Anionic antimicrobial peptides from eukaryotic organisms

Current Protein and Peptide Science

Volumn 10, Issue 6, 2009, Pages 585-606

  Harris, Frederick ^a   Dennison, Sarah R ^a   Phoenix, David A ^a  

^a UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

Author keywords

Amphiphilic helix; Anionic peptide; Antimicrobial peptide

Indexed keywords

APOLIPOPROTEIN C[21-53]; BOMBININ; CHLORHEXIDINE; CHROMACIN; CHROMOGRANIN A; CYCLOTIDE; DERMCIDIN; ENKELYTIN; FETIDIN; FIBRINOPEPTIDE A; FIBRINOPEPTIDE B; HEVEIN; KALATA B2; KAPPACIN A; KAPPACIN B; LYSENIN; MAXIMIN H5; PEPTIDE B; POLYPEPTIDE ANTIBIOTIC AGENT; PROENKEPHALIN A; SCYGONADIN 2; SPHINGOMYELIN; SURFACTANT ASSOCIATED ANIONIC PEPTIDE; TEMPORIN; THEROMACIN; THEROMYZIN; THYMOSIN BETA4; TRYPSINOGEN ACTIVATION PEPTIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VICILIN;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ATOPIC DERMATITIS; BACTERIAL MEMBRANE; CYSTIC FIBROSIS; DENTAL CARIES; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; LUNG LAVAGE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PERIODONTAL DISEASE; PNEUMONIC PASTEURELLOSIS; PROTEIN PROCESSING; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; ANIONS; ANTI-INFECTIVE AGENTS; HUMANS; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDES; PLANT PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

AMPHIBIA; EUKARYOTA; FUNGI; HEXAPODA; INVERTEBRATA; VERTEBRATA;

EID: 73549121068     PISSN: 13892037     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920309789630589     Document Type: Review

References (228)

1. Sang Y.; Blecha, F. Porcine host defense peptides: expanding repertoire and functions. Dev. Comp. Immunol., 2009, 33, 334-343.
2. Hirsch T.; Jacobsen, F.; Steinau, H.U.; Steinstraesser, L. Host defense peptides and the new line of defence against multiresistant infections. Protein Pept. Lett., 2008, 15, 238-243.
3. van Dijk A.; Veldhuizen, E.J.; Haagsman, H.P. Avian defensins. Vet. Immunol. Immunopathol., 2008, 124, 1-18.
4. Tavares L.S.; Santos Mde, O.; Viccini, L.F.; Moreira, J.S.; Miller, R.N.; Franco, O.L. Biotechnological potential of antimicrobial peptides from flowers. Peptides, 2008, 29, 1842-1851.
5. Mookherjee N.; Hancock, R.E. Cationic host defence peptides: innate immune regulatory peptides as a novel approach for treating infections. Cell Mol. Life Sci., 2007, 64, 922-933.
6. Aerts A.M.; Francois, I.; Cammue, B.P.A.; Thevissen, K. The mode of antifungal action of plant, insect and human defensins. Cell Mol. Life Sci., 2008, 65, 2069-2079.
7. Nizet V. Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targets. J. Allergy Clin. Immunol., 2007, 120, 13-22.
8. Zaiou M. Multifunctional antimicrobial peptides: therapeutic targets in several human diseases. J. Mol. Med., 2007, 85, 317-329.
9. Wong J.H.; Xia, L.; Ng, T.B. A review of defensins of diverse origins. Curr. Protein Pept. Sci., 2007, 8, 446-459.
10. Lofgren S.E.; Miletti, L.C.; Steindel, M.; Bachere, E.; Barracco, M.A. Trypanocidal and leishmanicidal activities of different antimicrobial peptides (AMPs) isolated from aquatic animals. Exp. Parasitol., 2008, 118, 197-202.
11. Lu C.X.; Nan, K.J.; Lei, Y. Agents from amphibians with anticancer properties. Anticancer Drugs, 2008, 19, 931-939.
12. Hoskin D.W.; Ramamoorthy, A. Studies on anticancer activities of antimicrobial peptides. Biochim. Biophys. Acta Biomembr., 2008, 1778, 357-375.
13. Slocinska M.; Marciniak, P.; Rosinski, G. Insects antiviral and anticancer peptides: new leads for the future? Protein Pept. Lett., 2008, 15, 578-585.
14. Dennison S.R.; Whittaker, M.; Harris, F.; Phoenix, D.A. Anticancer alpha-helical peptides and structure/function relationships underpinning their interactions with tumour cell membranes. Curr. Protein Pept. Sci., 2006, 7, 487-499.
15. Thevissen K.; Kristensen, H.H.; Thomma, B.P.; Cammue, B.P.; Francois, I.E. Therapeutic potential of antifungal plant and insect defensins. Drug Discov. Today, 2007, 12, 966-971.
16. Cole A.M. Innate host defense of human vaginal and cervical mucosae. Curr. Top. Microbiol. Immunol., 2006, 306, 199-230.
17. Pachon J.; Vila, J. Treatment of multiresistant Acinetobacter baumannii infections. Curr. Opin. Investig. Drugs, 2009, 10, 150-156.
18. Linde A.; Ross, C.R.; Davis, E.G.; Dib, L.; Blecha, F.; Melgarejo, T. Innate immunity and host defense peptides in veterinary medicine. J. Vet. Intern. Med., 2008, 22, 247-265.
19. Ramanathan B.; Davis, E.G.; Ross, C.R.; Blecha, F. Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity. Microbes. Infect., 2002, 4, 361-372.
20. Matsuzaki K. Control of cell selectivity of antimicrobial peptides. Biochim. Biophys. Acta, 2009, 1788(8): 1687-1692.
21. Giuliani A.; Pirri, G.; Nicoletto, S.F. Antimicrobial peptides: an overview of a promising class of therapeutics. Cent. Eur. J. Biol., 2007, 2, 1-33.
22. Brogden K.A. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol., 2005, 3, 238-250.
23. Hamill P.; Brown, K.; Jenssen, H.; Hancock, R.E. Novel antiinfectives: is host defence the answer? Curr. Opin. Biotechnol., 2008, 19, 628-636.
24. Finlay B.B.; Hancock, R.E. Can innate immunity be enhanced to treat microbial infections? Nat. Rev. Microbiol., 2004, 2, 497-504.
25. Hale J.D.; Hancock, R.E. Alternative mechanisms of action of cationic antimicrobial peptides on bacteria. Expert Rev. Anti. Infect. Ther., 2007, 5, 951-959.
26. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature, 2002, 415, 389-395.
27. Kraus D.; Peschel, A. Staphylococcus aureus evasion of innate antimicrobial defense. Future Microbiol., 2008, 3, 437-451.
28. Perron G.G.; Zasloff, M.; Bell, G. Experimental evolution of resistance to an antimicrobial peptide. Proc. R. Soc. B, 2006, 273, 251-256.
29. Buckling A.; Brockhurst, M. Microbiology - RAMP resistance. Nature, 2005, 438, 170-171.
30. Marr A.K.; Gooderham, W.J.; Hancock, R.E.W. Antibacterial peptides for therapeutic use: obstacles and realistic outlook. Curr. Opin. Pharmacol., 2006, 6, 468-472.
