Piecing together a ciliome

Trends in Genetics

Volumn 22, Issue 9, 2006, Pages 491-500

  Inglis, Peter N ^a   Boroevich, Keith A ^a   Leroux, Michel R ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; PROTEOME; RAB PROTEIN; TRANSCRIPTOME;

ALSTROM SYNDROME; BARDET BIEDL SYNDROME; BIOGENESIS; BIOINFORMATICS; CELL FUNCTION; CELL MOTILITY; CELL ORGANELLE; CELL SPECIFICITY; CELL STRUCTURE; CELL TRANSPORT; CELL VACUOLE; CHRONIC RESPIRATORY TRACT DISEASE; CILIARY MOTILITY; DATA BASE; EUKARYOTIC FLAGELLUM; GENETIC ANALYSIS; GENOMICS; HUMAN; HYDROCEPHALUS; INFERTILITY; KIDNEY POLYCYSTIC DISEASE; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEOMICS; RETINA DEGENERATION; REVIEW; SITUS INVERSUS; SPECIES DIFFERENCE;

ANIMALS; CILIA; COMPUTATIONAL BIOLOGY; GENOMICS; HUMANS; MODELS, BIOLOGICAL; ORGANELLES; PROTEOME; PROTEOMICS;

EUKARYOTA;

EID: 33747199910     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2006.07.006     Document Type: Review

References (71)

