-
1
-
-
0030058725
-
Tnk1: A novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells
-
Hoehn GT, Stokland T, Amin S, et al. Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells. Oncogene 1996;12:903-13.
-
(1996)
Oncogene
, vol.12
, pp. 903-913
-
-
Hoehn, G.T.1
Stokland, T.2
Amin, S.3
-
2
-
-
34948864394
-
Thirty-eight-negative kinase1 (TNK1) facilitates TNFα-induced apoptosis by blocking NF-κB activation
-
Azoitei N, Brey A, Busch T, Fulda S, Adler G, Seufferlein T. Thirty-eight-negative kinase1 (TNK1) facilitates TNFα-induced apoptosis by blocking NF-κB activation. Oncogene 2007;26:6536-45.
-
(2007)
Oncogene
, vol.26
, pp. 6536-6545
-
-
Azoitei, N.1
Brey, A.2
Busch, T.3
Fulda, S.4
Adler, G.5
Seufferlein, T.6
-
3
-
-
0038121760
-
Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
-
Hoare K, Hoare S, Smith OM, Kalmaz G, Small D, May WS. Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling. Oncogene 2003;22:3562-77.
-
(2003)
Oncogene
, vol.22
, pp. 3562-3577
-
-
Hoare, K.1
Hoare, S.2
Smith, O.M.3
Kalmaz, G.4
Small, D.5
May, W.S.6
-
4
-
-
0027235324
-
A nonreceptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
-
Manser E, Leung T, Salihuddin H, Tan L, Lim L. A nonreceptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 1993;363:364-67.
-
(1993)
Nature
, vol.363
, pp. 364-367
-
-
Manser, E.1
Leung, T.2
Salihuddin, H.3
Tan, L.4
Lim, L.5
-
5
-
-
0030779042
-
Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain
-
Yang W, Cerione RA. Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain. J Biol Chem 1997;272:24819-24.
-
(1997)
J Biol Chem
, vol.272
, pp. 24819-24824
-
-
Yang, W.1
Cerione, R.A.2
-
6
-
-
0034667593
-
Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
-
Kolch W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 2000;351:289-5.
-
(2000)
Biochem J
, vol.351
, pp. 289-295
-
-
Kolch, W.1
-
7
-
-
27644575157
-
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
-
Kolch W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 2005;6:827-37.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 827-837
-
-
Kolch, W.1
-
8
-
-
0026729382
-
The SH2 and SH3 domain containing protein Grb2 links receptor tyrosine kinases to Ras signaling
-
Lowenstein EJ. The SH2 and SH3 domain containing protein Grb2 links receptor tyrosine kinases to Ras signaling. Cell 1992;70:431-42.
-
(1992)
Cell
, vol.70
, pp. 431-442
-
-
Lowenstein, E.J.1
-
9
-
-
0035834388
-
The guanine nucleotide-binding switch in three dimensions
-
Vetter IR, Wittinghofer A. The guanine nucleotide-binding switch in three dimensions. Science 2001;294:1299-4.
-
(2001)
Science
, vol.294
, pp. 1299-1304
-
-
Vetter, I.R.1
Wittinghofer, A.2
-
10
-
-
1542271463
-
Ras oncogenes: The first 30 years
-
Malumbres M, Barbacid M. Ras oncogenes: the first 30 years. Nat Rev 2002;3:7-13.
-
(2002)
Nat Rev
, vol.3
, pp. 7-13
-
-
Malumbres, M.1
Barbacid, M.2
-
11
-
-
0025091465
-
The Neurofibromatosis type1 gene encodes a protein related to GAP
-
Xu G F, O'Connell P, Viskochil D, et al. The Neurofibromatosis type1 gene encodes a protein related to GAP. Cell 1990;62:599-8.
-
(1990)
Cell
, vol.62
, pp. 599-608
-
-
Xu, G.F.1
O'Connell, P.2
Viskochil, D.3
-
12
-
-
0024502703
-
Ras GTPase activating protein: Signal transmitter and signal terminator
-
McCormick F. Ras GTPase activating protein: signal transmitter and signal terminator. Cell 1989;56:5-8.
-
(1989)
Cell
, vol.56
, pp. 5-8
-
-
McCormick, F.1
-
13
-
-
0027304731
-
Human Sos1: A guanine nucleotide exchange factor for Ras that binds to Grb2
-
Chardin P, Camonis JH, Gale NW, et al. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to Grb2. Science 1993;260:1338-43.
