Chitinase-3-Like 1 (CHI3L1) Gene and Schizophrenia: Genetic Association and a Potential Functional Mechanism

Biological Psychiatry

Volumn 64, Issue 2, 2008, Pages 98-103

  Yang, Mao Sheng ^a,b   Morris, Derek W ^a   Donohoe, Gary ^a   Kenny, Elaine ^a   O'Dushalaine, Colm T ^a   Schwaiger, Siobhan ^a   Nangle, Jeanne Marie ^a   Clarke, Sarah ^a   Scully, Paul ^c   Quinn, John ^c   Meagher, David ^c   Baldwin, Patrizia ^c   Crumlish, Niall ^d   O'Callaghan, Eadbhard ^d   Waddington, John L ^c,e   Gill, Michael ^a   Corvin, Aiden ^a  

^a Institute of Molecular Medicine   (Ireland)

^b CHONGQING MEDICAL UNIVERSITY   (China)

^c St Davnet's Hospital   (Ireland)

^d Cluain Mhuire Family Centre   (Ireland)

^e ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

Binding site; C EBP AML 1; CHI3L1 gene; function; genetic association; schizophrenia

Indexed keywords

CHITINASE; CHITINASE 3 LIKE 1;

ADULT; ALLELE; ARTICLE; AUTOPSY; CAUCASIAN; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CELL SURVIVAL; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CROSS-CULTURAL COMPARISON; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLYCOPROTEINS; HETEROZYGOTE DETECTION; HUMANS; MALE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS; RNA-BINDING PROTEINS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SOCIAL ENVIRONMENT;

EID: 45449116310     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2007.12.012     Document Type: Article

References (41)

