:3562-77.
    • (2003) Oncogene , vol.22 , pp. 3562-3577
    • Hoare, K.1    Hoare, S.2    Smith, O.M.3    Kalmaz, G.4    Small, D.5    May, W.S.6
  • 4
    • 0027235324 scopus 로고
    • A nonreceptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
    • Manser E, Leung T, Salihuddin H, Tan L, Lim L. A nonreceptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 1993;363:364-67.
    • (1993) Nature , vol.363 , pp. 364-367
    • Manser, E.1    Leung, T.2    Salihuddin, H.3    Tan, L.4    Lim, L.5
  • 5
    • 0030779042 scopus 로고    scopus 로고
    • Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain
    • Yang W, Cerione RA. Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain. J Biol Chem 1997;272:24819-24.
    • (1997) J Biol Chem , vol.272 , pp. 24819-24824
    • Yang, W.1    Cerione, R.A.2
  • 6
    • 0034667593 scopus 로고    scopus 로고
    • Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
    • Kolch W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 2000;351:289-5.
    • (2000) Biochem J , vol.351 , pp. 289-295
    • Kolch, W.1
  • 7
    • 27644575157 scopus 로고    scopus 로고
    • Coordinating ERK/MAPK signalling through scaffolds and inhibitors
    • Kolch W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 2005;6:827-37.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 827-837
    • Kolch, W.1
  • 8
    • 0026729382 scopus 로고
    • The SH2 and SH3 domain containing protein Grb2 links receptor tyrosine kinases to Ras signaling
    • Lowenstein EJ. The SH2 and SH3 domain containing protein Grb2 links receptor tyrosine kinases to Ras signaling. Cell 1992;70:431-42.
    • (1992) Cell , vol.70 , pp. 431-442
    • Lowenstein, E.J.1
  • 9
    • 0035834388 scopus 로고    scopus 로고
    • The guanine nucleotide-binding switch in three dimensions
    • Vetter IR, Wittinghofer A. The guanine nucleotide-binding switch in three dimensions. Science 2001;294:1299-4.
    • (2001) Science , vol.294 , pp. 1299-1304
    • Vetter, I.R.1    Wittinghofer, A.2
  • 10
    • 1542271463 scopus 로고    scopus 로고
    • Ras oncogenes: The first 30 years
    • Malumbres M, Barbacid M. Ras oncogenes: the first 30 years. Nat Rev 2002;3:7-13.
    • (2002) Nat Rev , vol.3 , pp. 7-13
    • Malumbres, M.1    Barbacid, M.2
  • 11
    • 0025091465 scopus 로고
    • The Neurofibromatosis type1 gene encodes a protein related to GAP
    • Xu G F, O'Connell P, Viskochil D, et al. The Neurofibromatosis type1 gene encodes a protein related to GAP. Cell 1990;62:599-8.
    • (1990) Cell , vol.62 , pp. 599-608
    • Xu, G.F.1    O'Connell, P.2    Viskochil, D.3
  • 12
    • 0024502703 scopus 로고
    • Ras GTPase activating protein: Signal transmitter and signal terminator
    • McCormick F. Ras GTPase activating protein: signal transmitter and signal terminator. Cell 1989;56:5-8.
    • (1989) Cell , vol.56 , pp. 5-8
    • McCormick, F.1
  • 13
    • 0027304731 scopus 로고
    • Human Sos1: A guanine nucleotide exchange factor for Ras that binds to Grb2
    • Chardin P, Camonis JH, Gale NW, et al. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to Grb2. Science 1993;260:1338-43.
    • (1993) Science , vol.260 , pp. 1338-1343
    • Chardin, P.1    Camonis, J.H.2    Gale, N.W.3
  • 14
    • 0027465064 scopus 로고
    • Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts
    • Buday L, Downward J. Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts. Mol Cell Biol 1993;13:1903-10.
    • (1993) Mol Cell Biol , vol.13 , pp. 1903-1910
    • Buday, L.1    Downward, J.2
  • 15
    • 0037264633 scopus 로고    scopus 로고
    • Targeting Ras signaling pathways in cancer therapy
    • Downward, J. Targeting Ras signaling pathways in cancer therapy. Nat Rev Cancer 2003;3:11-22.
