메뉴 건너뛰기




Volumn 679, Issue 1-2, 2009, Pages 109-115

Pharmacological modulators of the circadian clock as potential therapeutic drugs

Author keywords

Chemical library; Circadian clock; CLOCK BMAL1 mediated transcription; Genotoxic stress; High throughput screening; Pharmacological modulators

Indexed keywords

ARTICLE; CHEMOTHERAPY; CHROMATIN ASSEMBLY AND DISASSEMBLY; DEMETHYLATION; E BOX ELEMENT; FEEDBACK SYSTEM; GENE EXPRESSION; GENE MUTATION; HIGH THROUGHPUT SCREENING; LIGHT DARK CYCLE; METHYLATION; MICROARRAY ANALYSIS; MOLECULAR CLOCK; PRIORITY JOURNAL; STRESS; SUPRACHIASMATIC NUCLEUS; CIRCADIAN RHYTHM; DISEASE ASSOCIATION; DRUG RESEARCH; FEASIBILITY STUDY; HUMAN; NONHUMAN;

EID: 72149125854     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2009.07.015     Document Type: Article
Times cited : (15)

References (76)
  • 1
    • 58549093572 scopus 로고    scopus 로고
    • Phenotypic effects of genetic variability in human clock genes on circadian and sleep parameters
    • von Schantz M. Phenotypic effects of genetic variability in human clock genes on circadian and sleep parameters. J. Genet. 87 (2008) 513-519
    • (2008) J. Genet. , vol.87 , pp. 513-519
    • von Schantz, M.1
  • 2
    • 0037352799 scopus 로고    scopus 로고
    • Health disorders of shift workers
    • Knutsson A. Health disorders of shift workers. Occup. Med. (Lond.) 53 (2003) 103-108
    • (2003) Occup. Med. (Lond.) , vol.53 , pp. 103-108
    • Knutsson, A.1
  • 3
    • 63149129183 scopus 로고    scopus 로고
    • Circadian variation within hemostasis: an underrecognized link between biology and disease?
    • Montagnana M., Salvagno G.L., and Lippi G. Circadian variation within hemostasis: an underrecognized link between biology and disease?. Semin. Thromb. Hemost. 35 (2009) 23-33
    • (2009) Semin. Thromb. Hemost. , vol.35 , pp. 23-33
    • Montagnana, M.1    Salvagno, G.L.2    Lippi, G.3
  • 4
    • 34547134725 scopus 로고    scopus 로고
    • Circadian proteins in the regulation of cell cycle and genotoxic stress responses
    • Kondratov R.V., and Antoch M.P. Circadian proteins in the regulation of cell cycle and genotoxic stress responses. Trends Cell Biol. 17 (2007) 311-317
    • (2007) Trends Cell Biol. , vol.17 , pp. 311-317
    • Kondratov, R.V.1    Antoch, M.P.2
  • 5
    • 33847270682 scopus 로고    scopus 로고
    • The role of mammalian circadian proteins in normal physiology and genotoxic stress responses
    • Kondratov R.V., Gorbacheva V.Y., and Antoch M.P. The role of mammalian circadian proteins in normal physiology and genotoxic stress responses. Curr. Top Dev. Biol. 78 (2007) 173-216
    • (2007) Curr. Top Dev. Biol. , vol.78 , pp. 173-216
    • Kondratov, R.V.1    Gorbacheva, V.Y.2    Antoch, M.P.3
  • 6
    • 4544362674 scopus 로고    scopus 로고
    • Mammalian circadian biology: elucidating genome-wide levels of temporal organization
    • Lowrey P.L., and Takahashi J.S. Mammalian circadian biology: elucidating genome-wide levels of temporal organization. Annu. Rev. Genomics Hum. Genet. 5 (2004) 407-441
    • (2004) Annu. Rev. Genomics Hum. Genet. , vol.5 , pp. 407-441
    • Lowrey, P.L.1    Takahashi, J.S.2
  • 8
    • 33749031807 scopus 로고    scopus 로고
    • Molecular components of the mammalian circadian clock
    • Spec No 2
    • Ko C.H., and Takahashi J.S. Molecular components of the mammalian circadian clock. Hum. Mol. Genet. 15 (2006) R271-277 Spec No 2
    • (2006) Hum. Mol. Genet. , vol.15
    • Ko, C.H.1    Takahashi, J.S.2
  • 9
