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Volumn 102, Issue 2, 2003, Pages 541-548

Functional phenotype of phosphoinositide 3-kinase p85α-null platelets characterized by an impaired response to GP VI stimulation

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 O METHYLPHORBOL 13 ACETATE 12 MYRISTATE; ADENOSINE DIPHOSPHATE; BOTROCETIN; COLLAGEN; GLYCOPROTEIN; PADGEM PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PROTEIN KINASE B; PROTEIN P85; THROMBIN;

EID: 0037818568     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-11-3327     Document Type: Article
Times cited : (85)

References (56)
  • 1
    • 0035190026 scopus 로고    scopus 로고
    • Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
    • Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol. 2001;17:615-675.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 615-675
    • Katso, R.1    Okkenhaug, K.2    Ahmadi, K.3    White, S.4    Timms, J.5    Waterfield, M.D.6
  • 2
    • 0034911881 scopus 로고    scopus 로고
    • Synthesis and function of 3-phosphorylated inositol lipids
    • Vanhaesebroeck B, Leevers SJ, Ahmadi K, et al. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem. 2001;70:535-602.
    • (2001) Annu Rev Biochem , vol.70 , pp. 535-602
    • Vanhaesebroeck, B.1    Leevers, S.J.2    Ahmadi, K.3
  • 3
    • 0033605718 scopus 로고    scopus 로고
    • The role of phosphoinositide 3-kinase lipid products in cell function
    • Rameh LE, Cantley LC. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem. 1999;274:8347-8350.
    • (1999) J Biol Chem , vol.274 , pp. 8347-8350
    • Rameh, L.E.1    Cantley, L.C.2
  • 4
    • 0029855991 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase activation and platelet function
    • Rittenhouse SE. Phosphoinositide 3-kinase activation and platelet function. Blood. 1996;88:4401-4414.
    • (1996) Blood , vol.88 , pp. 4401-4414
    • Rittenhouse, S.E.1
  • 5
    • 0029964243 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or betaphorbol myristate acetate and roles in promoting the ligand-binding function of alpha11bbeta3 integrin
    • Zhang J, Shattil SJ, Cunningham MC, Rittenhouse SE. Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or betaphorbol myristate acetate and roles in promoting the ligand-binding function of alpha11bbeta3 integrin. J Biol Chem. 1996;271:6265-6272.
    • (1996) J Biol Chem , vol.271 , pp. 6265-6272
    • Zhang, J.1    Shattil, S.J.2    Cunningham, M.C.3    Rittenhouse, S.E.4
  • 6
    • 0036041437 scopus 로고    scopus 로고
    • Human platelets contain p110delta phosphoinositide 3-kinase
    • Zhang J, Vanhaesebroeck B. Human platelets contain p110delta phosphoinositide 3-kinase. Biochem Biophys Res Commun. 2002;296:178-181.
    • (2002) Biochem Biophys Res Commun , vol.296 , pp. 178-181
    • Zhang, J.1    Vanhaesebroeck, B.2
  • 7
    • 0030271565 scopus 로고    scopus 로고
    • Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene
    • Fruman DA, Cantley LC, Carpenter CL. Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. Genomics. 1996;37:113-121.
    • (1996) Genomics , vol.37 , pp. 113-121
    • Fruman, D.A.1    Cantley, L.C.2    Carpenter, C.L.3
  • 8
    • 0036490708 scopus 로고    scopus 로고
    • Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit
    • Chan TO, Rodeck U, Chan AM, et al. Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell. 2002;1:181-191.
    • (2002) Cancer Cell , vol.1 , pp. 181-191
    • Chan, T.O.1    Rodeck, U.2    Chan, A.M.3
  • 9
    • 0030869757 scopus 로고    scopus 로고
    • Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide
    • Kurosu H, Maehama T, Okada T, et al. Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide. J Biol Chem. 1997;272:24252-24256.
    • (1997) J Biol Chem , vol.272 , pp. 24252-24256
    • Kurosu, H.1    Maehama, T.2    Okada, T.3
  • 10
    • 0028178715 scopus 로고
    • A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol
    • Thomason PA, James SR, Casey PJ, Downes CP. A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. J Biol Chem. 1994;269:16525-16528.
    • (1994) J Biol Chem , vol.269 , pp. 16525-16528
    • Thomason, P.A.1    James, S.R.2    Casey, P.J.3    Downes, C.P.4
  • 11
    • 0033567185 scopus 로고    scopus 로고
    • A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets
    • Pasquet JM, Bobe R, Gross B, et al. A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets. Biochem J. 1999;342:171-177.
