A conserved lysine in β-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis

ChemBioChem

Volumn 10, Issue 18, 2009, Pages 2904-2912

  Raber, Mary L ^a   Castillo, Alvaro ^b   Greer, Alexander ^b   Townsend, Craig A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Beta lactam; Biosynthesis; Clavulanic acid; Density functional theory; pH rate profiles

Indexed keywords

ADENOSINE; ALANINE; BETA LACTAMASE; CARBAPENEM; CLAVULANIC ACID; DEUTERIUM; HISTIDINE; KETENE DERIVATIVE; LYSINE; MAGNESIUM; METHIONINE; SYNTHETASE;

ADENYLATION; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; DENSITY FUNCTIONAL THEORY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTON TRANSPORT; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; STEADY STATE; X RAY CRYSTALLOGRAPHY;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; CARBAPENEMS; CLAVULANIC ACIDS; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; ETHYLENES; HYDROGEN-ION CONCENTRATION; KETONES; KINETICS; LYSINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE ALIGNMENT; THERMODYNAMICS;

EID: 72949100766     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900389     Document Type: Article

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