A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance.

Nucleic acids research

Volumn 36, Issue 17, 2008, Pages 5635-5644

  Losasso, Carmen ^a   Cretaio, Erica ^a   Fiorani, Paola ^a   D'Annessa, Ilda ^a   Chillemi, Giovanni ^a   Benedetti, Piero ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA; DNA TOPOISOMERASE; ENZYME INHIBITOR; THREONINE; TOPOISOMERASE IB, HUMAN;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; DRUG ANTAGONISM; DRUG RESISTANCE; GENETICS; HUMAN; METABOLISM; MUTATION; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CATALYSIS; DNA; DNA TOPOISOMERASES, TYPE I, EUKARYOTIC; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; HUMANS; MUTATION; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; THREONINE;

EID: 55249089257     PISSN: None     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn557     Document Type: Article

References (0)