Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation

Radiotherapy and Oncology

Volumn 76, Issue 2, 2005, Pages 162-167

  Krause, Mechthild ^a   Ostermann, Gernot ^a   Petersen, Cordula ^a   Yaromina, Ala ^a   Hessel, Franziska ^a   Harstrick, Andreas ^b   Van Der Kogel, Albert J ^c   Thames, Howard D ^d   Baumann, Michael ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b MERCK KGAA   (Germany)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

C225; EGFR inhibition; Fractionated irradiation; Local tumour control; Molecular targeting; Reoxygenation; Repopulation; Squamous cell carcinoma

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER CONTROL; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GENE TARGETING; HYPOXIA; IRRADIATION; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; REOXYGENATION; SQUAMOUS CELL CARCINOMA;

ANIMALS; ANTIBODIES, MONOCLONAL; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; CELL LINE, TUMOR; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR CELLS, CULTURED;

EID: 28444438451     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2005.06.032     Document Type: Conference Paper

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