High serum YKL-40 level in a cohort of octogenarians is associated with increased risk of all-cause mortality

Clinical and Experimental Immunology

Volumn 151, Issue 2, 2008, Pages 260-266

  Johansen, J S ^a   Pedersen, A N ^b   Schroll, M ^a   Jorgensen T ^c   Pedersen, B K ^a   Bruunsgaard, H ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c Research Center for Prevention and Health   (Denmark)

Author keywords

Ageing; CHI3L1; IL 6; Inflammation; YKL 40

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 6; PLASMA PROTEIN; PROTEIN YKL 40; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ARTICLE; CD4 CD8 RATIO; COHORT ANALYSIS; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MORTALITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION;

ADOLESCENT; ADULT; AGED, 80 AND OVER; AGING; BIOLOGICAL MARKERS; DENMARK; FEMALE; FOLLOW-UP STUDIES; GLYCOPROTEINS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; MALE; MORTALITY; PROGNOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 37849030677     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03561.x     Document Type: Article

References (47)

1. Harris TB, Ferrucci L, Tracy RP et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 1999 106 : 506 12.
2. Bruunsgaard H, Andersen-Ranberg K, Hjelmborg JvB, Pedersen BK, Jeune B. Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am J Med 2003 115 : 278 83.
3. Bruunsgaard H, Ladelund S, Pedersen AN, Schroll M, Jørgensen T, Pedersen BK. Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin Exp Immunol 2003 132 : 24 31.
4. Krabbe S, Pedersen M, Bruunsgaard H. Inflammatory mediators in the elderly. Exp Gerontol 2004 39 : 687 99.
5. Kritchevsky SB, Cesari M, Pahor M. Inflammatory markers and cardiovascular health in older adults. Cardiovasc Res 2005 66 : 265 75.
6. Kushner I, Rzewnicki D, Samols D. What does minor elevation of C-reactive protein signify? Am J Med 2006 119 : 17 28.
7. Maggio M, Guralnik JM, Longo DL, Ferrucci L. Interleukin-6 in aging and chronic disease: a magnificient pathway. J Gerontol Med Sci 2006 61A : 575 84.
8. Hakala BE, White C, Recklies AD. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J Biol Chem 1993 268 : 25803 10.
9. Rehli M, Krause SW, Andreesen R. Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation. Genomics 1997 43 : 221 5.
10. Funkhouser JD, Aronson NN. Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family. BMC Evol Biol 2007 7 : 1 16.
11. Johansen JS, Jensen BV, Roslind A, Nielsen D, Price PA. Serum YKL-40, a new prognostic biomarker in cancer patients? Rev Cancer Epidemiol Biomarkers Prev 2006 15 : 194 202.
12. Nishikawa KC, Millis AJT. gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Exp Cell Res 2003 287 : 79 87.
13. Renkema GH, Boot RG, Au FL et al. Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. Eur J Biochem 1998 251 : 504 9.
14. Hashimoto S, Suzuki T, Dong H-Y, Yamazaki N, Matsushima K. Serial analysis of gene expression in human monocytes and macrophages. Blood 1999 94 : 837 44.
15. Volck B, Price PA, Johansen JS et al. YKL-40, a mammalian member of the bacterial chitinase family, is a matrix protein of specific granules in human neutrophils. Proc Assoc Am Physicians 1998 110 : 351 60.
16. Boot RG, van Achterberg AE, van Aken BE et al. Strong induction of members of the chitinase family of proteins in atherosclerosis. Chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. Arterioscler Thromb Vasc Biol 1999 19 : 687 94.
17. Johansen JS, Baslund B, Garbarsch C et al. YKL-40 in giant cells and macrophages from patients with giant cell arteritis. Arthritis Rheum 1999 42 : 2624 30.
18. Baeten D, Boots AMH, Steenbakkers PGA et al. Human cartilage gp-39+,CD16+ monocytes in peripheral blood and synovium. Correlation with joint destruction in rheumatoid arthritis. Arthritis Rheum 2000 43 : 1233 43.
19. Johansen JS, Milman N, Hansen M, Garbarsch C, Price PA, Graudal N. Increased serum YKL-40 in patients with pulmonary sarcoidosis - a potential marker of disease activity? Respir Med 2005 99 : 396 402.
20. Junker N, Johansen JS, Andersen CB, Kristjansen PEG. Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer. Lung Cancer 2005 48 : 223 31.
