Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines

Journal of Medicinal Chemistry

Volumn 43, Issue 16, 2000, Pages 3125-3133

  Gangjee, A ^a   Zeng, Y ^a   McGuire, J J ^b   Kisliuk, R L ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; FOLYLPOLYGLUTAMATE SYNTHASE; N [4 [1 METHYL 2 (2,4 DIAMINOFURO[2,3 D]PYRIMIDIN 5 YL)ETHYL]BENZOYL]GLUTAMIC ACID; PYRIMIDINE DERIVATIVE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IC 50; LACTOBACILLUS CASEI; NONHUMAN; RAT; SQUAMOUS CELL CARCINOMA; STRUCTURE ACTIVITY RELATION; T CELL LEUKEMIA;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL DIVISION; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; ESCHERICHIA COLI; FOLIC ACID; FOLIC ACID ANTAGONISTS; HUMANS; LACTOBACILLUS CASEI; RATS; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE; TOXOPLASMA; TUMOR CELLS, CULTURED;

EID: 0034632877     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000130i     Document Type: Article

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