31. Cherkasov A.; Hilpert, K.; Jenssen, H.; Fjell, C.D.; Waldbrook, M.; Mullaly, S.C.; Volkmer, R.; Hancock, R.E. Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. ACS Chem. Biol., 2009, 4, 65-74.
32. Ghiselli R.; Giacomefti, A.; Cirioni, O.; Mocchegiani, F.; Orlando, F.; Silvestri, C.; Di Mafteo, F.; Abbruzzeffi, A.; Scalise, G.; Saba, V. Efficacy of the bovine antimicrobial peptide indolicidin combined with pipeyacillin/ tazobactam in experimental rat models of polymicrobial peritonitis. Crit. Care Med., 2008, 36, 240-245.
33. Mangoni M.L.; Maisetta, G.; Di Luca, M.; Gaddi, L.M.; Esin, S.; Florio, W.; Brancatisano, F.L.; Barra, D.; Campa, M.; Batoni, G. Comparative analysis of the bactericidal activities of amphibian peptide analogues against multidrug-resistant nosocomial bacterial strains. Antimicrob. Agents Chemother., 2008, 52, 85-91.
34. Cirioni O.; Ghiselli, R.; Kamysz, W.; Orlando, F.; Silvestri, C.; Mocchegiani, F.; Di Matteo, F.; Kamysz, E.; Riva, A.; Rocchi, M.; Saba, V.; Scalise, G.; Giacometti, A. Tachyplesin III and granulocyte-colony stimulating factor enhance the efficacy of tazobactam/piperacillin in a neutropenic mouse model of polymicrobial peritonitis. Peptides, 2008, 29, 31-38.
35. Cirioni O.; Ghiselli, R.; Silvestri, C.; Kamysz, W.; Orlando, F.; Mocchegiani, F.; Di Matteo, F.; Riva, A.; Lukasiak, J.; Scalise, G.; Saba, V.; Giacometti, A. Efficacy of tachyplesin III, colistin, and imipenem against a multiresistant Pseudomonas aeruginosa strain. Antimicrob. Agents Chemother., 2007, 51, 2005-2010.
36. Ramasundara M.; Leach, S.T.; Lemberg, D.A.; Day, A.S. Defensins and inflammation: the role of defensins in inflammatory bowel disease. J. Gastroenterol. Hepatol., 2009, 24, 202-208.
37. McDermott A.M. The role of antimicrobial peptides at the ocular surface. Ophthalmic Res., 2009, 41, 60-75.
38. Nijnik A.; Hancock, R.E. The roles of cathelicidin LL-37 in immune defences and novel clinical applications. Curr. Opin. Hematol., 2009, 16, 41-47.
39. Zhang L.; Falla, T.J. Host defense peptides for use as potential therapeutics. Curr. Opin. Investig. Drugs, 2009, 10, 164-171.
40. Gottler L.M.; Ramamoorthy, A. Structure, membrane orientation, mechanism, and function of pexiganan - A highly potent antimicrobial peptide designed from magainin. Biochim. Biophys. Acta, 2008, In press.
41. Mayo K.H. Novel therapeutic agents against endotoxemia and septic shock. Drugs Future, 2008, 33, 65-73.
42. Ding J.L.; Li, P.; Ho, B. The Sushi peptides: structural characterization and mode of action against Gram-negative bacteria. Cell Mol. Life Sci., 2008, 65, 1202-1219.
43. Kai-Larsen Y.; Agerberth, B. The role of the multifunctional peptide LL-37 in host defense. Front Biosci., 2008, 13, 3760-3767.
44. Scott M.G.; Dullaghan, E.; Mookherjee, N.; Glavas, N.; Waldbrook, M.; Thompson, A.; Wang, A.; Lee, K.; Doria, S.; Hamill, P.; Yu, J.J.; Li, Y.; Donini, O.; Guarna, M.M.; Finlay, B.B.; North, J.R.; Hancock, R.E. An anti-infective peptide that selectively modulates the innate immune response. Nat. Biotechnol., 2007, 25, 465-472.
45. Salzet M. Neuropeptide-derived antimicrobial peptides from invertebrates for biomedical applications. Curr. Med. Chem., 2005, 12, 3055-3061.
46. Marshall S.H.; Arenas, G. Antimicrobial peptides: a natural alternative to chemical antibiotics and a potential for applied biotechnology. Electr. J. Biotech., 2003, 6: http://www.scielo.cl/pdf/ejb/v6n3/a02.pdf (accessed May 12, 2009).
47. Boman H.G. Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol., 1995, 13, 61-92.
48. Boman H.G. Antibacterial peptides: key components needed in immunity. Cell, 1991, 65, 205-207.
49. LaForce F.M.; Boose, D.S. Effect of zinc and phosphate on an antibacterial peptide isolated from lung lavage. Infect. Immun., 1984, 45, 692-696.
50. Laforce F.M.; Boose, D.S. Sublethal damage of Escherichia coli by lung lavage. Am. Rev. Respir. Dis., 1981, 124, 733-737.
51. Caverly J.M.; Radi, Z.A.; Andreasen, C.B.; Dixon, R.A.; Brogden, K.A.; Ackermann, M.R. Comparison of bronchoalveolar lavage fluid obtained from Mannheimia haemolytica-inoculated calves with and without prior treatment with the selectin inhibitor TBC1269. Am. J. Vet. Res., 2001, 62, 665-672.
52. Brogden K.A.; De Lucca, A.J.; Bland, J.; Elliott, S. Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica. Proc. Natl. Acad. Sci. USA, 1996, 93, 412-416.
53. Grubor B.; Meyerholz, D.K.; Ackermann, M.R. Collectins and cationic antimicrobial peptides of the respiratory epithelia. Vet. Pathol., 2006, 43, 595-612.
54. Schutte B.C.; McCray, P.B.; Jr. [beta]-defensins in lung host defense. Annu. Rev. Physiol., 2002, 64, 709-748.
55. Heidari M.; Hamir, A.; Cutlip, R.C.; Brogden, K.A. Antimicrobial anionic peptide binds in vivo to Mannheimia (Pasteurella) haemolytica attached to ovine alveolar epithelium. Int. J. Antimicrob. Agents, 2002, 20, 69-72.
56. Brogden K.A.; Ackermann, M.; McCray, P.B.; Jr.; Tack, B.F. Antimicrobial peptides in animals and their role in host defences. Int. J. Antimicrob. Agents, 2003, 22, 465-478.
57. Anderson R.C.; Wilkinson, B.; Yu, P.L. Ovine antimicrobial peptides: new products from an age-old industry. Aust. J. Agric. Res., 2004, 55, 69-75.
58. Brogden K.A.; Ackermann, M.; Huttner, K.M. Detection of anionic antimicrobial peptides in ovine bronchoalveolar lavage fluid and respiratory epithelium. Infect. Immun., 1998, 66, 5948-5954.
59. Fales-Williams A.J.; Brogden, K.A.; Huffman, E.; Gallup, J.M.; Ackermann, M.R. Cellular distribution of anionic antimicrobial peptide in normal lung and during acute pulmonary inflammation. Vet. Pathol., 2002, 39, 706-711.
