Collectins and cationic antimicrobial peptides of the respiratory epithelia

Veterinary Pathology

Volumn 43, Issue 5, 2006, Pages 595-612

  Grubor, B ^a,b   Meyerholz, D K ^a   Ackermann, M R ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB COMPANY   (United States)

Author keywords

Defensins; Innate immunity; Lung; Surfactant proteins

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; COLLECTIN;

ANIMAL; METABOLISM; RESPIRATORY TRACT MUCOSA; REVIEW;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; COLLECTINS; RESPIRATORY MUCOSA;

EID: 33748626871     PISSN: 03009858     EISSN: 03009858     Source Type: Journal    
DOI: 10.1354/vp.43-5-595     Document Type: Review

References (157)

1. Aarbiou J, Rabe KF, Hiemstra PS: Role of defensins in inflammatory lung disease. Ann Med 34:96-101, 2002
2. Ackermann MR, Gallup JM, Zabner J, Evans RB, Brockus CW, Meyerholz DK, Grubor B, Brogden KA: Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia. Microb Pathog 37:21-27, 2004
3. Aderem A, Underhill DM: Mechanisms of phagocytosis in macrophages. Annu Rev Immunol 17:593-623, 1999
4. Alcorn JF, Wright JR: Degradation of pulmonary surfactant protein D by Pseudomonas aeruginosa elastase abrogates innate immune function. J Biol Chem 279:30871-30879, 2004
5. Attalah HL, Wu Y, Alaoui-El-Azher M, Thouron F, Koumanov K, Wolf C, Brochard L, Harf A, Delclaux C, Touqui L: Induction of type-IIA secretory phospholipase A2 in animal models of acute lung injury. Eur Respir J 21:1040-1045, 2003
6. Ballard PL, Ning Y, Polk D, Ikegami M, Jobe AH: Glucocorticoid regulation of surfactant components in immature lambs. Am J Physiol 273:L1048-1057, 1997
7. Bals R: Roles of antimicrobial peptides in pulmonary disease. In: Mammalian Host Defense Peptides, ed. Devine DA and Hancock REW, 1st ed., pp. 349-373. Cambridge University Press, New York, NY, 2004
8. Bals R, Wang X, Meegalla RL, Wattler S, Weiner DJ, Nehls MC, Wilson JM: Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect Immun 67:3542-3547, 1999
9. Bals R, Wang X, Zasloff M, Wilson JM: The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci USA 95:9541-9546, 1998
10. Bals R, Weiner DJ, Moscioni AD, Meegalla RL, Wilson JM: Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide. Infect Immun 67:6084-6089, 1999
11. Barnes PJ: Neurogenic inflammation in the airways. Respir Physiol 125:145-154, 2001
12. Beers MF, Solarin KO, Guttentag SH, Rosenbloom J, Kormilli A, Gonzales LW, Ballard PL: TGF-beta1 inhibits surfactant component expression and epithelial cell maturation in cultured human fetal lung. Am J Physiol 275:L950-960, 1998
13. Bingle CD, Craven CJ: PLUNC: a novel family of candidate host defense proteins expressed in the upper airways and nasopharynx. Hum Mol Genet 11:937-943, 2002
14. Boggaram V: Regulation of lung surfactant protein gene expression. Front Biosci 8:d751-764, 2003
15. Boman HG: Innate immunity and the normal microflora. Immunol Rev 173:5-16, 2000
16. Brogden KA, Ackermann M, Huttner KM: Detection of anionic antimicrobial peptides in ovine bronchoalveolar lavage fluid and respiratory epithelium. Infect Immun 66:5948-5954, 1998
17. Brogden KA, Ackermann M, McCray PB Jr, Tack BF: Antimicrobial peptides in animals and their role in host defenses. Int J Antimicrob Agents 22:465-478, 2003