    • (1999) Biochem J , vol.342 , pp. 171-177
    • Pasquet, J.M.1    Bobe, R.2    Gross, B.3
  • 12
    • 0032545307 scopus 로고    scopus 로고
    • The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin
    • Gibbins JM, Briddon S, Shutes A, et al. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin. J Biol Chem. 1998;273:34437-34443.
    • (1998) J Biol Chem , vol.273 , pp. 34437-34443
    • Gibbins, J.M.1    Briddon, S.2    Shutes, A.3
  • 13
    • 0034915926 scopus 로고    scopus 로고
    • The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen
    • Watson SP, Asazuma N, Atkinson B, et al. The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen. Thromb Haemost. 2001;86:276-288.
    • (2001) Thromb Haemost , vol.86 , pp. 276-288
    • Watson, S.P.1    Asazuma, N.2    Atkinson, B.3
  • 14
    • 0034668382 scopus 로고    scopus 로고
    • FcgammaRIIA requires a Gi-dependent pathway for an efficient stimulation of phosphoinositide 3-kinase, calcium mobilization, and platelet aggregation
    • Gratacap MP, Herault JP, Viala C, et al. FcgammaRIIA requires a Gi-dependent pathway for an efficient stimulation of phosphoinositide 3-kinase, calcium mobilization, and platelet aggregation. Blood. 2000;96:3439-3446.
    • (2000) Blood , vol.96 , pp. 3439-3446
    • Gratacap, M.P.1    Herault, J.P.2    Viala, C.3
  • 15
    • 0033593215 scopus 로고    scopus 로고
    • Fc receptor-mediated platelet activation is dependent on phosphatidylinositol 3-kinase activation and involves p120(Cbl)
    • Saci A, Pain S, Rendu F, Bachelot-Loza C. Fc receptor-mediated platelet activation is dependent on phosphatidylinositol 3-kinase activation and involves p120(Cbl). J Biol Chem. 1999;274:1898-1904.
    • (1999) J Biol Chem , vol.274 , pp. 1898-1904
    • Saci, A.1    Pain, S.2    Rendu, F.3    Bachelot-Loza, C.4
  • 16
    • 0034661839 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta
    • Munday AD, Mitchell CA. Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta. Blood. 2000;96:577-584.
    • (2000) Blood , vol.96 , pp. 577-584
    • Munday, A.D.1    Mitchell, C.A.2
  • 17
    • 0034554857 scopus 로고    scopus 로고
    • Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/ FcR gamma-chain complex
    • Falet H, Barkalow KL, Barnes MJ, Geha RS, Hartwig JH. Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/ FcR gamma-chain complex. Blood. 2000;96:3786-3792.
    • (2000) Blood , vol.96 , pp. 3786-3792
    • Falet, H.1    Barkalow, K.L.2    Barnes, M.J.3    Geha, R.S.4    Hartwig, J.H.5
  • 18
    • 0028951464 scopus 로고
    • Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase
    • Guinebault C, Payrastre B, Racaud-Sultan C, Breton M, Mauco G, Chap H. Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase. J Cell Biol. 1995;129:831-842.
    • (1995) J Cell Biol , vol.129 , pp. 831-842
    • Guinebault, C.1    Payrastre, B.2    Racaud-Sultan, C.3    Breton, M.4    Mauco, G.5    Chap, H.6
  • 19
    • 0035860407 scopus 로고    scopus 로고
    • The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha (IIb)beta(3) integrin - A phosphoinositide 3-kinase-dependent mechanism
    • Kauffenstein G, Bergmeier W, Eckly A, et al. The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha (IIb)beta(3) integrin - a phosphoinositide 3-kinase-dependent mechanism. FEBS Lett. 2001;505:281-290.
    • (2001) FEBS Lett , vol.505 , pp. 281-290
    • Kauffenstein, G.1    Bergmeier, W.2    Eckly, A.3
  • 20
    • 0032701416 scopus 로고    scopus 로고
    • A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin
    • Lauener RW, Stevens CM, Sayed MR, Salari H, Duronio V. A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin. Biochim Biophys Acta. 1999;1452:197-208.
    • (1999) Biochim Biophys Acta , vol.1452 , pp. 197-208
    • Lauener, R.W.1    Stevens, C.M.2    Sayed, M.R.3    Salari, H.4    Duronio, V.5
  • 21
    • 0029148780 scopus 로고
    • G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase Shc adapter protein signaling complexes
    • Ptasznik A, Traynor-Kaplan A, Bokoch GM. G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase Shc adapter protein signaling complexes. J Biol Chem. 1995;270:19969-19973.