60. Fales-Williams A.J.; Gallup, J.M.; Ramirez-Romero, R.; Brogden, K.A.; Ackermann, M.R. Increased anionic peptide distribution and intensity during progression and resolution of bacterial pneumonia. Clin. Diagn. Lab. Immunol., 2002, 9, 28-32.
61. Kalfa V.C.; Palmquist, D.; Ackermann, M.R.; Brogden, K.A. Suppression of Mannheimia (Pasteurella) haemolytica serovar 1 infection in lambs by intrapulmonary administration of ovine antimicrobial anionic peptide. Int. J. Antimicrob. Agents, 2001, 17, 505-510.
62. Rao X.C.; Li, S.; Hu, J.C.; Jin, X.L.; Hu, X.M.; Huang, J.J.; Chen, Z.J.; Zhu, J.M.; Hu, F.Q. A novel carrier molecule for high-level expression of peptide antibiotics in Escherichia coli. Protein Expr. Purif., 2004, 36, 11-18.
63. Meyerholz D.K.; Ackermann, M.R. Antimicrobial peptides and surfactant proteins in ruminant respiratory tract disease. Vet. Immunol. Immunopathol., 2005, 108, 91-96.
64. Brogden K.A.; Ackermann, M.; Huttner, K.M. Small, anionic, and charge-neutralizing propeptide fragments of zymogens are antimicrobial. Antimicrob. Agents Chemother., 1997, 41, 1615-1617.
65. Malmsten M.; Davoudi, M.; Walse, B.; Rydengard, V.; Pasupuleti, M.; Morgelin, M.; Schmidtchen, A. Antimicrobial peptides derived from growth factors. Growth Factors, 2007, 25, 60-70.
66. Mak P. Hemocidins in a functional and structural context of human antimicrobial peptides. Front Biosci., 2008, 13, 6859-6871.
67. Helle K.B.; Corti, A.; Metz-Boutigue, M.H.; Tota, B. The endocrine role for chromogranin A: a prohormone for peptides with regulatory properties. Cell Mol. Life Sci., 2007, 64, 2863-2886.
68. Metz-Boutigue M.H.; Goumon, Y.; Strub, J.M.; Lugardon, K.; Aunis, D. Antimicrobial chromogranins and proenkephalin-Aderived peptides: Antibacterial and antifungal activities of chromogranins and proenkephalin-A-derived peptides. Ann. N Y Acad. Sci., 2003, 992, 168-178.
69. Strub J.M.; Goumon, Y.; Lugardon, K.; Capon, C.; Lopez, M.; Moniatte, M.; Van Dorsselaer, A.; Aunis, D.; Metz-Boutigue, M.H. Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules. J. Biol. Chem., 1996, 271, 28533-28540.
70. Strub J.M.; Sorokine, O.; Van Dorsselaer, A.; Aunis, D.; Metz-Boutigue, M.H. Phosphorylation and O-glycosylation sites of bovine chromogranin A from adrenal medullary chromaffin granules and their relationship with biological activities. J. Biol. Chem., 1997, 272, 11928-11936.
71. Metz-Boutigue M.H.; Goumon, Y.; Lugardon, K.; Strub, J.M.; Aunis, D. Antibacterial peptides are present in chromaffin cell secretory granules. Cell Mol. Neurobiol., 1998, 18, 249-266.
72. Goumon Y.; Strub, J.M.; Moniatte, M.; Nullans, G.; Poteur, L.; Hubert, P.; Van Dorsselaer, A.; Aunis, D.; Metz-Boutigue, M.H. The C-terminal bisphosphorylated proenkephalin-A-(209-237)-peptide from adrenal medullary chromaffin granules possesses antibacterial activity. Eur. J. Biochem., 1996, 235, 516-525.
73. Stern A.S.; Jones, B.N.; Shively, J.E.; Stein, S.; Undenfriend, S. Two adrenal opioid polypeptides: proposed intermediates in the processing of proenkephalin. Proc. Natl. Acad. Sci. USA, 1981, 78, 1962-1966.
74. Goumon Y.; Lugardon, K.; Kieffer, B.; Lefevre, J.F.; Van Dorsselaer, A.; Aunis, D.; Metz-Boutigue, M.H. Characterization of antibacterial COOH-terminal proenkephalin-A-derived peptides (PEAP) in infectious fluids. Importance of enkelytin, the antibacterial PEAP209-237 secreted by stimulated chromaffin cells. J. Biol. Chem., 1998, 273, 29847-29856.
75. Lindberg I.; White, L. Distribution of immunoreactive peptide B in the rat brain. Biochem. Biophys. Res. Commun., 1986, 139, 1024-1032.
76. Goumon Y.; Lugardon, K.; Gadroy, P.; Strub, J.M.; Welters, I.D.; Stefano, G.B.; Aunis, D.; Metz-Boutigue, M.H. Processing of proenkephalin-A in bovine chromaffin cells. Identification of natural derived fragments by N-terminal sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry. J. Biol. Chem., 2000, 275, 38355-38362.
77. Stefano G.B.; Fricchione, G.L.; Goumon, Y.; Esch, T. Pain, immunity, opiate and opioid compounds and health. Med. Sci. Monit., 2005, 11, Ms47-Ms53.
78. Salzet M.; Vieau, D.; Day, R. Crosstalk between nervous and immune systems through the animal kingdom: focus on opioids. Trends Neurosci., 2000, 23, 550-555.
79. Salzet M.; Tasiemski, A. Involvement of pro-enkephalin-derived peptides in immunity. Dev. Comp. Immunol., 2001, 25, 177-185.
80. Salzet M. Invertebrates to human. Neuro. Endocrinol. Lett., 2001, 22, 467-474.
81. Malkoski M.; Dashper, S.G.; O'Brien-Simpson, N.M.; Talbo, G.H.; Macris, M.; Cross, K.J.; Reynolds, E.C. Kappacin, a novel antibacterial peptide from bovine milk. Antimicrob. Agents Chemother., 2001, 45, 2309-2315.
82. Rizzello C.G.; Losito, I.; Gobbetti, M.; Carbonara, T.; De Bari, M.D.; Zambonin, P.G. Antibacterial activities of peptides from the water-soluble extracts of Italian cheese varieties. J. Dairy Sci., 2005, 88, 2348-2360.
83. Thoma-Worringer C.; Sorensen, J.; Lopez-Findino, R. Health effects and technological features of caseinomacropeptide. Int. Dairy J., 2006, 16, 1324-1333.
84. Dashper S.G.; Liu, S.W.; Reynolds, E.C. Antimicrobial peptides and their potential as oral therapeutic agents. Int. J. Pept. Res. Ther., 2007, 13, 505-516.
85. Dashper S.G.; O'Brien-Simpson, N.M.; Cross, K.J.; Paolini, R.A.; Hoffmann, B.; Catmull, D.V.; Malkoski, M.; Reynolds, E.C. Divalent metal cations increase the activity of the antimicrobial Peptide kappacin. Antimicrob. Agents Chemother., 2005, 49, 2322-2328.