18. Brogden KA, Ackermann MR, McCray PB Jr, Huttner KM: Differences in the concentrations of small, anionic, antimicrobial peptides in bronchoalveolar lavage fluid and in respiratory epithelia of patients with and without cystic fibrosis. Infect Immun 67:4256-4259, 1999
19. Brogden KA, Heidari M, Sacco RE, Palmquist D, Guthmiller JM, Johnson GK, Jia HP, Tack BF, McCray PB: Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease. Oral Microbiol Immunol 18:95-99, 2003
20. Brown KR, England KM, Goss KL, Snyder JM, Acarregui MJ: VEGF induces airway epithelial cell proliferation in human fetal lung in vitro. Am J Physiol Lung Cell Mol Physiol 281:L1001-1010, 2001
21. Cao Y, Tao JQ, Bates SR, Beers MF, Haczku A: IL-4 induces production of the lung collectin surfactant protein-D. J Allergy Clin Immunol 113:439-444, 2004
22. Cazzola M, Sanduzzi A, Matera MG: Novelties in the field of antimicrobial compounds for the treatment of lower respiratory tract infections. Pulm Pharmacol Ther 16:131-145, 2003
23. Chang TL, Francois F, Mosoian A, Klotman ME: CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition. J Virol 77:6777-6784, 2003
24. Clark H, Reid K: The potential of recombinant surfactant protein D therapy to reduce inflammation in neonatal chronic lung disease, cystic fibrosis, and emphysema. Arch Dis Child 88:981-984, 2003
25. Clark H, Reid KB: Structural requirements for SP-D function in vitro and in vivo: therapeutic potential of recombinant SP-D. Immunobiology 205:619-631, 2002
26. Condon JC, Jeyasuria P, Faust JM, Mendelson CR: Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition. Proc Natl Acad Sci U S A 101:4978-4983, 2004
27. Crouch E, Hartshorn K, Ofek I: Collectins and pulmonary innate immunity. Immunol Rev 173:52-65, 2000
28. Crouch E, Parghi D, Kuan SF, Persson A: Surfactant protein D: subcellular localization in nonciliated bronchiolar epithelial cells. Am J Physiol 263:L60-66, 1992
29. Crouch EC: Surfactant protein-D and pulmonary host defense. Respir Res 1:93-108, 2000
30. Dahlin K, Mager EM, Allen L, Tigue Z, Goodglick L, Wadehra M, Dobbs L: Identification of genes differentially expressed in rat alveolar type I cells. Am J Respir Cell Mol Biol 31:309-316, 2004
31. Dekowski SA, Snyder JM: Insulin regulation of messenger ribonucleic acid for the surfactant-associated proteins in human fetal lung in vitro. Endocrinology 131:669-676, 1992
32. Diamond G, Legarda D, Ryan LK: The innate immune response of the respiratory epithelium. Immunol Rev 173:27-38, 2000
33. Diamond G, Russell JP, Bevins CL: Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc Natl Acad Sci U S A 93:5156-5160, 1996
34. Dubin RF, Robinson SK, Widdicombe JH: Secretion of lactoferrin and lysozyme by cultures of human airway epithelium. Am J Physiol Lung Cell Mol Physiol 286:L750-755, 2004
35. Dulkerian SJ, Gonzales LW, Ning Y, Ballard PL: Regulation of surfactant protein D in human fetal lung. Am J Respir Cell Mol Biol 15:781-786, 1996
36. Dungworth DL: The respiratory system. In: Pathology of Domestic Animals, ed. Jubb KVF, Kennedy PC, and Palmer N, 4th ed., pp. 539-699. Academic, San Diego, CA, 1993
37. Durbin AP, Elkins WR, Murphy BR: African green monkeys provide a useful nonhuman primate model for the study of human parainfluenza virus types-1, -2, and -3 infection. Vaccine 18:2462-2469, 2000
38. Dutton JM, Goss K, Khubchandani KR, Shah CD, Smith RJ, Snyder JM: Surfactant protein A in rabbit sinus and middle ear mucosa. Ann Otol Rhinol Laryngol 108:915-924, 1999