    • (1995) J Biol Chem , vol.270 , pp. 19969-19973
    • Ptasznik, A.1    Traynor-Kaplan, A.2    Bokoch, G.M.3
  • 22
    • 0032511082 scopus 로고    scopus 로고
    • Platelets interact with soluble and insoluble collagens through characteristically different reactions
    • Jung SM, Moroi M. Platelets interact with soluble and insoluble collagens through characteristically different reactions. J Biol Chem. 1998;273:14827-14837.
    • (1998) J Biol Chem , vol.273 , pp. 14827-14837
    • Jung, S.M.1    Moroi, M.2
  • 23
    • 0030615068 scopus 로고    scopus 로고
    • p85 gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI3-Kinase), p50α, p55α, and p85α, with different PI3-Kinase activity elevating responses to insulin
    • Inukai K, Funaki M, Ogihara T, et al. p85 gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI3-Kinase), p50α, p55α, and p85α, with different PI3-Kinase activity elevating responses to insulin. J Biol Chem. 1997;272:7873-7882.
    • (1997) J Biol Chem , vol.272 , pp. 7873-7882
    • Inukai, K.1    Funaki, M.2    Ogihara, T.3
  • 24
    • 0032909703 scopus 로고    scopus 로고
    • Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
    • Terauchi Y, Tsuji Y, Satoh S, et al. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet. 1999;21:230-235.
    • (1999) Nat Genet , vol.21 , pp. 230-235
    • Terauchi, Y.1    Tsuji, Y.2    Satoh, S.3
  • 25
    • 0033555829 scopus 로고    scopus 로고
    • Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
    • Suzuki H, Terauchi Y, Fujiwara M, et al. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science. 1999;283:390-392.
    • (1999) Science , vol.283 , pp. 390-392
    • Suzuki, H.1    Terauchi, Y.2    Fujiwara, M.3
  • 26
    • 0030756508 scopus 로고    scopus 로고
    • Defective platelet activation in Gαq-deficient mice
    • Offermanns S, Toombs CF, Hu Y, Simon MI. Defective platelet activation in Gαq-deficient mice. Nature. 1997;389:183-186.
    • (1997) Nature , vol.389 , pp. 183-186
    • Offermanns, S.1    Toombs, C.F.2    Hu, Y.3    Simon, M.I.4
  • 27
    • 0033757592 scopus 로고    scopus 로고
    • Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p852α
    • Fruman DA, Mauvais-Jarvis F, Pollard DA, et al. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p852α. Nat Genet. 2000;26:379-382.
    • (2000) Nat Genet , vol.26 , pp. 379-382
    • Fruman, D.A.1    Mauvais-Jarvis, F.2    Pollard, D.A.3
  • 28
    • 0030917981 scopus 로고    scopus 로고
    • The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen
    • Poole A, Gibbins JM, Turner M, et al. The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J. 1997;16:2333-2341.
    • (1997) EMBO J , vol.16 , pp. 2333-2341
    • Poole, A.1    Gibbins, J.M.2    Turner, M.3
  • 29
    • 0345654297 scopus 로고    scopus 로고
    • Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice
    • Clements JL, Lee JR, Gross B, et al. Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice. J Clin Invest. 1999;103:19-25.
    • (1999) J Clin Invest , vol.103 , pp. 19-25
    • Clements, J.L.1    Lee, J.R.2    Gross, B.3
  • 30
    • 0033624638 scopus 로고    scopus 로고
    • Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors
    • Wang D, Feng J, Wen R, et al. Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity. 2000;13:25-35.
    • (2000) Immunity , vol.13 , pp. 25-35
    • Wang, D.1    Feng, J.2    Wen, R.3
  • 31
    • 0033500154 scopus 로고    scopus 로고
    • LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI
    • Pasquet JM, Gross B, Quek L, et al. LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI. Mol Cell Biol. 1999;19:8326-8334.
    • (1999) Mol Cell Biol , vol.19 , pp. 8326-8334
    • Pasquet, J.M.1    Gross, B.2    Quek, L.3
  • 32
    • 0032497629 scopus 로고    scopus 로고
    • A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen
    • Quek LS, Bolen J, Watson SP. A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen. Curr Biol. 1998;8:1137-1140.
    • (1998) Curr Biol , vol.8 , pp. 1137-1140
    • Quek, L.S.1    Bolen, J.2    Watson, S.P.3
  • 33
    • 17644442615 scopus 로고    scopus 로고
    • Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking
    • Oda A, Ikeda Y, Ochs HD, et al. Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking. Blood. 2000;95:1663-1670.
