Alternative mechanisms of action of cationic antimicrobial peptides on bacteria

Expert Review of Anti-Infective Therapy

Volumn 5, Issue 6, 2007, Pages 951-959

  Hale, John D F ^a   Hancock, Robert E W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Antibacterial; Cationic antimicrobial peptide; Mechanism of action; Synergy

Indexed keywords

ALAMETHICIN; ANTIBIOTIC AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; APIDAECIN; BACTENECIN; BACTERIAL DNA; BACTERIAL RNA; BACTERIOCIN; BETA LACTAM ANTIBIOTIC; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CECROPIN; CP10A; DERMASEPTIN; DROSOCIN; GALLIDERMIN; GALLINACIN; INDOLICIDIN; LACTACIN; LANTIBIOTIC; MACROLIDE; MAGAININ 2; MICROCIN; MUTACIN; NISIN; PEP5 PROTEIN; PLEUROCIDIN DERIVATIVE; PR 39; PROTEGRIN; PYRRHOCORICIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; BACTERIAL CELL WALL; BACTERIAL INFECTION; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; CELL DIVISION; COMMERCIAL PHENOMENA; DRUG DESIGN; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG POTENTIATION; DRUG SYNTHESIS; DRUG TARGETING; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; MEMBRANE DAMAGE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN FOLDING; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA; REVIEW;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; BACTERIAL INFECTIONS; BACTERIAL PROTEINS; CELL DIVISION; CELL MEMBRANE; DRUG DESIGN; DRUG SYNERGISM; HUMANS; NUCLEIC ACIDS; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 37349104237     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.5.6.951     Document Type: Review

References (66)