39. Epand RM, Vogel HJ: Diversity of antimicrobial peptides and their mechanisms of action. Biochim Biophys Acta 1462:11-28, 1999
40. Fales-Williams AJ, Brogden KA, Huffman E, Gallup JM, Ackermann MR: Cellular distribution of anionic antimicrobial peptide in normal lung and during acute pulmonary inflammation. Vet Pathol 39:706-711, 2002
41. Fales-Williams AJ, Gallup JM, Ramirez-Romero R, Brogden KA, Ackermann MR: Increased anionic peptide distribution and intensity during progression and resolution of bacterial pneumonia. Clin Diagn Lab Immunol 9:28-32, 2002
42. Gallup JM, Grubor B, Barua AB, Mohammadi G, Brogden KA, Olson JA, Ackermann MR: Repeated intravenous doses of all-trans-retinoyl beta-D-glucuronide is not effective in the treatment of bacterial bronchopneumonia in lambs but is devoid of gross and acute toxicity. Med Sci Monit 8:BR345-353, 2002
43. Ganz T: Antimicrobial polypeptides. J Leukoc Biol 75:34-38, 2004
44. George TN, Miakotina OL, Goss KL, Snyder JM: Mechanism of all trans-retinoic acid and glucocorticoid regulation of surfactant protein mRNA. Am J Physiol 274:L560-566, 1998
45. Ghildyal R, Hartley C, Varrasso A, Meanger J, Voelker DR, Anders EM, Mills J: Surfactant protein A binds to the fusion glycoprotein of respiratory syncytial virus and neutralizes virion infectivity. J Infect Dis 180:2009-2013, 1999
46. Giacometti A, Cirioni O, Del Prete MS, Paggi AM, D'Errico MM, Scalise G: Combination studies between polycationic peptides and clinically used antibiotics against Gram-positive and Gram-negative bacteria. Peptides 21:1155-1160, 2000
47. Gimenez AP, Wu YZ, Paya M, Delclaux C, Touqui L, Goossens PL: High bactericidal efficiency of type IIA phospholipase A2 against Bacillus anthracis and inhibition of its secretion by the lethal toxin. J Immunol 173:521-530, 2004
48. Gjerstorff M, Hansen S, Jensen B, Dueholm B, Horn P, Bendixen C, Holmskov U: The genes encoding bovine SP-A, SP-D, MBL-A, conglutinin, CL-43 and CL-46 form a distinct collectin locus on Bos taurus chromosome 28 (BTA28) at position q.1.8-1.9. Anim Genet 35:333-337,2004
49. Gjerstorff M, Madsen J, Bendixen C, Holmskov U, Hansen S: Genomic and molecular characterization of bovine surfactant protein D (SP-D). Mol Immunol 41:369-376, 2004
50. Gotoh B, Komatsu T, Takeuchi K, Yokoo J: Paramyxovirus strategies for evading the interferon response. Rev Med Virol 12:337-357, 2002
51. Grubor B, Gallup JM, Meyerholz DK, Crouch EC, Evans RB, Brogden KA, Lehmkuhl HD, Ackermann MR: Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs. Clin Diagn Lab Immunol 11:599-607, 2004
52. Grubor B, Gallup JM, Ramirez-Romero R, Bailey TB, Crouch EC, Brogden KA, Ackermann MR: Surfactant protein D expression in normal and pneumonic ovine lung. Vet Immunol Immunopathol 101:235-242, 2004
53. Haagsman HP: Structural and functional aspects of the collectin SP-A. Immunobiology 205:476-489, 2002
54. Haataja R, Marttila R, Uimari P, Lofgren J, Ramet M, Hallman M: Respiratory distress syndrome: evaluation of genetic susceptibility and protection by transmission disequilibrium test. Hum Genet 109:351-355, 2001
55. Hancock RE, Diamond G: The role of cationic antimicrobial peptides in innate host defenses. Trends Microbiol 8:402-410, 2000
56. Hancock RE, Scott MG: The role of antimicrobial peptides in animal defenses. Proc Natl Acad Sci USA 97:8856-8861, 2000
