Netrin-1 is a survival factor during commissural neuron navigation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 38, 2008, Pages 14465-14470

  Furne, Céline ^a   Rama, Nicolas ^a   Corset, Véronique ^a   Chédotal, Alain ^b,c   Mehlen, Patrick ^a  

^a UNIVERSITÉ DE LYON   (France)

^b INSERM   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Apoptosis; Axon guidance; Deleted in colorectal cancer; Dependence receptor; Nervous system development

Indexed keywords

NETRIN 1; PROTEIN DCC; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN COMMISSURE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; FEMALE; NERVE CELL; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CHICK EMBRYO; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, DCC; HUMANS; MICE; MICE, KNOCKOUT; NERVE GROWTH FACTORS; NEURAL TUBE; NEURONS; RATS; SPINAL CORD; TUMOR SUPPRESSOR PROTEINS;

MUS;

EID: 55749092294     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0803645105     Document Type: Article

References (26)

1. Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759-767.
2. Fearon ER, et al. (1990) Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247:49-56.
3. Mehlen P, Fearon (2004) ER Role of the dependence receptor DCC in colorectal cancer pathogenesis. J Clin Oncol 22:3420-3428.
4. Keino-Masu K, et al. (1996) Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell 87:175-185.
5. Serafini T, et al. (1996) Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87:1001-1014.
6. Fazeli A, et al. (1997) Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 386:796-804.
7. Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE (1998) The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395:801-804.
8. Rabizadeh S, et al. (1993) Induction of apoptosis by the low-affinity NGF receptor. Science 261:345-348.
9. Bordeaux MC, et al. (2000) The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J 19:4056-4063.
10. Thibert C, Teillet MA, Lapointe F, Mazelin L, Le Douarin NM, Mehlen P (2003) Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science 301:843-846.
11. Matsunaga E, et al. (2004) RGM and its receptor neogenin regulate neuronal survival. Nat Cell Biol 6:749-755.
12. Mehlen P, Thibert C (2004) Dependence receptors: between life and death. Cell Mol Life Sci 61:1854-1866.
13. Tauszig-Delamasure S, et al. (2007) The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm. Proc Natl Acad Sci USA 104:13361-13366.
14. Chen YQ, et al. (1999) Induction of apoptosis and G2/M cell cycle arrest by DCC. Oncogene 18:2747-2754.
15. Shin SK, et al. (2007) Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology 133:1849-1857.
16. Mazelin L, et al. (2004) Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431:80-84.
17. Mehlen P, Llambi F (2005) Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers. Br J Cancer 93:1-6.
18. Grady WM (2007) Making the case for DCC and UNC5C as tumor-suppressor genes in the colon. Gastroenterology 133:2045-2049.
19. Fitamant J, et al. (2008) Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci USA 105:4850-4855.
20. Llambi F, Causeret F, Bloch-Gallego E, Mehlen P (2001) Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J 20:2715-2722.
21. Bernet A, et al. (2007) Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology 133:1840-1848.
22. Yao R, Cooper GM (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006.
23. Campbell DS, Holt CE (2003) Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones. Neuron 37:939-952.
24. Forcet C, et al. (2002) Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature 417:443-447.
25. Mahul-Mellier AL, Hemming FJ, Blot B, Fraboulet S, Sadoul R (2006) Alix, making a link between apoptosis-linked gene-2, the endosomal sorting complexes required for transport, and neuronal death in vivo. J Neurosci 26:542-549.
26. Furne C, Corset V, Herincs Z, Cahuzac N, Hueber AO, Mehlen P (2006) The dependence receptor DCC requires lipid raft localization for cell death signaling. Proc Natl Acad Sci USA 103:4128-4133.