Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes

Developmental Biology

Volumn 217, Issue 2, 2000, Pages 254-265

  Tole, Shubha ^a   Ragsdale, Clifton W ^a   Grove, Elizabeth A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Bmp; Cortical hem; Dlx2; Emx; Ephb1; Extra toes(J); Gli3; Hippocampus; Is11; Sonic hedgehog

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; GENE DELETION; GENE EXPRESSION REGULATION; GENE LOCATION; GENE MUTATION; GENETIC MARKER; MOUSE; NONHUMAN; PRIORITY JOURNAL; TELENCEPHALON; TRANSCRIPTION REGULATION;

ANIMALIA; ERINACEIDAE; MAMMALIA;

EID: 0034650621     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1999.9509     Document Type: Article

References (51)

1. Anderson S. A., Eisenstat D. D., Shi L., Rubenstein J. L. R. Interneuron migration from basal forebrain to neocortex: Dependence on Dlx genes. Science. 278:1997;474-476.
2. Buscher D., Bosse B., Heymer J., Ruther U. Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mechanisms of Development. 62:1997;175-182.
3. Buscher D., Grotewold L., Ruther U. The XtJ allele generates a Gli3 fusion transcript. Mamm. Genome. 9:1998;676-678.
4. Dai P., Akimaru H., Tanaka Y., Maekawa T., Nakafuku M., Ishii S. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274:1999;8143-8152.
5. Dale K. J., Vesque C., Lints T. J., Sampath T. K., Furley A., Dodd J., Placzek M. Cooperation of Bmp7 and Shh in the induction of forebrain ventral midline cells by prechordal mesenchyme. Cell. 90:1997;257-269.
6. Ding Q., Motoyama J., Gasca S., Mo R., Sasaki H., Rossant J., Hui C. C. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development. 125:1998;2533-2543.
7. Donoghue M. J., Rakic P. Molecular evidence for the early specification of presumptive functional domains in the embryonic primate cerebral cortex. J. Neurosci. 19:1999;5967-5979.
8. Dunn N. R., Winnier G. E., Hargett L. K., Schrick J. J., Fogo A. B., Hogan B. L. Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev. Biol. 188:1997;235-247.
9. Echelard Y., Epstein D. J., St-Jacques B., Shen L., Mohler J., McMahon J. A., McMahon A. P. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 75:1993;1417-1430.
10. Ericson J., Muhr J., Placzek M., Lints T., Jessell T. M., Edlund T. Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube. Cell. 81:1995;747-756.
11. Franz T. Extra-toes (Xt) homozygous mutant mice demonstrate a role for the Gli-3 gene in the development of the forebrain. Acta Anat. 150:1994;38-44.
12. Furuta Y., Piston D. W., Hogan B. L. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development. 124:1997;2203-2212.
13. Grindley J. C., Bellusci S., Perkins D., Hogan B. L. Evidence for the involvement of the Gli gene family in embryonic mouse lung development. Dev. Biol. 188:1997;337-348.
14. J mouse is associated with defects in medial telencephalic structures. Neurosci. Abstr. 24:1998a;1031.
15. Grove E. A., Tole S., Limon J., Yip L., Ragsdale C. W. The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development. 125:1998b;2315-2325.
16. Guazzi S., Price M., De Felice M., Damante G., Mattei M. G., Di Lauro R. Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J. 9:1990;3631-3639.
17. Hardcastle Z., Mo R., Hui C. C., Sharpe P. T. The Shh signalling pathway in tooth development: Defects in Gli2 and Gli3 mutants. Development. 125:1998;2803-2811.
18. Hui C.-C., Slusarski D., Platt K. A., Holmgren R., Joyner A. L. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3 in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol. 162:1994;402-413.
19. Hui C. C., Joyner A. L. A mouse model of greig cephalopolysyndactyly syndrome: The extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nature Genet. 3:1993;241-246.
20. Johnson D. R. Extra-toes: A new mutant gene causing multiple abnormalities in the mouse. J. Embryol. Exp. Morphol. 17:1967;543-581.
21. Karlsson O., Thor S., Norberg T., Ohlsson H., Edlund T. Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature. 344:1990;879-882.
22. Kohtz J. D., Baker D. P., Corte G., Fishell G. Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog. Development. 125:1998;5079-5089.
23. Lee J., Platt K. A., Censullo P., Ruiz i Altaba A. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development. 124:1997;2537-2552.