    • (2000) Blood , vol.95 , pp. 1663-1670
    • Oda, A.1    Ikeda, Y.2    Ochs, H.D.3
  • 34
    • 0037066732 scopus 로고    scopus 로고
    • Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI
    • Barry FA, Gibbins JM. Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. J Biol Chem. 2002;277:12874-12878.
    • (2002) J Biol Chem , vol.277 , pp. 12874-12878
    • Barry, F.A.1    Gibbins, J.M.2
  • 35
    • 0037166284 scopus 로고    scopus 로고
    • Lipid rafts orchestrate signaling by the platelet receptor glycoprotein VI
    • Locke D, Chen H, Liu Y, Liu C, Kahn ML. Lipid rafts orchestrate signaling by the platelet receptor glycoprotein VI. J Biol Chem. 2002;277:18801-18809.
    • (2002) J Biol Chem , vol.277 , pp. 18801-18809
    • Locke, D.1    Chen, H.2    Liu, Y.3    Liu, C.4    Kahn, M.L.5
  • 36
    • 0036566670 scopus 로고    scopus 로고
    • Constitutive and functional association of the platelet collagen receptor glycoprotein VI-Fc receptor gamma-chain complex with membrane rafts
    • Ezumi Y, Kodama K, Uchiyama T, Takayama H. Constitutive and functional association of the platelet collagen receptor glycoprotein VI-Fc receptor gamma-chain complex with membrane rafts. Blood. 2002;99:3250-3255.
    • (2002) Blood , vol.99 , pp. 3250-3255
    • Ezumi, Y.1    Kodama, K.2    Uchiyama, T.3    Takayama, H.4
  • 37
    • 0035909819 scopus 로고    scopus 로고
    • Production of phosphatidylinositol 3,4,5-trisphosphate and phosphatidic acid in platelet rafts: Evidence for a critical role of cholesterol-enriched domains in human platelet activation
    • Bodin S, Giuriato S, Ragab J, et al. Production of phosphatidylinositol 3,4,5-trisphosphate and phosphatidic acid in platelet rafts: evidence for a critical role of cholesterol-enriched domains in human platelet activation. Biochemistry. 2001;40:15290-15299.
    • (2001) Biochemistry , vol.40 , pp. 15290-15299
    • Bodin, S.1    Giuriato, S.2    Ragab, J.3
  • 38
    • 0035254644 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-dependent translocation of phospholipase Cgamma2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation
    • Bobe R, Wilde JI, Maschberger P, et al. Phosphatidylinositol 3-kinase-dependent translocation of phospholipase Cgamma2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation. Blood. 2001;97:678-684.
    • (2001) Blood , vol.97 , pp. 678-684
    • Bobe, R.1    Wilde, J.I.2    Maschberger, P.3
  • 39
    • 0037128640 scopus 로고    scopus 로고
    • Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling
    • Judd BA, Myung PS, Obergfell A, et al. Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. J Exp Med. 2002;195:705-717.
    • (2002) J Exp Med , vol.195 , pp. 705-717
    • Judd, B.A.1    Myung, P.S.2    Obergfell, A.3
  • 40
    • 0033556333 scopus 로고    scopus 로고
    • Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha
    • Fruman DA, Snapper SB, Yballe CM, et al. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science. 1999;283:393-397.
    • (1999) Science , vol.283 , pp. 393-397
    • Fruman, D.A.1    Snapper, S.B.2    Yballe, C.M.3
  • 41
    • 0036199607 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase in immunological systems
    • Fruman DA, Cantley LC. Phosphoinositide 3-kinase in immunological systems. Semin Immunol. 2002;14:7-18.
    • (2002) Semin Immunol , vol.14 , pp. 7-18
    • Fruman, D.A.1    Cantley, L.C.2
  • 42
    • 0035367398 scopus 로고    scopus 로고
    • Adapters in lymphocyte signalling
    • Leo A, Schraven B. Adapters in lymphocyte signalling. Curr Opin Immunol. 2001;13:307-316.
    • (2001) Curr Opin Immunol , vol.13 , pp. 307-316
    • Leo, A.1    Schraven, B.2
  • 43
    • 0034692690 scopus 로고    scopus 로고
    • Functional complementation of BLNK by SLP-76 and LAT linker proteins
    • Wong J, Ishiai M, Kurosaki T, Chan AC. Functional complementation of BLNK by SLP-76 and LAT linker proteins. J Biol Chem. 2000;275:33116-33122.