57. Hansen S, Holmskov U: Lung surfactant protein D (SP-D) and the molecular diverted descendants: conglutinin, CL-43 and CL-46. Immunobiology 205:498-517, 2002
58. Harder J, Meyer-Hoffert U, Teran LM, Schwichtenberg L, Bartels J, Maune S, Schroder JM: Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am J Respir Cell Mol Biol 22:714-721, 2000
59. Harder J, Meyer-Hoffert U, Wehkamp K, Schwichtenberg L, Schroder JM: Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid. J Invest Dermatol 123:522-529, 2004
60. Hartshorn KL, White MR, Shepherd V, Reid K, Jensenius JC, Crouch EC: Mechanisms of anti-influenza activity of surfactant proteins A and D: comparison with serum collectins. Am J Physiol 273:L1156-1166, 1997
61. Hawgood S, Brown C, Edmondson J, Stumbaugh A, Allen L, Goerke J, Clark H, Poulain F: Pulmonary collectins modulate strain-specific influenza a virus infection and host responses. J Virol 78:8565-8572, 2004
62. Hawgood S, Poulain FR: The pulmonary collectins and surfactant metabolism. Annu Rev Physiol 63:495-519, 2001
63. Hickling TP, Clark H, Malhotra R, Sim RB: Collectins and their role in lung immunity. J Leukoc Biol 75:27-33, 2004
64. Hinata N, Takemura T, Ikushima S, Yanagawa T, Ando T, Okada J, Oritsu M, Koike M: Phenotype of regenerative epithelium in idiopathic interstitial pneumonias. J Med Dent Sci 50:213-224, 2003
65. Hirche TO, Crouch EC, Espinola M, Brokelman TJ, Mecham RP, DeSilva N, Cooley J, Remold-O'Donnell E, Belaaouaj A: Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain. J Biol Chem 279:27688-27698, 2004
66. Hoffmann JA, Kafatos FC, Janeway CA, Ezekowitz RA: Phylogenetic perspectives in innate immunity. Science 284:1313-1318, 1999
67. Hoffmeyer MR, Scalia R, Ross CR, Jones SP, Lefer DJ: PR-39, a potent neutrophil inhibitor, attenuates myocardial ischemia-reperfusion injury in mice. Am J Physiol Heart Circ Physiol 279:H2824-2828, 2000
68. Holmskov U, Thiel S, Jensenius JC: Collectins and ficolins: humoral lectins of the innate immune defense. Annu Rev Immunol 21:547-578, 2003
69. Holmskov UL: Collectins and collectin receptors in innate immunity. APMIS Suppl 100:1-59, 2000
70. Hornef MW, Wick MJ, Rhen M, Normark S: Bacterial strategies for overcoming host innate and adaptive immune responses. Nat Immunol 3:1033-1040, 2002
71. Hung CH, Chen LC, Zhang Z, Chowdhury B, Lee WL, Plunkett B, Chen CH, Myers AC, Huang SK: Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein. J Allergy Clin Immunol 114:664-670, 2004
72. Huttner KM, Brezinski-Caliguri DJ, Mahoney MM, Diamond G: Antimicrobial peptide expression is developmentally regulated in the ovine gastrointestinal tract. J Nutr 128:297S-299S, 1998
73. Huttner KM, Lambeth MR, Burkin HR, Burkin DJ, Broad TE: Localization and genomic organization of sheep antimicrobial peptide genes. Gene 206:85-91, 1998
74. Jia HP, Schutte BC, Schudy A, Linzmeier R, Guthmiller JM, Johnson GK, Tack BF, Mitros JP, Rosenthal A, Ganz T, McCray PB, Jr.: Discovery of new human beta-defensins using a genomics-based approach. Gene 263:211-218, 2001
75. Juillerat-Jeanneret L, Aubert JD, Leuenberger P: Peptidases in human bronchoalveolar lining fluid, macrophages, and epithelial cells: dipeptidyl (amino) peptidase IV, aminopeptidase N, and dipeptidyl (carboxy)peptidase (angiotensin-converting enzyme). J Lab Clin Med 130:603-614, 1997
76. Katyal SL, Singh G, Locker J: Characterization of a second human pulmonary surfactant-associated protein SP-A gene. Am J Respir Cell Mol Biol 6:446-452, 1992
