Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 20, 2009, Pages 7324-7336

  Gangjee, Aleem ^a   Li, Wei ^a   Lin, Lu ^a   Zeng, Yibin ^a   Ihnat, Michael ^b   Warnke, Linda A ^b   Green, Dixy W ^b   Cody, Vivian ^c   Pace, Jim ^c   Queener, Sherry F ^d  

^a DUQUESNE UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^d INDIANA UNIVERSITY   (United States)

Author keywords

Dihydrofolate reductase; EGFR; Multitargeted inhibitors; PDGFR

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 5 [2 (2 METHOXYPHENYL)PROP 1 EN 1 YL]FURO[2,3 D]PYRIMIDINE 2,4 DIAMINE; 6,7 DIMETHYL 2 PHENYLQUINOXALINE; DIHYDROFOLATE REDUCTASE INHIBITOR; ERLOTINIB; FURO[2,3 D]PYRIMIDINE DERIVATIVE; GEFITINIB; METHOTREXATE; PROTEIN TYROSINE KINASE INHIBITOR; SEMAXANIB; TRIMETHOPRIM; UNCLASSIFIED DRUG; VANDETANIB;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NONHUMAN; OXIDATION REDUCTION REACTION; X RAY CRYSTALLOGRAPHY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 71749089638     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.044     Document Type: Article

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