Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 20, 2009, Pages 7093-7099

  Carta, Fabrizio ^a   Maresca, Alfonso ^a   Scozzafava, Andrea ^a   Vullo, Daniela ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

CA IX; CA XII; Carbonic anhydrase; Diazenylbenzenesulfonamides; Isoform selective inhibitor; Tumor associated isoforms

Indexed keywords

BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII;

ARTICLE; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYPOXIC CELL; SOLID TUMOR;

CARBONIC ANHYDRASE INHIBITORS; CYTOSOL; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; NEOPLASMS; SPECTROPHOTOMETRY, INFRARED; SULFONAMIDES;

EID: 71749095146     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.003     Document Type: Article

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