86. Plowman J.E.; Creamer, L.K.; Liddell, M.J.; Cross, J.J. Solution conformation of a peptide corresponding to bovine kappa-casein B residues 130-153 by circular dichroism spectroscopy and 1Hnuclear magnetic resonance spectroscopy. J. Dairy Res., 1997, 64, 377-397.
87. Marsh P.D. Dental plaque: biological significance of a biofilm and community life-style. J. Clin. Periodontol., 2005, 32 (Suppl 6), 7-15.
88. Ribeiro L.G.; Hashizume, L.N.; Maltz, M. The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: a systematic review of the literature. J. Dent., 2007, 35, 359-370.
89. Shapiro S.; Giertsen, E.; Guggenheim, B. An in vitro oral biofilm model for comparing the efficacy of antimicrobial mouthrinses. Caries Res., 2002, 36, 93-100.
90. Ellison R.T.; 3rd, Boose, D.; LaForce, F.M. Isolation of an antibacterial peptide from human lung lavage fluid. J. Infect. Dis., 1985, 151, 1123-1129.
91. Brogden K.A.; Ackermann, M.R.; McCray, P.B.; Jr.; Huttner, K.M. Differences in the concentrations of small, anionic, antimicrobial peptides in bronchoalveolar lavage fluid and in respiratory epithelia of patients with and without cystic fibrosis. Infect. Immun., 1999, 67, 4256-4259.
92. Harrison F. Microbial ecology of the cystic fibrosis lung. Microbiol., 2007, 153, 917-923.
93. Hiemstra P.S. Antimicrobial peptides in the real world: implications for cystic fibrosis. Eur. Respir. J., 2007, 29, 617-618.
94. Zeitlin P.L. Emerging drug treatments for cystic fibrosis. Expert Opin Emerg. Drugs, 2007, 12, 329-336.
95. Tang Y.Q.; Yeaman, M.R.; Selsted, M.E. Antimicrobial peptides from human platelets. Infect. Immun., 2002, 70, 6524-6533.
96. Vankerckhoven V.; Moreillon, P.; Piu, S.; Giddey, M.; Huys, G.; Vancanneyt, M.; Goossens, H.; Entenza, J.M. Infectivity of Lacto bacillus rhamnosus and Lactobacillus paracasei isolates in a rat model of experimental endocarditis. J. Med. Microbiol., 2007, 56, 1017-1024.
97. Reti R.; Kwon, E.; Qiu, P.; Wheater, M.; Sosne, G. Thymosin beta4 is cytoprotective in human gingival fibroblasts. Eur. J. Oral Sci., 2008, 116, 424-430.
98. Tasiemski A.; Salzet, M.; Benson, H.; Fricchione, G.L.; Bilfinger, T.V.; Goumon, Y.; Metz-Boutigue, M.H.; Aunis, D.; Stefano, G.B. The presence of antibacterial and opioid peptides in human plasma during coronary artery bypass surgery. J. Neuroimmunol., 2000, 109, 228-235.
99. Hipfel R.; Schittek, B.; Bodingbauer, Y.; Garbe, C. Specifically regulated genes in malignant melanoma tissues identified by subtractive hybridization. Br. J. Cancer, 2000, 82, 1149-1157.
100. Lowrie A.G.; Wigmore, S.J.; Wright, D.J.; Waddell, I.D.; Ross, J.A. Dermcidin expression in hepatic cells improves survival without N-glycosylation, but requires asparagine residues. Br. J. Cancer, 2006, 94, 1663-1671.
101. Cunningham T.J.; Jing, H.; Akerblom, I.; Morgan, R.; Fisher, T.S.; Neveu, M. Identification of the human cDNA for new survival/ evasion peptide (DSEP): studies in vitro and in vivo of overexpression by neural cells. Exp. Neurol., 2002, 177, 32-39.
102. Cunningham T.J.; Jing, H.; Wang, Y.; Hodge, L. Calreticulin binding and other biological activities of survival peptide Y-P30 including effects of systemic treatment of rats. Exp. Neurol., 2000, 163, 457-468.
103. Niyonsaba F.; Suzuki, A.; Ushio, H.; Nagaoka, I.; Ogawa, H.; Okumura, K. The human antimicrobial peptide dermcidin activates normal human keratinocytes. Br. J. Dermatol., 2009, 160, 243-249.
104. Stewart G.D.; Skipworth, R.J.; Pennington, C.J.; Lowrie, A.G.; Deans, D.A.; Edwards, D.R.; Habib, F.K.; Riddick, A.C.; Fearon, K.C.; Ross, J.A. Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines. Br. J. Cancer, 2008, 99, 126-132.
105. Stewart G.D.; Skipworth, R.J.; Ross, J.A.; Fearon, K.; Baracos, V.E. The dermcidin gene in cancer: role in cachexia, carcinogenesis and tumour cell survival. Curr. Opin. Clin. Nutr. Metab. Care, 2008, 11, 208-213.
106. Stewart G.D.; Lowrie, A.G.; Riddick, A.C.; Fearon, K.C.; Habib, F.K.; Ross, J.A. Dermcidin expression confers a survival advantage in prostate cancer cells subjected to oxidative stress or hypoxia. Prostate, 2007, 67, 1308-1317.
107. Kim K.A.; Ka, S.O.; Moon, W.S.; Yi, H.K.; Lee, Y.H.; Kwon, K.B.; Park, J.W.; Park, B.H. Effect of dermcidin, an antimicrobial peptide, on body fat mobilization in normal mice. J. Endocrinol., 2008, 198, 111-118.
108. Porter D.; Weremowicz, S.; Chin, K.; Seth, P.; Keshaviah, A.; Lahti-Domenici, J.; Bae, Y.K.; Monitto, C.L.; Merlos-Suarez, A.; Chan, J.; Hulette, C.M.; Richardson, A.; Morton, C.C.; Marks, J.; Duyao, M.; Hruban, R.; Gabrielson, E.; Gelman, R.; Polyak, K. A neural survival factor is a candidate oncogene in breast cancer. Proc. Natl. Acad. Sci. USA, 2003, 100, 10931-10936.
109. Moreira D.F.; Strauss, B.E.; Vannier, E.; Belizario, J.E. Genes upand down-regulated by dermcidin in breast cancer: a microarray analysis. Genet. Mol. Res., 2008, 7, 925-932.
110. Motoyama J.P.L.; Kim-Motoyama, H.; Kim, P.; Nakagama, H.; Miyagawa, K.; Suzuki, K. Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. Biochem. Biophys. Res. Commun., 2007, 357, 828-833.
111. Senyurek I.; Paulmann, M.; Sinnberg, T.; Kalbacher, H.; Deeg, M.; Gutsmann, T.; Hermes, M.; Kohler, T.; Gotz, F.; Wolz, C.; Peschel, A.; Schittek, B. Dermcidin-derived peptides show a different mode of action against Staphylococcus aureus than the cathelicidin LL-37. Antimicrob. Agents Chemother., 2009, 53(6): 2499-509.
112. Hata T.R.; Gallo, R.L. Antimicrobial peptides, skin infections, and atopic dermatitis. Semin. Cutan. Med. Surg., 2008, 27, 144-150.