-
(1993)
Science
, vol.260
, pp. 1338-1343
-
-
Chardin, P.1
Camonis, J.H.2
Gale, N.W.3
-
14
-
-
0027465064
-
Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts
-
Buday L, Downward J. Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts. Mol Cell Biol 1993;13:1903-10.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 1903-1910
-
-
Buday, L.1
Downward, J.2
-
15
-
-
0037264633
-
Targeting Ras signaling pathways in cancer therapy
-
Downward, J. Targeting Ras signaling pathways in cancer therapy. Nat Rev Cancer 2003;3:11-22.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
16
-
-
0011186077
-
Ha-Ras proteins exhibit GTPase activity: Point mutations that activate Ha-Ras gene product results in decreased GTPase activity
-
Manne V, Bekesi E, King H-F. Ha-Ras proteins exhibit GTPase activity: point mutations that activate Ha-Ras gene product results in decreased GTPase activity. Proc Natl Acad Sci U S A 1985;82:376-80.
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, pp. 376-380
-
-
Manne, V.1
Bekesi, E.2
King, H.-F.3
-
17
-
-
0024376173
-
Ras oncogene in human cancer
-
Bos JL. Ras oncogene in human cancer. Cancer Res 1989;49:4682-9.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
18
-
-
0030772378
-
The Ras-Ras GAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
-
Scheffzek K, Ahmadian MR, Kobsch N, et al. The Ras-Ras GAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 1997;277:333-8.
-
(1997)
Science
, vol.277
, pp. 333-338
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Kobsch, N.3
-
19
-
-
33749582985
-
A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation
-
Lao DH, Chandramouli S, Yusoff P, et al. A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation. J Biol Chem 2006;281:29993-0.
-
(2006)
J Biol Chem
, vol.281
, pp. 29993-30000
-
-
Lao, D.H.1
Chandramouli, S.2
Yusoff, P.3
-
20
-
-
0035824694
-
Mammalian Sprouty proteins inhibit cell growth and differentiation by preventing Ras activation
-
Gross I, Basset B, Benezra M, Licht JD. Mammalian Sprouty proteins inhibit cell growth and differentiation by preventing Ras activation. J Biol Chem 2001;276:46460-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 46460-46468
-
-
Gross, I.1
Basset, B.2
Benezra, M.3
Licht, J.D.4
-
21
-
-
0033515519
-
Negative feedback mechanism and their roles in pattern formation
-
Perrimon N, McMahon AP. Negative feedback mechanism and their roles in pattern formation. Cell 1999;97:13-6.
-
(1999)
Cell
, vol.97
, pp. 13-16
-
-
Perrimon, N.1
McMahon, A.P.2
-
22
-
-
0027439597
-
-
The I, Murthy AE, Hannigan GE, et al. Neurofibromatosis gene mutations in neuroblastoma. Nat Genet 1993;3:62-6.
-
The I, Murthy AE, Hannigan GE, et al. Neurofibromatosis gene mutations in neuroblastoma. Nat Genet 1993;3:62-6.
-
-
-
-
23
-
-
0026528368
-
ras contributes to malignant tumor growth in von Recklinghausen (type1) neurofibromatosis
-
ras contributes to malignant tumor growth in von Recklinghausen (type1) neurofibromatosis. Cell 1992;69:265-73.
-
(1992)
Cell
, vol.69
, pp. 265-273
-
-
DeClue, J.E.1
Papageorge, A.G.2
Fletcher, J.A.3
-
24
-
-
9044251606
-
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells
-
Bollag G, Clapp DW, Shih S, et al. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet 1996;12:144-8.
-
(1996)
Nat Genet
, vol.12
, pp. 144-148
-
-
Bollag, G.1
Clapp, D.W.2
Shih, S.3
-
25
-
-
0028307836
-
Tumor predisposition in mice heterozygous for a targeted mutation in NF1
-
Jacks T, Shih TS, Schmitt EM, Bronson RT, Bernards A, Weinberg RA. Tumor predisposition in mice heterozygous for a targeted mutation in NF1. Nat Genet 1994;7:353-61.
-
(1994)
Nat Genet
, vol.7
, pp. 353-361
-
-
Jacks, T.1
Shih, T.S.2
Schmitt, E.M.3
Bronson, R.T.4
Bernards, A.5
Weinberg, R.A.6
-
26
-
-
19944429131
-
Tumor susceptibility of Rassf1a knockout mice
-
Tommasi S, Dammann R, Zhang Z, et al. Tumor susceptibility of Rassf1a knockout mice. Cancer Res 2005;65:92-8.