1. Cavalier-Smith T. The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa. Int. J. Syst. Evol. Microbiol. 52 (2002) 297-354
2. Davenport J.R., and Yoder B.K. An incredible decade for the primary cilium: a look at a once-forgotten organelle. Am. J. Physiol. Renal Physiol. 289 (2005) 1159-1169
3. Scholey J.M. Intraflagellar transport. Annu. Rev. Cell Dev. Biol. 19 (2003) 423-443
4. Fuchs J.L., and Schwark H.D. Neuronal primary cilia: a review. Cell Biol. Int. 28 (2004) 111-118
5. Pazour G.J., and Witman G.B. The vertebrate primary cilium is a sensory organelle. Curr. Opin. Cell Biol. 15 (2003) 105-110
6. Rosenbaum J.L., and Witman G.B. Intraflagellar transport. Nat. Rev. Mol. Cell Biol. 3 (2002) 813-825
7. Ibanez-Tallon I., et al. To beat or not to beat: roles of cilia in development and disease. Hum. Mol. Genet. 12 (2003) 27-35
8. Snow J.J., et al. Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons. Nat. Cell Biol. 6 (2004) 1109-1113
9. Perkins L.A., et al. Mutant sensory cilia in the nematode Caenorhabditis elegans. Dev. Biol. 117 (1986) 456-487
10. Mesland D.A., et al. Flagellar tip activation stimulated by membrane adhesions in Chlamydomonas gametes. J. Cell Biol. 84 (1980) 599-617
11. Hidaka K., et al. Fine structure of the cilia in the pancreatic duct of WBN/Kob rat. Int. J. Pancreatol. 18 (1995) 207-213
12. Cole D.G. The intraflagellar transport machinery of Chlamydomonas reinhardtii. Traffic 4 (2003) 435-442
13. Piperno G., and Mead K. Transport of a novel complex in the cytoplasmic matrix of Chlamydomonas flagella. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 4457-4462
14. Cole D.G., et al. Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons. J. Cell Biol. 141 (1998) 993-1008
15. Ou G., et al. Functional coordination of intraflagellar transport motors. Nature 436 (2005) 583-587
16. Fan Y., et al. Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome. Nat. Genet. 36 (2004) 989-993
17. Blacque O.E., et al. Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev. 18 (2004) 1630-1642
18. Li J.B., et al. Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell 117 (2004) 541-552
19. Blacque O.E., et al. Functional genomics of the cilium, a sensory organelle. Curr. Biol. 15 (2005) 935-941
20. Murayama T., et al. The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans. J. Mol. Biol. 346 (2005) 677-687
21. Ou G., et al. The PKD protein qilin undergoes intraflagellar transport. Curr. Biol. 15 (2005) R410-R411
22. Han Y.G., et al. Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. Curr. Biol. 13 (2003) 1679-1686
23. Avidor-Reiss T., et al. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Cell 117 (2004) 527-539
24. Schneider L., et al. PDGFRαα signaling is regulated through the primary cilium in fibroblasts. Curr. Biol. 15 (2005) 1861-1866
25. Huangfu D., et al. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426 (2003) 83-87
26. Ross A.J., et al. Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat. Genet. 37 (2005) 1135-1140
27. Germino G.G. Linking cilia to Wnts. Nat. Genet. 37 (2005) 455-457
28. Pan J., et al. Cilium-generated signaling and cilia-related disorders. Lab. Invest. 85 (2005) 452-463
29. Afzelius B.A. Cilia-related diseases. J. Pathol. 204 (2004) 470-477
30. Pazour G.J., and Rosenbaum J.L. Intraflagellar transport and cilia-dependent diseases. Trends Cell Biol. 12 (2002) 551-555
31. Beales P.L. Lifting the lid on Pandora's box: the Bardet-Biedl syndrome. Curr. Opin. Genet. Dev. 15 (2005) 315-323
32. Zhang Q., et al. Loss of the Tg737 protein results in skeletal patterning defects. Dev. Dyn. 227 (2003) 78-90
33. Ansley S.J., et al. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 425 (2003) 628-633
34. Hearn T., et al. Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. Diabetes 54 (2005) 1581-1587
35. Kulaga H.M., et al. Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse. Nat. Genet. 36 (2004) 994-998
36. Nishimura D.Y., et al. Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 16588-16593
37. Swoboda P., et al. The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans. Mol. Cell 5 (2000) 411-421
38. Dubruille R., et al. Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation. Development 129 (2002) 5487-5498
39. Bonnafe E., et al. The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. Mol. Cell. Biol. 24 (2004) 4417-4427
40. Efimenko E., et al. Analysis of xbx genes in C. elegans. Development 132 (2005) 1923-1934
41. Mukhopadhyay A., et al. C. elegans tubby regulates life span and fat storage by two independent mechanisms. Cell Metab. 2 (2005) 35-42
42. Mak H.Y., et al. Polygenic control of Caenorhabditis elegans fat storage. Nat. Genet (2006)
43. Noben-Trauth K., et al. A candidate gene for the mouse mutation tubby. Nature 380 (1996) 534-538
44. Kleyn P.W., et al. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell 85 (1996) 281-290
45. Nishimura D.Y., et al. Comparative genomics and gene expression analysis identifies BBS9, a new Bardet-Biedl syndrome gene. Am. J. Hum. Genet. 77 (2005) 1021-1033
46. Smith U.M., et al. The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat. Nat. Genet. 38 (2006) 191-196
47. Kyttala M., et al. MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome. Nat. Genet. 38 (2006) 155-157
48. Hildebrandt F., and Otto E. Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease?. Nat. Rev. Genet. 6 (2005) 928-940
49. Davy B.E., and Robinson M.L. Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. Hum. Mol. Genet. 12 (2003) 1163-1170
50. Cuvillier A., et al. LdARL-3A, a Leishmania promastigote-specific ADP-ribosylation factor-like protein, is essential for flagellum integrity. J. Cell Sci. 113 (2000) 2065-2074
51. Chiang A.P., et al. Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3). Am. J. Hum. Genet. 75 (2004) 475-484
52. Sun Z., et al. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development 131 (2004) 4085-4093
53. Stolc V., et al. Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genes. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 3703-3707
54. Seixas C., et al. Subunits of the chaperonin CCT are associated with Tetrahymena microtubule structures and are involved in cilia biogenesis. Exp. Cell Res. 290 (2003) 303-321
55. Stirling P.C., et al. Getting a grip on non-native proteins. EMBO Rep. 4 (2003) 565-570
56. Corbeil D., et al. Prominin: a story of cholesterol, plasma membrane protrusions and human pathology. Traffic 2 (2001) 82-91
57. Colosimo M.E., et al. Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types. Curr. Biol. 14 (2004) 2245-2251
58. Ostrowski L.E., et al. A proteomic analysis of human cilia: identification of novel components. Mol. Cell. Proteomics 1 (2002) 451-465
59. Marshall W.F. Human cilia proteome contains homolog of zebrafish polycystic kidney disease gene qilin. Curr. Biol. 14 (2004) R913-R914
60. Smith J.C., et al. Robust method for proteome analysis by MS/MS using an entire translated genome: demonstration on the ciliome of Tetrahymena thermophila. J. Proteome Res. 4 (2005) 909-919
61. Banizs B., et al. Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus. Development 132 (2005) 5329-5339
62. Pazour G.J., et al. Proteomic analysis of a eukaryotic cilium. J. Cell Biol. 170 (2005) 103-113
63. Quarmby L.M., and Mahjoub M.R. Caught Nek-ing: cilia and centrioles. J. Cell Sci. 118 (2005) 5161-5169
64. Broadhead R., et al. Flagellar motility is required for the viability of the bloodstream trypanosome. Nature 440 (2006) 224-227
65. Niu Y., et al. MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation. FEBS Lett. 550 (2003) 139-143
66. Low S.H., et al. Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Dev. Cell 10 (2006) 57-69
67. Deneka M., et al. Regulation of membrane transport by rab GTPases. Crit. Rev. Biochem. Mol. Biol. 38 (2003) 121-142
68. Keller L.C., et al. Proteomic analysis of isolated Chlamydomonas centrioles reveals orthologs of ciliary-disease genes. Curr. Biol. 15 (2005) 1090-1098
69. Andersen J.S., et al. Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426 (2003) 570-574
70. Badano J.L., et al. The centrosome in human genetic disease. Nat. Rev. Genet. 6 (2005) 194-205
71. Katsanis N. Ciliary proteins and exencephaly. Nat. Genet. 38 (2006) 135-136