24. Lee, S. M, Tole, S, Grove, E. A, and, McMahon, A. P. A local Wnt3a signal is required for development of the mammalian hippocampus, Development, in press.
25. Liem K. F., Tremml G., Jessell T. M. A role for the roof plate and its resident TGFβ-related proteins in neuronal patterning in the dorsal spinal cord. Cell. 91:1997;127-138.
26. Liu J. K., Ghattas I., Liu S., Chen S., Rubenstein J. L. Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation. Dev. Dynam. 210:1997;498-512.
27. Marigo V., Johnson R. L., Vortkamp A., Tabin C. J. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol. 180:1996;273-283.
28. Masuya H., Sagai T., Wakana S., Moriwaki K., Shiroishi T. A duplicated zone of polarizing activity in polydactylous mouse mutants. Genes Dev. 9:1995;1645-1653.
29. Matise M. P., Epstein D. J., Park H. L., Platt K. A., Joyner A. L. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development. 125:1998;2759-2770.
30. Mo R., Freer A. M., Zinyk D. L., Crackower M. A., Michaud J., Heng H. H., Chik K. W., Shi X. M., Tsui L. C., Cheng S. H., Joyner A. L., Hui C. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development. 124:1997;113-123.
31. Motoyama J., Liu J., Mo R., Ding Q., Post M., Hui C. C. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nature Genet. 20:1998;54-57.
32. Orenic T. V., Slusarski D. C., Kroll K. L., Holmgren R. A. Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev. 4:1990;1053-1067.
33. Pearse R. V., Collier L. S., Scott M. P., Tabin C. J. Vertebrate homologs of Drosophila suppressor of fused interact with the Gli family of transcriptional regulators. Dev. Biol. 212:1999;323-336.
34. Pellegrini M., Mansouri A., Simeone A., Boncinelli E., Gruss P. Dentate gyrus formation requires Emx2. Development. 122:1996;3893-3898.
35. Pierani A., Brenner-Morton S., Chiang C., Jessell T. M. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell. 97:1999;903-915.
36. Puelles L., Rubenstein J. L. Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization. Trends Neurosci. 16:1993;472-479.
37. Ruiz i Altaba A. Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development. 125:1998;2203-2212.
38. Ruiz i Altaba A. Gli proteins encode context-dependent positive and negative functions: Implications for development and disease. Development. 126:1999;3205-3216.
39. Sasaki H., Nishizaki Y., Hui C., Nakafuku M., Kondoh H. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development. 126:1999;3915-3924.
40. Schimmang T., Lemaistre M., Vortkamp A., Ruther U. Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). Development. 116:1992;799-804.
41. Shimamura K., Rubenstein J. L. R. Inductive interactions direct early regionalization of the mouse forebrain. Development. 124:1997;2709-2718.
42. Shin S. H., Kogerman P., Lindstrom E., Toftgard R., Biesecker L. G. GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization. Proc. Natl. Acad. Sci. USA. 96:1999;2880-2884.
43. Simeone A., Gulisano M., Acampora D., Stronaiuolo A., Rambaldi M., Boncinelli E. Two vertebrate homeobox genes related to the Drosphila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 11:1992;2541-2550.
44. Sommer L., Ma Q., Anderson D. J. Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol. Cell. Neurosci. 8:1996;221-241.
45. Sussel L., Marin O., Kimura S., Rubenstein J. L. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: Evidence for a transformation of the pallidum into the striatum. Development. 126:1999;3359-3370.
46. Tanabe Y., Jessell T. M. Diversity and pattern in the developing spinal cord. Science. 274:1996;1115-1123.
47. Theil T., Alvarez-Bolado G., Walter A., Ruther U. Gli3 is required for Emx gene expression during dorsal telencephalon development. Development. 126:1999;3561-3571.
48. Vortkamp A., Franz T., Gessler M., Grzeschik K. H. Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt). Mamm. Genome. 3:1992;461-463.
49. Winnier G., Blessing M., Labosky P. A., Hogan B. L. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 9:1995;2105-2116.
50. Wisden W., Seeburg P. H. A complex mosaic of high-affinity kainate receptors in rat brain. J. Neurosci. 13:1993;3582-3598.
51. Yoshida M., Suda Y., Matsuo I., Miyamoto N., Takeda N., Kuratani S., Aizawa S. Emx1 and Emx2 functions in development of dorsal telencephalon. Development. 124:1997;101-111.