1. Hancock REW, Chapple DS. Peptide antibiotics. Antimicrob. Agents Chemother. 43(6), 1317-1323 (1999).
2. Jenssen H, Hamill P, Hancock REW. Peptide antimicrobial agents. Clin. Microbiol. Rev. 19(3), 491-511 (2006).
3. Brown KL, Hancock REW. Cationic host defense (antimicrobial) peptides. Curr. Opin. Immunol. 18(1), 24-30 (2006).
4. Powers JP, Hancock REW. The relationship between peptide structure and antibacterial activity. Peptides 24(11), 1681-1691 (2003).
5. Hancock REW, Sahl HG. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat. Biotechnol. 24(12), 1551-1557 (2006).
6. Peschel A, Sahl HG. The co-evolution of host cationic antimicrobial peptides and microbial resistance. Nat. Rev Microbiol. 4(7), 529-536 (2006).
7. Kraus D, Peschel A. Molecular mechanisms of bacterial resistance to antimicrobial peptides. Curr. Top. Microbiol. Immunol. 306, 231-250 (2006).
8. Hancock REW, Patrzykat A. Clinical development of cationic antimicrobial peptides: from natural to novel antibiotics. Curr. Drug Tarqets Infect. Disord. 2(1), 79-83 (2002).
9. Marshall SH, Arenas G. Antimicrobial peptides: a natural alternative to chemical antibiotics and a potential for applied biotechnology. Electron. J. Biotechnol. 6(2), 265-272 (2003).
10. Gifford JL, Hunter HN, Vogel HJ. Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. Cell. Mol. Life Sci. 62(22), 2588-2598 (2005).
11. Chen X, Niyonsaba F, Ushio H et al. Synergistic effect of antibacterial agents human β-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J. Dermatol. Sci. 40(2), 123-432 (2005).
12. Hilpert K, Volkmer-Engert R, Walter T, Hancock REW. High-throughput generation of small antibacterial peptides with improved activity. Nat Biotechnol. 23(8), 1008-1012 (2005).
13. Blondelle SE, Lohner K. Combinatorial libraries: a tool to design antimicrobial and antifungal peptide analogues having lytic specificities for structure-activity relationship studies. Biopolymers 55(1), 74-87 (2000).
14. Straus SK, Hancock REW. Mode of action of the new antibiotic for Gram-positive pathogens daptomycin: comparison with cationic antimicrobial peptides and lipopeptides. Biochim. Biophys. Acta 1758(9), 1215-1223 (2006).
15. Hancock REW. Peptide antibiotics. Lancet 349(9049), 418-422 (1997).
16. Brogden KA. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 3(3), 238-250 (2005).
17. Wu M, Maier E, Benz R, Hancock REW. Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli. Biochemistry 38(22), 7235-7242 (1999).
18. Yang L, Harroun TA, Heller WT, Weiss TM, Huang HW. Neutron off-plane scattering of aligned membranes. I. Method of measurement. Biophis. J. 75 (2), 641-645 (1998).
19. Matsuzaki K, Murase O, Fujii N, Miyajima K. An antimicrobial peptide, magainin 2, induced rapid flip-flop of phospholipids coupled with pore formation and peptide translocation. Biochemistry 35(35), 11361-11368 (1996).
20. Gazit E, Boman A, Boman HG, Shai Y. Interaction of the mammalian antibacterial peptide cecropin P1 with phospholipid vesicles. Biochemistry 34(36), 11479-11488 (1995).
21. Bechinger B, Lohner K. Detergent-like actions of linear amphipathic cationic antimicrobial peptides. Biochim. Biophys. Acta 1758(9), 1529-1539 (2006).
22. Shai Y. Molecular recognition between membrane-spanning polypeptides. Trends Biochem. Sci. 20(11), 460-464 (1995).
23. Patrzykat A, Friedrich CL, Zhang L, Mendoza V, Hancock REW. Sublethal concentrations of pleurocidin-derived antimicrobial pepticles inhibit macromolecular synthesis in Escherichia coli. Antimicrob. Agents Chemother. 46(3), 605-614 (2002).
24. Hong RW, Shchepetov M, Weiser JN, Axelsen PH. Transcriptional profile of the Escherichia coli response to the antimicrobial insect pepticle cecropin A. Antimicrob. Agents Chemother. 47(1), 1-6 (2003).
25. Haukland HH, Ulvatne H, Sandvik K, Vorland LH. The antimicrobial peptides lactoferricin B and magainin 2 cross over the bacterial cytoplasmic membrane and reside in the cytoplasm. FEBS Lett. 508(3), 389-393 (2001).
26. Park CB, Kim MS, Kim SC. A novel antimicrobial peptide from Bufo bufo gargarizans. Biochem. Biophys. Res. Commun. 218(1), 408-413 (1996).
27. Park CB, Kim HS, Kim SC. Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. Biochem. Biophys Res. Commun. 244(1), 253-257 (1998).
28. Park CB, Yi KS, Matsuzaki K, Kim MS, Kim SC. Structure-activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: the proline hinge is responsible for the cell-penetrating ability of buforin II. Proc. Natl Acad. Sci. USA 97(15), 8245-8250 (2000).
29. Hirsch JG. Bactericidal action of histone. J. Exp. Med. 108(6), 925-944 (1958).
30. Birkemo GA, Luders, T, Andersen O, Nes IF, Nissen-Meyer J. Hipposin, a histone-derived antimicrobial peptide in Atlantic halibut ( Hippoglossus hippoglossus L.). Biochim. Biophys. Acta 1646(1-2), 207-215 (2003).
31. Park IY, Park CB, Kim MS, Kim SC. Parasin I, an antimicrobial peptide derived from histone H2A in the catfish, Parasilurus asotus. FEBS Lett. 437(3), 258-262 (1998).
32. Hsu C-H, Chen C, Jou M-L et al. Structural and DNA-binding studies on the bovine antimicrobial peptide, indolicidin: evidence for multiple conformations involved in binding to membranes and DNA. Nucl. Acids Res. 33(13), 4053-4064 (2005).
33. Tomasinsig L, Zanetti M. The cathelicidins - structure, function and evolution. Curr. Protein Pept. Sci. 6(1), 23-34 (2005).
