Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2′-hydroxydibenz[b,f]azepin-5-yl)methylpteridine

Acta Crystallographica Section D: Biological Crystallography

Volumn 64, Issue 9, 2008, Pages 977-984

  Cody, Vivian ^a,b   Pace, Jim ^a   Rosowsky, Andre ^c  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Dihydrofolate reductase; Inhibitors

Indexed keywords

2,4 DIAMINO 6 (2' HYDROXYDIBENZ(B,F)AZEPIN 5 YL)METHYLPTERIDINE; 2,4-DIAMINO-6-(2'-HYDROXYDIBENZ(B,F)AZEPIN-5-YL)METHYLPTERIDINE; BENZAZEPINE DERIVATIVE; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; HOLOENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PTERIDINE DERIVATIVE;

ANIMAL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; MOUSE; X RAY CRYSTALLOGRAPHY;

ANIMALS; BENZAZEPINES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID ANTAGONISTS; HOLOENZYMES; MICE; MODELS, MOLECULAR; NADP; PTERIDINES; TETRAHYDROFOLATE DEHYDROGENASE;

MAMMALIA; PNEUMOCYSTIS; PNEUMOCYSTIS CARINII;

EID: 49749085217     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444908022348     Document Type: Article

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