1. Andreasen N.C., and Carpenter Jr. W.T. Diagnosis and classification of schizophrenia. Schizophr Bull 19 (1993) 199-214
2. Cardno A.G., and Gottesman I.I. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am J Med Genet 97 (2000) 12-17
3. Murray R.M., and Lewis S.W. Is schizophrenia a neurodevelopmental disorder?. BMJ 295 (1987) 681-682
4. Weinberger D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44 (1987) 660-669
5. Owen M.J., O'Donovan M.C., and Harrison P.J. Schizophrenia: a genetic disorder of the synapse?. BMJ 330 (2005) 158-159
6. Cannon M., Kendell R., Susser E., and Jones P. Prenatal and perinatal risk factors for schizophrenia. In: Murray R.M., Jones P.B., Susser E., van Os J., and Cannon M. (Eds). The Epidemiology of Schizophrenia (2003), Cambridge University Press, Cambridge 74-99
7. Shaw S.H., Kelly M., Smith A.B., Shields G., Hopkins P.J., Loftus J., et al. A genome-wide search for schizophrenia susceptibility genes. Am J Med Genet 81 (1998) 364-376
8. Ekelund J., Hennah W., Hiekkalinna T., Parker A., Meyer J., Lonnqvuist J., and Peltonen L. Replication of 1q42 linkage in Finnish schizophrenia pedigrees. Mol Psychiatry 9 (2004) 1037-1041
9. Gurling H.M., Kalsi G., Brynjolfson J., Sigmundsson T., Sherrington R., Mankoo B.S., et al. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 68 (2001) 661-673
10. Zhao X., Tang R., Gao B., Shi Y., Zhou J., Guo S., et al. Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia. Am J Hum Genet 80 (2007) 12-18
11. Chung C., Tallerico T., and Seeman P. Schizophrenia hippocampus has elevated expression of chondrex glycoprotein gene. Synapse 50 (2003) 29-34
12. Arion D., Unger T., Lewis D.A., Levitt P., and Mirnics K. Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry 62 (2007) 711-721
13. Craddock N., O'Donovan M.C., and Owen M.J. Genes for schizophrenia and bipolar disorder?. Implications for psychiatric nosology. Schizophr Bull 32 (2006) 9-16
14. O'Dushlaine C., Dolan C., Weale M.E., Stanton A., Croke D.T., Kalviainen R., et al. An assessment of the Irish population for large-scale genetic mapping studies. Eur J Hum Genet 16 (2008) 176-183
15. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
16. de Bakker P.I., Yelensky R., Pe'er I., Gabriel S.B., Daly M.J., and Altshuler D. Efficiency and power in genetic association studies. Nat Genet 37 (2005) 1217-1223
17. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25 (2003) 115-121
18. Wechsler D. The Wechsler Test of Adult Intelligence. 3rd edition (WAIS-III) (1999), Psychological Press, New York
19. Wechsler D. Weschler Test of Adult Reading (WTAR) (2001), Psychological Corporation, New York
20. Weschler D. Weschler Memory Scale. 3rd edition (WAIS-III) (1998), Psychological Corporation, New York
21. Cambridge Cognition. Cambridge Neuropsychological Test Automated Battery, Expedio version (CANTABexpedio) (2003), Cambridge Cognition, Cambridge
22. Donohoe G., Clarke S., Morris S., Nangle J.M., Schwaiger S., Gill M., et al. Are deficits in executive sub-processing simply reflecting more general cognitive decline in schizophrenia?. Schizophr Res 85 (2006) 168-173
23. Levene H. Robust tests for equality of variances. In: Olkin I. (Ed). Contributions to Probability and Statistics (1960), Stanford University Press, Palo Alto, CA
24. Sullivan P.F. Spurious genetic associations. Biol Psychiatry 61 (2007) 1121-1126
25. Helgason A., Palsson S., Thorleifsson G., Grant S.F., Emilsson V., Gunnarsdottir S., et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 39 (2007) 218-225
26. Rehli M., Niller H.H., Ammon C., Langmann S., Schwarzfischer L., Andreesen R., and Krause S.W. Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation. J Biol Chem 278 (2003) 44058-44067
27. Tsuji T., Matsuyama Y., Natsume N., Hasegawa Y., Kondo S., Kawakami H., et al. Analysis of chondrex (YKL-40, HC gp-39) in the cerebrospinal fluid of patients with spine disease. Spine 27 (2002) 732-735
28. Rothermundt M., Arolt V., and Bayer T.A. Review of immunological and immunopathological findings in schizophrenia. Brain Behav Immun 15 (2001) 319-339
29. Strous R.D., and Shoenfeld Y. Schizophrenia, autoimmunity and immune system dysregulation: A comprehensive model updated and revisited. J Autoimmun 27 (2006) 71-80
30. Kim Y.K., Myint A.M., Lee B.H., Han C.S., Lee H.J., Kim D.J., et al. Th1, Th2 and Th3 cytokine alteration in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 28 (2004) 1129-1134
31. Licinio J., Seibyl J.P., Altemus M., Charney D.S., and Krystal J.H. Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients. Am J Psychiatry 150 (1993) 1408-1410
32. Carter C.J. EIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia?. Schizophr Bull 33 (2007) 1343-1353
33. Emamian E.S., Hall D., Birnbaum M.J., Karayiorgou M., and Gogos J.A. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet 36 (2004) 131-137
34. Norton N., Williams H.J., Dwyer S., Carroll L., Peirce T., et al. Association analysis of AKT1 and schizophrenia in a UK case control sample. Schizophr Res 98 (2007) 58-65
35. Yu L., Yang M.S., Zhao J., Shi Y.Y., Zhao X.Z., et al. An association between polymorphisms of the interleukin-10 gene promoter and schizophrenia in the Chinese population. Schizophr Res 71 (2004) 179-183
36. Rasmussen H.B., Timm S., Wang A.G., Søeby K., Lublin H., Fenger M., et al. Association between the CCR5 32-bp deletion allele and late onset of schizophrenia. Am J Psychiatry 163 (2006) 507-511
37. Schwarz M.J., Krönig H., Riedel M., Dehning S., Douhet A., Spellmann I., et al. IL-2 and IL-4 polymorphisms as candidate genes in schizophrenia. Eur Arch Psychiatry Clin Neurosci 256 (2006) 72-76
38. Shirts B.H., Wood J., Yolken R.H., and Nimgaonkar V.L. Association study of IL10, IL1beta, and IL1RN and schizophrenia using tag SNPs from a comprehensive database: Suggestive association with rs16944 at IL1beta. Schizophr Res 88 (2006) 235-244
39. Chen X., Wang X., Hossain S., O'Neill F.A., Walsh D., van den Oord E., et al. Interleukin 3 and schizophrenia: the impact of sex and family history. Mol Psychiatry 12 (2007) 273-282
40. Lencz T., Morgan T.V., Athanasiou M., Dain B., Reed C.R., Kane J.M., et al. Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol Psychiatry 12 (2007) 572-580
41. Meyer-Lindenberg A., Straub R.E., Lipska B.K., Verchinski B.A., Goldberg T., Callicott J.H., et al. Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J Clin Invest 117 (2007) 672-682