-
(2005)
Cancer Res
, vol.65
, pp. 92-98
-
-
Tommasi, S.1
Dammann, R.2
Zhang, Z.3
-
28
-
-
0026774181
-
Nerve growth factor stimulation of the Ras-Guanine Nucleotide Exchange Factor and GAP Activities
-
Li B-Q, Kaplan D, Kung H, Kamata T. Nerve growth factor stimulation of the Ras-Guanine Nucleotide Exchange Factor and GAP Activities. Science 1992;256:1456-9.
-
(1992)
Science
, vol.256
, pp. 1456-1459
-
-
Li, B.-Q.1
Kaplan, D.2
Kung, H.3
Kamata, T.4
-
29
-
-
0035803494
-
Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: A novel regulatory mechanism for tyrosine kinase signaling
-
Li S, Couvillon AD, Brasher BB, Van Etten RA. Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling. EMBO J 2001;20:6793-4.
-
(2001)
EMBO J
, vol.20
, pp. 6793-6794
-
-
Li, S.1
Couvillon, A.D.2
Brasher, B.B.3
Van Etten, R.A.4
-
30
-
-
0030846212
-
Alterations in DNA methylation: A fundamental aspect of neoplasia
-
Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 1998;72:141-96.
-
(1998)
Adv Cancer Res
, vol.72
, pp. 141-196
-
-
Baylin, S.B.1
Herman, J.G.2
Graff, J.R.3
Vertino, P.M.4
Issa, J.P.5
-
31
-
-
0033601073
-
Methylation induced repression: Belts, braces and chromatin
-
Bird AP, Wolffe AP. Methylation induced repression: belts, braces and chromatin. Cell 1999;99:451-54.
-
(1999)
Cell
, vol.99
, pp. 451-454
-
-
Bird, A.P.1
Wolffe, A.P.2
-
32
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-28.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
33
-
-
0034709566
-
Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-γ1
-
Felscow DM, Civin CI, Hoehn GT. Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-γ1. BBRC 2000;273:294-1.
-
(2000)
BBRC
, vol.273
, pp. 294-301
-
-
Felscow, D.M.1
Civin, C.I.2
Hoehn, G.T.3
-
34
-
-
24744453982
-
Somatic mutations of the protein kinase gene family in human lung cancer
-
Davies H, Hunter C, Smith R, et al. Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 2005;65:7591-5.
-
(2005)
Cancer Res
, vol.65
, pp. 7591-7595
-
-
Davies, H.1
Hunter, C.2
Smith, R.3
-
35
-
-
0028938153
-
Crystal structure of the mammalian Grb2 adaptor
-
Maignan S, Guilloteau JP, Fromage N, et al. Crystal structure of the mammalian Grb2 adaptor. Science 1995;268:291-3.
-
(1995)
Science
, vol.268
, pp. 291-293
-
-
Maignan, S.1
Guilloteau, J.P.2
Fromage, N.3
-
36
-
-
0035885925
-
Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-1 complexes
-
Kardinal C, Konkol B, Lin H, et al. Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-1 complexes. Blood 2001;98:1773-81.
-
(2001)
Blood
, vol.98
, pp. 1773-1781
-
-
Kardinal, C.1
Konkol, B.2
Lin, H.3
-
37
-
-
0037352035
-
High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia
-
Feller SM, Tuchscherer G, Voss J. High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia. Leuk Lymphoma 2003;44:411-27.
-
(2003)
Leuk Lymphoma
, vol.44
, pp. 411-427
-
-
Feller, S.M.1
Tuchscherer, G.2
Voss, J.3
-
38
-
-
0028895008
-
Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation
-
Gishizky ML, Cortez D, Pendergast AM. Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation. Proc Natl Acad Sci U S A 1995;92:10889-93.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 10889-10893
-
-
Gishizky, M.L.1
Cortez, D.2
Pendergast, A.M.3
-
39
-
-
2542432915
-
Haploinsufficiency for tumor suppressor genes: When you don't need to go all the way
-
Santarosa M, Ashworth A. A. Haploinsufficiency for tumor suppressor genes: when you don't need to go all the way. Biochim Biophys Acta 2004;1654:105-22.
-
(2004)
Biochim Biophys Acta
, vol.1654
, pp. 105-122
-
-
Santarosa, M.1
Ashworth, A.A.2
-
40
-
-
0034643955
-
Accomodating haplosufficient tumor suppressor gene in Knudson's model
-
Cook WD, McCaw B J. Accomodating haplosufficient tumor suppressor gene in Knudson's model. Oncogene 2000;19:3434-8.
-
(2000)
Oncogene
, vol.19
, pp. 3434-3438
-
-
Cook, W.D.1
McCaw, B.J.2
|