Modulating the tumor microenvironment to increase radiation responsiveness

Cancer Biology and Therapy

Volumn 8, Issue 21, 2009, Pages 1994-2001

  Karar, Jayashree ^a   Maity, Amit ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Akt; EGFR; HIF; PI3 kinase; Radiation; Radiosensitization; Tumor microenvironment; Vascular normalization; VEGF

Indexed keywords

1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)INDAZOLE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3' ETHYNYLCYTIDINE; 4 [BIS(2 CHLOROETHYL)OXIDOAMINO]PHENYLALANINE; BEVACIZUMAB; CC I779; CEDIRANIB; CETUXIMAB; COMBRETASTATIN A1 PHOSPHATE; DEFOROLIMUS; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; GEFITINIB; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; N ACETYLCOLCHINOL PHOSPHATE; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULAR TARGETING AGENT; VASCULOTROPIN; VATALANIB; VECTOIBIX; WORTMANNIN; [1 (4 OXO 8 PHENYL 4H 1 BENZOPYRAN 2 YL)MORPHOLINIO]METHOXYSUCCINYLARGINYLGLYCYLASPARTYLSERINE ACETATE;

ANTINEOPLASTIC ACTIVITY; CANCER CELL; CANCER INHIBITION; COLON CANCER; DNA REPAIR; DRUG HALF LIFE; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; ENZYME ACTIVATION; EXTERNAL BEAM RADIOTHERAPY; HEAD AND NECK CANCER; HUMAN; IONIZING RADIATION; LEUKEMIA; LUNG CANCER; MICROENVIRONMENT; MODULATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGENATION; PROTEIN PHOSPHORYLATION; RADIATION RESPONSE; RADIOSENSITIZATION; REVIEW; SIGNAL TRANSDUCTION; TISSUE PRESSURE; TUMOR; TUMOR BLOOD FLOW; TUMOR RECURRENCE; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

EID: 73549100417     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.21.9988     Document Type: Review

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