Interference with netrin-1 and tumor cell death in non-small cell lung cancer

Journal of the National Cancer Institute

Volumn 101, Issue 4, 2009, Pages 237-247

  Delloye Bourgeois, Céline ^a   Brambilla, Elisabeth ^b   Coissieux, Marie May ^a   Guenebeaud, Céline ^a   Pedeux, Rémy ^b   Firlej, Virginie ^c   Cabon, Florence ^c   Brambilla, Christian ^b   Mehlen, Patrick ^a   Bernet, Agnès ^a  

^a UNIVERSITÉ DE LYON   (France)

^b INSTITUT ALBERT BONNIOT   (France)

^c INSTITUT ANDRÉ LWOFF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DEATH ASSOCIATED PROTEIN KINASE; MEMBRANE RECEPTOR; NETRIN 1; PROTEIN DCC; PROTEIN UNC5H; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CANCER REGRESSION; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 3; CELL LINE, TUMOR; COLORING AGENTS; DISEASE PROGRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG NEOPLASMS; MICE; MICE, NUDE; NERVE GROWTH FACTORS; PLASMIDS; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; TRYPAN BLUE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 60749089170     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djn491     Document Type: Article

References (42)

1. Serafini T, Colamarino SA, Leonardo ED, et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell. 1996;87(6):1001-1014.
2. Keino-Masu K, Masu M, Hinck L, et al. Deleted in colorectal cancer (DCC) encodes a netrin receptor. Cell. 1996;87(2):175-185.
3. Forcet C, Stein E, Pays L, et al. Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature. 2002;417(6887):443-447.
4. Ackerman SL, Kozak LP, Przyborski SA, Rund LA, Boyer BB, Knowles BB. The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature. 1997;386(6627):838-842.
5. Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M, Stein E. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell. 1999;97(7):927-941.
6. Cirulli V, Yebra M. Netrins: beyond the brain. Nat Rev Mol Cell Biol. 2007;8(4):296-306.
7. Mehlen P, Furne C. Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis. Cell Mol Life Sci. 2005;62(22):2599-2616.
8. Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature. 1998;395(6704):801-804.
9. Llambi F, Causeret F, Bloch-Gallego E, Mehlen P. Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. Embo J. 2001;20(11):2715-2722.
10. Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H. p53RDL1 regulates p53-dependent apoptosis. Nat Cell Biol. 2003;5(3):216-223.
11. Mehlen P, Thibert C. Dependence receptors: between life and death. Cell Mol Life Sci. 2004;61(15):1854-1866.
12. Bredesen DE, Mehlen P, Rabizadeh S. Receptors that mediate cellular dependence. Cell Death Differ. 2005;12(8):1031-1043.
13. Mehlen P, Bredesen DE. The dependence receptor hypothesis. Apoptosis. 2004;9(1):37-49.
14. Williams ME, Strickland P, Watanabe K, Hinck L. UNC5H1 induces apoptosis via its juxtamembrane domain through an interaction with NRAGE. J Biol Chem. 2003;278(19):17483-17490.
15. Llambi F, Lourenco FC, Gozuacik D, et al. The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. Embo J. 2005;24(6):1192-1201.
16. Thiebault K, Mazelin L, Pays L, et al. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci USA. 2003;100(7):4173-4178.
17. Fearon ER, Cho KR, Nigro JM, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990;247(4938):49- 56.
18. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell. 1996;87(2):159-170.
19. Bernet A, Mazelin L, Coissieux MM, et al. Inactivation of the UNC5C netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology. 2007;133(6):1840-1848.
20. Inbal B, Cohen O, Polak-Charcon S, et al. DAP kinase links the control of apoptosis to metastasis. Nature. 1997;390(6656):180-184.
21. Raval A, Tanner SM, Byrd JC, et al. Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell. 2007;129(5):879-890.
22. Fitamant J, Guenebeaud C, Guix C, et al. Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci USA. 2008;105(12):4850-4855.
23. Risch A, Plass C. Lung cancer epigenetics and genetics. Int J Cancer. 2008;123(1):1-7.
24. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin. 2007;57(1):43-66.
25. Travis WD, Brambilla E, Muller-Hemerlink HK, Harris CC. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Lung, Pleura, Thymus and Heart. Lyon, France: IARC Press; 2004.
26. Ghoumari AM, Wehrle R, Bernard O, Sotelo C, Dusart I. Implication of Bcl-2 and Caspase-3 in age-related Purkinje cell death in murine organotypic culture: an in vitro model to study apoptosis. Eur J Neurosci. 2000;12(8):2935-2949.
27. Mehlen P, Fearon ER. Role of the dependence receptor DCC in colorectal cancer pathogenesis. J Clin Oncol. 2004;22(16):3420-3428.
28. Bialik S, Kimchi A. The death-associated protein kinases: structure, function, and beyond. Annu Rev Biochem. 2006;75:189-210.
29. Tang X, Wu W, Sun SY, Wistuba, II, Hong WK, Mao L. Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells. Mol Cancer Res. 2004;2(12):685-691.
30. Dalvin S, Anselmo MA, Prodhan P, Komatsuzaki K, Schnitzer JJ, Kinane TB. Expression of netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung. Gene Expr Patterns. 2003;3(3):279283.
31. Link BC, Reichelt U, Schreiber M, et al. Prognostic implications of netrin-1 expression and its receptors in patients with adenocarcinoma of the pancreas. Ann Surg Oncol. 2007;14(9):2591-2599.
32. Hinck L. The versatile roles of "axon guidance" cues in tissue morphogenesis. Dev Cell. 2004;7(6):783-793.
33. Liu Y, Stein E, Oliver T, et al. Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. Curr Biol. 2004;14(10):897-905.
34. Yanagawa N, Tamura G, Oizumi H, et al. Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers. Lung Cancer. 2007;58(1):131-138.
35. Mazelin L, Bernet A, Bonod-Bidaud C, et al. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature. 2004;431(7004):80-84.
36. Yebra M, Montgomery AM, Diaferia GR, et al. Recognition of the neural chemoattractant netrin-1 by integrins alpha6beta4 and alpha3-beta1 regulates epithelial cell adhesion and migration. Dev Cell. 2003;5(5):695-707.
37. Nikolopoulos SN, Giancotti FG. Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning. Cell Cycle. 2005;4(3):e131-e135.
38. Park KW, Crouse D, Lee M, et al. The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci USA. 2004;101(46):16210-16215.
39. Lu X, Le Noble F, Yuan L, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004;432(7014):179-186.
40. Nguyen A, Cai H. Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc Natl Acad Sci USA. 2006; 103(17):6530-6535.
41. Wilson BD, Ii M, Park KW, et al. Netrins promote developmental and therapeutic angiogenesis. Science. 2006;313(5787):640-644.
42. Carvalho AL, Chuang A, Jiang WW, et al. Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma. Cancer Res. 2006;66(19):9401-9407.