77. King RJ, Ruch J, Gikas EG, Platzker AC, Creasy RK: Appearance of paoproteins of pulmonary surfactant in human amniotic fluid. J Appl Physiol 39:735-741, 1975
78. Koczulla AR, Bals R: Antimicrobial peptides: current status and therapeutic potential. Drugs 63:389-406, 2003
79. Kudo K, Sano H, Takahashi H, Kuronuma K, Yokota S, Fujii N, Shimada K, Yano I, Kumazawa Y, Voelker DR, Abe S, Kuroki Y: Pulmonary collectins enhance phagocytosis of Mycobacterium avium through increased activity of mannose receptor. J Immunol 172:7592-7602, 2004
80. Kumar V, Husain AN: The lung. In: Robbins and Cotran Pathologic Basis of Disease, 7th ed., pp. 711-722. Elsevier, Philadelphia, PA, 2005
81. Lehrer RI, Ganz T: Defensins of vertebrate animals. Curr Opin Immunol 14:96-102, 2002
82. LeVine AM, Elliott J, Whitsett JA, et al.: Surfactant protein-d enhances phagocytosis and pulmonary clearance of respiratory syncytial virus. Am J Respir Cell Mol Biol 31:193-199, 2004
83. Li J, Gao E, Seidner SR, Mendelson CR: Differential regulation of baboon SP-A1 and SP-A2 genes: structural and functional analysis of 5′-flanking DNA. Am J Physiol 275:L1078-1088, 1998
84. Li P, Chan HC, He B, So SC, Chung YW, Shang Q, Zhang YD, Zhang YL: An antimicrobial peptide gene found in the male reproductive system of rats. Science 291:1783-1785, 2001
85. Lillehoj ER, Kim KC: Airway mucus: its components and function. Arch Pharm Res 25:770-780, 2002
86. Lin Z, deMello D, Phelps DS, Koltun WA, Page M, Floros J: Both human SP-A1 and Sp-A2 genes are expressed in small and large intestine. Pediatr Pathol Mol Med 20:367-386, 2001
87. Lin Z, Wang Y, Zhu K, Floros J: Differential allele expression of host defense genes, pulmonary surfactant protein-A and Osteopontin, in rat. Mol Immunol 41:1155-1165, 2004
88. Lindbom J, Ljungman AG, Lindahl M, Tagesson C: Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma. J Interferon Cytokine Res 22:947-955, 2002
89. Liu L, Wang L, Jia HP, Zhao C, Heng HH, Schutte BC, McCray PB, Jr., Ganz T: Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene 222:237-244, 1998
90. Liu L, Zhao C, Heng HH, Ganz T: The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. Genomics 43:316-320, 1997
91. Lopez A: Respiratory system, thoracic cavity, and pleura. In: Thomson's Special Veterinary Pathology, 3rd ed., pp. 125-195. Mosby, St. Louis, MO, 2001
92. MacNeill C, Umstead TM, Phelps DS, Lin Z, Floros J, Shearer DA, Weisz J: Surfactant protein A, an innate immune factor, is expressed in the vaginal mucosa and is present in vaginal lavage fluid. Immunology 111:91-99, 2004
93. Madsen J, Tornoe I, Nielsen O, Koch C, Steinhilber W, Holmskov U: Expression and localization of lung surfactant protein A in human tissues. Am J Respir Cell Mol Biol 29:591-597, 2003
94. Matsui H, Randell SH, Peretti SW, Davis CW, Boucher RC: Coordinated clearance of periciliary liquid and mucus from airway surfaces. J Clin Invest 102:1125-1131, 1998
95. Matsuzaki K: Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes. Biochim Biophys Acta 1462:1-10, 1999
96. McCormack FX, Whitsett JA: The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung. J Clin Invest 109:707-712, 2002
97. McCray PB Jr, Bentley L: Human airway epithelia express a beta-defensin. Am J Respir Cell Mol Biol 16:343-349, 1997
98. McIntosh JC, Swyers AH, Fisher JH, Wright JR: Surfactant proteins A and D increase in response to intratracheal lipopolysaccharide. Am J Respir Cell Mol Biol 15:509-519, 1996
