Antiangiogenic and antitumor agents: Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 23, 2003, Pages 5155-5170

  Gangjee, Aleem ^a   Yang, Jie ^a   Ihnat, Michael A ^b   Kamat, Shekhar ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(4 CHLORO 2 FLUOROPHENYL)(6,7 DIMETHOXYQUINAZOLIN 4 YL)AMINE; 2 AMINO 4 (3 BROMOANILINO) 6 (1 NAPHTHYLMETHYL)PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 (2 CHLOROBENZYL)PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 (2 METHYLBENZYL)PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 (2 NAPHTHYLMETHYL)PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 (2,4 DICHLOROBENZYL)PYRRPLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 (2,5 DIMETHOXYBENZYL)PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 (3,4 DICHLOROBENZYL)PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 (3,4,5 TRIMETHOXYBENZYL)PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 (4 CHLOROBENZYL)PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 (4 PHENYLBENZYL)PYRROLO[2,3 D]PYRIMIDINE; 2 AMINO 4 (3 BROMOANILINO) 6 BENZYLPYRROLO[2,3 D]PYRIMIDINE; 4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 6,7 DIMETHYL 2 PHENYLQUINOXALINE; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; KETONE DERIVATIVE; N [4 (3 BROMOANILINO) 6 QUINAZOLINYL]ACRYLAMIDE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; PYRIMIDINONE DERIVATIVE; SEMAXANIB; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ARTICLE; ASSAY; CELL GROWTH; CHEMICAL REACTION KINETICS; CHLORINATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; POLYMERIZATION; STRUCTURE ACTIVITY RELATION;

GALLUS GALLUS;

EID: 0242329791     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.08.034     Document Type: Article

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