β-defensins in lung host defense

Annual Review of Physiology

Volumn 64, Issue , 2002, Pages 709-748

  Schutte, Brian C ^a   McCray Jr , Paul B ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Antimicrobial peptides; Epithelia; Innate defense; Mucosa

Indexed keywords

BETA DEFENSIN;

AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; BRONCHUS SECRETION; HOST RESISTANCE; HUMAN; IMMUNITY; IMMUNOREGULATION; LUNG; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; BETA-DEFENSINS; HUMANS; LUNG; MOLECULAR SEQUENCE DATA; RESPIRATORY TRACT INFECTIONS;

EID: 0036197412     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.64.081501.134340     Document Type: Review

References (199)

1. On a remarkable bacteriolytic element found in tissues and secretions
2. Observations on a bacteriolytic substance ("lysozyme") found in secretions and tissues
3. Antibiotic peptides from higher eukaryotes: Biology and applications
4. Defensins and other antimicrobial peptides
5. Antimicrobial peptides as mediators of epithelial host defense
6. The evolution and genetics of innate immunity
7. Commentary. Self-defense: The fruit fly style
8. Phylogenetic perspectives in innate immunity
9. Innate immunity and the normal microflora
10. Toll-like receptor-mediated NF-kappaB activation: A phylogenetically conserved paradigm in innate immunity
11. Antimicrobial peptides and proteins in the innate defense of the airway surface
12. Pulmonary macrophages
13. Newly identified proteins in human nasal and bronchoalveolar lavage fluids: Potential biomedical and clinical applications
14. Two-dimensional gel electrophoresis of nasal and bronchoalveolar lavage fluids after occupational exposure
15. Demonstration of different forms of the anti-inflammatory proteins lipocortin-1 and Clara cell protein-16 in human nasal and bronchoalveolar lavage fluids
16. Human bronchoalveolar lavage fluid protein two-dimensional database: Study of interstitial lung diseases
17. Transport function of airway epithelia and submucosal glands
18. Human airway ion transport part II
19. Innate antimicrobial activity of nasal secretions
20. Activity of abundant antimicrobials of the human airway
21. Antibacterial peptides in bronchoalveolar lavage fluid
22. Human lung lysozyme: Sources and properties
23. Tissue distribution of antileukoprotease and lysozyme in humans
24. Antibacterial activity of antileukiprotease
25. Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin
26. Immunohistochemical localization and bacteriostatic properties of an iron-binding protein from bronchial mucus
27. Lower respiratory tract lactoferrin and lysozyme arise primarily in the airways and are elevated in association with chronic bronchitis
28. Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria
29. The potent anti-Staphylococcus aureus activity of a sterile rabbit inflammatory fluid is due to a 14-kD phospholipase A2
30. Integrated host defense against infections
31. Antimicrobial peptides of phagocytes and epithelia
32. Surfactant protein A-deficient mice are susceptible to group B streptococcal infection
33. Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection
34. Minireview: Collectins and pulmonary host defense
35. Surfactant protein A and surfactant protein D in health and disease
36. Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica
37. Isolation and characterization of a peroxidase from the airway
38. Cathelicidins: A novel protein family with a common proregion and a variable C-terminal antimicrobial domain
39. Structural features and biological activities of the cathelicidin-derived antimicrobial peptides
40. Anti-microbial activity and cell binding are controlled by sequence determinants in the anti-microbial peptide PR-39
41. FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis
42. Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse
43. Structural and functional analysis of horse cathelicidin peptides
44. Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide
45. cDNA sequences of three sheep myeloid cathelicidins
46. SMAP-29: A potent antibacterial and antifungal peptide from sheep leukocytes
47. Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients
48. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface
49. Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules
50. Human enteric defensins - Gene structure and developmental expression
51. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins
52. A peptide antibiotic from human skin
53. Ocular surface epithelia express mRNA for human beta defensin-2
54. Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands
55. A novel murine beta-defensin expressed in tongue, esophagus, and trachea
56. Expression of the peptide antibiotic human β-defensin 1 in cultured gingival epithelial cells and gingival tissue
57. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium
58. Human β-defensin-1, an antimicrobial peptide of urogenital tissues
59. Human β-defensin-1: A urinary peptide present in variant molecular forms and its putative functional implication
60. Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung
61. Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis
62. Human airway epithelia express a β-defensin
