Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: Regulation by transient integrin activation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 27, Issue 11, 2007, Pages 2484-2490

  Munnix, Imke C A ^a   Kuijpers, Marijke J E ^a   Auger, Jocelyn ^b   Thomassen, Christella M L G D ^a   Panizzi, Peter ^c   Van Zandvoort, Marc A M ^a   Rosing, Jan ^a   Bock, Paul E ^a,c   Watson, Steve P ^b   Heemskerk, Johan W M ^a,d  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Aggregation; Coagulation; Integrin activation; Microdomains; Platelets

Indexed keywords

FIBRIN; INTEGRIN; PHOSPHATIDYLSERINE; PROCOAGULANT; SEROTONIN; FIBRINOGEN RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL POPULATION; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; FLOW; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOGENESIS; THROMBOSIS; THROMBUS; ANIMAL; BLOOD CLOTTING; BLOOD RHEOLOGY; CYTOLOGY; METABOLISM; PHYSIOLOGY; THROMBOCYTE;

ANIMALS; BLOOD COAGULATION; BLOOD PLATELETS; HEMORHEOLOGY; HUMANS; MICE; MICROSCOPY, FLUORESCENCE; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; THROMBOSIS;

EID: 36048996511     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.107.151100     Document Type: Article

References (20)

1. Heemskerk JWM, Kuijpers MJE, Munnix ICA, Siljander PRM. Platelet collagen receptors and coagulation. Trends Cardiovasc Med. 2005;15:86-92.
2. Zwaal RFA, Schroit AJ. Pathophysiologic implications of membrane phospholipid assymetry in blood cells. Blood. 1997;89:1121-1132.
3. Munnix ICA, Harmsma M, Giddings JC, Collins PW, Feijge MAH, Comfurius P, Heemskerk JWM, Bevers EM. Store-mediated calcium entry in the regulation of phosphatidylserine exposure in blood cells from Scott patients. Thromb Hemost. 2003;89:687-695.
4. Butenas S, van 't Veer C, Mann KG. 'Normal' thrombin generation. Blood. 1999;94:2169-2178.
5. Monroe DM, Hoffman M, Roberts HR. Platelets and thrombin generation. Arterioscler Thromb Vasc Biol. 2002;22:1381-1389.
6. London fractionalshortening (FS), Marcinkiewicz M, Walsh PN. A subpopulation of platelets responds to thrombin- or SFLLRN-stimulation with binding sites for factor IXa. J Biol Chem. 2004;279:19854-19859.
7. Kempton CL, Hoffman M, Roberts HR, Monroe DM. Platelet heterogeneity: variation in coagulation complexes on platelet subpopulations. Arterioscler Thromb Vasc Biol. 2005;25:861-866.
8. Panteleev MA, Ananyeva NM, Greco NJ, Ataullakhanov FI. Two subpopulations of thrombin-activated platelets differ in their binding of the components of the intrinsic factor Xa-activating complex. J Thromb Hemost. 2005;3:2545-2553.
9. Kulkarni S, Jackson SP. Platelet factor XIII and calpain negatively regulate integrin aIIbb3 adhesive function and thrombus growth. J Biol Chem. 2004;279:30697-30706.
10. Szasz R, Dale GL. Thrombospondin and fibrinogen bind serotonin- derivatized proteins on COAT-platelets. Blood. 2002;100:2827-2831.
11. Dale GL. Coated-platelets: an emergic component of the procoagulant response. J Thromb Hemost. 2005;3:2185-2192.
12. Jobe SM, Leo L, Eastvold JS, Dickneite G, Ratliff TL, Lentz SR, Di Paola J. Role of FcRγ and factor XIIIa in coated platelet formation. Blood. 2005;106:4146-4151.
13. Auger JM, Kuijpers MJE, Senis YA, Watson SP, Heemskerk JWM. Adhesion of human and mouse platelets to collagen under shear: a unifying model. FASEB J. 2005;19:825-827.
14. Bock PE. Active-site-selective labeling of blood coagulation proteinases with fluorescence probes by the use of thioester peptide chloromethyl ketones. Properties of thrombin derivatives as reporters of prothrombin fragment 2 binding and specificity of the labeling approach for other proteinases. J Biol Chem. 1992;267:14974-14981.
15. Siljander PRM, Munnix ICA, Smethurst PA, Deckmyn H, Lindhout T, Ouwehand WH, Farndale RW, Heemskerk JWM. Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood. Blood. 2004;103:1333-1341.
16. Munnix ICA, Strehl A, Kuijpers MJE, Auger JM, van der Meijden PEJ, van Zandvoort MAM, oude Egbrink MGA, Nieswandt B, Heemskerk JWM. The glycoprotein VI-phospholipase Cγ2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2005;25:2673-2678.
17. Tans G, Rosing J, Thomassen MCLGD, Heeb MJ, Zwaal RFA, Griffin JH. Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles. Blood. 1991;77:2641-2648.
18. Massberg S, Gawaz M, Grüner S, Schulte V, Konrad I, Zohlnhofer D, Heinzmann U, Nieswandt B. A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med. 2003;197:41-49.
19. Ni H, Denis CV, Subbarao S, Degen JL, Sato TN, Hynes RO, Wagner DD. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest. 2000;106:385-392.
20. Siljander P, Carpen O, Lassila R. Platelet-derived microparticles associate with fibrin during thrombosis. Blood. 1996;87:4651-4663.