21. Kronborg G, Østergaard C, Weis N et al. Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated to the outcome of the disease. Scand J Infect Dis 2002 34 : 323 6.
22. Nøjgaard C, Johansen JS, Christensen E et al. Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease. J Hepatol 2003 39 : 179 86.
23. Harvey S, Weisman M, O'Dell J et al. Chondrex: new marker of joint disease. Clin Chem 1998 44 : 509 16.
24. Vind I, Johansen JS, Price PA, Munkholm P. Serum YKL-40, a potential new marker of disease activity in patients with inflammatory bowel disease. Scand J Gastroenterol 2003 38 : 599 605.
25. Johansen JS, Krabbe KS, Møller K, Pedersen BK. Circulating YKL-40 levels during human endotoxaemia. Clin Exp Immunol 2005 140 : 343 8.
26. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999 340 : 448 54.
27. DelaRosa O, Pawelec G, Peralbo E et al. Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity. Biogerontology 2006 7 : 471 81.
28. Schroll M. A ten-year prospective study, 1964-1974, of cardiovascular risk factors in men and women from the Glostrup population born in 1914. Dan Med Bull 1982 29 : 213 52.
29. Bruunsgaard H, Pedersen AN, Schroll M, Skinhøj P, Pedersen BK. Decreased natural killer cell activity is associated with atherosclerosis in elderly humans. Exp Gerontol 2001 37 : 127 36.
30. Bruunsgaard H, Pedersen AN, Schroll M, Skinhøj P, Pedersen BK. Proliferative responses of blood mononuclear cells (BMNC) in a cohort of elderly humans: role of lymphocyte phenotype and cytokine production. Clin Exp Immunol 2000 119 : 433 40.
31. Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med 1998 128 : 127 37.
32. Trikha M, Corringham R, Klein B, Rossi J-F. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin Cancer Res 2003 9 : 4653 65.
33. Zhao X, Tang R, Gao B et al. Functional variants in the promoter region of chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia. Am J Hum Genet 2007 80 : 12 18.
34. Kruit A, Grutters JC, Ruven HJT, van Moorsel CCM, van den Bosch JMM. A CHI3L1 gene polymorphism is associated with serum levels of YKL-40, a novel sarcoidosis marker. Respir Med 2007 101 : 1563 71.
35. Dupuis J, Larson MG, Vasan RS et al. Genome scan of systemic biomarkers of vascular inflammation in the Framingham Hearth Study: evidence for susceptibility loci on 1q. Atherosclerosis 2005 182 : 307 14.
36. Johansen JS, Hvolris J, Hansen M, Backer V, Lorenzen I, Price PA. Serum YKL-40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint. Br J Rheumatol 1996 35 : 553 9.
37. Cohen HJ, Pieper CF, Harris TB, Rao KMK, Currie MS. The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J Gerontol Med Sci 1997 52A : M201 8.
38. Franceschi C, Bonafe M, Valensin S et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000 980 : 244 54.
39. ++ monocytes are a major source of TNF. J Immunol 2002 168 : 3536 42.
40. Kucur M, Isman FK, Karadag B, Vural VA, Tavsanoglu S. Serum YKL-40 levels in patients with coronary artery disease. Coron Artery Dis 2007 18 : 391 6.
41. Millis AJT, Hoyle M, Reich E, Mann DM. Isolation and characterization of a Mr = 38 000 protein from differentiating smooth muscle cells. J Biol Chem 1985 260 : 3754 61.
42. Malinda KM, Ponce L, Kleinman HK, Shackelton LM, Millis AJT. Gp38k, a protein synthesized by vascular smooth muscle cells, stimulates directional migration of human umbilical vein endothelial cells. Exp Cell Res 1999 250 : 168 73.
43. Junker N, Johansen JS, Hansen LT, Lund EL, Kristjansen PEG. Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cells. Cancer Sci 2005 96 : 183 90.
44. De Ceuninck F, Gaufillier S, Bonnaud A, Sabatini M, Lesur C, Pastoureau P. YKL-40 (cartilage gp-39) induces proliferative events in cultured chondrocytes and synoviocytes and increases glycosaminoglycan synthesis in chondrocytes. Biochem Biophys Res Commun 2001 285 : 926 31.
45. Recklies AD, White C, Ling H. The chitinase 3-like protein human cartilage 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase-and protein kinase B-mediated signalling pathways. Biochem J 2002 365 : 119 26.
46. Ling H, Recklies AD. The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha. Biochem J 2004 380 : 651 9.
47. Recklies AD, Ling H, White C, Bernier SM. Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes. J Biol Chem 2005 280 : 41213 21.