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 16
    • 0011186077 scopus 로고
    • Ha-Ras proteins exhibit GTPase activity: Point mutations that activate Ha-Ras gene product results in decreased GTPase activity
    • Manne V, Bekesi E, King H-F. Ha-Ras proteins exhibit GTPase activity: point mutations that activate Ha-Ras gene product results in decreased GTPase activity. Proc Natl Acad Sci U S A 1985;82:376-80.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 376-380
    • Manne, V.1    Bekesi, E.2    King, H.-F.3
  • 17
    • 0024376173 scopus 로고
    • Ras oncogene in human cancer
    • Bos JL. Ras oncogene in human cancer. Cancer Res 1989;49:4682-9.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 18
    • 0030772378 scopus 로고    scopus 로고
    • The Ras-Ras GAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
    • Scheffzek K, Ahmadian MR, Kobsch N, et al. The Ras-Ras GAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 1997;277:333-8.
    • (1997) Science , vol.277 , pp. 333-338
    • Scheffzek, K.1    Ahmadian, M.R.2    Kobsch, N.3
  • 19
    • 33749582985 scopus 로고    scopus 로고
    • A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation
    • Lao DH, Chandramouli S, Yusoff P, et al. A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation. J Biol Chem 2006;281:29993-0.
    • (2006) J Biol Chem , vol.281 , pp. 29993-30000
    • Lao, D.H.1    Chandramouli, S.2    Yusoff, P.3
  • 20
    • 0035824694 scopus 로고    scopus 로고
    • Mammalian Sprouty proteins inhibit cell growth and differentiation by preventing Ras activation
    • Gross I, Basset B, Benezra M, Licht JD. Mammalian Sprouty proteins inhibit cell growth and differentiation by preventing Ras activation. J Biol Chem 2001;276:46460-8.
    • (2001) J Biol Chem , vol.276 , pp. 46460-46468
    • Gross, I.1    Basset, B.2    Benezra, M.3    Licht, J.D.4
  • 21
    • 0033515519 scopus 로고    scopus 로고
    • Negative feedback mechanism and their roles in pattern formation
    • Perrimon N, McMahon AP. Negative feedback mechanism and their roles in pattern formation. Cell 1999;97:13-6.
    • (1999) Cell , vol.97 , pp. 13-16
    • Perrimon, N.1    McMahon, A.P.2
  • 22
    • 0027439597 scopus 로고    scopus 로고
    • The I, Murthy AE, Hannigan GE, et al. Neurofibromatosis gene mutations in neuroblastoma. Nat Genet 1993;3:62-6.
    • The I, Murthy AE, Hannigan GE, et al. Neurofibromatosis gene mutations in neuroblastoma. Nat Genet 1993;3:62-6.
  • 23
    • 0026528368 scopus 로고
    • ras contributes to malignant tumor growth in von Recklinghausen (type1) neurofibromatosis
    • ras contributes to malignant tumor growth in von Recklinghausen (type1) neurofibromatosis. Cell 1992;69:265-73.
    • (1992) Cell , vol.69 , pp. 265-273
    • DeClue, J.E.1    Papageorge, A.G.2    Fletcher, J.A.3
  • 24
    • 9044251606 scopus 로고    scopus 로고
    • Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells
    • Bollag G, Clapp DW, Shih S, et al. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet 1996;12:144-8.
    • (1996) Nat Genet , vol.12 , pp. 144-148
    • Bollag, G.1    Clapp, D.W.2    Shih, S.3
  • 26
    • 19944429131 scopus 로고    scopus 로고
    • Tumor susceptibility of Rassf1a knockout mice
    • Tommasi S, Dammann R, Zhang Z, et al. Tumor susceptibility of Rassf1a knockout mice. Cancer Res 2005;65:92-8.
    • (2005) Cancer Res , vol.65 , pp. 92-98
    • Tommasi, S.1    Dammann, R.2    Zhang, Z.3
  • 28
    • 0026774181 scopus 로고
    • Nerve growth factor stimulation of the Ras-Guanine Nucleotide Exchange Factor and GAP Activities
    • Li B-Q, Kaplan D, Kung H, Kamata T. Nerve growth factor stimulation of the Ras-Guanine Nucleotide Exchange Factor and GAP Activities. Science 1992;256:1456-9.