34. Falla TJ, Karunaratne DN, Hancock RE. Mode of action of the antimicrobial peptide indolicidin. J. Biol. Chem. 271(32), 19298-19303 (1996).
35. Subbalakshrni C, Sitaram N. Mechanism of antimicrobial action of indolicidin. FEMS Microbiol. Lett. 160(1), 91-96 (1998).
36. Marchand C, Krajewski K, Lee HF et al. Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites. Nucl. Acids Res. 34(18), 5157-5165 (2006).
37. Friedrich CL, Rozek A, Patrzykat A, Hancock REW. Structure and mechanism of action of an indolicidin peptide derivative with improved activity against Gram-positive bacteria. J. Biol. Chem. 276(26), 24015-24022 (2001).
38. Ageroerth B, Lee JY, Bergman T et al. Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides. Eur. J. Biochem. 202(3), 849-854 (1991).
39. Shi J, Ross CR, Chengappa MM, Blecha F. Identification of a proline-arginine-rich antibacterial peptide from neutrophils that is analogous to PR-39, an antibacterial peptide from the small intestine. J. Leukoc. Biol. 56(6), 807-811 (1994).
40. Boman HG, Agerberth B, Boman A. Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infect. Immun. 61(7), 2978-2984 (1993).
41. Cole AM, Weis P, Diamond G. Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder. J. Biol. Chem. 272(18), 12008-12013 (1997).
42. Otvos L Jr, O I, Rogers ME et al. Interaction between heat shock proteins and antimicrobial peptides. Biochemistry 39(46), 14150-14159 (2000).
43. Kragol G, Lovas S, Varadi G et al. The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding. Biochemistry 40(10), 3016-3026 (2001).
44. Salomon RA, Farias RN. Microcin 25, a novel antimicrobial peptide produced by Escherichia coli. J. Bacteriol. 174(22), 7428-7435 (1992).
45. Sahl HG, Pag U, Bonness S et al. Mammalian defensins: structures and mechanism of antibiotic activity. J. Leukoc. Biol. 77(4), 466-475 (2005).
46. Brotz H, Josten M, Wiedemann I et al. Role of lipid-bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics. Mol. Microbiol. 30(2), 317-327 (1998).
47. Breukink E, Wiedemann I, van Kraaij C et al. Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic. Science 286(5448), 2361-2364 (1999).
48. Breukink E, de Kruijff B. Lipid II as a target for antibiotics. Nat. Rev. Drug Discov. 5(4), 321-332 (2006).
49. Bierbaum G, Sahl HG. Autolytic system of Staphylococcus simulans 22: influence of cationic peptides on activity of N-acetylmuramoyl-L-alanine amidase. J. Bacteriol. 169(12), 5452-5458 (1987).
50. Hasper HE, Kramer NE, Smith JL et al. An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II. Science 313 (5793), 1636-1637 (2006).
51. Morency H, Mota-Meira M, LaPointe G, Lacroix C, Lavoie MC. Comparison of the activity spectra against pathogens of bacterial strains producing a mutacin or a lantibiotic. Can. J. Microbiol. 47(4), 322-331 (2001).
52. Amsterdam D. Susceptibility testing of antimicrobials in liquid media. In: Antibiotics in Laboratory Medicine. Lorian V (Ed.). Williams and Wilkins, MD, USA 52-111 (1996).
53. Yan H, Hancock REW. Synergistic interactions between mammalian antimicrobial defense peptides. Antimicrob. Agents Chemother. 45(5), 1558-1560 (2001).
54. Milona P, Townes CL, Bevan RM, Hall J. The chicken host peptides, gallinacins 4, 7, and 9 have antimicrobial activity against Salmonella serovars. Biochem. Biophys. Res. Commun. 356(1), 169-174 (2007).
55. Scott MG, Yan H, Hancock REW. Biological properties of structurally related α-helical cationic antimicrobial peptides. Infect. Immun. 67(4), 2005-2009 (1999).
56. Cirioni O, Giacometti A, Kamysz W et al. In vitro activities of tachyplesin III against Pseudomonas aeruginosa. Peptides 28(4), 747-751 (2007).
57. Otvos L Jr, de Olivier Inacio V, Wade JD, Cudic P. Prior antibacterial peptide-mediated inhibition of protein folding in bacteria mutes resistance enzymes. Antimicrob. Agents Chemother. 50(9), 3146-3149 (2006).
58. Mookherjee N, Brown KL, Bowdish DM et al. Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J. Immunol. 176(4), 2455-2464 (2006).
59. Dennis EA, Rhee SG, Billah MM, Hannun YA. Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J. 5(7), 2068-2077 (1991).
60. Qu XD, Lehrer RI. Secretory phospholipase A2 is the principal bactericide for staphylococci and other Gram-positive bacteria in human tears. Infect. Immun. 66(6), 2791-2797 (1998).
61. Zhao H, Kinnunen PK. Modulation of the activity of secretory phospholipase A2 by antimicrobial peptides. Antimicrob. Agents Chemother. 47(3), 965-971 (2003).
62. Jia X, Patrzykat A, Devlin RH et al. Antimicrobial peptides protect coho salmon from Vibrio anguillarum infections. Appl. Environ. Microbiol. 66(5), 1928-1932 (2000).
63. Blondelle SE, Perez-Paya E, Houghten RA. Synthetic combinatorial libraries: novel discovery strategy for identification of antimicrobial agents. Antimicrob. Agents Chemother. 40(5), 1067-1071 (1996).
64. Loose C, Jensen K, Rigoutsos I, Stephanopoulos G. A linguistic model for the rational design of antimicrobial peptides. Nature 443(7113), 867-869 (2006).
65. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 415(6870), 389-395 (2002).
66. Bechinger B. The structure, dynamics and orientation of antimicrobial peptides in membranes by multidimensional solid-state NMR spectroscopy. Biochim. Biophys. Acta 1462(1-2), 157-183 (1999).