Netrin-1 and its dependence receptors as original targets for cancer therapy

Current Opinion in Oncology

Volumn 22, Issue 1, 2010, Pages 46-54

  Mehlen, Patrick ^a   Guenebeaud, Céline ^a  

^a CENTRE LÉON BÉRARD   (France)

Author keywords

Apoptosis; Cancer; Dependence receptor; Netrin 1; Targeted therapy

Indexed keywords

NETRIN 1;

APOPTOSIS; BREAST CANCER; CANCER INHIBITION; CANCER THERAPY; HOMEOSTASIS; HUMAN; LUNG CANCER; NEUROBLASTOMA; PANCREAS CANCER; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; DRUG DELIVERY SYSTEMS; HUMANS; NEOPLASMS; NERVE GROWTH FACTORS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 73849101144     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCO.0b013e328333dcd1     Document Type: Review

References (58)

1. Mehlen P, Thibert C. Dependence receptors: between life and death. Cell Mol Life Sci 2004; 61:1854-1866.
2. Bredesen DE, Mehlen P, Rabizadeh S. Apoptosis and dependence receptors: a molecular basis for cellular addiction. Physiol Rev 2004; 84:411-430.
3. Bredesen DE, Mehlen P, Rabizadeh S. Receptors that mediate cellular dependence. Cell Death Differ 2005; 12:1031-1043.
4. Serafini T, Kennedy TE, Galko MJ, et al. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 1994; 78:409-424.
5. Serafini T, Colamarino SA, Leonardo ED, et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 1996; 87:1001-1014.
6. Bloch-Gallego E, Ezan F, Tessier-Lavigne M, Sotelo C. Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons. J Neurosci 1999; 19:4407-4420.
7. Yebra M, Montgomery AM, Diaferia GR, et al. Recognition of the neural chemoattractant netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Dev Cell 2003; 5:695-707.
8. Jiang Y, Min-tsai L, Gershon MD. Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. Development 2003; 258:364-384.
9. Srinivasan K, Strickland P, Valdes A, et al. Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. Dev Cell 2003; 4:371-382.
10. Liu Y, Stein E, Oliver T, et al. Novel role for netrins in regulating epithelial behavior during lung branching morphogenesis. Curr Biol 2004; 14:897-905.
11. Lu X, Le Noble F, Yuan L, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004; 432:179-186.
12. Park KW, Crouse D, Lee M, et al. The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci U S A 2004; 101:16210-16215.
13. Larrivee B, Freitas C, Trombe M, et al. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev 2007; 21:2433-2447.
14. Manitt C, Kennedy TE. Where the rubber meets the road: netrin expression and function in developing and adult nervous systems. Prog Brain Res 2002; 137:425-442.
15. Carvalho AL, Chuang A, Jiang WW, et al. Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma. Cancer Res 2006; 66:9401-9407.
16. Fearon ER, Cho KR, Nigro JM, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990; 247:49-56.
17. Mehlen P, Rabizadeh S, Snipas SJ, et al. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 1998; 395:801-804.
18. Chen YQ, Hsieh JT, Yao F, et al. Induction of apoptosis and G2/M cell cycle arrest by DCC. Oncogene 1999; 18:2747-2754.
19. Forcet C, Ye X, Granger L, et al. The dependence receptor DCC (Deleted in Colorectal Cancer) defines an alternative mechanism for caspase activation. Proc Natl Acad Sci U S A 2001; 98:3416-3421.
20. Liu J, Yao F, Wu R, et al. Mediation of the DCC apoptotic signal by DIP13 alpha. J Biol Chem 2002; 277:26281-26285.
21. Chan SS, Zheng H, Su MW, et al. UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 1996; 87:187-195.
22. Hong K, Hinck L, Nishiyama M, et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrininduced growth cone attraction to repulsion. Cell 1999; 97:927-941.
23. Llambi F, Causeret F, Bloch-Gallego E, Mehlen P. Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J 2001; 20:2715-2722.
24. Tanikawa C, Matsuda K, Fukuda S, et al. p53RDL1 regulates p53-dependent apoptosis. Nat Cell Biol 2003; 5:216-223.
25. Furne C, Rama N, Corset V, et al. Netrin-1 is a survival factor during commissural neuron navigation. Proc Natl Acad Sci U S A 2008; 105: 14465-14470.
26. Tang X, Jang SW, Okada M, et al. Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Nat Cell Biol 2008; 10:698-706.
