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Volumn 5, Issue 7, 2009, Pages 1065-1082

Plasma YKL-40: A potential new cancer biomarker?

Author keywords

Biomarker; Cancer; CHI3L1; Inflammation; Tissue remodeling; YKL 40

Indexed keywords

BIOLOGICAL MARKER; GLYCOPROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG; YKL 40; AUTOANTIGEN; CHI3L1 PROTEIN, HUMAN; GROWTH PROMOTOR; LECTIN;

EID: 73349094080     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.09.66     Document Type: Review
Times cited : (133)

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    • Erzin Y, Uzun H, Karatas A, Celik AF: Serum YKL-40 as a marker of disease activity and stricture formation in patiens with Crohn's disease. J. Gastroenterol. Hepatol. 23, E357-E362 (2008).
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    • Determination of serum levels of YKL-40 and hyaluronic acid in patients with hepatic fibrosis due to schistosomiasis japonica and appraisal of their clinical value
    • Zheng M, Cai WM, Zhao JK, Zhu SM, Liu RH: Determination of serum levels of YKL-40 and hyaluronic acid in patients with hepatic fibrosis due to schistosomiasis japonica and appraisal of their clinical value. Acta Trop. 96, 148-152 (2005).
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    • Fontana RJ, Bonkovsky HL, Naishadham D et al.: Serum fibrosis marker levels decrease after successful antiviral treatment in chronic hepatitis C patients with advanced fibrosis. Clin. Gastroenterol. Hepatol. 7, 219-226 (2009).
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    • Serum fibrosis markers can predict rapid fibrosis progression after liver transplantation for hepatitis C
    • Pungpapong S, Nunes DP, Krishna M et al.: Serum fibrosis markers can predict rapid fibrosis progression after liver transplantation for hepatitis C. Liver Transpl. 14, 1294-1302 (2008).
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    • Diagnostic accuracy of serum hyaluronic acid, FIBROSpect II, and YKL-40 for discriminating fibrosis stages in chronic hepatitis C
    • Mehta P, Ploutz-Snyder R, Nandi J, Rawlins SR, Sanderson SO, Levine RA: Diagnostic accuracy of serum hyaluronic acid, FIBROSpect II, and YKL-40 for discriminating fibrosis stages in chronic hepatitis C. Am. J. Gastroenterol. 103, 928-936 (2008).
    • (2008) Am. J. Gastroenterol , vol.103 , pp. 928-936
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  • 184
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    • Serum levels of YKL-40 and hyaluronic acid as non-invasive markers of liver fibrosis in haemodialysis patients with chronic hepatitis C virus infection
    • Schiavon LL, Narciso-Schiavon JL, Carvalho Filho RJ et al.: Serum levels of YKL-40 and hyaluronic acid as non-invasive markers of liver fibrosis in haemodialysis patients with chronic hepatitis C virus infection. J. Viral Hepat. 15, 666-674 (2008).
    • (2008) J. Viral Hepat , vol.15 , pp. 666-674
    • Schiavon, L.L.1    Narciso-Schiavon, J.L.2    Carvalho Filho, R.J.3
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    • Elevated C-reactive protein in atherosclerosis - chicken or egg?
    • Schunkert H, Samani NJ: Elevated C-reactive protein in atherosclerosis - chicken or egg? N. Engl. J. Med. 359, 1953-1955 (2008).
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    • Plasma tissue inhibitor of metalloproteinases-1 (TIMP-1): A novel biological marker in the detection of primary colorectal cancer. Protocol outlines of the Danish-Australian endoscopy study group on colorectal cancer detection
    • Nielsen HJ, Brünner, Frederiksen C et al.: Plasma tissue inhibitor of metalloproteinases-1 (TIMP-1): a novel biological marker in the detection of primary colorectal cancer. Protocol outlines of the Danish-Australian endoscopy study group on colorectal cancer detection. Scand. J. Gastroenterol. 43, 242-248 (2008).
