Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase

Acta Crystallographica - Section D Biological Crystallography

Volumn 59, Issue 9, 2003, Pages 1603-1609

  Cody, Vivian ^a   Luft, Joseph R ^a   Pangborn, Walter ^a   Gangjee, Aleem ^b  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b DUQUESNE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 6 ((3',4',5' TRIMETHOXY N METHYLANILINO)METHYL)PYRIDO(3,2 D)PYRIMIDINE; 2,4-DIAMINO-6-((3',4',5'-TRIMETHOXY-N-METHYLANILINO)METHYL)PYRIDO(3,2-D)PYRIMIDINE; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; PYRIMIDINE DERIVATIVE;

ARTICLE; BINDING SITE; CHEMISTRY; CRYSTALLIZATION; HUMAN; PROTEIN BINDING; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID ANTAGONISTS; HUMANS; PROTEIN BINDING; PROTEIN CONFORMATION; PYRIMIDINES; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0042786613     PISSN: 09074449     EISSN: None     Source Type: Journal    
DOI: 10.1107/S0907444903014963     Document Type: Article

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