Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant

Nucleic Acids Research

Volumn 37, Issue 20, 2009, Pages 6849-6858

  Fiorani, Paola ^a   Tesauro, Cinzia ^a   Mancini, Giordano ^b   Chillemi, Giovanni ^b   D'Annessa, Ilda ^a,b   Graziani, Grazia ^a   Tentori, Lucio ^a   Muzi, Alessia ^a   Desideri, Alessandro ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b CASPUR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; DNA TOPOISOMERASE; LYSINE; MUTANT PROTEIN;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; WILD TYPE; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; POINT MUTATION; PROTEIN TERTIARY STRUCTURE; STATIC ELECTRICITY;

ALANINE; BASE SEQUENCE; CATALYSIS; CATALYTIC DOMAIN; DNA TOPOISOMERASES, TYPE I; HUMANS; LYSINE; MOLECULAR SEQUENCE DATA; MUTATION; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; STATIC ELECTRICITY;

EID: 73349101566     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp669     Document Type: Article

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