113. Yamasaki K.; Gallo, R.L. Antimicrobial peptides in human skin disease. Eur. J. Dermatol., 2008, 18, 11-21.
114. Lai Y.; Villaruz, A.E.; Li, M.; Cha, D.J.; Sturdevant, D.E.; Otto, M. The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci. Mol. Microbiol. 2007, 63, 497-506.
115. Lai Y.P.; Peng, Y.F.; Zuo, Y.; Li, J.; Huang, J.; Wang, L.F.; Wu, Z.R. Functional and structural characterization of recombinant dermcidin-1L, a human antimicrobial peptide. Biochem. Biophys. Res. Commun., 2005, 328, 243-250.
116. Barak O.; Treat, J.R.; James, W.D. Antimicrobial peptides: effectors of innate immunity in the skin. Adv. Dermatol., 2005, 21, 357-374.
117. Lominadze G.; Powell, D.W.; Luerman, G.C.; Link, A.J.; Ward, R.A.; McLeish, K.R. Proteomic analysis of human neutrophil granules. Mol. Cell Proteomics, 2005, 4, 1503-1521.
118. Ambatipudi K.; Deane, E.M. In search of neutrophil granule proteins of the tammar wallaby (Macropus eugenii). Mol. Immunol., 2008, 45, 690-700.
119. Ambatipudi K.; Joss, J.; Raftery, M.; Deane, E. A proteomic approach to analysis of antimicrobial activity in marsupial pouch secretions. Dev. Comp. Immunol., 2008, 32, 108-120.
120. Schittek B.; Hipfel, R.; Sauer, B.; Bauer, J.; Kalbacher, H.; Stevanovic, S.; Schirle, M.; Schroeder, K.; Blin, N.; Meier, F.; Rassner, G.; Garbe, C. Dermcidin: a novel human antibiotic peptide secreted by sweat glands. Nat. Immunol., 2001, 2, 1133-1137.
121. Rieg S.; Garbe, C.; Sauer, B.; Kalbacher, H.; Schittek, B. Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions. Br. J. Dermatol., 2004, 151, 534-539.
122. Kaus A.; Jacobsen, F.; Sorkin, M.; Rittig, A.; Voss, B.; Daigeler, A.; Sudhoff, H.; Steinau, H.U.; Steinstraesser, L. Host defence peptides in human burns. Burns, 2008, 34, 32-40.
123. Baechle D.; Flad, T.; Cansier, A.; Steffen, H.; Schittek, B.; Tolson, J.; Herrmann, T.; Dihazi, H.; Beck, A.; Mueller, G.A.; Mueller, M.; Stevanovic, S.; Garbe, C.; Mueller, C.A.; Kalbacher, H. Cathepsin D is present in human eccrine sweat and involved in the post-secretory processing of the antimicrobial peptide DCD-1L. J. Biol. Chem., 2006, 281, 5406-5415.
124. Rieg S.; Seeber, S.; Steffen, H.; Humeny, A.; Kalbacher, H.; Stevanovic, S.; Kimura, A.; Garbe, C.; Schittek, B. Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites. J. Invest. Dermatol., 2006, 126, 354-365.
125. Sagawa K.; Kimura, A.; Saito, Y.; Inoue, H.; Yasuda, S.; Nosaka, M.; Tsuji, T. Production and characterization of a monoclonal antibody for sweat-specific protein and its application for sweat identification. Int. J. Legal Med., 2003, 117, 90-95.
126. Flad T.; Bogumil, R.; Tolson, J.; Schittek, B.; Garbe, C.; Deeg, M.; Mueller, C.A.; Kalbacher, H. Detection of dermcidin-derived peptides in sweat by ProteinChip technology. J. Immunol. Methods, 2002, 270, 53-62.
127. Schroder J.M.; Harder, J. Antimicrobial skin peptides and proteins. Cell Mol. Life Sci., 2006, 63, 469-486.
128. McGirt L.Y.; Beck, L.A. Innate immune defects in atopic dermatitis. J. Allergy Clin. Immunol., 2006, 118, 202-208.
129. Kimata H. Increase in dermcidin-derived peptides in sweat of patients with atopic eczema caused by a humorous video. J. Psychosom. Res., 2007, 62, 57-59.
130. Rieg S.; Steffen, H.; Seeber, S.; Humeny, A.; Kalbacher, H.; Dietz, K.; Garbe, C.; Schittek, B. Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. J. Immunol., 2005, 174, 8003-8010.
131. Murakami M.; Ohtake, T.; Dorschner, R.A.; Schittek, B.; Garbe, C.; Gallo, R.L. Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin. J. Invest. Dermatol., 2002, 119, 1090-1095.
132. Vuong C.; Voyich, J.M.; Fischer, E.R.; Braughton, K.R.; Whitney, A.R.; DeLeo, F.R.; Otto, M. Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system. Cell Microbiol., 2004, 6, 269-275.
133. Vuong C.; Otto, M. Staphylococcus epidermidis infections. Microbes Infect., 2002, 4, 481-489.
134. Cipakova I.; Gasperik, J.; Hostinova, E. Expression and purification of human antimicrobial peptide, dermcidin, in Escherichia coli. Protein Expr. Purif., 2006, 45, 269-274.
135. Majczak G.; Lilla, S.; Garay-Malpartida, M.; Markovic, J.; Medrano, F.J.; de Nucci, G.; Belizario, J.E. Prediction and biochemical characterization of intrinsic disorder in the structure of proteolysis-inducing factor/dermcidin. Genet. Mol. Res., 2007, 6, 1000-1011.
136. Steffen H.; Rieg, S.; Wiedemann, I.; Kalbacher, H.; Deeg, M.; Sahl, H.G.; Peschel, A.; Gotz, F.; Garbe, C.; Schittek, B. Naturally processed dermcidin-derived peptides do not permeabilize bacterial membranes and kill microorganisms irrespective of their charge. Antimicrob. Agents Chemother., 2006, 50, 2608-2620.
137. Hall S.H.; Yenugu, S.; Radhakrishnan, Y.; Avellar, M.C.; Petrusz, P.; French, F.S. Characterization and functions of beta defensins in the epididymis. Asian J. Androl., 2007, 9, 453-462.
138. Yenugu S.; Hamil, K.G.; French, F.S.; Hall, S.H. Antimicrobial actions of the human epididymis 2 (HE2) protein isoforms, HE2alpha, HE2beta1 and HE2beta2. Reprod. Biol. Endocrinol., 2004, 2, 61.
139. Schutte B.C.; Mitros, J.P.; Bartlett, J.A.; Walters, J.D.; Jia, H.P.; Welsh, M.J.; Casavant, T.L.; McCray, P.B.; Jr. Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc. Natl. Acad. Sci. USA, 2002, 99, 2129-2133.
140. von Horsten H.H.; Derr, P.; Kirchhoff, C. Novel antimicrobial peptide of human epididymal duct origin. Biol. Reprod., 2002, 67, 804-813.
141. von Horsten H.H.; Schafer, B.; Kirchhoff, C. SPAG11/isoform HE2C, an atypical anionic beta-defensin-like peptide. Peptides, 2004, 25, 1223-1233.
142. 3+-doped anatase titania-coated nickel ferrite composite nanoparticles: a biomaterial system. Acta Biomater., 2006, 2, 421-432.
