Reduced expression of deleted colorectal carcinoma (DCC) protein in established colon cancers

British Journal of Cancer

Volumn 77, Issue 3, 1998, Pages 466-471

  Goi, T ^a   Yamaguchi, A ^a   Nakagawara, G ^a   Urano, T ^b   Shiku, H ^c   Furukawa, K ^d,e  

^a UNIVERSITY OF FUKUI   (Japan)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MIE UNIVERSITY   (Japan)

^d NAGASAKI UNIVERSITY   (Japan)

^e NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Colon cancer; Deleted colorectal carcinoma; Metastasis; Tumour suppressor gene

Indexed keywords

CELL SURFACE PROTEIN; HYBRID PROTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY;

ADENOMA; ARTICLE; CANCER CELL CULTURE; CLINICAL ARTICLE; COLON CANCER; COLORECTAL CARCINOMA; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; LIVER METASTASIS; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

EID: 0031983199     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.74     Document Type: Article

References (34)

1. Baker SJ, Fearon ER, Nigro JM, Hamilton SR, Preisinger AC, Jessup JM, Van Tuinen P, Ledbetter DH, Baker DF, Nakamura Y, White R and Vogelstein B (1989) Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244: 217-221
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72: 248-254
3. Cho JH, Noguchi M, Ochiai A and Hirohashi S (1996) Loss of heterozygosity of multiple tumor suppressor genes in human gastric cancers by polymerase chain reaction. Laboratory Invest 74: 835-841
4. Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159
5. Ekstrand BC, Mansfield TA, Binger SH and Fearon ER (1995) DCC expression is altered by multiple mechanisms in brain tumours. Oncogene 7: 2393-2402
6. Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW and Vogelstein B (1990) Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247: 49-56
7. Fearon ER, Ekstrand BC, Hu G, Pierceall WE, Reale MA and Bigner SH (1994) Studies of the deleted in colorectal cancer gene in normal and neoplastic tissues. Cold Spring Harbor Symposia on Quantitative Biology 59: 637-643
8. Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM and Dryja TP (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323: 643-646
9. Hedrick L, Cho KR, Boyd J, Risinger J and Vogelstein B (1992) DCC: a tumor suppressor gene expressed on the cell surface. Cold Spring Harbor Symposium on Quantitative Biology 27: 345-351, 1992
10. Hedrick L, Cho KR, Fearon ER, Wu TC, Kinzler KW and Vogelstein B (1994) The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes Dev 8: 1174-1183
11. Hohne MW, Halatsch ME, Kahl GF and Weinel RJ (1992) Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma. Cancer Res 52: 2616-1619
12. Iacopetta B, DiGrandi S, Dix B, Haig C, Soong RA and House A (1994) Loss of heterozygosity of tumor suppressor gene loci in human colorectal carcinoma. Eur J Cancer 30: 664-670
13. Iino H, Fukayama M, Maeda Y, Koike M, Mori T, Takahashi T, Kikuchi-Yanoshita R, Miyake M, Mizuno S and Watanabe S (1994) Molecular genetics for clinical management of colorectal carcinoma. 17p, 18q, and 22q loss of heterozygosity and decreased DCC expression are correlated with the metastatic potential. Cancer 73: 1324-1331
14. Inokuchi K, Miyake K, Takahashi H, Dan K and Nomura T (1996) DCC expression in hematopoietic cell populations and its relation to leukemogenesis. J Clin Inv 97: 852-857
15. Itoh F, Hinoda Y, Ohe M, Ohe Y, Ban T, Endo T, Imai K and Yachi A (1993) Decreased expression of DCC mRN A in human colorectal cancers. Int J Cancer 53: 260-263
16. Kashiwaba M, Tamura G and Ishida M (1995) Frequent loss of heterozygosity at the deleted in colorectal carcinoma gene locus and its association with histologic phenotypes in breast carcinoma. Virchows Archiv 426: 441-446
17. Kataoka M, Okabayashi T and Orita K (1995) Decreased expression of DCC mRNA in gastric and colorectal cancer. Surg Today 25: 1001-1007
18. Kato M, Ito Y, Kobayashi S and Isono K (1996) Detection of DCC and Ki-ras gene alterations in colorectal carcinoma tissue as prognostic markers for liver metastatic recurrence. Cancer 77: 1729-1735
19. Kern SE, Fearon ER, Tersmette KWF, Eeterline JP, Leppert M, Nakamura Y, White R, Vogelstein B and Hamilton SR (1989) Allelic loss in colorectal carcinoma. JAMA 261: 3099-3103
20. Kikuchi-Yanoshita R, Konishi M, Fukunari H, Tanaka K and Miyake M (1992) Loss of expression of the DCC gene during progression of colorectal carcinomas in familial adenomatous polyposis and non-familial adenomatous polyposis patients. Cancer Res 52: 3801-3803
21. Klingelhutz AJ, Hedrick L, Cho KR and McDougall JK (1995) The DCC gene suppresses the malignant phenotype of transformed human epithelial cells. Oncogene 10: 1581-1586
22. Laelor KG and Narayanan R (1992) Persistent expression of the tumor suppressor gene DCC is essential for neuronal differentiation. Cell Growth Diff 3: 609-616
23. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
24. Miyake S, Nagai K, Yoshino K, Oto M, Endo M and Yuasa Y (1994) Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis. Cancer Res 54: 3007-3010
25. Murty VV, Li RG, Houldswonh J, Bronson DL, Reuter VE, Bosl GJ and Chaganti RS (1994) Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors. Oncogene 9: 3227-3231
26. Nowell PC (1986) Mechanisms of tumor progression. Cancer Res 46: 2203-2207
27. Ookawa K, Sakamoto M, Hirohashi S, Yoshida Y, Sugimura T, Terada M and Yokota J (1993) Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma. Int J Cancer 53: 382-337
28. Sato Y, Mukai K, Watanabe S, Goto M and Shimosato Y (1986) The AmeX method: a simplified technique of tissue processing and paraffin embedding with improved preservation of antigens for immunostaining. Am J Pathol 125: 431-435
29. Shibata D, Reale MA, Lavin P, Silverman M, Fearon ER, Steele G, Jessup JM, Loda M and Summerhayes IC (1996) The DCC protein and prognosis in colorectal cancer. N Engl J Med 335: 1727-1732
30. Smith DB and Johnson KS (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67: 31-40
31. Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JK, Markowitz S, Hamilton SR, Kern SE, Kinzler KW and Vogelstein B (1996) Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nature Genet 13: 343-346
32. Turley H, Pezzella F, Kocialkowski S, Comley M, Kaklamanis L, Fawcett J, Simmons D, Harris AL and Gatter KC (1995) The distribution of the deleted in colon cancer (DCC) protein in human tissues. Cancer Res 55: 5628-5631
33. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AMM and Bos JL (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319: 525-530
34. Yamashiro S, Ruan S, Furukawa K, Tai T, Lloyd KO, Shiku H and Furukawa K (1993) Genetic and enzymatic basis for the differential expression of GM2 and GD2 gangliosides in human cancer cell lines. Cancer Res 53: 5395-5400