    • (1992) Science , vol.256 , pp. 1456-1459
    • Li, B.-Q.1    Kaplan, D.2    Kung, H.3    Kamata, T.4
  • 29
    • 0035803494 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: A novel regulatory mechanism for tyrosine kinase signaling
    • Li S, Couvillon AD, Brasher BB, Van Etten RA. Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling. EMBO J 2001;20:6793-4.
    • (2001) EMBO J , vol.20 , pp. 6793-6794
    • Li, S.1    Couvillon, A.D.2    Brasher, B.B.3    Van Etten, R.A.4
  • 31
    • 0033601073 scopus 로고    scopus 로고
    • Methylation induced repression: Belts, braces and chromatin
    • Bird AP, Wolffe AP. Methylation induced repression: belts, braces and chromatin. Cell 1999;99:451-54.
    • (1999) Cell , vol.99 , pp. 451-454
    • Bird, A.P.1    Wolffe, A.P.2
  • 32
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-28.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 33
    • 0034709566 scopus 로고    scopus 로고
    • Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-γ1
    • Felscow DM, Civin CI, Hoehn GT. Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-γ1. BBRC 2000;273:294-1.
    • (2000) BBRC , vol.273 , pp. 294-301
    • Felscow, D.M.1    Civin, C.I.2    Hoehn, G.T.3
  • 34
    • 24744453982 scopus 로고    scopus 로고
    • Somatic mutations of the protein kinase gene family in human lung cancer
    • Davies H, Hunter C, Smith R, et al. Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 2005;65:7591-5.
    • (2005) Cancer Res , vol.65 , pp. 7591-7595
    • Davies, H.1    Hunter, C.2    Smith, R.3
  • 35
    • 0028938153 scopus 로고
    • Crystal structure of the mammalian Grb2 adaptor
    • Maignan S, Guilloteau JP, Fromage N, et al. Crystal structure of the mammalian Grb2 adaptor. Science 1995;268:291-3.
    • (1995) Science , vol.268 , pp. 291-293
    • Maignan, S.1    Guilloteau, J.P.2    Fromage, N.3
  • 36
    • 0035885925 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-1 complexes
    • Kardinal C, Konkol B, Lin H, et al. Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-1 complexes. Blood 2001;98:1773-81.
    • (2001) Blood , vol.98 , pp. 1773-1781
    • Kardinal, C.1    Konkol, B.2    Lin, H.3
  • 37
    • 0037352035 scopus 로고    scopus 로고
    • High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia
    • Feller SM, Tuchscherer G, Voss J. High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia. Leuk Lymphoma 2003;44:411-27.
    • (2003) Leuk Lymphoma , vol.44 , pp. 411-427
    • Feller, S.M.1    Tuchscherer, G.2    Voss, J.3
  • 38
    • 0028895008 scopus 로고
    • Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation
    • Gishizky ML, Cortez D, Pendergast AM. Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation. Proc Natl Acad Sci U S A 1995;92:10889-93.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 10889-10893
    • Gishizky, M.L.1    Cortez, D.2    Pendergast, A.M.3
  • 39
    • 2542432915 scopus 로고    scopus 로고
    • Haploinsufficiency for tumor suppressor genes: When you don't need to go all the way
    • Santarosa M, Ashworth A. A. Haploinsufficiency for tumor suppressor genes: when you don't need to go all the way. Biochim Biophys Acta 2004;1654:105-22.
    • (2004) Biochim Biophys Acta , vol.1654 , pp. 105-122
    • Santarosa, M.1    Ashworth, A.A.2
  • 40
    • 0034643955 scopus 로고    scopus 로고
    • Accomodating haplosufficient tumor suppressor gene in Knudson's model
    • Cook WD, McCaw B J. Accomodating haplosufficient tumor suppressor gene in Knudson's model. Oncogene 2000;19:3434-8.
    • (2000) Oncogene , vol.19 , pp. 3434-3438
    • Cook, W.D.1    McCaw, B.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.