27. Castets M, Coissieux MM, Delloye-Bourgeois C, et al. Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis. Dev Cell 2009; 16:614-620.
28. Mille F, Llambi F, Guix C, et al. Interfering with netrin-1 receptors multimerization triggers apoptosis. Cell Death Differ 2009; 16:1344-1351.
29. Li W, Aurandt J, Jurgensen C, et al. FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. J Cell Sci 2006; 119:47-55.
30. Killeen M, Tong J, Krizus A, et al. UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains. Dev Biol 2002; 251:348-366.
31. Franke TF. PI3K/Akt: getting it right matters. Oncogene 2008; 27:6473-6488.
32. Bordeaux MC, Forcet C, Granger L, et al. The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J 2000; 19:4056-4063.
33. Thibert C, Teillet MA, Lapointe F, et al. Inhibition of neuroepithelial patchedinduced apoptosis by sonic hedgehog. Science 2003; 301:843-846.
34. Williams ME, Strickland P, Watanabe K, Hinck L. UNC5H1 induces apoptosis via its juxtamembrane domain through an interaction with NRAGE. J Biol Chem 2003; 278:17483-17490.
35. Dhanasekaran DN, Reddy EP. JNK signaling in apoptosis. Oncogene 2008; 27:6245-6251.
36. Wang R, Wei Z, Jin H, et al. Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor. Mol Cell 2009; 33:692-703.
37. Llambi F, Lourenco FC, Gozuacik D, et al. The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. EMBO J 2005; 24:1192-1201.
38. Gozuacik D, Bialik S, Raveh T, et al. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death Differ 2008; 15:1875-1886.
39. Mazelin L, Bernet A, Bonod-Bidaud C, et al. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 2004; 431:80-84.
40. Bernet A, Mazelin L, Coissieux MM, et al. Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology 2007; 133:1840-1848.
41. Grady WM. Making the case for DCC and UNC5C as tumor-suppressor genes in the colon. Gastroenterology 2007; 133:2045-2049.
42. Cho KR, Oliner JD, Simons JW, et al. The DCC gene: structural analysis and mutations in colorectal carcinomas. Genomics 1994; 19:525-531.
43. Thiagalingam S, Lengauer C, Leach FS, et al. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 1996; 13:343-346.
44. Goi T, Yamaguchi A, Nakagawara G, et al. Reduced expression of Deleted Colorectal Carcinoma (DCC) protein in established colon cancers. Br J Cancer 1998; 77:466-471.
45. Carethers JM, Hawn MT, Greenson JK, et al. Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer. Gastroenterology 1998; 114:1188-1195.
46. Velcich A, Corner G, Palumbo L, Augenlicht L. Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene. Oncogene 1999; 18:2599-2606.
47. Kato H, Zhou Y, Asanoma K, et al. Suppressed tumorigenicity of human endometrial cancer cells by the restored expression of the DCC gene. Br J Cancer 2000; 82:459-466.
48. Shin SK, Nagasaka T, Jung BH, et al. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology 2007; 133:1849-1857.
49. Thiebault K, Mazelin L, Pays L, et al. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci U S A 2003; 100:4173-4178.
50. Fazeli A, Dickinson SL, Hermiston ML, et al. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 1997; 386: 796-804.
51. Mehlen P, Puisieux A. Metastasis: a question of life or death. Nat Rev Cancer 2006; 6:449-458.
52. Fitamant J, Guenebeaud C, Coissieux MM, et al. Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci U S A 2008; 105:4850-4855.
53. Delloye-Bourgeois C, Brambilla E, Coissieux MM, et al. Interference with netrin-1 and tumor cell death in nonsmall cell lung cancer. J Natl Cancer Inst 2009; 101:237-247.
54. Delloye-Bourgeois C, Fitamant J, Paradisi A, et al. Netrin-1 acts as a survival factor for aggressive neuroblastoma. J Exp Med 2009; 206:833-847.
55. Link BC, Reichelt U, Schreiber M, et al. Prognostic implications of netrin-1 expression and its receptors in patients with adenocarcinoma of the pancreas. Ann Surg Oncol 2007; 14:2591-2599.
56. Paradisi A, Maisse C, Bernet A, et al. NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors. Gastroenterology 2008; 135:1248-1257.
57. Paradisi A, Maisse C, Coissieux MM, et al. Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. Proc Natl Acad Sci U S A 2009; 106:17146-17151.
58. Mille F, Thibert C, Fombonne J, et al. The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. Nat Cell Biol 2009; 11:739-746.