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    • Nielsen, H.J.1    Brünner, F.C.2
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    • Nielsen HJ; the Danish Colorectal Cancer Study Group: Serum YKL-40 in risk assessment for colorectal cancer. A population based, prospective study of 4987 subjects at risk of colorectal cancer
    • Abstract 4136
    • Johansen JS, Christensen IJ, Price PA, Nielsen HJ; the Danish Colorectal Cancer Study Group: Serum YKL-40 in risk assessment for colorectal cancer. A population based, prospective study of 4987 subjects at risk of colorectal cancer. ASCO Ann. Meet. Proc. 26, 212 (2008) (Abstract 4136).
    • (2008) ASCO Ann. Meet. Proc , vol.26 , pp. 212
    • Johansen, J.S.1    Christensen, I.J.2    Price, P.A.3
  • 188
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    • Serum YKL-40: A new potential marker of prognosis and location of metastases of patients with recurrent breast cancer
    • Johansen JS, Cintin C, Jørgensen M, Kamby C, Price PA: Serum YKL-40: a new potential marker of prognosis and location of metastases of patients with recurrent breast cancer. Eur. J. Cancer 31A, 1437-1442 (1995).
    • (1995) Eur. J. Cancer , vol.31 A , pp. 1437-1442
    • Johansen, J.S.1    Cintin, C.2    Jørgensen, M.3    Kamby, C.4    Price, P.A.5
  • 189
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    • High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer
    • Jensen BV, Johansen JS, Price PA: High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer. Clin. Cancer Res. 9, 501-512 (2003).
    • (2003) Clin. Cancer Res , vol.9 , pp. 501-512
    • Jensen, B.V.1    Johansen, J.S.2    Price, P.A.3
  • 190
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    • High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survival
    • Johansen JS, Christensen IJ, Riisbro R et al.: High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survival. Breast Cancer Res. Treat. 80, 15-21 (2003).
    • (2003) Breast Cancer Res. Treat , vol.80 , pp. 15-21
    • Johansen, J.S.1    Christensen, I.J.2    Riisbro, R.3
  • 191
    • 35448956544 scopus 로고    scopus 로고
    • Locally advanced breast carcinoma treated with neoadjuvant chemotherapy: Are the changes in serum levels of YKL-40, MMP-2 and MMP-9 correlated with tumor response?
    • Coskun U, Yamac D, Gulbahar O, Sancak B, Karaman N, Ozkan S: Locally advanced breast carcinoma treated with neoadjuvant chemotherapy: are the changes in serum levels of YKL-40, MMP-2 and MMP-9 correlated with tumor response? Neoplasma 54, 348-352 (2007).
    • (2007) Neoplasma , vol.54 , pp. 348-352
    • Coskun, U.1    Yamac, D.2    Gulbahar, O.3    Sancak, B.4    Karaman, N.5    Ozkan, S.6
  • 192
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    • Serum YKL-40 levels as a prognostic factor in patients with locally advanced breast cancer
    • Yamac D, Ozturk B, Coskun U et al.: Serum YKL-40 levels as a prognostic factor in patients with locally advanced breast cancer. Adv. Ther. 25, 801-809 (2008).
    • (2008) Adv. Ther , vol.25 , pp. 801-809
    • Yamac, D.1    Ozturk, B.2    Coskun, U.3
  • 194
  • 195
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    • Association of biomarkers of inflammation and YKL-40 with survival of patients with metastatic colorectal cancer
    • Orlando, FL, USA , Abstract 323
    • Jensen BV, Qvortrup C, Christensen IJ et al.: Association of biomarkers of inflammation and YKL-40 with survival of patients with metastatic colorectal cancer. Proceedings of 2008 Gastrointestinal Cancer Symposium. Orlando, FL, USA (2008) (Abstract 323).
    • (2008) Proceedings of 2008 Gastrointestinal Cancer Symposium
    • Jensen, B.V.1    Qvortrup, C.2    Christensen, I.J.3
  • 196
    • 1242312462 scopus 로고    scopus 로고
    • High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival
    • Høgdall EVS, Johansen JS, Kjaer SK et al.: High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival. Oncol. Rep. 10, 1535-1538 (2003).
    • (2003) Oncol. Rep , vol.10 , pp. 1535-1538
    • Høgdall, E.V.S.1    Johansen, J.S.2    Kjaer, S.K.3
  • 197
    • 0037361965 scopus 로고    scopus 로고
    • Plasma YKL-40, as a prognostic tumor marker in recurrent ovarian cancer
    • Dehn H, Høgdall EVS, Johansen JS et al.: Plasma YKL-40, as a prognostic tumor marker in recurrent ovarian cancer. Acta Obstet. Gynecol. Scand. 82, 287-293 (2003).