99. Meng Y, Zhao J, Ruan YM: Effect of exogenous pulmonary surfactant on isolated lung injury induced by ischemia-reperfusion in rats [in Chinese]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26:302-305, 2004
100. Mescher EJ, Platzker AC, Ballard PL, Kitterman JA, Clements JA, Tooley WH: Ontogeny of tracheal fluid, pulmonary surfactant, and plasma corticoids in the fetal lamb. J Appl Physiol 39:1017-1021, 1975
101. Meyerholz DK, Gallup JM, Grubor BM, Evans RB, Tack BF, McCray PB, Jr., Ackermann MR: Developmental expression and distribution of sheep beta-defensin-2. Dev Comp Immunol 28:171-178, 2004
102. Meyerholz DK, Grubor B, Gallup JM, Lehmkuhl HD, Anderson RD, Lazic T, Ackermann MR: Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs. J Clin Microbiol 42:4780-4787, 2004
103. Miakotina OL, Snyder JM: TNF-alpha inhibits SP-A gene expression in lung epithelial cells via p38 MAPK. Am J Physiol Lung Cell Mol Physiol 283:L418-427, 2002
104. Moraes TJ, Chow CW, Downey GP: Proteases and lung injury. Crit Care Med 31:S189-194, 2003
105. Nakos G, Kitsiouli EI, Tsangaris I, Lekka ME: Bronchoalveolar lavage fluid characteristics of early intermediate and late phases of ARDS. Alterations in leukocytes, proteins, PAF and surfactant components. Intensive Care Med 24:296-303, 1998
106. Nguyen KB, Cousens LP, Doughty LA, Pien GC, Durbin JE, Biron CA: Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox. Nat Immunol 1:70-76, 2000
107. Nosratabadi AR, Ljungman AG, Lindahl M, Welch R, Pilon A, Tagesson C: Clara cell 10-KDA protein inhibits endotoxin-induced airway contraction in isolated perfused rat lungs. Exp Lung Res 29:455-473, 2003
108. Orgeig S, Daniels CB, Johnston SD, Sullivan LC: The pattern of surfactant cholesterol during vertebrate evolution and development: does ontogeny recapitulate phylogeny? Reprod Fertil Dev 15:55-73, 2003
109. Otvos L Jr., O I, Rogers ME, Consolvo PJ, Condie BA, Lovas S, Bulet P, Blaszczyk-Thurin M: Interaction between heat shock proteins and antimicrobial peptides. Biochemistry 39:14150-14159, 2000
110. Paananen R, Sormunen R, Glumoff V, van Eijk M, Hallman M: Surfactant proteins A and D in eustachian tube epithelium. Am J Physiol Lung Cell Mol Physiol 281:L660-667, 2001
111. Palaniyar N, Nadesalingam J, Clark H, Shih MJ, Dodds AW, Reid KB: Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J Biol Chem 279:32728-32736, 2004
112. Piedimonte G: Tachykinin peptides, receptors, and peptidases in airway disease. Exp Lung Res 21:809-834, 1995
113. Prakobphol A, Xu F, Hoang VM, Larsson T, Bergstrom J, Johansson I, Frangsmyr L, Holmskov U, Leffler H, Nilsson C, Boren T, Wright JR, Stromberg N, Fisher SJ: Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340. J Biol Chem 275:39860-39866, 2000
114. Ramanathan B, Davis EG, Ross CR, Blecha F: Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity. Microbes Infect 4:361-372, 2002
115. Reading PC, Allison J, Crouch EC, Anders EM: Increased susceptibility of diabetic mice to influenza virus infection: compromise of collectin-mediated host defense of the lung by glucose? J Virol 72:6884-6887, 1998
116. Reading PC, Holmskov U, Anders EM: Antiviral activity of bovine collectins against rotaviruses. J Gen Virol 79(Pt 9): 2255-2263, 1998
117. Reading PC, Morey LS, Crouch EC, Anders EM: Collectin-mediated antiviral host defense of the lung: evidence from influenza virus infection of mice. J Virol 71:8204-8212, 1997