    • 0037178787 scopus 로고    scopus 로고
    • The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
    • Preitner N., Damiola F., Lopez-Molina L., Zakany J., Duboule D., Albrecht U., and Schibler U. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110 (2002) 251-260
    • (2002) Cell , vol.110 , pp. 251-260
    • Preitner, N.1    Damiola, F.2    Lopez-Molina, L.3    Zakany, J.4    Duboule, D.5    Albrecht, U.6    Schibler, U.7
  • 10
    • 33645863768 scopus 로고    scopus 로고
    • Transcriptional regulation of metabolism
    • Desvergne B., Michalik L., and Wahli W. Transcriptional regulation of metabolism. Physiol. Rev. 86 (2006) 465-514
    • (2006) Physiol. Rev. , vol.86 , pp. 465-514
    • Desvergne, B.1    Michalik, L.2    Wahli, W.3
  • 13
    • 0141557951 scopus 로고    scopus 로고
    • DNA microarray analyses of circadian timing: the genomic basis of biological time
    • Duffield G.E. DNA microarray analyses of circadian timing: the genomic basis of biological time. J. Neuroendocrinol. 15 (2003) 991-1002
    • (2003) J. Neuroendocrinol. , vol.15 , pp. 991-1002
    • Duffield, G.E.1
  • 14
    • 0037426839 scopus 로고    scopus 로고
    • Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
    • Etchegaray J.P., Lee C., Wade P.A., and Reppert S.M. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature 421 (2003) 177-182
    • (2003) Nature , vol.421 , pp. 177-182
    • Etchegaray, J.P.1    Lee, C.2    Wade, P.A.3    Reppert, S.M.4
  • 15
    • 33644617485 scopus 로고    scopus 로고
    • Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions
    • Ripperger J.A., and Schibler U. Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat. Genet. 38 (2006) 369-374
    • (2006) Nat. Genet. , vol.38 , pp. 369-374
    • Ripperger, J.A.1    Schibler, U.2
  • 16
    • 33646145721 scopus 로고    scopus 로고
    • Circadian regulator CLOCK is a histone acetyltransferase
    • Doi M., Hirayama J., and Sassone-Corsi P. Circadian regulator CLOCK is a histone acetyltransferase. Cell 125 (2006) 497-508
    • (2006) Cell , vol.125 , pp. 497-508
    • Doi, M.1    Hirayama, J.2    Sassone-Corsi, P.3
  • 18
    • 33847779219 scopus 로고    scopus 로고
    • Post-translational modifications regulate the ticking of the circadian clock
    • Gallego M., and Virshup D.M. Post-translational modifications regulate the ticking of the circadian clock. Nat. Rev. Mol. Cell. Biol. 8 (2007) 139-148
    • (2007) Nat. Rev. Mol. Cell. Biol. , vol.8 , pp. 139-148
    • Gallego, M.1    Virshup, D.M.2
  • 19
    • 33947193633 scopus 로고    scopus 로고
    • Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression
    • Dardente H., Fortier E.E., Martineau V., and Cermakian N. Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression. Biochem. J. 402 (2007) 525-536
    • (2007) Biochem. J. , vol.402 , pp. 525-536
    • Dardente, H.1    Fortier, E.E.2    Martineau, V.3    Cermakian, N.4
  • 20
    • 33746235094 scopus 로고    scopus 로고
    • Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES
    • Kondratov R.V., Kondratova A.A., Lee C., Gorbacheva V.Y., Chernov M.V., and Antoch M.P. Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES. Cell Cycle 5 (2006) 890-895
    • (2006) Cell Cycle , vol.5 , pp. 890-895
    • Kondratov, R.V.1    Kondratova, A.A.2    Lee, C.3    Gorbacheva, V.Y.4    Chernov, M.V.5    Antoch, M.P.6
  • 21
    • 33749169177 scopus 로고    scopus 로고
    • BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer
