Antimalarial acridines: Synthesis, in vitro activity against P. falciparum and interaction with hematin

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 23, 2009, Pages 8032-8039

  Guetzoyan, Lucie ^a   Yu, Xiao Min ^a   Ramiandrasoa, Florence ^a   Pethe, Stéphanie ^a   Rogier, Christophe ^b   Pradines, Bruno ^b   Cresteil, Thierry ^c   Perrée Fauvet, Martine ^a   Mahy, Jean Pierre ^a  

^a UNIVERSITÉ PARIS SUD   (France)

^b AIX MARSEILLE UNIVERSITÉ   (France)

^c CNRS   (France)

Author keywords

Aminoacridine; Antimalarial; Plasmodium falciparum; Hematin

Indexed keywords

9 (6 AMMONIOETHYLAMINO) 6 CHLORO 2 METHOXYACRIDINIUM DICHLORIDE; ACRIDINE DERIVATIVE; ANTIMALARIAL AGENT; CHLOROQUINE; HEMATIN; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

MAMMALIA; PLASMODIUM FALCIPARUM;

EID: 72149093269     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.005     Document Type: Article

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