A conserved family of calcineurin regulators

Genes and Development

Volumn 14, Issue 13, 2000, Pages 1595-1604

  Kingsbury, Tami J ^a   Cunningham, Kyle W ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Calcineurin; Calcium signaling; DSCR1; Rcn1p; ZAKI 4

Indexed keywords

CALCINEURIN; PHOSPHOPROTEIN PHOSPHATASE;

ARTICLE; DOWN SYNDROME; ENZYME INHIBITION; FEEDBACK SYSTEM; GENETIC CONSERVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CALCINEURIN; CALCIUM SIGNALING; DNA PRIMERS; DNA, RECOMBINANT; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; PHENOTYPE; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; FUNGI; MAMMALIA;

EID: 0034234963     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Alessi, D.R., Street, A.J., Cohen, P., and Cohen, P.T. 1993. Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme. Eur. J. Biochem. 213: 1055-1066.
2. Beals, C.R., Sheridan, C.M., Turck, C.W., Gardner, P., and Crabtree, G.R. 1997. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275: 1930-1934.
3. Chin, E.R., Olson, E.N., Richardson, J.A., Yang, Q., Humphries, C., Shelton, J.M., Wu, H., Zhu, W., Bassel-Duby, R., and Williams, R.S. 1998. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes & Dev. 12: 2499-2509.
4. Chow, C.W., Rincon, M., Cavanagh, J., Dickens, M., and Davis, R.J. 1997. Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science 278: 1638-1641.
5. Coghlan, V.M., Perrino, B.A., Howard, M., Langeberg, L.K., Hicks, J.B., Gallatin, W.M., and Scott, J.D. 1995. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science 267: 108-111.
6. 2+, calcineurin, and NF-AT. Cell 96: 611-614.
7. Crawford, D.R., Leahy, K.P., Abramova, N., Lan, L., Wang, Y., and Davies, K.J. 1997. Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress. Arch. Biochem. Biophys. 342: 6-12.
8. 2+ transport in Saccharomyces cerevisiae. J. Exp. Biol. 196: 157-166.
9. 2+ ATPases. J. Cell Biol. 124: 351-363.
10. 2+ ATPases in yeast. Mol. Cell. Biol. 16: 2226-2237.
11. 2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone. Mol. Cell. Biol. 12: 3460-3469.
12. Cyert, M.S., Kunisawa, R., Kaim, D., and Thorner, J. 1991. Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase. Proc. Natl. Acad. Sci. 88: 7376-7380.
13. Epstein, C.J. 1995. Down Syndrome (Trisomy 21) (ed. C.R. Scriber, A.L. Beaudet, W.S. Sly, and D. Vaile), pp. McGraw-Hill, Inc.
14. Fruman, D.A., Pai, S.Y., Klee, C.B., Burakoff, S.J., and Bierer, B.E. 1996. Measurement of calcineurin phosphatase activity in cell extracts. Methods 9: 146-154.
15. Fuentes, J.J., Genescà, L., Kingsbury, T.J., Cunningham, K.W., Pérez-Riba, M., Estivill, X., and de la Luna, S. 2000. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum. Mol. Gen. (in press).
16. Fuentes, J.J., Pritchard, M.A., Planas, A.M., Bosch, A., Ferrer, I., and Estivill, X. 1995. A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Hum. Mol. Genet. 4: 1935-1944.
17. Geiser, J.R., van Tuinen, D., Brockerhoff, S.E., Neff, M.M., and Davis, T.N. 1991. Can calmodulin function without binding calcium? Cell 65: 949-959.
18. Hemenway, C.S. and Heitman, J. 1999. Calcineurin: Structure, function, and inhibition. Cell Biochem. Biophys. 30: 115-151.
19. Hubbard, M.J. and Cohen, P. 1993. On target with a new mechanism for the regulation of protein phosphorylation. Trends Biochem. Sci. 18: 172-177.
20. Hughes, S.M. 1998. Muscle development: Electrical control of gene expression. Curr. Biol. 8: 892-894.
21. Kashishian, A., Howard, M., Loh, C., Gallatin, W.M., Hoekstra, M.F., and Lai, Y. 1998. AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region. J. Biol. Chem. 273: 27412-27419.
22. Klee, C.B., Ren, H., and Wang, X. 1998. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J. Biol. Chem. 273: 13367-13370.
23. Krebs, J. 1998. The role of calcium in apoptosis. Biometals 11: 375-382.
24. Kuno, T., Tanaka, H., Mukai, H., Chang, C.D., Hiraga, K., Miyakawa, T., and Tanaka, C. 1991. cDNA cloning of a calcineurin B homolog in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 180: 1159-1163.
25. Lai, M.M., Burnett, P.E., Wolosker, H., Blackshaw, S., and Snyder, S.H. 1998. Cain, a novel physiologic protein inhibitor of calcineurin. J. Biol. Chem. 273: 18325-18331.
26. Leahy, K.P., Davies, K.J., Dull, M., Kort, J.J., Lawrence, K.W., and Crawford, D.R. 1999. adapt78, a stress-inducible mRNA, is related to the glucose-regulated protein family of genes. Arch. Biochem. Biophys. 368: 67-74.