    • Kwon I., Lee J., Chang S.H., Jung N.C., Lee B.J., Son G.H., Kim K., and Lee K.H. BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer. Mol. Cell Biol. 26 (2006) 7318-7330
    • (2006) Mol. Cell Biol. , vol.26 , pp. 7318-7330
    • Kwon, I.1    Lee, J.2    Chang, S.H.3    Jung, N.C.4    Lee, B.J.5    Son, G.H.6    Kim, K.7    Lee, K.H.8
  • 25
    • 0035910387 scopus 로고    scopus 로고
    • Entrainment of the circadian clock in the liver by feeding
    • Stokkan K.A., Yamazaki S., Tei H., Sakaki Y., and Menaker M. Entrainment of the circadian clock in the liver by feeding. Science 291 (2001) 490-493
    • (2001) Science , vol.291 , pp. 490-493
    • Stokkan, K.A.1    Yamazaki, S.2    Tei, H.3    Sakaki, Y.4    Menaker, M.5
  • 28
    • 0035861573 scopus 로고    scopus 로고
    • Circadian regulation of diverse gene products revealed by mRNA expression profiling of synchronized fibroblasts
    • Grundschober C., Delaunay F., Puhlhofer A., Triqueneaux G., Laudet V., Bartfai T., and Nef P. Circadian regulation of diverse gene products revealed by mRNA expression profiling of synchronized fibroblasts. J. Biol. Chem. 276 (2001) 46751-46758
    • (2001) J. Biol. Chem. , vol.276 , pp. 46751-46758
    • Grundschober, C.1    Delaunay, F.2    Puhlhofer, A.3    Triqueneaux, G.4    Laudet, V.5    Bartfai, T.6    Nef, P.7
  • 29
    • 27844565269 scopus 로고    scopus 로고
    • Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue
    • Ando H., Yanagihara H., Hayashi Y., Obi Y., Tsuruoka S., Takamura T., Kaneko S., and Fujimura A. Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. Endocrinology 146 (2005) 5631-5636
    • (2005) Endocrinology , vol.146 , pp. 5631-5636
    • Ando, H.1    Yanagihara, H.2    Hayashi, Y.3    Obi, Y.4    Tsuruoka, S.5    Takamura, T.6    Kaneko, S.7    Fujimura, A.8
  • 30
    • 33748663947 scopus 로고    scopus 로고
    • Transcriptional profiling in the adrenal gland reveals circadian regulation of hormone biosynthesis genes and nucleosome assembly genes
    • Oster H., Damerow S., Hut R.A., and Eichele G. Transcriptional profiling in the adrenal gland reveals circadian regulation of hormone biosynthesis genes and nucleosome assembly genes. J. Biol. Rhythms 21 (2006) 350-361
    • (2006) J. Biol. Rhythms , vol.21 , pp. 350-361
    • Oster, H.1    Damerow, S.2    Hut, R.A.3    Eichele, G.4
  • 33
    • 38649109805 scopus 로고    scopus 로고
    • Analysis of daily and circadian gene expression in the rat pineal gland
    • Fukuhara C., and Tosini G. Analysis of daily and circadian gene expression in the rat pineal gland. Neurosci. Res. 60 (2008) 192-198
    • (2008) Neurosci. Res. , vol.60 , pp. 192-198
    • Fukuhara, C.1    Tosini, G.2
  • 36
    • 25444439285 scopus 로고    scopus 로고
    • Beta2-adrenoceptor agonists induce the mammalian clock gene, hPer1, mRNA in cultured human bronchial epithelium cells in vitro
    • Takata M., Burioka N., Ohdo S., Fukuoka Y., Miyata M., Endo M., Suyama H., and Shimizu E. Beta2-adrenoceptor agonists induce the mammalian clock gene, hPer1, mRNA in cultured human bronchial epithelium cells in vitro. Chronobiol. Int. 22 (2005) 777-783
    • (2005) Chronobiol. Int. , vol.22 , pp. 777-783
    • Takata, M.1    Burioka, N.2    Ohdo, S.3    Fukuoka, Y.4    Miyata, M.5    Endo, M.6    Suyama, H.7    Shimizu, E.8
  • 38
    • 34848891194 scopus 로고    scopus 로고
    • It's about time: clock genes unveiled in the gut
    • Scheving L.A., and Russell W.E. It's about time: clock genes unveiled in the gut. Gastroenterology 133 (2007) 1373-1376