    • (2000) J Biol Chem , vol.275 , pp. 33116-33122
    • Wong, J.1    Ishiai, M.2    Kurosaki, T.3    Chan, A.C.4
  • 44
    • 0034606219 scopus 로고    scopus 로고
    • Severe B cell deficiency in mice lacking the lec kinase family members Tec and Btk
    • Ellmeier W, Jung S, Sunshine MJ, et al. Severe B cell deficiency in mice lacking the lec kinase family members Tec and Btk. J Exp Med. 2000;192:1611-1624.
    • (2000) J Exp Med , vol.192 , pp. 1611-1624
    • Ellmeier, W.1    Jung, S.2    Sunshine, M.J.3
  • 45
    • 0033945186 scopus 로고    scopus 로고
    • The role of Bruton's tyrosine kinase in B-cell development and function: A genetic perspective
    • Satterthwaite AB, Witte ON. The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective. Immunol Rev. 2000;175:120-127.
    • (2000) Immunol Rev , vol.175 , pp. 120-127
    • Satterthwaite, A.B.1    Witte, O.N.2
  • 47
    • 12944284595 scopus 로고    scopus 로고
    • A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase
    • Satterthwaile AB, Willis F, Kanchanastit P, et al. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000;97:6687-6692.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6687-6692
    • Satterthwaile, A.B.1    Willis, F.2    Kanchanastit, P.3
  • 48
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 1995;81:53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 49
    • 0035798144 scopus 로고    scopus 로고
    • Characterisation of Rac activation in thrombin- and collagen-stimulaled human blood platelets
    • Soulet C, Gendreau S, Missy K, Benard V, Plantavid M, Payrastre B. Characterisation of Rac activation in thrombin- and collagen-stimulaled human blood platelets. FEBS Lett. 2001;507:253-258.
    • (2001) FEBS Lett , vol.507 , pp. 253-258
    • Soulet, C.1    Gendreau, S.2    Missy, K.3    Benard, V.4    Plantavid, M.5    Payrastre, B.6
  • 50
    • 0030945262 scopus 로고    scopus 로고
    • Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, et al. Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets. Blood. 1997;89:2789-2798.
    • (1997) Blood , vol.89 , pp. 2789-2798
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3
  • 51
    • 0029050557 scopus 로고
    • Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation
    • Kovacsovics TJ, Bachelot C, Toker A, et al. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J Biol Chem. 1995;270:11358-11366.
    • (1995) J Biol Chem , vol.270 , pp. 11358-11366
    • Kovacsovics, T.J.1    Bachelot, C.2    Toker, A.3
  • 52
    • 0028788181 scopus 로고
    • Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase
    • Toker A, Bachelot C, Chen CS, et al. Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. J Biol Chem. 1995;270:29525-29531.
    • (1995) J Biol Chem , vol.270 , pp. 29525-29531
    • Toker, A.1    Bachelot, C.2    Chen, C.S.3
  • 53
    • 0032486378 scopus 로고    scopus 로고
    • A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate
    • Zhang J, Banfic H, Straforini F, Tosi L, Volinia S, Rittenhouse SE. A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate. J Biol Chem. 1998;273:14081-14084.
    • (1998) J Biol Chem , vol.273 , pp. 14081-14084
    • Zhang, J.1    Banfic, H.2    Straforini, F.3    Tosi, L.4    Volinia, S.5    Rittenhouse, S.E.6
  • 55
    • 0032570711 scopus 로고    scopus 로고
    • Physical proximity and functional interplay of the glycoprotein Ib-IX-V complex and the Fc receptor FcgammaRIIA on the platelet plasma membrane
    • Sullam PM, Hyun WC, Szollosi J, Dong J, Foss WM, Lopez JA. Physical proximity and functional interplay of the glycoprotein Ib-IX-V complex and the Fc receptor FcgammaRIIA on the platelet plasma membrane. J Biol Chem. 1998;273:5331-5336.
    • (1998) J Biol Chem , vol.273 , pp. 5331-5336
    • Sullam, P.M.1    Hyun, W.C.2    Szollosi, J.3    Dong, J.4    Foss, W.M.5    Lopez, J.A.6
  • 56
    • 0035877994 scopus 로고    scopus 로고
    • Role of Fc receptor gamma-chain in platelet glycoprotein II-mediated signaling
    • Wu Y, Suzuki-Inoue K, Satoh K, et al. Role of Fc receptor gamma-chain in platelet glycoprotein II-mediated signaling. Blood. 2001;97:3836-3845.
    • (2001) Blood , vol.97 , pp. 3836-3845
    • Wu, Y.1    Suzuki-Inoue, K.2    Satoh, K.3


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