    • (2003) Acta Obstet. Gynecol. Scand , vol.82 , pp. 287-293
    • Dehn, H.1    Høgdall, E.V.S.2    Johansen, J.S.3
  • 198
    • 4344704083 scopus 로고    scopus 로고
    • Early detection and prognosis of ovarian cancer using serum YKL-40
    • Addresses YKL-40 and early detection of ovarian cancer, •
    • Dupont J, Tanwar MK, Thaler HT et al.: Early detection and prognosis of ovarian cancer using serum YKL-40. J. Clin. Oncol. 22, 3330-3339 (2004). • Addresses YKL-40 and early detection of ovarian cancer.
    • (2004) J. Clin. Oncol , vol.22 , pp. 3330-3339
    • Dupont, J.1    Tanwar, M.K.2    Thaler, H.T.3
  • 199
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    • Pre-treatment prediction of chemoresistance in second-line chemotherapy of ovarian carcinoma: Value of serological tumor marker determination (tetranectin, YKL-40, CASA, CA125)
    • Grønlund B, Høgdall EVS, Christensen IJ et al.: Pre-treatment prediction of chemoresistance in second-line chemotherapy of ovarian carcinoma: value of serological tumor marker determination (tetranectin, YKL-40, CASA, CA125). Int. J. Biol. Markers 21, 141-148 (2006).
    • (2006) Int. J. Biol. Markers , vol.21 , pp. 141-148
    • Grønlund, B.1    Høgdall, E.V.S.2    Christensen, I.J.3
  • 200
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    • YKL-40 tissue expression and plasma levels in patients with ovarian cancer
    • Høgdall EVS, Ringsholt M, Høgdall CK et al.: YKL-40 tissue expression and plasma levels in patients with ovarian cancer. BMC Cancer 9, 8 (2009).
    • (2009) BMC Cancer , vol.9 , pp. 8
    • Høgdall, E.V.S.1    Ringsholt, M.2    Høgdall, C.K.3
  • 201
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    • Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer
    • Fredriksson S, Horecka J, Brustugun OT et al.: Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer. Clin. Chem. 54, 582-589 (2008).
    • (2008) Clin. Chem , vol.54 , pp. 582-589
    • Fredriksson, S.1    Horecka, J.2    Brustugun, O.T.3
  • 202
    • 8444236654 scopus 로고    scopus 로고
    • High serum YKL-40 level in patients with small cell lung cancer is related to early death
    • Johansen JS, Drivsholm L, Price PA, Christensen IJ: High serum YKL-40 level in patients with small cell lung cancer is related to early death. Lung Cancer 46, 333-340 (2004).
    • (2004) Lung Cancer , vol.46 , pp. 333-340
    • Johansen, J.S.1    Drivsholm, L.2    Price, P.A.3    Christensen, I.J.4
  • 203
    • 75249097523 scopus 로고    scopus 로고
    • Elevated pretreatment serum concentration of YKL-40 - an independent prognostic biomarker for poor survival in patients with metastatic non-small cell lung cancer
    • Abstract 313P
    • Thöm I, Adritzky B, Schuch G et al.: Elevated pretreatment serum concentration of YKL-40 - an independent prognostic biomarker for poor survival in patients with metastatic non-small cell lung cancer. Ann. Oncol. 19(Suppl. 8) (2008) (Abstract 313P).
    • (2008) Ann. Oncol , Issue.SUPPL. 8 , pp. 19
    • Thöm, I.1    Adritzky, B.2    Schuch, G.3
  • 204
    • 33645351695 scopus 로고    scopus 로고
    • Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma
    • Brasso K, Christensen IJ, Johansen JS et al.: Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma. Prostate 66, 503-513 (2006).