118. Ridsdale RA, Palaniyar N, Holterman CE, Inchley K, Possmayer F, Harauz G: Cation-mediated conformational variants of surfactant protein A. Biochim Biophys Acta 1453:23-34, 1999
119. Rubin BK: Physiology of airway mucus clearance. Respir Care 47:761-768, 2002
120. Rubio F, Cooley J, Accurso FJ, Remold-O'Donnell E: Linkage of neutrophil serine proteases and decreased surfactant protein-A (SP-A) levels in inflammatory lung disease. Thorax 59:318-323, 2004
121. Russell JP, Diamond G, Tarver AP, Scanlin TF, Bevins CL: Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect Immun 64:1565-1568, 1996
122. Rust K, Bingle L, Mariencheck W, Persson A, Crouch EC: Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids. Am J Respir Cell Mol Biol 14:121-130, 1996
123. Sabatini LM, Warner TF, Saitoh E, Azen EA: Tissue distribution of RNAs for cystatins, histatins, statherin, and proline-rich salivary proteins in humans and macaques. J Dent Res 68:1138-1145, 1989
124. Salaun B, de Saint-Vis B, Pacheco N, Pacheco Y, Riesler A, Isaac S, Leroux C, Clair-Moninot V, Pin JJ, Griffith J, Treilleux I, Goddard S, Davoust J, Kleijmeer M, Lebecque S: CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol 164:861-871, 2004
125. Sallenave JM: Antimicrobial activity of antiproteinases. Biochem Soc Trans 30:111-115, 2002
126. Sallenave JM: The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease. Respir Res 1:87-92, 2000
127. Salvatore F, Scudiero O, Castaldo G: Genotype-phenotype correlation in cystic fibrosis: the role of modifier genes. Am J Med Genet 111:88-95, 2002
128. Sano H, Nagai K, Tsutsumi H, Kuroki Y: Lactoferrin and surfactant protein A exhibit distinct binding specificity to F protein and differently modulate respiratory syncytial virus infection. Eur J Immunol 33:2894-2902, 2003
129. Schneemann M, Schaffner A: Host defense mechanism in Aspergillus fumigatus infections. Contrib Microbiol 2:57-68, 1999
130. Schroder JM, Harder J: Human beta-defensin-2. Int J Biochem Cell Biol 31:645-651, 1999
131. Schutte BC, McCray PB Jr: [beta]-defensins in lung host defense. Annu Rev Physiol 64:709-748, 2002
132. Scott MG, Hancock RE: Cationic antimicrobial peptides and their multifunctional role in the immune system. Crit Rev Immunol 20:407-431, 2000
133. Scott MG, Vreugdenhil AC, Buurman WA, Hancock RE, Gold MR: Cutting edge: cationic antimicrobial peptides block the binding of lipopolysaccharide (LPS) to LPS binding protein. J Immunol 164:549-553, 2000
134. Shin SY, Park EJ, Yang ST, Jung HJ, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI: Structure-activity analysis of SMAP-29, a sheep leukocytes-derived antimicrobial peptide. Biochem Biophys Res Commun 285:1046-1051, 2001
135. Singh PK, Tack BF, McCray PB Jr, Welsh MJ: Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am J Physiol Lung Cell Mol Physiol 279:L799-805, 2000
136. Spurlock SL, Hanie EA: Antibiotics in the treatment of wounds. Vet Clin North Am Equine Pract 5:465-482, 1989
137. Steinberg DA, Hurst MA, Fujii CA, Kung AH, Ho JF, Cheng FC, Loury DJ, Fiddes JC: Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity. Antimicrob Agents Chemother 41:1738-1742, 1997
138. Stuart RB, Ovadia B, Suzara VV, Ross PA, Thelitz S, Fineman JR, Gutierrez JA: Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb. Am J Physiol Lung Cell Mol Physiol 285:L628-633, 2003