    • (2007) Gastroenterology , vol.133 , pp. 1373-1376
    • Scheving, L.A.1    Russell, W.E.2
  • 41
    • 0037184977 scopus 로고    scopus 로고
    • A web of circadian pacemakers
    • Schibler U., and Sassone-Corsi P. A web of circadian pacemakers. Cell 111 (2002) 919-922
    • (2002) Cell , vol.111 , pp. 919-922
    • Schibler, U.1    Sassone-Corsi, P.2
  • 42
  • 43
    • 0037126636 scopus 로고    scopus 로고
    • Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators
    • Le Minh N., Damiola F., Tronche F., Schutz G., and Schibler U. Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators. Embo J. 20 (2001) 7128-7136
    • (2001) Embo J. , vol.20 , pp. 7128-7136
    • Le Minh, N.1    Damiola, F.2    Tronche, F.3    Schutz, G.4    Schibler, U.5
  • 44
    • 0033637383 scopus 로고    scopus 로고
    • Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
    • Damiola F., Le Minh N., Preitner N., Kornmann B., Fleury-Olela F., and Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev. 14 (2000) 2950-2961
    • (2000) Genes Dev. , vol.14 , pp. 2950-2961
    • Damiola, F.1    Le Minh, N.2    Preitner, N.3    Kornmann, B.4    Fleury-Olela, F.5    Schibler, U.6
  • 46
    • 0032511229 scopus 로고    scopus 로고
    • A serum shock induces circadian gene expression in mammalian tissue culture cells
    • Balsalobre A., Damiola F., and Schibler U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 93 (1998) 929-937
    • (1998) Cell , vol.93 , pp. 929-937
    • Balsalobre, A.1    Damiola, F.2    Schibler, U.3
  • 48
    • 0033987157 scopus 로고    scopus 로고
    • Forskolin induces circadian gene expression of rPer1, rPer2 and dbp in mammalian rat-1 fibroblasts
    • Yagita K., and Okamura H. Forskolin induces circadian gene expression of rPer1, rPer2 and dbp in mammalian rat-1 fibroblasts. FEBS Lett. 465 (2000) 79-82
    • (2000) FEBS Lett. , vol.465 , pp. 79-82
    • Yagita, K.1    Okamura, H.2
  • 49
    • 0034687223 scopus 로고    scopus 로고
    • Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts
    • Balsalobre A., Marcacci L., and Schibler U. Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts. Curr. Biol. 10 (2000) 1291-1294
    • (2000) Curr. Biol. , vol.10 , pp. 1291-1294
    • Balsalobre, A.1    Marcacci, L.2    Schibler, U.3
  • 50
    • 0035853525 scopus 로고    scopus 로고
    • Molecular mechanisms of the biological clock in cultured fibroblasts
    • Yagita K., Tamanini F., van Der Horst G.T., and Okamura H. Molecular mechanisms of the biological clock in cultured fibroblasts. Science 292 (2001) 278-281
    • (2001) Science , vol.292 , pp. 278-281
    • Yagita, K.1    Tamanini, F.2    van Der Horst, G.T.3    Okamura, H.4
  • 51
    • 0037113902 scopus 로고    scopus 로고
    • Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts
    • Hirota T., Okano T., Kokame K., Shirotani-Ikejima H., Miyata T., and Fukada Y. Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. J. Biol. Chem. 277 (2002) 44244-44251
    • (2002) J. Biol. Chem. , vol.277 , pp. 44244-44251
    • Hirota, T.1    Okano, T.2    Kokame, K.3    Shirotani-Ikejima, H.4    Miyata, T.5    Fukada, Y.6
  • 52
    • 16844378484 scopus 로고    scopus 로고
    • Resetting of peripheral circadian clock by prostaglandin E2
    • Tsuchiya Y., Minami I., Kadotani H., and Nishida E. Resetting of peripheral circadian clock by prostaglandin E2. EMBO Rep. 6 (2005) 256-261
    • (2005) EMBO Rep. , vol.6 , pp. 256-261
    • Tsuchiya, Y.1    Minami, I.2    Kadotani, H.3    Nishida, E.4
  • 53
    • 33750456947 scopus 로고    scopus 로고