    • (2006) Prostate , vol.66 , pp. 503-513
    • Brasso, K.1    Christensen, I.J.2    Johansen, J.S.3
  • 205
    • 34250648459 scopus 로고    scopus 로고
    • Changes of biochemical markers of bone turnover and YKL-40 following hormonal treatment for metastatic prostate cancer are related to survival
    • Johansen JS, Brasso K, Iversen P et al.: Changes of biochemical markers of bone turnover and YKL-40 following hormonal treatment for metastatic prostate cancer are related to survival. Clin. Cancer Res. 13, 3244-3249 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 3244-3249
    • Johansen, J.S.1    Brasso, K.2    Iversen, P.3
  • 206
    • 37649015894 scopus 로고    scopus 로고
    • Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia
    • Kucur M, Isman FK, Balci C, Onal B, Hacibekiroglu M, Ozkan F: Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia. Urol. Oncol. 26, 47-52 (2008).
    • (2008) Urol. Oncol , vol.26 , pp. 47-52
    • Kucur, M.1    Isman, F.K.2    Balci, C.3    Onal, B.4    Hacibekiroglu, M.5    Ozkan, F.6
  • 207
    • 33644512815 scopus 로고    scopus 로고
    • High pretreatment serum level of YKL-40 is related to short survival in patients with advanced renal cell carcinoma treated with high-dose continuous intravenous infusion of interleukin-2
    • Abstract 1603
    • Geertsen PF, Johansen JS, von der Maase H, Jensen BV, Price PA: High pretreatment serum level of YKL-40 is related to short survival in patients with advanced renal cell carcinoma treated with high-dose continuous intravenous infusion of interleukin-2. Ann. Meet. Proc. 22, 399 (2003) (Abstract 1603).
    • (2003) Ann. Meet. Proc , vol.22 , pp. 399
    • Geertsen, P.F.1    Johansen, J.S.2    von der Maase, H.3    Jensen, B.V.4    Price, P.A.5
  • 208
    • 75249100497 scopus 로고    scopus 로고
    • Plasma YKL-40, a potential new biomarker for advanced upper gastrointestinal adenocarcinomas
    • Presented at:, CA, USA, 15-17 January, Abstract 176
    • Schultz NA, Berglund Å, Johansen et al.: Plasma YKL-40, a potential new biomarker for advanced upper gastrointestinal adenocarcinomas. Presented at: 2009 Gastrointestinal Cancer Symposium. CA, USA, 15-17 January 2009 (Abstract 176).
    • (2009) 2009 Gastrointestinal Cancer Symposium
    • Schultz, N.A.1    Berglund, A.2    Johansen3
  • 209
    • 33846525654 scopus 로고    scopus 로고
    • Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer
    • Diefenbach CS, Shah Z, Iasonos A et al.: Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer. Gynecol. Oncol. 104, 435-442 (2007).
    • (2007) Gynecol. Oncol , vol.104 , pp. 435-442
    • Diefenbach, C.S.1    Shah, Z.2    Iasonos, A.3
  • 210
    • 33846675418 scopus 로고    scopus 로고
    • Serum YKL-40 levels in patients with cervical cancer are elevated compared with patients with cervical intraepithelial neoplasia and healthy controls
    • Abstract 5047
    • Johansen JS, Roslind A, Palle C et al.: Serum YKL-40 levels in patients with cervical cancer are elevated compared with patients with cervical intraepithelial neoplasia and healthy controls. ASCO Ann. Meet. Proc. 24, 267 (2006) (Abstract 5047).
    • (2006) ASCO Ann. Meet. Proc , vol.24 , pp. 267
    • Johansen, J.S.1    Roslind, A.2    Palle, C.3
  • 211
    • 58949083842 scopus 로고    scopus 로고
    • Serum YKL-40 as a marker for cervical adenocarcinoma
    • Mitsuhashi A, Matsui H, Usui H et al.: Serum YKL-40 as a marker for cervical adenocarcinoma. Ann. Oncol. 20, 71-77 (2009).
    • (2009) Ann. Oncol , vol.20 , pp. 71-77
    • Mitsuhashi, A.1    Matsui, H.2    Usui, H.3
  • 212
    • 38349076275 scopus 로고    scopus 로고
    • High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival
    • Roslind A, Johansen JS, Christensen IJ et al.: High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival. Int. J. Cancer 122, 857-863 (2008).
