Platelet adhesion enhances the glycoprotein VI-dependent procoagulant response: Involvement of p38 MAP kinase and calpain

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 4, 2001, Pages 618-627

  Siljander, Pia ^a,b,c   Farndale, Richard W ^c   Feijge, Marion A H ^b   Comfurius, Paul ^b   Kos, Snjezana ^b   Bevers, Edouard M ^b   Heemskerk, Johan W M ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Adhesion; Glycoprotein VI; Platelets; Procoagulant activity; Signal transduction

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMINOPHOSPHOLIPID; CALCIUM ION; CALPAIN; CALPEPTIN; COLLAGEN; COLLAGEN RELATED PEPTIDE; CONVULXIN; FIBRINOGEN; GLYCOPROTEIN; GLYCOPROTEIN VI; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLSERINE; PROCOAGULANT; PROTEIN INHIBITOR; PROTEINASE INHIBITOR; SNAKE VENOM; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOTTING; CASE REPORT; CELL SUSPENSION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MEMBRANE VESICLE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE MEMBRANE;

EID: 0035045208     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.21.4.618     Document Type: Article

References (45)

1. Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets
2. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells
3. Lipid protein interactions in blood coagulation
4. Isolation of human platelet membrane microparticles from plasma and serum
5. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane: Studies in Scott syndrome: An isolated defect in platelet procoagulant activity
6. 2+ responses
7. Aminophospholipid exposure, microvesiculation and abnormal protein tyrosine phosphorylation in the platelets of a patient with Scott syndrome: A study using physiologic agonists and local anaesthetics
8. Role of the membrane skeleton in preventing the shedding of procoagulant-rich microvesicles from the platelet plasma membrane
9. Alterations in Bcl-Bax protein levels in platelets form part of an ionomycin-induced process that resembles apoptosis
10. Role of caspase in a subset of human platelet activation responses
11. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation
12. Scott syndrome: A disorder of platelet coagulant activity
13. Function of glycoprotein VI and integrin α2β1 in the procoagulant response of single, collagen-adherent platelets
14. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcaR and the natural killer receptors
15. Collagen-stimulated activation of Syk but not c-Src is severely compromised in human platelets lacking membrane glycoprotein VI
16. A novel association of Fc receptor γ-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets
17. A collagen-like peptide stimulates tyrosine phosphorylation of Syk and phospholipase C γ2 in platelets independent of the integrin α2β1
18. Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet GpVI and mediates platelet activation by collagen
19. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor
20. The p38 MAP kinase pathway and its biological function
21. The activation of p38 and apoptosis by the inhibition of ERK is antagonized by the phosphoinositide 3-kinase/Akt pathway
22. A dual function for p38 MAP kinase in hematopoietic cells: Involvement of apoptosis and cell activation
23. A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia
24. Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles
25. Convulxin, a potent platelet-aggregating protein from Crotalus durissus terrificus venom, specifically binds to platelets
26. 2+-signalling
27. Studies of adhesion-dependent platelet activation: Distinct roles for different participating receptors can be dissociated by proteolysis of collagen
28. 2+-ATPase in calcium responses of single, fibrinogen-bound platelets
29. The tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate, inhibit the activation of phospholipase A2 in human platelets
30. Binding of vascular anticoagulant a (VACα) to planar phospholipid layers
31. SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis
32. Pyridinyl imidazole inhibitors of p38 mitogen activated protein kinase bind in the ATP site
33. Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
34. Effects of the mitogen-activated protein (MAP) kinase kinase inhibitor 2-(2′-amino-3′-methoxyphenyl)-oxanaphthalen-4-one (PD98059) on human platelet activation
35. Synthesis of a new cell penetrating calpain inhibitor (calpeptin)
36. Adhesion and activation of human platelets induced by convulxin involve glycoprotein VI and integrin α2β1
37. Convulxin binding to platelet receptor GPVI: Competition with collagen related peptides
38. Tyrosine phosphorylation and cytoskeletal reorganisation in platelets are triggered by interaction of integrin receptors with their immobilized ligands
39. Integrin signalling: The platelet paradigm
40. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes
41. Activation of p38 mitogen-activated protein kinase by PYK2/related adhesion focal tyrosine kinase-dependent mechanism
42. Focal adhesion kinase mediates integrin signalling requirement for growth factor activation of MAPK kinase
43. 2+-ATPase inhibitors
44. Microvesicle release is associated with extensive protein tyrosine dephosphorylation in platelets stimulated by A23187 or a mixture of thrombin and collagen
45. Heterogeneity in microparticle formation and exposure of anionic phospholipids at the plasma membrane of single adherent platelets