139. Tan RC, Ikegami M, Jobe AH, Yao LY, Possmayer F, Ballard PL: Developmental and glucocorticoid regulation of surfactant protein mRNAs in preterm lambs. Am J Physiol 277:L1142-1148, 1999
140. van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS: Defensins: key players or bystanders in infection, injury, and repair in the lung? J Allergy Clin Immunol 104:1131-1138, 1999
141. van Wetering S, van der Linden AC, van Sterkenburg MA, de Boer WI, Kuijpers AL, Schalkwijk J, Hiemstra PS: Regulation of SLPI and elafin release from bronchial epithelial cells by neutrophil defensins. Am J Physiol Lung Cell Mol Physiol 278:L51-58, 2000
142. Wang W, Cole AM, Hong T, Waring AJ, Lehrer RI: Retrocyclin, an antiretroviral theta-defensin, is a lectin. J Immunol 170:4708-4716, 2003
143. Weston WM, LeClair EE, Trzyna W, McHugh KM, Nugent P, Lafferty CM, Ma L, Tuan RS, Greene RM: Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung. J Biol Chem 274:13698-13703, 1999
144. Wheeler TT, Haigh BJ, McCracken JY, Wilkins RJ, Morris CA, Grigor MR: The BSP30 salivary proteins from cattle, LUNX/PLUNC and von Ebner's minor salivary gland protein are members of the PSP/LBP superfamily of proteins. Biochim Biophys Acta 1579:92-100, 2002
145. Williams MC: Alveolar type I cells: molecular phenotype and development. Annu Rev Physiol 65:669-695, 2003
146. Wright JR: Host defense functions of pulmonary surfactant. Biol Neonate 85:326-332, 2004
147. Wu H, Kuzmenko A, Wan S, Schaffer L, Weiss A, Fisher JH, Kim KS, McCormack FX: Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability. J Clin Invest 111:1589-1602, 2003
148. Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, Anderson M, Schroder JM, Wang JM, Howard OM, Oppenheim JJ: Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286:525-528, 1999
149. Yang D, Chertov O, Oppenheim JJ: The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity. Cell Mol Life Sci 58:978-989, 2001
150. Yang Y, Zhang Z, Mukherjee AB, Linnoila RI: Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4- (methylnitrosamino)-1- (3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke. J Biol Chem 279:29336-29340, 2004
151. Yano T, Mason RJ, Pan T, Deterding RR, Nielsen LD, Shannon JM: KGF regulates pulmonary epithelial proliferation and surfactant protein gene expression in adult rat lung. Am J Physiol Lung Cell Mol Physiol 279:L1146-1158, 2000
152. Yao XL, Levine SJ, Cowan MJ, Logun C, Shelhamer JH: Tumor necrosis factor-alpha stimulates human Clara cell secretory protein production by human airway epithelial cells. Am J Respir Cell Mol Biol 19:629-635, 1998
153. Zabner J, Seiler MP, Launspach JL, Karp PH, Kearney WR, Look DC, Smith JJ, Welsh MJ: The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing. Proc Natl Acad Sci USA 97:11614-11619, 2000
154. Zanetti M: Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol 75:39-48, 2004
155. Zasloff M: Antibiotic peptides as mediators of innate immunity. Curr Opin Immunol 4:3-7, 1992
156. Zeng X, Gray M, Stahlman MT, Whitsett JA: TGF-beta1 perturbs vascular development and inhibits epithelial differentiation in fetal lung in vivo. Dev Dyn 221:289-301, 2001
157. Zucht HD, Grabowsky J, Schrader M, Liepke C, Jurgens M, Schulz-Knappe P, Forssmann WG: Human beta-defensin-1: a urinary peptide present in variant molecular forms and its putative functional implication. Eur J Med Res 3:315-323, 1998