    • (2008) Int. J. Cancer , vol.122 , pp. 857-863
    • Roslind, A.1    Johansen, J.S.2    Christensen, I.J.3
  • 213
    • 33750316189 scopus 로고    scopus 로고
    • YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas
    • Hormigo A, Gu B, Karimi S et al.: YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas. Clin. Cancer Res. 12, 5698-5704 (2006).
    • (2006) Clin. Cancer Res , vol.12 , pp. 5698-5704
    • Hormigo, A.1    Gu, B.2    Karimi, S.3
  • 214
    • 33644534470 scopus 로고    scopus 로고
    • Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanoma
    • Schmidt H, Johansen JS, Gehl J, Geertsen PF, Fode K, von der Maase H: Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanoma. Cancer 106, 1130-1139 (2006).
    • (2006) Cancer , vol.106 , pp. 1130-1139
    • Schmidt, H.1    Johansen, J.S.2    Gehl, J.3    Geertsen, P.F.4    Fode, K.5    von der Maase, H.6
  • 215
    • 33644850748 scopus 로고    scopus 로고
    • Serum YKL-40 predicts relapse-free and overall survival in patients with American Joint Committee on Cancer stage I and II melanoma
    • Discusses YKL-40 as a prognostic marker and a marker to monitor after operation, •
    • Schmidt H, Johansen JS, Sjoegren P et al.: Serum YKL-40 predicts relapse-free and overall survival in patients with American Joint Committee on Cancer stage I and II melanoma. J. Clin. Oncol. 24, 798-804 (2006). • Discusses YKL-40 as a prognostic marker and a marker to monitor after operation.
    • (2006) J. Clin. Oncol , vol.24 , pp. 798-804
    • Schmidt, H.1    Johansen, J.S.2    Sjoegren, P.3
  • 216
    • 75249088976 scopus 로고    scopus 로고
    • Predictive and prognostic value of serum YKL-40 post surgery in patients with stage IIB-III melanoma receiving adjvant interferon therapy
    • Presented at:, The Hague, The Netherlands, 2-4 October
    • Krogh M, Bastholt L, Johansen JS et al.: Predictive and prognostic value of serum YKL-40 post surgery in patients with stage IIB-III melanoma receiving adjvant interferon therapy. Presented at: Perspectives in Melanoma XII. The Hague, The Netherlands, 2-4 October 2008.
    • (2008) Perspectives in Melanoma XII
    • Krogh, M.1    Bastholt, L.2    Johansen, J.S.3
  • 217
    • 29344449079 scopus 로고    scopus 로고
    • High serum concentration of YKL-40 is associated with short survival in patients with acute myeloid leukemia
    • Bergmann OJ, Johansen JS, Klausen TW et al.: High serum concentration of YKL-40 is associated with short survival in patients with acute myeloid leukemia. Clin. Cancer Res. 11, 8644-8652 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 8644-8652
    • Bergmann, O.J.1    Johansen, J.S.2    Klausen, T.W.3
  • 218
    • 40449134510 scopus 로고    scopus 로고
    • High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients
    • Mylin AK, Abildgaard N, Johansen JS et al.: High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients. Eur. J. Haematol. 80, 310-317 (2008).
    • (2008) Eur. J. Haematol , vol.80 , pp. 310-317
    • Mylin, A.K.1    Abildgaard, N.2    Johansen, J.S.3
  • 219
    • 60549092917 scopus 로고    scopus 로고
    • Serum YKL-40 and bone marrow angiogenesis in multiple myeloma
    • Mylin AK, Andersen NF, Johansen JS et al.: Serum YKL-40 and bone marrow angiogenesis in multiple myeloma. Int. J. Cancer 124, 1492-1494 (2009).
    • (2009) Int. J. Cancer , vol.124 , pp. 1492-1494
    • Mylin, A.K.1    Andersen, N.F.2    Johansen, J.S.3
  • 220
    • 58149241012 scopus 로고    scopus 로고
    • Serum YKL-40 and IL-6 levels in Hodgkin lymphoma
    • Biggar RJ, Johansen JS, Smedby KE et al.: Serum YKL-40 and IL-6 levels in Hodgkin lymphoma. Clin. Cancer Res. 14, 6974-6979 (2008).
    • (2008) Clin. Cancer Res , vol.14 , pp. 6974-6979
    • Biggar, R.J.1    Johansen, J.S.2    Smedby, K.E.3
  • 221
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.