143. Weinberg A.; Quinones-Mateu, M.E.; Lederman, M.M. Role of human beta-defensins in HIV infection. Adv. Dent. Res., 2006, 19, 42-48.
144. Wechselberger C. Cloning of cDNAs encoding new peptides of the dermaseptin-family. Biochim. Biophys. Acta, 1998, 1388, 279-283.
145. Zairi A.; Tangy, F.; Saadi, S.; Hani, K. In vitro activity of dermaseptin S4 derivatives against genital infections pathogens. Regul. Toxicol. Pharmacol., 2008, 50, 353-358.
146. Lorin C.; Saidi, H.; Belaid, A.; Zairi, A.; Baleux, F.; Hocini, H.; Belec, L.; Hani, K.; Tangy, F. The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro. Virology, 2005, 334, 264-275.
147. Nicolas P.; Mor, A. Peptides as weapons against microorganisms in the chemical defense system of vertebrates. Annu. Rev. Microbiol., 1995, 49, 277-304.
148. Mangoni M.L. Temporins, anti-infective peptides with expanding properties. Cell Mol. Life Sci., 2006, 63, 1060-1069.
149. Isaacson T.; Soto, A.; Iwamuro, S.; Knoop, F.C.; Conlon, J.M. Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica. Peptides, 2002, 23, 419-425.
150. Rosenfeld Y.; Barra, D.; Simmaco, M.; Shai, Y.; Mangoni, M.L. A synergism between temporins toward Gram-negative bacteria overcomes resistance imposed by the lipopolysaccharide protective layer. J. Biol. Chem., 2006, 281, 28565-28574.
151. Mangoni M.L.; Marcellini, H.G.; Simmaco, M. Biological characterization and modes of action of temporins and bombinins H, multiple forms of short and mildly cationic anti-microbial peptides from amphibian skin. J. Pept. Sci., 2007, 13, 603-613.
152. Mangoni M.L.; Grovale, N.; Giorgi, A.; Mignogna, G.; Simmaco, M.; Barra, D. Structure-function relationships in bombinins H, antimicrobial peptides from Bombina skin secretions. Peptides, 2000, 21, 1673-1679.
153. Lai R.; Liu, H.; Hui Lee, W.; Zhang, Y. An anionic antimicrobial peptide from toad Bombina maxima. Biochem. Biophys. Res. Commun., 2002, 295, 796-799.
154. Dennison S.R.; Howe, J.; Morton, L.H.; Brandenburg, K.; Harris, F.; Phoenix, D.A. Interactions of an anionic antimicrobial peptide with Staphylococcus aureus membranes. Biochem. Biophys. Res. Commun., 2006, 347, 1006-1010.
155. Dennison S.R.; Morton, L.H.; Brandenburg, K.; Harris, F.; Phoenix, D.A. Investigations into the ability of an oblique alpha-helical template to provide the basis for design of an antimicrobial anionic amphiphilic peptide. FEBS J., 2006, 273, 3792-3803.
156. Lindberg I.; White, L. Distribution of Immunoreactive Peptide-B in the rat-brain. Biochem. Biophys. Res. Commun., 1986, 139, 1024-1032.
157. Lansac G.; Dong, W.; Dubois, C.M.; Benlarbi, N.; Afonso, C.; Fournier, I.; Salzet, M.; Day, R. Lipopolysaccharide mediated regulation of neuroendocrine associated proprotein convertases and neuropeptide precursor processing in the rat spleen. J. Neuroimmunol., 2006, 171, 57-71.
158. Landgraf P.; Sieg, F.; Wahle, P.; Meyer, G.; Kreutz, M.R.; Pape, H.C. A maternal blood-borne factor promotes survival of the developing thalamus. FASEB J., 2005, 19, 225-227.
159. Cuthbertson B.J.; Deterding, L.J.; Williams, J.G.; Tomer, K.B.; Etienne, K.; Blackshear, P.J.; Bullesbach, E.E.; Gross, P.S. Diversity in penaeidin antimicrobial peptide form and function. Dev. Comp. Immunol., 2008, 32, 167-181.
160. Destoumieux-Garzon D.; Saulnier, D.; Garnier, J.; Jouffrey, C.; Bulet, P.; Bachere, E. Crustacean immunity: antifungal peptides are generated from the C terminus of shrimp hemocyanin in response to microbial challenge. J. Biol. Chem., 2001, 276, 47070-47077.
161. Huang W.S.; Wang, K.J.; Yang, M.; Cai, J.J.; Li, S.J.; Wang, G.Z. Purification and part characterization of a novel antibacterial protein Scygonadin, isolated from the seminal plasma of mud crab, Scylla serrata (Forskal, 1775). J. Ex. Mar. Biol. Ecol., 2006, 339, 37-42.
162. Wang K.J.; Huang, W.S.; Yang, M.; Chen, H.Y.; Bo, J.; Li, S.J.; Wang, G.Z. A male-specific expression gene, encodes a novel anionic antimicrobial peptide, scygonadin, in Scylla serrata. Mol. Immunol., 2007, 44, 1961-1968.
163. Huang W.S.; Li, S.; Wang, K.J. Transcription Expression Analysis of an Antimicrobial Peptide Gene, Scygonadin, in Scylla serrata Using Dot-blot Assay Xiamen Daxue Xuebao (Ziran Kexue Ban), 2008, 47, 897-901.
164. Salzet M.; Tasiemski, A.; Cooper, E. Innate immunity in lophotrochozoans: the annelids. Curr. Pharm. Des., 2006, 12, 3043-3050.
165. Tasiemski A.; Vandenbulcke, F.; Mitta, G.; Lemoine, J.; Lefebvre, C.; Sautiere, P.E.; Salzet, M. Molecular characterization of two novel antibacterial peptides inducible upon bacterial challenge in an annelid, the leech Theromyzon tessulatum. J. Biol. Chem., 2004, 279, 30973-30982.
166. Sitaram N. Antimicrobial peptides with unusual amino acid compositions and unusual structures. Curr. Med. Chem., 2006, 13, 679-696.
167. De Smet K.; Contreras, R. Human antimicrobial peptides: defensins, cathelicidins and histatins. Biotechnol. Lett., 2005, 27, 1337-1347.
168. Schikorski D.; Cuvillier-Hot, V.; Leippe, M.; Boidin-Wichlacz, C.;
169. Tasiemski A.; Verger-Bocquet, M.; Cadet, M.; Goumon, Y.; Metz-Boutigue, M.H.; Aunis, D.; Stefano, G.B.; Salzet, M. Proenkephalin A-derived peptides in invertebrate innate immune processes. Brain Res. Mol. Brain Res., 2000, 76, 237-252.
170. Salzet M.; Stefano, G. Chromacin-like peptide in leeches. Neuroendocrinol. Lett., 2003, 24, 227-232.
171. Bruhn H.; Winkelmann, J.; Andersen, C.; Andra, J.; Leippe, M. Dissection of the mechanisms of cytolytic and antibacterial activity of lysenin, a defence protein of the annelid Eisenia fetida. Dev. Comp. Immunol., 2006, 30, 597-606.
