A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 52, 2008, Pages 20746-20751

  Hirota, Tsuyoshi ^a,b   Lewis, Warren G ^a,b   Liu, Andrew C ^a,b   Jae, Wook Lee ^b,c   Schultz, Peter G ^b,c   Kay, Steve A ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Kinase; Screening; Small molecule library

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; LITHIUM; SMALL INTERFERING RNA;

ARTICLE; CHEMOLUMINESCENCE; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME STRUCTURE; GENE CONTROL; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BIOLOGICAL CLOCKS; CELL LINE, TUMOR; CIRCADIAN RHYTHM; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LITHIUM; RNA, SMALL INTERFERING;

MAMMALIA;

EID: 58549103297     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811410106     Document Type: Article

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