The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways

Biochemical Journal

Volumn 365, Issue 1, 2002, Pages 119-126

  Recklies, Anneliese D ^a   White, Chantal ^a   Ling, Hua ^a  

^a SHRINERS HOSPITAL FOR CHILDREN   (Canada)

Author keywords

Chondrocyte; Growth factor; Mitogen activated protein kinase (MAP kinase); Mitogenesis; Synovial cell

Indexed keywords

CELLS; PATHOLOGY; PROTEINS; TISSUE;

MACROPHAGES;

CARTILAGE;

CHITINASE; GLYCOPROTEIN GP 39; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B;

ARTICLE; CARTILAGE CELL; CELL GROWTH; CELL PROLIFERATION; CONNECTIVE TISSUE CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROSIS; HOMEOSTASIS; HUMAN; HUMAN CELL; MACROPHAGE; MITOGENESIS; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN SECRETION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE;

CARTILAGE, ARTICULAR; CELL DIVISION; CELLS, CULTURED; CHITINASE; CONNECTIVE TISSUE CELLS; GLYCOPROTEINS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 0036645699     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020075     Document Type: Article

References (48)

1. Human cartilage GP-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family
2. Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein
3. Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages
4. Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family
5. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase
6. Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins
7. Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization
8. The distribution of YKL-40 in osteoarthritic and normal human articular cartilage
9. Serum YKL-40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint
10. A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid
11. Identification of a 38-kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodeling
12. Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period
13. Molecular characterization of the gene for human cartilage gp-39 (CH13L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation
14. Differential screening identifies genetic markers of monocyte to macrophage maturation
15. Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages
16. Serum YKL-40: A new potential marker of prognosis and location of metastases of patients with recurrent breast cancer
17. Serum YKL-40 and colorectal cancer
18. Plasma YKL-40: A new potential marker of fibrosis in patients with alcoholic cirrhosis?
19. Neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors
20. Isolation and characterization of a novel 39 kilodalton whey protein from bovine mammary secretions collected during the nonlactating period
21. Synthesis, sorting, and processing into distinct isoforms of human macrophage chitotriosidase
22. Identification of glutamic acid 204 and aspartic acid 200 in chitinase A1 of Bacillus circulans WL-12 as essential residues for chitinase activity
23. Crystal structure of bacterial chitinase at 2.3 A resolution
24. A new family of growth factors produced by the fat body and active on Drosophila imaginal disc cells
25. YKL-40 (cartilage gp-39) induces proliferative events in cultured chondrocytes and synoviocytes and increases glycosaminoglycan synthesis in chondrocytes
26. HC-gp39 is a growth factor for connective tissue cells
27. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
28. Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not β2-microglobulin in human synovial cells and fibroblasts
29. Induction of synthesis and release of interleukin-8 from human articular chondrocytes and cartilage explants
30. Changes in translational yield regulate tissue-specific expression of beta-glucuronidase
31. Analysis of cytoskeletal structures using blot-purified monospecific antibodies
32. Regulation of YKL-40 production by human articular chondrocytes
33. Roles of the MAP kinase cascade in vertebrates
34. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
35. Cellular survival: A play in three Akts
36. Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation
37. Serum YKL-40 concentrations in patients with rheumatoid arthritis: Relation to disease activity
38. Multiple Ras effector pathways contribute to G1 cell cycle progression
39. Growth-factor-dependent mitogenesis requires two distinct phases of signalling
40. The crystal structure of a novel mammalian lectin, Ym1, suggests a saccharide binding site
41. A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin
42. Eosinophil chemotactic lymphokine produced by spleen cells of Schistosoma japonicum-infected mice
43. Identification of a novel eosinophil chemotactic cytokine (ECF-L) as a chitinase family protein
44. Expression of the Ym2 lectin binding protein is dependent on IL-4 and IL-13 signal transduction: Identification of a novel allergy-associated protein
45. Gp38k, a protein synthesized by vascular smooth muscle cells, stimulates directional migration of human umbilical vein endothelial cells
46. Insulin-like growth factor-I extends in vitro replicative life span of skeletal muscle satellite by enhancing G1/S cell cycle progression via the activation of phosphatidylinositol 3′-kinase/Akt signaling pathway
47. Proteinases, cell cycle regulation, and apoptosis during mammary gland involution
48. Inhibition of mitogen-activated protein kinase kinase induces apoptosis of human chondrocytes