    • Quantitative analyses of circadian gene expression in mammalian cell cultures
    • Izumo M., Sato T.R., Straume M., and Johnson C.H. Quantitative analyses of circadian gene expression in mammalian cell cultures. PLoS Comput. Biol. 2 (2006) e136
    • (2006) PLoS Comput. Biol. , vol.2
    • Izumo, M.1    Sato, T.R.2    Straume, M.3    Johnson, C.H.4
  • 54
    • 0029056609 scopus 로고
    • Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans
    • Dijk D.J., and Czeisler C.A. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J. Neurosci. 15 (1995) 3526-3538
    • (1995) J. Neurosci. , vol.15 , pp. 3526-3538
    • Dijk, D.J.1    Czeisler, C.A.2
  • 56
    • 67651155864 scopus 로고    scopus 로고
    • Shift work and metabolic syndrome: respective impacts of job strain, physical activity, and dietary rhythms
    • Esquirol Y., Bongard V., Mabile L., Jonnier B., Soulat J.M., and Perret B. Shift work and metabolic syndrome: respective impacts of job strain, physical activity, and dietary rhythms. Chronobiol. Int. 26 (2009) 544-559
    • (2009) Chronobiol. Int. , vol.26 , pp. 544-559
    • Esquirol, Y.1    Bongard, V.2    Mabile, L.3    Jonnier, B.4    Soulat, J.M.5    Perret, B.6
  • 57
    • 14644415433 scopus 로고    scopus 로고
    • Circadian disruption and breast cancer: from melatonin to clock genes
    • Stevens R.G. Circadian disruption and breast cancer: from melatonin to clock genes. Epidemiology 16 (2005) 254-258
    • (2005) Epidemiology , vol.16 , pp. 254-258
    • Stevens, R.G.1
  • 58
    • 63149163425 scopus 로고    scopus 로고
    • Adverse metabolic and cardiovascular consequences of circadian misalignment
    • Scheer F.A., Hilton M.F., Mantzoros C.S., and Shea S.A. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc. Natl. Acad. Sci. USA 106 (2009) 4453-4458
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 4453-4458
    • Scheer, F.A.1    Hilton, M.F.2    Mantzoros, C.S.3    Shea, S.A.4
  • 59
    • 60449113184 scopus 로고    scopus 로고
    • The pathophysiology of jet lag
    • Sack R.L. The pathophysiology of jet lag. Travel Med. Infect Dis. 7 (2009) 102-110
    • (2009) Travel Med. Infect Dis. , vol.7 , pp. 102-110
    • Sack, R.L.1
  • 61
    • 63449110958 scopus 로고    scopus 로고
    • Bright light therapy
    • Prasko J. Bright light therapy. Neuro Endocrinol. Lett. 29 Suppl 1 (2008) 33-64
    • (2008) Neuro Endocrinol. Lett. , vol.29 , Issue.SUPPL. 1 , pp. 33-64
    • Prasko, J.1
  • 62
    • 14744278784 scopus 로고    scopus 로고
    • Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex
    • Gorbacheva V.Y., Kondratov R.V., Zhang R., Cherukuri S., Gudkov A.V., Takahashi J.S., and Antoch M.P. Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc. Natl. Acad. Sci. USA 102 (2005) 3407-3412
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 3407-3412
    • Gorbacheva, V.Y.1    Kondratov, R.V.2    Zhang, R.3    Cherukuri, S.4    Gudkov, A.V.5    Takahashi, J.S.6    Antoch, M.P.7
  • 63
    • 25444501006 scopus 로고    scopus 로고
    • Circadian clock genes as modulators of sensitivity to genotoxic stress
    • Antoch M.P., Kondratov R.V., and Takahashi J.S. Circadian clock genes as modulators of sensitivity to genotoxic stress. Cell Cycle 4 (2005) 901-907
    • (2005) Cell Cycle , vol.4 , pp. 901-907
    • Antoch, M.P.1    Kondratov, R.V.2    Takahashi, J.S.3
  • 65
    • 33746191906 scopus 로고    scopus 로고
    • Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock
    • Kondratov R.V., Kondratova A.A., Gorbacheva V.Y., Vykhovanets O.V., and Antoch M.P. Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev. 20 (2006) 1868-1873
    • (2006) Genes Dev. , vol.20 , pp. 1868-1873
    • Kondratov, R.V.1    Kondratova, A.A.2    Gorbacheva, V.Y.3    Vykhovanets, O.V.4    Antoch, M.P.5
  • 66
    • 0037020198 scopus 로고    scopus 로고
    • The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo
    • Fu L., Pelicano H., Liu J., Huang P., and Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111 (2002) 41-50
    • (2002) Cell , vol.111 , pp. 41-50
    • Fu, L.1    Pelicano, H.2    Liu, J.3    Huang, P.4    Lee, C.5
  • 67
    • 33646237094 scopus 로고    scopus 로고
    • Relationships between Molecular Complexity, Biological Activity, and Structural Diversity
    • Schuffenhauer A., Brown N., Selzer P., Ertl P., and Jacoby E. Relationships between Molecular Complexity, Biological Activity, and Structural Diversity. J. Chem. Inf. Model 46 (2006) 525-535
    • (2006) J. Chem. Inf. Model , vol.46 , pp. 525-535
    • Schuffenhauer, A.1    Brown, N.2    Selzer, P.3    Ertl, P.4    Jacoby, E.5
  • 68
    • 33847668394 scopus 로고    scopus 로고
    • Image-based screening for the identification of novel proteasome inhibitors
    • Rickardson L., Wickstrom M., Larsson R., and Lovborg H. Image-based screening for the identification of novel proteasome inhibitors. J. Biomol. Screen 12 (2007) 203-210
    • (2007) J. Biomol. Screen , vol.12 , pp. 203-210
    • Rickardson, L.1    Wickstrom, M.2    Larsson, R.3    Lovborg, H.4
  • 70
    • 33644855557 scopus 로고    scopus 로고
    • Recent developments in focused library design: targeting gene-families
    • Miller J.L. Recent developments in focused library design: targeting gene-families. Curr. Top Med. Chem. 6 (2006) 19-29
    • (2006) Curr. Top Med. Chem. , vol.6 , pp. 19-29
    • Miller, J.L.1
  • 71
    • 16844383352 scopus 로고    scopus 로고
    • Real-time reporting of circadian-regulated gene expression by luciferase imaging in plants and mammalian cells
    • Welsh D.K., Imaizumi T., and Kay S.A. Real-time reporting of circadian-regulated gene expression by luciferase imaging in plants and mammalian cells. Methods Enzymol. 393 (2005) 269-288
    • (2005) Methods Enzymol. , vol.393 , pp. 269-288
    • Welsh, D.K.1    Imaizumi, T.2    Kay, S.A.3
  • 72
    • 58549103297 scopus 로고    scopus 로고
    • A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta
    • Hirota T., Lewis W.G., Liu A.C., Lee J.W., Schultz P.G., and Kay S.A. A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proc. Natl. Acad. Sci. USA 105 (2008) 20746-20751
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 20746-20751
    • Hirota, T.1    Lewis, W.G.2    Liu, A.C.3    Lee, J.W.4    Schultz, P.G.5    Kay, S.A.6
  • 73
    • 0034523281 scopus 로고    scopus 로고
    • The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5
    • Wilsbacher L.D., Sangoram A.M., Antoch M.P., and Takahashi J.S. The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5. Genome Res. 10 (2000) 1928-1940
    • (2000) Genome Res. , vol.10 , pp. 1928-1940
    • Wilsbacher, L.D.1    Sangoram, A.M.2    Antoch, M.P.3    Takahashi, J.S.4
  • 76
    • 0033003760 scopus 로고    scopus 로고
    • A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays
    • Zhang J.H., Chung T.D., and Oldenburg K.R. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J. Biomol. Screen 4 (1999) 67-73
    • (1999) J. Biomol. Screen , vol.4 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.