172. Prochazkova P.; Silerova, M.; Felsberg, J.; Joskova, R.; Beschin, A.; De Baetselier, P.; Bilej, M. Relationship between hemolytic molecules in Eisenia fetida earthworms. Dev. Comp. Immunol., 2006, 30, 381-392.
173. Cooper E.L.; Kauschke, E.; Cossarizza, A. Digging for innate immunity since Darwin and Metchnikoff. Bioessays, 2002, 24, 319-333.
174. Shakor A.B.; Czurylo, E.A.; Sobota, A. Lysenin, a unique sphingomyelin-binding protein. FEBS Lett., 2003, 542, 1-6.
175. Reig N.; van der Goot, F.G. About lipids and toxins. FEBS Lett., 2006, 580, 5572-5579.
176. Wright S.D.; Kolesnick, R.N. Does endotoxin stimulate cells by mimicking ceramide? Immunol. Today, 1995, 16, 297-302.
177. Herec M.; Gagos, M.; Kulma, M.; Kwiatkowska, K.; Sobota, A.; Gruszecki, W.I. Secondary structure and orientation of the poreforming toxin lysenin in a sphingomyelin-containing membrane. Biochim. Biophys. Acta, 2008, 1778, 872-879.
178. Kwiatkowska K.; Hordejuk, R.; Szymczyk, P.; Kulma, M.; Abdel-Shakor, A.B.; Plucienniczak, A.; Dolowy, K.; Szewczyk, A.; Sobota, A. Lysenin-His, a sphingomyelin-recognizing toxin, requires tryptophan 20 for cation-selective channel assembly but not for membrane binding. Mol. Membr. Biol., 2007, 24, 121-134.
179. Shogomori H.; Kobayashi, T. Lysenin: a sphingomyelin specific pore-forming toxin. Biochim. Biophys. Acta, 2008, 1780, 612-618.
180. Kobayashi H.; Ohta, N.; Umeda, M. Biology of lysenin, a protein in the coelomic fluid of the earthworm Eisenia. foetida. Int. Rev. Cytol., 2004, 236, 45-99.
181. Hullin-Matsuda F.; Kobayashi, T. Monitoring the distribution and dynamics of signaling microdomains in living cells with lipid-specific probes. Cell Mol. Life Sci., 2007, 64, 2492-2504.
182. Liu Y.Q.; Sun, Z.J.; Wang, C.; Li, S.J.; Liu, Y.Z. Purification of a novel antibacterial short peptide in earthworm Eisenia foetida. Acta Biochim. Biophys. Sin. (Shanghai), 2004, 36, 297-302.
183. Zhang X.C.; Sun, Z.J.; Zhuo, R.P.; Hou, Q.M.; Lin, G.Q. Purification and characterization of two antibacterial peptides from Eisenia fetida. Prog. Biochem. Phys., 2002, 29, 955-960.
184. Taylor D. Innate Immunity in Ticks: a review. J. Acarol. Soc. Japan, 2006, 15, 109-127
185. Lai R.; Lomas, L.O.; Jonczy, J.; Turner, P.C.; Rees, H.H. Two novel non-cationic defensin-like antimicrobial peptides from haemolymph of the female tick, Amblyomma hebraeum. Biochem. J., 2004, 379, 681-685.
186. Zhou J.; Liao, M.; Ueda, M.; Gong, H.; Xuan, X.; Fujisaki, K. Sequence characterization and expression patterns of two defensin-like antimicrobial peptides from the tick Haemaphysalis longicornis. Peptides, 2007, 28, 1304-1310.
187. Zeng X.C.; Wang, S.X.; Zhu, Y.; Zhu, S.Y.; Li, W.X. Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch. Peptides, 2004, 25, 143-150.
188. Diego-Garcia E.; Batista, C.V.; Garcia-Gomez, B.I.; Lucas, S.; Candido, D.M.; Gomez-Lagunas, F.; Possani, L.D. The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function. Toxicon, 2005, 45, 273-283.
189. Uvell H.; Engstrom, Y. A multilayered defense against infection: combinatorial control of insect immune genes. Trends Genet., 2007, 23, 342-349.
190. Tamang D.G.; Saier, M.H.; Jr. The cecropin superfamily of toxic peptides. J. Mol. Microbiol. Biotechnol., 2006, 11, 94-103.
191. Andrejko M.; Mizerska-Dudka, M.; Jakubowicz, T. Antibacterial activity in vivo and in vitro in the hemolymph of Galleria mellonella infected with Pseudomonas aeruginosa. Comp. Biochem. Physiol. B Biochem. Mol. Biol., 2009, 152, 118-123.
192. Aperis G.; Fuchs, B.B.; Anderson, C.A.; Warner, J.E.; Calderwood, S.B.; Mylonakis, E. Galleria mellonella as a model host to study infection by the Francisella tularensis live vaccine strain. Microbes Infect., 2007, 9, 729-734.
193. Ponnuvel K.M.; Yamakawa, M. Immune responses against bacterial infection in Bombyx mori and regulation of host gene expression. Curr. Sci., 2002, 83, 447-454.
194. Cytrynska M.; Mak, P.; Zdybicka-Barabas, A.; Suder, P.; Jakubowicz, T. Purification and characterization of eight peptides from Galleria mellonella immune hemolymph. Peptides, 2007, 28, 533-546.
195. Hou L.; Shi, Y.; Zhai, P.; Le, G. Antibacterial activity and in vitro anti-tumor activity of the extract of the larvae of the housefly (Musca domestica). J. Ethnopharmacol., 2007, 111, 227-231.
196. Tang Y.L.; Shi, Y.H.; Zhao, W.; Hao, G.; Le, G.W. Discovery of a novel antimicrobial peptide using membrane binding-based approach. Food Control, 2009, 20, 149-156.
197. Tang Y.L.; Shi, Y.H.; Zhao, W.; Hao, G.; Le, G.W. Insertion mode of a novel anionic antimicrobial peptide MDpep5 (Val-Glu-Ser-Trp-Val) from Chinese traditional edible larvae of housefly and its effect on surface potential of bacterial membrane. J. Pharm. Biomed. Anal., 2008, 48, 1187-1194.
198. Tang Y.L.; Shi, Y.H.; Zhao, W.; Hao, G.; Le, G. Discovery of a novel antimicrobial peptide using membrane binding-based approach. Food Control, 2009, 20, 149-156.
199. Roller S.; Ed.; Natural Antimicrobials for the Minimal Processing of Foods, Camebridge, UK: Woodhouse; 2003.
200. Sels J.; Mathys, J.; De Coninck, B.M.; Cammue, B.P.; De Bolle, M.F. Plant pathogenesis-related (PR) proteins: a focus on PR peptides. Plant Physiol. Biochem., 2008, 46, 941-950.
201. Hammami R.; Ben Hamida, J.; Vergoten, G.; Fliss, I. PhytAMP: a database dedicated to antimicrobial plant peptides. Nucleic Acids Res., 2009, 37, D963-968.
202. Marcus J.P.; Green, J.L.; Goulter, K.C.; Manners, J.M. A family of antimicrobial peptides is produced by processing of a 7S globulin protein in Macadamia integrifolia kernels. Plant J., 1999, 19, 699-710.