63. hBD-1: A novel beta-defensin from human plasma
64. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic
65. Discovery of new human beta-defensins using a genomics-based approach
66. Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of a cDNA
67. Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene
68. Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils
69. Gallinacin-3, an inducible epithelial beta-defensin in the chicken
70. Differential expression of caprine beta-defensins in digestive and respiratory tissues
71. Molecular cloning and tissue expression of porcine β-defensin-1
72. An antimicrobial peptide gene found in the male reproductive system of rats
73. Antimicrobial peptide expression is developmentally regulated in the ovine gastrointestinal tract
74. Enteric β-defensin: Molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with cryptosporidium parvum infection
75. A novel mouse beta defensin. Defb2, which is upregulated in the airways by lipopolysaccharide
76. Expression of beta-defensin-1 in chimpanzee (Pan troglodytes) airways
77. Multiple promoter and splicing mRNA variants of the epididymis-specific gene EP2
78. Initial sequencing and analysis of the human genome
79. The sequence of the human genome
80. Genomics. Public-private project to deliver mouse genome in 6 months
81. Generation of a high-density rat EST map
82. Generation and analysis of 25 Mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning
83. The mouse genome encodes a single homolog of the antimicrobial peptide human β-defensin 1
84. A novel murine beta-defensin expressed in tongue, esophagus, and trachea
85. Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins
86. Solution structure of bovine neutrophil β-defensin-12: The peptide fold of the β-defensins is identical to that of the classical defensins
87. The NMR structure of human beta-defensin-2 reveals a novel alpha- helical segment
88. The structure of human beta-defensin-2 shows evidence of higher order oligomerization
89. Solution structure of a defensin-like peptide from platypus venom
90. Cloning and analysis of mRNAs expressed specifically in the human epididymis
91. Region-specific variation of gene expression in the human epididymis as revealed by in situ hybridization with tissue-specific cDNAs
92. Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis
93. Organization of the human gene encoding the epididymis-specific ep2 protein variants and its relationship to defensin genes
94. HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human
95. Structure, function, and membrane integration of defensins
96. Mouse β-defensin 1 is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogenital tract
97. Production of β-defensins by human airway epithelia
98. Mouse beta defensin-1 is a functional homolog of human beta defensin-1
99. Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs
100. Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations
101. Crystal structure of defensin HNP-3, an amphiphilic dimer: Mechanisms of membrane permeabilization
102. Solution structures of the rabbit neutrophil defensin NP-5
103. NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1
104. Somatic cell mapping of β-defensin genes to cattle syntenic group U25 and fluorescence in situ localization to chromosome 27
105. The human-beta-defensin-1 and alpha-defensins are encoded by adjacent genes: Two peptide families with differing disulfide topology share a common ancestry
106. Mapping of the gene encoding human β-defensin-2 (DEFB2) to chromosome region 8p22-p23.1
107. Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation
108. A 450-kb contig of defensin genes on human chromosome 8p23
109. Localization and genomic organization of sheep antimicrobial peptide genes
110. Cloning and characterization of the gene for a new epithelial beta-defensin. Genomic structure, chromosomal localization, and evidence for its constitutive expression
111. Basic local alignment search tool
112. Deletion 8p syndrome
113. Epithelial antibiotics induced at sites of intimation
114. Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha
115. Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells
116. Efficient killing of inhaled bacteria in deltaF508 mice: Role of airway surface liquid composition
117. A novel mouse β-defensin, mBD-6, predominantly expressed in skeletal muscle
118. Mucoid Pseudomonas aeruginosa. TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia
119. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells
120. Detection of a cystic fibrosis modifier locus for meconium ileus on human chromosome 19q13
121. Identification of human β-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia
122. Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellular infection
123. Abundant human beta-defensin-1 expression in milk and mammary gland epithelium
124. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
125. From the cover: Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
126. CD14-dependent lipopolysaccharide-induced beta-defensin-2 expression in human tracheobronchial epithelium
127. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
128. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
129. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
130. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
131. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
132. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
133. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
134. A Toll-like receptor recognizes bacterial DNA
135. Expression and activity of β-defensins-1 and 2 (hBD-1 and hBD-2) in airway epithelia
136. Direct inactivation of viruses by human granulocyte defensins
137. Effects of synthetic form of tracheal antimicrobial peptide on respiratory pathogens
138. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity
139. Synergistic and additive killing by antimicrobial factors found in human airway surface liquid
140. Beta-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
141. Defensins and host defense
142. CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha
143. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC
144. Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells
145. Antigen presentation in the lung
146. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
147. MHC class II antigen-beating dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations
148. Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces
149. Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli
150. Inflammatory infiltration of the upper airway epithelium during Sendai virus infection: Involvement of epithelial dendritic cells
151. Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2
152. Cloning and characterization of exodus, a novel beta-chemokine
153. Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors
154. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue
155. CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses
156. Defensins are mitogenic for epithelial cells and fibroblasts
157. Defensin modulates tissue-type plasminogen activator and plasminogen binding to fibrin and endothelial cells
158. Isolation and structure of corticostatin peptides from rabbit fetal and adult lung
159. Defensins purified from human granulocytes bind C1q and activate the classical complement pathway like the transmembrane glycoprotein gp41 of HIV-1
160. Effect of neutrophil serine proteinases and defensins on lung epithelial cells: Modulation of cytotoxicity and IL-8 production
161. Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3
162. Evolutionary diversification of the mammalian defensins
163. Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution
164. Phylogenetic tests of the hypothesis of block duplication of homologous genes on human chromosomes 6, 9, and 1
165. Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils
166. Bactericidal activity of mammalian cathelicidin-derived peptides
167. Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages
168. 3-transport in mutations associated with cystic fibrosis
169. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid
170. Minireview. Cystic fibrosis and the salt controversy
171. A sensitive defense: Salt and cystic fibrosis
172. Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects
173. Topical review - Molecular insights into the physiology of the 'thin film' of airway surface liquid
174. Ontogeny of immunity
175. A longitudinal analysis of infant morbidity and the extent of breast-feeding in the United States
176. Beta-defensin expression in human mammary gland epithelia
177. Causes of death in the extremely low birth weight infant
178. Decreased sodium ion absorption across nasal epithelium of very premature infants with respiratory distress syndrome
179. Epithelial Na(+) channel (ENaC) expression in the developing normal and abnormal human perinatal lung
180. Defensins reduce the barrier integrity of a cultured epithelial monolayer without cytotoxicity
181. Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion
182. Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: Effects on pulmonary epithelium
183. Defensins: Key players or bystanders in infection, injury, and repair in the lung?
184. Purification and characterization of defensins from cystic fibrosis sputum
185. Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator
186. The new antibiotics: Can novel antibacterial treatments combat the rising tide of drug-resistant infections?
187. Engineered salt-insensitive alpha-defensins with end-to-end circularized structures
188. Cationic peptides: A new source of antibiotics
189. Using host defenses to fight infectious diseases
190. Expression of beta-defensin genes in bovine alveolar macrophages
191. Cloning and expression of bovine neutrophil beta-defensins. Biosynthetic profile during neutrophilic maturation and localization of mature peptide to novel cytoplasmic dense granules
192. Gallinacins: Cysteine-rich antimicrobial peptides of chicken leukocytes
193. Characterization of beta-defensin prepropeptide mRNA from chicken and turkey bone marrow
194. Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells
195. Cloning and nucleotide sequences of crotamine genes
196. Isolation of antimicrobial peptides from avian heterophils
197. MOLMOL: A program for display and analysis of macromolecular structures
198. A comprehensive genetic map of the human genome based on 5,264 microsatellites