27. Liu, J., Farmer, Jr., J., Lane, W.S., Friedman, J., Weissman, I., and Schreiber, S.L. 1991a. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66: 807-815.
28. Liu, J., Albers, M.W., Wandless, T.J., Luan, S., Alberg, D.G., Belshaw, P.J., Cohen, P., MacKintosh, C., Klee, C.B., and Schreiber, S.L. 1992. Inhibition of T-cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. Biochemistry 31: 3896-3901.
29. Liu, Y., Ishii, S., Tokai, M., Tsutsumi, H., Ohki, O., Akada, R., Tanaka, K., Tsuchiya, E., Fukui, S., and Miyakawa, T. 1991b. The Saccharomyces cerevisiae genes (CMP1 and CMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B. Mol. Gen. Genet. 227: 52-59.
30. Mansuy, I.M., Mayford, M., Jacob, B., Kandel, E.R., and Bach, M.E. 1998. Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92: 39-49.
31. Matheos, D.P., Kingsbury, T.J., Ahsan, U.S., and Cunningham, K.W. 1997. Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae. Genes & Dev. 11: 3445-3458.
32. Mendizabal, I., Rios, G., Mulet, J.M., Serrano, R., and de Larrinoa, I.F. 1998. Yeast putative transcription factors involved in salt tolerance. FEBS Lett. 425: 323-328.
33. 2+ levels in S. cerevisiae. FEBS Lett. 451: 132-136.
34. Miyazaki, T., Kanou, Y., Murata, Y., Ohmori, S., Niwa, T., Maeda, K., Yamamura, H., and Seo, H. 1996. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts. J. Biol. Chem. 271: 14567-14571.
35. Molkentin, J.D., Lu, J.R., Antos, C.L., Markham, B., Richardson, J., Robbins, J., Grant, S.R., and Olson, E.N. 1998. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93: 215-228.
36. 2+-calmodulin-dependent protein kinase. Mol. Cell. Biol. 16: 4824-4831.
37. 2+ exchangers. Mol. Cell. Biol. 16: 3730-3741.
38. Rao, A., Luo, C., and Hogan, P.G. 1997. Transcription factors of the NFAT family: Regulation and function. Annu. Rev. Immunol. 15: 707-747.
39. Rothermel, B., Vega, R.B., Yang, J., Wu, H., Bassel-Duby, R., and Williams, R.S. 2000. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J. Biol. Chem. 275: 8719-8725.
40. Sagoo, J.K., Fruman, D.A., Wesselborg, S., Walsh, C.T., and Bierer, B.E. 1996. Competitive inhibition of calcineurin phosphatase activity by its autoinhibitory domain. Biochem. J. 320: 879-884.
41. 2+-activated cell death in mammalian cells. J. Cell. Biol. 131: 735-743.
42. Sikorski, R.S. and Hieter, P. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
43. Sim, A.T. and Scott, J.D. 1999. Targeting of PKA, PKC, and protein phosphatases to cellular microdomains. Cell. Calcium 26: 209-217.
44. Stathopoulos, A.M. and Cyert, M.S. 1997. Calcineurin acts through the CRZ1/TCN1 encoded transcription factor to regulate gene expression in yeast. Genes & Dev. 11: 3432-3444.
45. Stathopoulos-Gerontides, A., Guo, J.J., and Cyert, M.S. 1999. Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation. Genes & Dev. 13: 798-803.
46. Sun, L., Youn, H.D., Loh, C., Stolow, M., He, W., and Liu, J.O. 1998. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. Immunity 8: 703-711.
47. Sussman, M.A., Lim, H.W., Gude, N., Taigen, T., Olson, E.N., Robbins, J., Colbert, M.C., Gualberto, A., Wieczorek, D.F., and Molkentin, J.D. 1998. Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science 281: 1690-1693.
48. Tung, H.Y., Wang, W., and Chan, C.S. 1995. Regulation of chromosome segregation by Glc8p, a structural homolog of mammalian inhibitor 2 that functions as both an activator and an inhibitor of yeast protein phosphatase 1. Mol. Cell. Biol. 15: 6064-6074.
49. Wang, X., Culotta, V.C., and B., K.C. 1996. Superoxide dismutase protects calcineurin from inactivation. Nature 383: 434-437.
50. Winder, D.G., Mansuy, I.M., Osman, M., Moallem, T.M., and Kandel, E.R. 1998. Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell 92: 25-37.
51. Ye, R.R. and Bretscher, A. 1992. Identification and molecular characterization of the calmodulin-binding subunit gene (CMP1) of protein phosphatase 2B from Saccharomyces cerevisiae. An alpha-factor inducible gene. Eur. J. Biochem. 204: 713-723.
52. 2+-induced release of the transcription factor MEF2. Science 286: 790-793.
53. Zhu, J., Shibasaki, F., Price, R., Guillemot, J.C., Yano, T., Dotsch, V., Wagner, G., Ferrara, P., and McKeon, F. 1998. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Cell 93: 851-861.