203. De Lucca A.J.; Cleveland, T.E.; Wedge, D.E. Plant-derived antifungal proteins and peptides. Can. J. Microbiol., 2005, 51, 1001-1014.
204. Broekaert W.; Lee, H.I.; Kush, A.; Chua, N.H.; Raikhel, N. Wound-induced accumulation of messenger-rna containing a hevein sequence in laticifers of Rubber Tree (Hevea-Brasiliensis). Proc. Natl. Acad. Sci. USA, 1990, 87, 7633-7637.
205. Kiba A.; Saitoh, H.; Nishihara, M.; Omiya, K.; Yamamura, S. Cterminal domain of a hevein-like protein from Wasabia japonica has potent antimicrobial activity. Plant Cell Physiol., 2003, 44, 296-303.
206. Teixeira F.R.; Lima, M.C.O.P.; Almeida, H.O.; Romeiro, R.S.; Silva, D.J.H.; Pereira, P.R.G.; Fontes, E.P.B.; Baracat-Pereira, M.C. Bioprospection of cationic and anionic antimicrobial peptides from bell pepper leaves for inhibition of Ralstonia solanacearum and Clavibacter michiganensis ssp michiganensis growth. J. Phytopathol., 2006, 154, 418-421.
207. Mandal S.M.; Dey, S.; Mandal, M.; Sarkar, S.; Maria-Neto, S.; Franco, O.L. Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water. Peptides, 2009, 30, 633-637.
208. Pelegrini P.B.; Quirino, B.F.; Franco, O.L. Plant cyclotides: an unusual class of defense compounds. Peptides, 2007, 28, 1475-1481.
209. Gruber C.W.; Cemazar, M.; Anderson, M.A.; Craik, D.J. Insecticidal plant cyclotides and related cystine knot toxins. Toxicon, 2007, 49, 561-575.
210. Gran L. An oxytocic principle found in Oldenlandia affinis DC. Meddelelser fra Norsk Farmaceutisk Selskap, 1970, 32, 173-180.
211. Gran L. On the effect of a polypeptide isolated from "Kalata- Kalata" (Oldenlandia affinis DC) on the oestrogen dominated uterus. Acta Pharmacol. Toxicol. (Copenh), 1973, 33, 400-408.
212. Nair S.S.; Romanuka, J.; Billeter, M.; Skjeldal, L.; Emmett, M.R.; Nilsson, C.L.; Marshall, A.G. Structural characterization of an unusually stable cyclic peptide, kalata B2 from Oldenlandia affinis. Biochim. Biophys. Acta, 2006, 1764, 1568-1576.
213. Jennings C.V.; Rosengren, K.J.; Daly, N.L.; Plan, M.; Stevens, J.; Scanlon, M.J.; Waine, C.; Norman, D.G.; Anderson, M.A.; Craik, D.J. Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Mobius strips exist in nature? Biochemistry, 2005, 44, 851-860.
214. Colgrave M.L.; Kotze, A.C.; Huang, Y.H.; O'Grady, J.; Simonsen, S.M.; Craik, D.J. Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep. Biochemistry, 2008, 47, 5581-5589.
215. Plan M.R.; Saska, I.; Cagauan, A.G.; Craik, D.J. Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail). J. Agric. Food Chem., 2008, 56, 5237-5241.
216. Wang C.K.; Colgrave, M.L.; Gustafson, K.R.; Ireland, D.C.; Goransson, U.; Craik, D.J. Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. J. Nat. Prod., 2008, 71, 47-52.
217. Ireland D.C.; Wang, C.K.; Wilson, J.A.; Gustafson, K.R.; Craik, D.J. Cyclotides as natural anti-HIV agents. Biopolymers, 2008, 90, 51-60.
218. Ireland D.C.; Colgrave, M.L.; Craik, D.J. A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. Biochem. J., 2006, 400, 1-12.
219. Chen B.; Colgrave, M.L.; Wang, C.; Craik, D.J. Cycloviolacin H4, a hydrophobic cyclotide from Violahederaceae. J. Nat. Prod., 2006, 69, 23-28.
220. Chen B.; Colgrave, M.L.; Daly, N.L.; Rosengren, K.J.; Gustafson, K.R.; Craik, D.J. Isolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide. J. Biol. Chem., 2005, 280, 22395-22405.
221. Gran L.; Sletten, K.; Skjeldal, L. Cyclic peptides from Oldenlandia affinis DC. Molecular and biological properties. Chem. Biodivers., 2008, 5, 2014-2022.
222. Craik D.J.; Clark, R.J.; Daly, N.L. Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins. Expert. Opin. Investig. Drugs, 2007, 16, 595-604.
223. Yamada K.; Lim, J.; Dale, J.M.; Chen, H.; Shinn, P.; Palm, C.J.; Southwick, A.M.; Wu, H.C.; Kim, C.; Nguyen, M.; Pham, P.; Cheuk, R.; Karlin-Newmann, G.; Liu, S.X.; Lam, B.; Sakano, H.; Wu, T.; Yu, G.; Miranda, M.; Quach, H.L.; Tripp, M.; Chang, C.H.; Lee, J.M.; Toriumi, M.; Chan, M.M.; Tang, C.C.; Onodera, C.S.; Deng, J.M.; Akiyama, K.; Ansari, Y.; Arakawa, T.; Banh, J.; Banno, F.; Bowser, L.; Brooks, S.; Carninci, P.; Chao, Q.; Choy, N.; Enju, A.; Goldsmith, A.D.; Gurjal, M.; Hansen, N.F.; Hayashizaki, Y.; Johnson-Hopson, C.; Hsuan, V.W.; Iida, K.; Karnes, M.; Khan, S.; Koesema, E.; Ishida, J.; Jiang, P.X.; Jones, T.; Kawai, J.; Kamiya, A.; Meyers, C.; Nakajima, M.; Narusaka, M.; Seki, M.; Sakurai, T.; Satou, M.; Tamse, R.; Vaysberg, M.; Wallender, E.K.; Wong, C.; Yamamura, Y.; Yuan, S.; Shinozaki, K.; Davis, R.W.; Theologis, A.; Ecker, J.R. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003, 302, 842-846.
224. Goudet C.; Chi, C.W.; Tytgat, J. An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch. Toxicon, 2002, 40, 1239-1258.
225. Plan M.R.; Goransson, U.; Clark, R.J.; Daly, N.L.; Colgrave, M.L.; Craik, D.J. The cyclotide fingerprint in Oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides. Chem. Biochem., 2007, 8, 1001-1011.
226. Simonsen S.M.; Sando, L.; Ireland, D.C.; Colgrave, M.L.; Bharathi, R.; Goransson, U.; Craik, D.J. A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae). Plant Cell, 2005, 17, 3176-3189.
227. Goransson U.; Luijendijk, T.; Johansson, S.; Bohlin, L.; Claeson, P. Seven novel macrocyclic polypeptides from Viola arvensis. J. Nat. Prod., 1999, 62, 283-286.
228. Bokesch H.R.; Pannell, L.K.; Cochran, P.K.; Sowder, R.C.; 2nd, McKee, T.C.; Boyd, M.R. A novel anti-HIV macrocyclic peptide from Palicourea condensata. J. Nat. Prod., 2001, 64, 249-250.